دانلود مقالات ISI درباره Bace-1 Inhibitors + ترجمه فارسی

2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies

Keywords: Alzheimer's disease; BACE-1 inhibitors; Docking study; BBB; Permeability; Surface Plasmon Resonance (SPR); PAMPA;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and in vitro evaluation studies of sulfonyl-amino-acetamides as small molecule BACE-1 inhibitors

Keywords: Alzheimer’s disease; BACE-1 inhibitors; Sulfonyl-amino-acetamide; Docking simulation; FRET assay

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies

Keywords: Alzheimer's disease; BACE-1 inhibitors; 4-Oxo-1,4-dihydro-quinoline-3-carboxamide; Docking study

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy

Keywords: Alzheimer's disease (AD); β-Secretase; BACE-1 inhibitors; Aminoimidazoles; Efflux; In vivo brain efficacy;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors

Keywords: BACE-1 inhibitors; Alzheimer’s disease; BACE-1 crystallography; P-gp knockout mice

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Investigation of α-phenylnorstatine and α-benzylnorstatine as transition state isostere motifs in the search for new BACE-1 inhibitors

Keywords: Alzheimer's disease; BACE-1 inhibitors; tert-Hydroxyl; Transition state mimic; α-Phenylnorstatine; α-Benzylnorstatine;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Macrocyclic BACE-1 inhibitors acutely reduce Aβ in brain after po application

Keywords: Alzheimer’s disease; BACE-1 inhibitors; MDR1–MDCK; P-Glycoprotein; Reduction of Abeta in transgenic APP51/16 mice

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Discovery of potent BACE-1 inhibitors containing a new hydroxyethylene (HE) Scaffold: Exploration of P1′ alkoxy residues and an aminoethylene (AE) central core

Keywords: Alzhemier’s disease; BACE-1 inhibitors; Hydroxyethylene (HE) isostere; Aminoethylene (AE) isostere; P1′ modifications; Peptidomimetics

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors

Keywords: BACE-1 inhibitors; Hydroxyethylamine; 1,4-Dihydropyridine; Alzheimer's disease1,4-DHP, 1,4-Dihydropyridine; Aβ40, 40-Residue β-amyloid peptide; Aβ42, 42-Residue β-amyloid peptide; AD, Alzheimer's diseases; AP, Alkaline phosphatase; APP, β-Amyloid precurso

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis of potent BACE-1 inhibitors incorporating a hydroxyethylene isostere as central core

Keywords: Alzheimer's disease; BACE-1 inhibitors; Hydroxylethylene; Transition state isostere

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Synthesis and evaluation of a new class of tertiary alcohol based BACE-1 inhibitors

Keywords: Alzheimer's disease; BACE-1 inhibitors; Transitions state isostere;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues

Keywords: Alzheimer’s disease; BACE-1 inhibitors; P1 modifications; Peptidomimetics

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Discovery and SAR of isonicotinamide BACE-1 inhibitors that bind β-secretase in a N-terminal 10s-loop down conformation

Keywords: BACE-1 inhibitors; Alzheimer’s disease; 2,6-Diamino-isonicotinamide

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه