3-Benzimidazol-2-yl-1H-indazoles as potent c-ABL inhibitors

The 3-benzimidazol-2-yl-1H-indazole scaffold was developed as an alternate scaffold for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, it was discovered that a subset of these compounds potently inhibit the enzyme c-ABL. The SAR of these compounds is described.

The 3-benzimidazol-2-yl-1H-indazole scaffold was developed for our receptor tyrosine kinase (RTK) inhibitor program. In exploring the SAR of this series, a subset of these compounds were found to potently inhibit the enzyme c-ABL. The SAR of these compounds is described.Figure optionsDownload as PowerPoint slide