Keywords: 4-ABP; 4-aminobiphenyl; ARNT; AHR nuclear translocator; AHR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BPDE; BaP diol epoxide; CAP; concentrated ambient particles; COX-1,-2; cyclooxygenase-1,-2; EGFR; epidermal growth factor receptor; FICZ; 6-formyl
مقالات ISI (ترجمه نشده)
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Keywords: AHR; aromatic hydrocarbon receptor; BP; benzo[a]pyrene; BPDE; benzo[a]pyrene diolepoxide; CYP; cytochrome P450; ELISA; enzyme linked immunosorbent assay; GST; glutathione S-transferase; LBW; low birth weight LD linkage disequilibrium; LOD; limit of detect
Keywords: Air pollution; Carcinogenic PAH; Dioxin-like activity; DNA adducts; Oxidative damage; Particulate matter; 8-oxodG; 8-oxodeoxyguanosine; dae; aerodynamic diameter; B[a]P; benzo[a]pyrene; B[b]F; benzo[b]fluoranthene; B[k]F; benzo[k]fluoranthene; B[a]A; benz
Keywords: BaP; benzo(a)pyrene; BPDE; benzo(a)pyrene diol epoxide; CI; confidence interval; DiMeIQX; 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline; HCA; heterocyclic amine; HWE; Hardy Weinberg Equilibrium; LRT; likelihood ratio test; MeIQx; 2-amino-3,8-dimethylim
Keywords: AhR; aryl hydrocarbon receptor; BaP; benzo(a)pyrene; BPDE; benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide; BW; body weight; FDR; false discovery rate; GO; Gene Ontology; GSH; glutathione; MHC; major histocompatibility complex; NKT; natural killer T cells; PA
GC-APLI-MS as a powerful tool for the analysis of BaP-tetraol in human urine
Keywords: APLI; atmospheric pressure laser ionization; BPDE; anti-benzo[a]pyrene 7,8-dihydrodiol-9,10-epoxide; OH-PAH; monohydroxylated PAH; BaP; benzo[a]pyrene; PAH; polycyclic aromatic hydrocarbons; Benzo[a]pyrene-tetraol; Atmospheric pressure laser ionization; G
Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats
Keywords: AhR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BPDE; benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; COMT; catechol-O-methyltransferase; CYP; cytochrome P450; EE2; 17α-ethinylestradiol; DMSO; dimethylsulfoxide; ED; endocrine disruptor; dG-N2-BPDE; 10-
Recent technical and biological development in the analysis of biomarker N-deoxyguanosine-C8-4-aminobiphenyl
Keywords: 4-ABP; 4-aminobiphenyl; dG-C8-4-ABP; N-deoxyguanosine-C8-4-aminobiphenyl; LC-MS; liquid chromatography-mass spectrometry; PAHs; polycyclic aromatic hydrocarbons; NOCs; N-nitroso compounds; AAs; aromatic amines; CYP1A2; cytochrome P450 1A2; N-OH-ABP; N-hyd
Benzo(a)pyren-7,8-dihydrodiol-9,10-epoxide induces human trophoblast Swan 71 cell dysfunctions due to cell apoptosis through disorder of mitochondrial fission/fusion
Keywords: BPDE; Human trophoblast Swan 71 cell; Mitochondria; Apoptosis; Fission/fusion;
Inorganic arsenic inhibits the nucleotide excision repair pathway and reduces the expression of XPC
Keywords: Arsenic; UV light; Nucleotide excision repair; XPC; Skin cancer; Lung cancer; 6-4 PP; 6-4 Photoproduct; B[a]P; Benzo(a)pyrene; BPDE; Benzo(a)pyrene diol epoxide; CPD; Cyclobutane pyrimidine dimer; DDB2; Damaged DNA Binding Protein; NER; Nucleotide Excisio
Benzo[a]pyrene-induced DNA damage associated with mutagenesis in primary human activated T lymphocytes
Keywords: AhR; aryl hydrocarbon receptor; AMC; 7-amino-4-methylcoumarin; α-NF; alpha-naphthoflavone; ATM; ataxia telangiectasia mutated; B[a]P; benzo[a]pyrene; BPDE; B[a]P diol epoxide; CYPs; cytochromes P-450; DMSO; dimethyl sulfoxide; DDR; DNA damage response; D
Benzo[a]pyrene-7,8-diol-9,10-epoxide suppresses the migration and invasion of human extravillous trophoblast HTR-8/SVneo cells by down-regulating MMP2 through inhibition of FAK/SRC/PI3K/AKT pathway
Keywords: ANOVA; analysis of variance; BaP; benzo[a]pyrene; BPDE; benzo[a]pyren-7,8-dihydrodiol-9,10-epoxide; DMSO; dimethylsulfoxide; ECM; extracellular matrix; EVT; extravillous trophoblast; EGF; epidermal growth factor; eNOS; endothelial nitric oxide synthase; F
DNA methylation in lung tissues of mouse offspring exposed in utero to polycyclic aromatic hydrocarbons
Keywords: Polycyclic aromatic hydrocarbon; Lung cancer; DNA methylation; Transplacental; Epigenetics; Methylated DNA immunoprecipitation; AdjBaP; lung tissue adjacent to a tumor from BaP-exposed offspring; AdjDBC; lung tissue adjacent to a tumor from BaP-exposed of
Inhibition of the formation of benzo[a]pyrene adducts to DNA in A549 lung cells exposed to mixtures of polycyclic aromatic hydrocarbons
Keywords: B[a]A; benz[a]anthracene; B[a]P; benzo[a]pyrene; B[b]F; benzo[b]fluoranthene; B[e]P; benzo[e]pyrene; B[ghi]P; benzo[g,h,i]perylene; B[j]F; benzo[j]fluoranthene; B[k]F; benzo[k]fluoranthene; BPDE; benzo[a]pyrene diol epoxide; Chrys; chrysene; CYP450; cytoc
Combined effects of AHR, CYP1A1, and XRCC1 genotypes and prenatal maternal smoking on infant birth size: Biomarker assessment in the Hokkaido Study
Keywords: AHR; aromatic hydrocarbon receptor; BP; benzo[a]pyrene; BPDE; benzo[a]pyrene 7,8-diol oxide; CI; confidence interval; CYP; cytochrome P450; dbSNP; database single nucleotide polymorphism; GST; glutathione S-transferase; PAH; polycyclic aromatic hydrocarbo
Resveratrol ameliorates benzo(a)pyrene-induced testicular dysfunction and apoptosis: involvement of p38 MAPK/ATF2/iNOS signaling
Keywords: AhR; aryl hydrocarbon receptor; ATF2; activating transcription factor 2; BPDE; benzo(a)pyrene-7,8-diol-9,10-epoxide; CYP11A1; cytochrome P450 11A1; CYP1A1; cytochrome P450 1A1; iNOS; inducible nitric oxide synthase; MDA; malondialdehyde; PARP; poly-ADP ri
Polymorphisms in ERCC1 and ERCC2/XPD genes and carcinogen DNA adducts in human lung
Keywords: ADC; adenocarcinoma; BPDE; benzo[a]pyrene diol epoxide; ERCC1; excision repair cross-complementing group 1; DRC; DNArepair capacity; ERCC2/XPD; excision repair cross-complementing group 2/xeroderma pigmentosum group D; GM; geometric mean; GSD; geometric s
Protective effects of green tea polyphenols against benzo[a]pyrene-induced reproductive and trans-generational toxic effects in Japanese Medaka (Oryzias latipes)
Keywords: BaP; benzo[a]pyrene; GTP; green tea polyphenols; VTG; vitellogenin; CYP1A1; cytochrome P450 1A1; CYP17; cytochrome P450-17a; GSH-Px; glutathione peroxidase; RPL-7; ribosomal Protein L7; GST; glutathione (GSH) S-transferases; dph; days post hatch; BPDE; be
Lung cancer risk from PAHs emitted from biomass combustion
Keywords: 2-MeN; 2-methylnapthalene; Ace; acenaphthene; Acy; acenapthylene; B[a]P; benzo[a]pyrene; B[a]Peq; equivalent concentration of benzo[a]pyrene, ng/m3; BaA; benzo[a]anthracene; BeP; benzo[e]pyrene; BgP; benzo[g,h,i]perylene; BPDE; benzo[a]pyrene diol-epoxide
Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
Keywords: A549; human adenocarcinoma alveolar basal epithelial cells, type II; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; DB[a,l]P; dibenzo[a,l]pyrene; B[k]F; benzo[k]fluoranthene; BPDE; benzo[a]pyrene diolepoxide; cDNA; complementary DNA; c-PAH; carcin
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Keywords: AFB; aflatoxin B1; AhR; aryl hydrocarbon receptor; APAP; acetaminophen; BaP; benzo(α) pyrene; BMD; benchmark dose; BNA; Bayesian network analysis; BPDE; benzo(a) pyrene diolepoxide; CDKN1A; cyclin-dependent kinase inhibitor 1A; cDNA; copy DNA; CES; criti
Single nucleotide polymorphism in hMLH1 promoter and risk of tobacco-related oral carcinoma in high-risk Asian Indians
Keywords: hMLH1; human MutL homolog 1; MMR; mismatch repair; SNP; single nucleotide polymorphism; OSCC; oral squamous cell carcinoma; PCR-RFLP; polymerase chain reaction-restriction fragment length polymorphism; BPDE; benzo(a)pyrene diol epoxide; DRC; DNA repair ca
Ultrafine particles are not major carriers of carcinogenic PAHs and their genotoxicity in size-segregated aerosols
Keywords: Air pollution; Ultrafine particles; Carcinogenic PAHs; DNA adducts; Genotoxicity; dae; aerodynamic diameter; B[a]P; benzo[a]pyrene; B[b]F; benzo[b]fluoranthene; B[k]F; benzo[k]fluoranthene; B[a]A; benz[a]anthracene; BPDE; benzo[a]pyrene-r-7,t-8-dihydrodio
Dioxin suppresses benzo[a]pyrene-induced mutations and DNA adduct formation through cytochrome P450 1A1 induction and (±)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide inactivation in human hepatoma cells
Keywords: Benzo[a]pyrene; BPDE; DNA adduct; TCDD; Cytochrome P450 1A1
Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in human bronchiolar epithelium cells independent of the mitochondria permeability transition pore
Keywords: 16HBE; human bronchiolar epithelium cells; ÎΨm; mitochondrial membrane potential; B[a]P; benzo[a]pyrene; BPDE; anti-benzo[a]pyrene-7,8-diol-9,10-epoxide; cyt c; cytochrome c; DCFH-DA; 2â²,7â²-dichloro-cluorescein diacetate; DMSO; dimethyl sulfoxide; J
On stabilization of a neutral aromatic ligand by Ï-cation interactions in monoclonal antibodies
Keywords: Ab; antibody; Arg; arginine; mAb; monoclonal antibody; BP; benzo[a]pyrene; BPDE; benzo[a]pyrene diolepoxide; BPT; benzo[a]pyrene tetrol; CE; capillary electrophoresis; FLNS; fluorescence line-narrowing spectroscopy; fwhm; full width at half maximum; LIF;
The impact of EGFR stimulation and inhibition on BPDE induced DNA fragmentation in oral/oropharyngeal mucosa in vitro
Keywords: EGFR; Mutagen sensitivity; BPDE; Comet assay;
Phenylalanine 171 is a molecular brake for translesion synthesis across benzo[a]pyrene-guanine adducts by human DNA polymerase kappa
Keywords: Pol; DNA polymerase; TLS; translesion DNA synthesis; dG; N2-deoxyguanosine; BP; benzo[a]pyrene; BPDE; benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; (+)-BPDE-N2-dG; (+)-trans-anti-BPDE-N2-dG; (â)-BPDE-N2-dG; (â)-trans-anti-BPDE-N2-dG; F171; phenylalanin
Concentration dependent effects of tobacco particulates from different types of cigarettes on expression of drug metabolizing proteins, and benzo(a)pyrene metabolism in primary normal human oral epithelial cells
Keywords: AhR; aryl hydrocarbon receptor; BaP; benzo(a)pyrene; BPDE; (±)-anti-dihydrodiol 9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene; ECL; Eclipse; MS; mentholated smooth; NOE; normal oral epithelial cells; PAH; polycyclic aromatic hydrocarbon; Pt; patient; 2RF4
Advances in carcinogenesis: A historical perspective from observational studies to tumor genome sequencing and TP53 mutation spectrum analysis
Keywords: 6,4-PPs; pyrimidine(6-4)pyrimidone photoproducts; AK; Actinic Keratosis; BaP; benzo(a)pyrene; BPDE; benzo(a)pyrene diol epoxide; BCC; Basal cell carcinoma; CPD; cyclobutane pyrimidine dimers; CRC; colorectal carcinoma; ER; estrogen receptor; ERG; ETS re
Assessment of the protective effects of selected dietary anticarcinogens against DNA damage and cytogenetic effects induced by benzo[a]pyrene in C57BL/6J mice
Keywords: B[a]P; benzo[a]pyrene; BITC; benzyl isothiocyanate; BPDE; Benzo(a)pyrene diolepoxide; CHL; chlorophyllin; dN; deoxyribonucleotides; EA; ellagic acid; FACS; fluorescenceactivated cell sorting; FPG; formamidopyrimidine glycosylase; GT; glyceryl trioctanoin;
DNA repair and replication influence the number of mutations per adduct of polycyclic aromatic hydrocarbons in mammalian cells
Keywords: PAH; polycyclic aromatic hydrocarbons; PAH-DE; polycyclic aromatic hydrocarbon diolepoxide; BPDE; (+)-anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo-[a]pyrene; DBADE; (±)-anti-3,4-dihydroxy-1,2-epoxy-1,2,3,4-tetrahydrodibenz-[a,h]anthracene; DBPD
Silymarin protects PBMC against B(a)P induced toxicity by replenishing redox status and modulating glutathione metabolizing enzymes-An in vitro study
Keywords: PAHs; Polycyclic aromatic hydrocarbons; B(a)P; Benzo(a)pyrene; QD; Quinone derivatives; ROS; Reactive oxygen species; LPO; Lipid peroxidation; PO; Protein oxidation; GSH; Reduced glutathione; GSSG; Oxidised glutathione; GR; Glutathione reductase; GPx; Glu
Transforming Growth Factor-alpha reduces carcinogen-induced DNA damage in mini-organ cultures from head-and-neck cancer patients
Keywords: EGFR; TGF-α; Mucosa tissue cultures; BPDE; Comet assay
H2AX phosphorylation in A549 cells induced by the bulky and stable DNA adducts of benzo[a]pyrene and dibenzo[a,l]pyrene diol epoxides
Keywords: PAH; Diol epoxide; BPDE; DBPDE; DNA adducts; H2AX
DNA repair and chromosomal alterations
Keywords: Chromosomal aberrations; DNA double strand breaks; DNA repair; Ionising radiation; BPDE; Acetaldehyde
DNA repair deficiency and BPDE-induced chromosomal alterations in CHO cells
Keywords: BPDE; DNA repair; Chromosomal aberrations; Sister chromatid exchanges; Benzo(α)pyrene;
Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions
Keywords: ANPG; alkyl-DNA-glycosylase; ApoE-KO; apolipoprotein E knockout; BPDE; benzo(a)pyrene diolepoxide; DRZ; diagonal radioactive zone; ÉdA; 1,N6-ethenodeoxyadenine; ÉdC; 3,N4-ethenodeoxycytosine; HNE; trans-4-hydroxy-2-nonenal; LOH; loss of heterozigosity;
Translesion DNA replication proteins as molecular targets for cancer prevention
Keywords: Mutagenesis; Translesion DNA synthesis; RAD18; REV1; UV; BPDE;
Benzo[a]pyrene and its metabolites combined with ultraviolet A synergistically induce 8-hydroxy-2â²-deoxyguanosine via reactive oxygen species
Keywords: BaP; benzo[a]pyrene; BPDE; benzo[a]pyrene-r-7,t-8-dihydrodiol-t-9,10-epoxide (+/â)(anti); NBT; nitroblue tetrazolium; RNO; p-nitrosodimethylaniline; 8-OHdG; 8-hydroxy-2â²-deoxyguanosine; Benzo[a]pyrene; Metabolite; BPDE; Ultraviolet A; 8-Hydroxy-2â²-d
Coffee consumption induces GSTP in plasma and protects lymphocytes against (±)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: Results of controlled human intervention trials
Keywords: Coffee; Glutathione-S-transferase; Human intervention; SCGE; BPDE; DNA protection;
Induction of CYP1A1 and CYP1B1 and formation of carcinogen-DNA adducts in normal human mammary epithelial cells treated with benzo[a]pyrene
Keywords: Polycyclic aromatic hydrocarbons; Chemiluminescence immunoassay; Metabolic activation; Cell culture; Carcinogenesis; DNA damage; BP; benzo[a]pyrene; BP-7,8-oxide; benzo[a]pyrene-7,8-epoxide; BP-7,8-dihydrodiol; trans-7,8-dihydro-7,8-dihydroxybenzo[a]pyren
Perspectives on the molecular epidemiology of aerodigestive tract cancers
Keywords: ADH; alcohol dehydrogenase; APC; adenomatous polyposis coli; 5-AZA-CdR; 5-azacytidine2â²deoxycytidine; BPDE; benzo(a)pyrene diol epoxide; BRCA1; breast cancer1; CCND1; cyclin D1; CDH1; cadherin 1; CDH13; cadherin 13; CDK4; cyclin-dependent kinase 4; CDKN