Keywords: c-abl; tyrosine kinase inhibitors; diabetes mellitus; c-Abl; PDGFR; VEGFR; EGFR
مقالات ISI c-abl (ترجمه نشده)
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c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity
Keywords: c-abl; c-Abl; Tyrosine kinase; Protein phosphorylation; Transcription factor; Gene regulation; YY1;
Amyloid-β oligomers synaptotoxicity: The emerging role of EphA4/c-Abl signaling in Alzheimer's disease
Keywords: c-abl; Synaptotoxicity; EphA4; c-Abl; Alzheimer's disease; Aβ oligomers;
Molecular radiobiologyHead and neck cancer cell radiosensitization upon dual targeting of c-Abl and beta1-integrin
Keywords: c-abl; Beta1-integrin; c-Abl; Imatinib; Ionizing radiation; DNA-repair;
Imatinib ameliorates bronchiolitis obliterans via inhibition of fibrocyte migration and differentiation
Keywords: c-abl; imatinib; bronchiolitis obliterans; tyrosine kinase inhibitor; fibrocyte; c-Abl; PDGF;
Enhancement of TGF-β-induced Smad3 activity by c-Abl-mediated tyrosine phosphorylation of its coactivator SKI-interacting protein (SKIP)
Keywords: c-abl; Transforming growth factor-β (TGF-β); Smad3; SKI-interacting protein (SKIP, SNW1, NCoA62); Nuclear cofactor; c-Abl;
Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways
Keywords: c-abl; AD; Alzheimer's disease; Aβ; Amyloid beta; APP; Amyloid precursor protein; NFTs; Neurofibrillary tangles; BACE1; β-secretase 1; TNF-α; Tumor necrosis factor; iNOS; Inducible nitric oxide synthase; NSAIDs; Non-steroidal anti-inflammatory drugs; PPARγ;
c-Abl contributes to glucose-promoted apoptosis via p53 signaling pathway in podocytes
Keywords: c-abl; Podocytes; High glucose; c-Abl; Apoptosis;
Non-receptor tyrosine kinase inhibitors enhances β-cell survival by suppressing the PKCδ signal transduction pathway in streptozotocin - induced β-cell apoptosis
Keywords: c-abl; c-Abl; cellular Abelson tyrosine kinase; STZ; streptozotocin; MMP; mitochondrial membrane potential; CML; chronic myeloid leukemia; JNK; c-Jun N-terminal kinase; PKCδ; protein kinase c delta; ROS; reactive oxygen species; GNF-2; GNF-2 3-[6-[[4-(Trifluoro
Exposure of neuroblastoma cell lines to imatinib results in the upregulation of the CDK inhibitor p27KIP1 as a consequence of c-Abl inhibition
Keywords: c-abl; Imatinib; Neuroblastoma; p27KIP1; c-Abl; CDK2; pRbImatinib (PubChem CID: 123596); Cycloheximide (PubChem CID: 6197); 5-bromo-2′-deoxyuridine (PubChem CID: 6035); Hoechst 33258 (PubChem CID: 16218619)CDK, cyclin-dependent kinase; c-Abl, abelson tyrosine-pr
A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts
Keywords: c-abl; HN; humanin, an endogenous 24-amino acid peptide; HNG; HN in which the serine 14 is replaced by glycine; MI-R; myocardial ischemia-reperfusion; ROS; reactive oxygen species; GPx; glutathione peroxidase; SOD; superoxide dismutase; MMP; mitochondrial me
Targeting DNA damage response: Threshold, chromatin landscape and beyond
Keywords: c-abl; DSBs; double strand breaks; γ-H2AX; phosphorylation of histone variant H2AX in Ser139; SUMO; small ubiquitin modifier; ROS; reactive oxygen species; IR; ionizing radiation; Tip60; Tat-interactive 60; HAT; histone acetyltransferase; HDAC; histone deacetyl
Overexpression of c-Abl predicts unfavorable outcome in epithelial ovarian cancer
Keywords: c-abl; c-Abl; Epithelial ovarian cancer; Prognosis; Metastasis; Invasion;
Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A
Keywords: c-abl; AD; Alzheimer's disease; NFT; neurofibrillary tangles; PHF; paired helical filaments; SP; senile plaques; APP; apolipoprotein; PP1; protein phosphatase-1; PP2A; protein phosphatase-2A; PP2B; protein phosphatase-2B; PP5; protein phosphatase-5; PTEN; phosph
Tau protein kinases: Involvement in Alzheimer's disease
Keywords: c-abl; AD; Alzheimer's disease; APP; amyloid precursor protein; Arg; Abl-related gene; SFK; Src family kinase; Aβ; β-amyloid; BBB; blood brain barrier; LD50; lethal dose 50; c-Abl; c-Abelson; Cables; c-Abl-binding adaptator protein; CaMKII; Ca2+/calmodulin-dep
p73 haploinsufficiency causes tau hyperphosphorylation and tau kinase dysregulation in mouse models of aging and Alzheimer's disease
Keywords: c-abl; p73; p53 family; Tau phosphorylation; Pin1; Alzheimer's disease; Aging; Neurodegeneration; GSK-3β; c-Abl; Cdk5; Tauopathy; Paired helical filaments; TgCRND8
Kardionkologia - odpowiedź na wyzwania wspóÅczesnej terapii
Keywords: c-abl; antracykliny; biomarkery; chemioterapia; kardioprotekcja; kardiotoksycznoÅÄ; Anthracyclines; Biomarkers; Cardioprotection; Cardiotoxicity; Chemotherapy; ACEI; (Angiotensin Converting Enzyme Inhibitor) ihibitory konwertazy angiotensyny; AML; (Acute Myelo
Role of c-Abl in L-selectin shedding from the neutrophil surface
Keywords: c-abl; ABL1; c-Abl; CML; Chronic myelogenous leukemia; DPBS; Dulbecco's phosphate buffered saline; Gly-CAM1; Glycosylation-dependent cell adhesion molecule 1; IL-8; Interleukin-8; MEKK1; MAP kinase kinase kinase 1; Mac-1; Membrane attack complex type 1; MAPK; Mi
The LAR protein tyrosine phosphatase enables PDGF β-receptor activation through attenuation of the c-Abl kinase activity
Keywords: c-abl; LAR, leukocyte common antigen-related; MEF, mouse embryonic fibroblast; PDGF, platelet-derived growth factor; PTP, protein tyrosine phosphatase; RPTP, receptor protein tyrosine phosphatasePDGF β-receptor; Receptor protein tyrosine phosphatase; LAR; c-Abl;
Dual inhibition of the homologous recombinational repair and the nonhomologous end-joining repair pathways in chronic lymphocytic leukemia therapy
Keywords: c-abl; Nilotinib; Imatinib; Chronic lymphocytic leukemia; DNA-PK; c-abl; DNA damage and repair mechanisms; Nonhomologous end-joining repair; Homologous recombinational repair;
Identification and functional analysis of a new phosphorylation site (Y398) in the SH3 domain of Abi-1
Keywords: c-abl; c-Abl; Bcr-Abl; Mena; Abi-1; trans-Activation; Leukemic cell adhesion;
c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice
Keywords: c-abl; c-Abl; Cdk5; Neurotoxicity; Tau phosphorylation; Apoptosis; Amyloid-β-peptide; Alzheimer's disease; Transgenic mice model
Imatinib does not induce cardiotoxicity at clinically relevant concentrations in preclinical studies
Keywords: c-abl; ADP; adenosine diphosphate; ATP; adenosine triphosphate; AUC; area under the concentration-time curve; Cmax; maximal concentration; c-Abl; C-terminus of Abl gene; CML; chronic myeloid leukemia; ED; end-diastole; ER; endoplasmic reticulum; ES; end-systol
Evaluation of ARG protein expression in mature B cell lymphomas compared to non-neoplastic reactive lymph node
Keywords: c-abl; Follicular Lymphoma (FL); Diffused Large B Cell Lymphoma (DLBCL); Burkitt’s Lymphoma (BL); Abl-Related Gene (ARG); ABL-2; c-Abl; Abl-1
c-ABL tyrosine kinase stabilizes RAD51 chromatin association
Keywords: c-abl; Homologous recombination repair; RAD51; BRCA2; ATM; c-ABL; Tyrosine phosphorylation;
Tyrosine kinase inhibition: Ligand binding and conformational change in c-Kit and c-Abl
Keywords: c-abl; c-Kit; c-Abl; Imatinib mesylate; Ellipticine; Docking; Molecular dynamics
Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa; its implications during capacitation
Keywords: c-abl; PKA, protein kinase A; PE, phosphatidylethanolamine; SM, sphingomyelin; sAC, soluble adenylyl cyclase; Abl, c-AblTyrosine phosphorylation; Capacitation; c-ABL; PKA; Spermatozoa; Gleevac; Post-translational modification; Maturation; SRC
Epigallocatechin gallate (EGCG) suppresses β-amyloid-induced neurotoxicity through inhibiting c-Abl/FE65 nuclear translocation and GSK3β activation
Keywords: c-abl; (−)-Epigallocatechin gallate; β-amyloid; c-Abl; FE65; Glycogen synthase kinase 3β
Evidence for a direct involvement of hMSH5 in promoting ionizing radiation induced apoptosis
Keywords: c-abl; hMSH5; hMSH5P29S; c-Abl; Apoptosis; p73; Ionizing radiation; DNA damage response
Expression, mutational analysis and in vitro response of imatinib mesylate and nilotinib target genes in ovarian granulosa cell tumors
Keywords: c-abl; Tyrosine kinase; c-kit; c-Abl; Platelet-derived growth factor receptors; Ovarian cancer
Allosteric inhibition of the nonMyristoylated c-Abl tyrosine kinase by phosphopeptides derived from Abi1/Hssh3bp1
Keywords: c-abl; c-Abl; Tyrosine kinase activity; Abi1; Hssh3bp1; Allosteric mechanism; SH3 and SH2 domain
Tyrosine 311 is phosphorylated by c-Abl and promotes the apoptotic effect of PKCδ in glioma cells
Keywords: c-abl; PKCδ; Tyrosine phosphorylation; Apoptosis; c-Abl; Src; H2O2; Glioma;
C3G is required for c-Abl-induced filopodia and its overexpression promotes filopodia formation
Keywords: c-abl; C3G; Guanine nucleotide exchange factor; Filopodia; c-Abl; Actin cytoskeleton
3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors
Keywords: c-abl; Protein tyrosine kinase; c-ABL; Chronic myelogenous leukemia (CML); Indazole; Benzimidazole
Imatinib mesylate (Gleevec) protects against streptozotocin-induced diabetes and islet cell death in vitro
Keywords: c-abl; Imatinib; Pancreatic islet; Diabetes; JNK; Apoptosis; c-Abl; cellular Abelson tyrosine kinase; STZ; streptozotocin; NMRI; Naval Medical Research Institute established; KRBH; Krebs-Ringer Bicarbonate buffer; RPMI; Roswell Park Memorial Institute; MEKK-1; M
NESH (Abi-3) is present in the Abi/WAVE complex but does not promote c-Abl-mediated phosphorylation
Keywords: c-abl; Abl interactor; c-Abl; Adaptor; NESH; WAVESH3, Src homology 3; GST, glutathione S-transferase; HUVEC, human umbilical vein endothelial cells
Abl kinase interacts with and phosphorylates vinexin
Keywords: c-abl; SH, Src homology; ArgBP2, Arg-binding protein 2; WAVE, Wiskott–Aldrich syndrome protein family verprolin-homologous proteinVinexin; c-Abl; Actin cytoskeleton; Membrane ruffles; SH3
Imatinib mesylate radiosensitizes human glioblastoma cells through inhibition of platelet-derived growth factor receptor
Keywords: c-abl; Gleevec®; STI571; c-Abl; PDGF receptor; Radiation sensitizer;
C-Abl as a modulator of p53
Keywords: c-abl; p53; c-Abl; Mdm2; Mdmx; Bcr-Abl; HPV-E6; Ubiquitination; Degradation; Phosphorylation;