Future therapeutic options for patients with Waldenström macroglobulinemia
Keywords: BTK; BTK; BCL2; CD38; CXCR4; MYD88; Waldenström;
مقالات ISI BTK (ترجمه نشده)
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Btk inhibition treats TLR7/IFN driven murine lupus
Keywords: BTK; Btk; Bruton's tyrosine kinase; TLR7; Toll-like receptor 7; BCR; B cell receptor; FcR; Fc receptor; SLE; systemic lupus erythematosus; IFN; interferon; FACS; fluorescence-activated cell sorting; MMF; mycophenolate mofetil; Lupus; Bruton's tyrosine kinase;
Immunoreceptors on neutrophils
Keywords: BTK; ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
The Neutrophil Btk Signalosome Regulates Integrin Activation during Sterile Inflammation
Keywords: BTK; Btk; fMLF; Src family kinases; phospholipase C; WASp; signaling; integrin
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
Keywords: BTK; APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas
Finding the perfect spot for fluorine: Improving potency up to 40-fold during a rational fluorine scan of a Bruton's Tyrosine Kinase (BTK) inhibitor scaffold
Keywords: BTK; Bruton's Tyrosine Kinase; BTK; Structure-based drug design; Fluorine scan; Rational fluorine scan;
Development and pharmacological validation of novel methods of B cell activation in rat whole blood
Keywords: BTK; B cell; BTK; Dextran-coupled anti-IgD; Methods; PI3Kδ; Rat; Synergy; SYK; TLR9; Whole blood;
Potent and selective Bruton's tyrosine kinase inhibitors: Discovery of GDC-0834
Keywords: BTK; Kinase inhibitor; Bruton's tyrosine kinase; Btk; Rheumatoid arthritis; GDC-0834; Amide hydrolysis; Single dose IND;
PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene
Keywords: BTK; ARF6; ADP ribosylation factor 6; BAC; bacterial artificial chromosome; BLAST; basic local alignment search tool; BSAP; B-cell lineage specific activator protein; BTK; Bruton's tyrosine kinase; CD; cluster of differentiation; Cq; quantitative PCR cycle; CT
The Ras/Rap GTPase activating protein RASA3: From gene structure to in vivo functions
Keywords: BTK; Ras; Rap; GTPase activating protein; RASA3; Megakaryocyte; Platelet; Cancer; Leukemia; AML; acute myeloid leukemia; Btk; Bruton tyrosine kinase; [Ca2+]i; intracellular calcium concentration; EBV; Epstein-Barr virus; GAP; GTPase activating protein; GEF; gu
Revascularization for Critical Limb Ischemia Using the SpiderFX Embolic Protection Device in the Below-the-Knee Circulation: Initial Results
Keywords: BTK; BTK; below-the-knee; CLI; critical limb ischemia; EPD; embolic protection device; MALE; major adverse limb event; PAD; peripheral arterial disease;
Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases
Keywords: BTK; BTK; Autoimmune diseases; Purine;
The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss
Keywords: BTK; Osteoclast; Btk; Ibrutinib; Osteoporosis; Inflammatory bone destruction;
The pivotal position of the actin cytoskeleton in the initiation and regulation of B cell receptor activation
Keywords: BTK; Abp1; actin binding protein 1; BCR; B cell receptor; Btk; Bruton's tyrosine kinase; ERM; ezrin/radixin/moesin; ITAMs; immunoreceptor tyrosine-based activation motifs; mIg; membrane immunoglobulin; PI3K; phosphatidylinositol-3 kinase; PI(3,4,5)P3; phosphat
The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies
Keywords: BTK; Chronic lymphocytic leukemia; CLL; Microenvironment; Nurselike cells; Stromal cells; CXCR4; CXCL12; B cell receptor; BCR; SYK; BTK; PI3Kδ; Chemokines; Chemokine receptors; T cells; NK cells;
Microenvironment dependency in Chronic Lymphocytic Leukemia: The basis for new targeted therapies
Keywords: BTK; Chronic Lymphocytic Leukemia; microenvironment; nurselike cells; stromal cells; CXCR4; CXCL12; B cell receptor; SYK; BTK; PI3Kδ
Contemporary Systematic Review and Meta-Analysis of Early Outcomes with Percutaneous Treatment for Infrapopliteal Atherosclerotic Disease
Keywords: BTK; BMS; bare metal stent; BTK; below the knee; CLI; critical limb ischemia; DES; drug-eluting stent; PTA; percutaneous transluminal angioplasty; TLR; target lesion revascularization;
Drug Delivering Technology for Endovascular Management of Infrainguinal Peripheral Artery Disease
Keywords: BTK; drug-coated stents; drug-coated balloons; peripheral artery disease; review; BMS; bare-metal stent(s); BTK; below-the-knee; CLI; critical limb ischemia; DCB; drug-coated balloon(s); DCS; drug-coated stent(s); PAD; peripheral artery disease; PES; paclitaxe
Immune deficiencies, infection, and systemic immune disordersThe BLNK adaptor protein has a nonredundant role in human B-cell differentiation
Keywords: BTK; Agammaglobulinemia; B-lymphocyte; lymphopoiesis; BLNK protein; gene rearrangement; pre-B-cell receptor; SCID-hu mouse; gene therapy; BCR; B-cell receptor; BM; Bone marrow; Btk; Bruton tyrosine kinase; INSERM; Institut National de la Santé et de la Rech
Structural evaluation of BTK and PKCδ mediated phosphorylation of MAL at positions Tyr86 and Tyr106
Keywords: BTK; MAL; TIRAP; BTK; PKCδ; Protein–protein interactions (PPIs); Tyr86; Tyr106; Adenosine triphosphate (ATP)
Molecular targets on mast cells and basophils for novel therapies
Keywords: BTK; Mast cell; basophil; mediator; receptor; signaling protein; survival protein; drug; therapy; BCL-2; B-cell lymphoma 2; BH; BCL-2 homology; Bs; Basophils; BTK; Bruton tyrosine kinase; CB; Endocannabinoid receptor; CRAC; Calcium release-activated calcium;
Btk-dependent epithelial cell rearrangements contribute to the invagination of nearby tubular structures in the posterior spiracles of Drosophila
Keywords: BTK; Respiratory system; Posterior spiracles; Organogenesis; Morphogenesis; Planar cell rearrangements; Invagination; Btk; Tec; src kinases;
Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis
Keywords: BTK; Sphingosine-1-phosphate; B cells; migration; autoimmunity; circulation; fingolimod; FTY720; primary immunodeficiencies; ALL; Acute lymphoblastic leukemia; B-CLL; B-cell chronic lymphocytic leukemia; BCR; B-cell receptor; BFP; Blue fluorescent protein; BTK
BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB
Keywords: BTK; BAFF; B cell-activating factor; BTK; Bruton's tyrosine kinase; CLL; chronic lymphocytic leukaemia; FLIP; FLICE (caspase-8)-like inhibitory protein; ibrutinib; 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-o
Combined CpG and poly I:C stimulation of monocytes results in unique signaling activation not observed with the individual ligands
Keywords: BTK; TLRs; Toll-like receptors; CpG; unmethylated CpG oligodeoxynucleotides; poly I:C; polyinosinic-polycytidylic acid; NO; nitric oxide; iNOS; inducible nitric oxide synthase; CREB; cAMP response element-binding protein; NFκB; nuclear factor κB; PRRs; pat
B-cell biology and development
Keywords: BTK; B cell; B lymphocyte; immunodeficiency; development; humoral immunity; autoimmunity; tolerance; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B-cell activator of the TNF-α family (aka BLYS); BAFF-R; BAFF recept
B-lymphocyte lineage cells and the respiratory system
Keywords: BTK; B cells; plasma cells; plasmablasts; respiratory diseases; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B cell-activating factor of the TNF family; BAL; Bronchoalveolar lavage; BCMA; B-cell maturation antigen
Bruton's Tyrosine Kinase mediates platelet receptor-induced generation of microparticles: A potential mechanism for amplification of inflammatory responses in rheumatoid arthritis synovial joints
Keywords: BTK; BTK; GPVI; CLEC2; Platelets; Microparticles
The biological rationale and clinical efficacy of inhibition of signaling kinases in chronic lymphocytic leukemia
Keywords: BTK; Chronic lymphocytic leukemia; Microenvironment; Signaling; BTK; Syk; PI-3 kinase
17p Deletion in Chronic Lymphocytic Leukemia
Keywords: BTK; CLL; 17p deletion; High-risk; Targeted therapy; BTK; PI3K; BH3 mimetic;
A novel BTK-like protein involved in immune response in Lethenteron japonicum
Keywords: BTK; BTK; Lethenteron japonicum; Signal transduction; Immune response
Technical and Clinical Long-Term Results of Infrapopliteal Percutaneous Transluminal Angioplasty for Critical Limb Ischemia
Keywords: BTK; ATK; above the knee; BTK; below the knee; CLI; critical limb ischemia; LSR; limb salvage rate; PTA; percutaneous transluminal angioplasty; SFA; superficial femoral artery; TF; technical failure; TS; technical success; TVD; total vessel dilation;
Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
Keywords: BTK; Haemophilus influenzae; infections; immunoglobulins; IgM; immunodeficiency; AID; Activation-induced deaminase; BTK; Bruton tyrosine kinase; CD40L; CD40 ligand; HIgM; Hyper-IgM; NTHi; Nontypeable Haemophilus influenzae; PHG; Panhypogammaglobulinemia; RR; R
STIM1 tyrosine-phosphorylation is required for STIM1-Orai1 association in human platelets
Keywords: BTK; STIM1; Stromal interaction molecule 1; SOCE; operated Ca2+ entry mechanism; SERCA2b; sarco-endoplasmic Ca2+-ATPase isotype 2b; IP3R II; inositol trisphosphate receptor; TRPC; transient receptor potential channel; SKFs; Src family of tyrosine kinases; Btk;
Defects in acute responses to TLR4 in Btk-deficient mice result in impaired dendritic cell-induced IFN-γ production by natural killer cells
Keywords: BTK; Btk; TLRs; IFN-γ; Antigen presenting cells; Natural killer cells
Interactions between age, sex, and hormones in experimental ischemic stroke
Keywords: BTK; AChE; acetylcholinesterase; AIF; apoptosis inducing factor; AMP; adenosine monophosphate; ATP; adenosine-5â²-triphosphate; AVPV; anteroventral periventricular nucleus; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; BTK; Br
Toll-like receptor 4-, 7-, and 8-activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines
Keywords: BTK; Bruton tyrosine kinase; X-linked agammaglobulinemia; Toll-like receptors; MyD88 adapter-like protein; Toll-IL-1 receptor domain-containing adapter protein; BTK; Bruton tyrosine kinase; CVID; Common variable immunodeficiency; ERK; Extracellular signal-
CommentaryClinical perspectives for irreversible tyrosine kinase inhibitors in cancer
Keywords: BTK; AE; adverse event; BTK; Bruton's tyrosine kinase; CI; confidence interval; CLL; chronic lymphocytic leukemia; CR; complete response; DTL; dose limiting toxicity; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth factor receptor; HR; hazard r
The microenvironment in mantle cell lymphoma: Cellular and molecular pathways and emerging targeted therapies
Keywords: BTK; Mantle cell lymphoma (MCL); Microenvironment; CXCR4; CXCR5; BTK; SYK; PI3 K;
GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk
Keywords: BTK; AKT; acutely transforming retrovirus AKT8 in rodent T cell lymphoma; BCR; B cell receptor; Btk; Bruton's tyrosine kinase; ChIP; chromatin immunoprecipitation; GCN5; general control non-depressible 5; H2O2; hydrogen peroxide; HAT; histone acetyltransfera
Imidazo[1,5-a]quinoxalines as irreversible BTK inhibitors for the treatment of rheumatoid arthritis
Keywords: BTK; BTK; Autoimmune; Rheumatoid arthritis; Covalent kinase inhibitor; Imidazo[1,5-a]quinoxaline
Endovascular Revascularization of Below-the-Knee Arteries: Prospective Short-Term Angiographic and Clinical Follow-Up
Keywords: BTK; ABI; ankle-brachial index; BTK; below the knee; CI; confidence interval; CLI; critical limb ischemia; HR; hazard ratio; IC; intermittent claudication; TER; target extremity revascularization; TLR; target lesion revascularization;
The transcription factor Bright plays a role in marginal zone B lymphocyte development and autoantibody production
Keywords: BTK; Bright; B cell regulator of immunoglobulin heavy chain transcription; MZ; marginal zone; ARID; AT-rich interaction domain; Ig; immunoglobulin; Btk; Bruton's tyrosine kinase; FO; follicular; BrTg; Bright transgenic; ANA; antinuclear antibody; BCR; B cell r
TLR signaling and effector functions are intact in XLA neutrophils
Keywords: BTK; XLA; X-linked agammaglobulinemia; Btk; Bruton's tyrosine kinase; Ig; immunoglobulin; TLR; Toll-like receptor; LPS; lipopolysaccharide; MFI; mean fluorescence intensity; DHR; dihydrorhodamine 123; SOD; superoxide dismutase; PMA; phorbol 12-myristate 13-ace
The Src, Syk, and Tec family kinases: Distinct types of molecular switches
Keywords: BTK; Syk; Zap-70; Btk; Itk; Kinase; Switch
Interannual variability of subsurface temperature in summer induced by the Kuroshio over Bungo Channel, Tosa Bay, and Kii Channel, south of Japan
Keywords: BTK; BTK; Interannual variability; Subsurface temperature; Shelf and slope; Coastal sea level; Kuroshio
Characterization of Bruton's tyrosine kinase mutations in Mexican patients with X-linked agammaglobulinemia
Keywords: BTK; Btk; XLA; Splicing; Missense; Nonsense; Insertions; Deletions
Identification of a Btk mutation in a dysgammaglobulinemic patient with reduced B cells: XLA diagnosis or not?
Keywords: BTK; XLA; Btk; Sclerosing cholangitis; Chronic obstructive pancreatitis
High yield expression of non-phosphorylated protein tyrosine kinases in insect cells
Keywords: BTK; Kinase; Phosphatase; Phosphorylation; Baculovirus; Insect cells; Coexpression; BTK; JAK3; EphA2; YopH;
The docking properties of SHIP2 influence both JIP1 tyrosine phosphorylation and JNK activity
Keywords: BTK; SHIP2; SH2-domain containing inositol polyphosphate 5-phosphatase 2; JNK; c-Jun N-terminal kinase; JIP1; JNK-interacting protein 1; MLK3; mixed-lineage kinase3; MAPK; mitogen-activated protein kinase; MKK7; MAPK kinase 7; DLK; dual leucine zipper-bearing