Keywords: Myocardial infarction; Snakegourd peel; Apoptosis; p-JNK; p-p38MAPK; MI; myocardial infarction; SP; Snakegourd Peel injection; TTC; triphenyltetrazolium chloride; ± dp/dt max; maximum rate of left ventricular pressure rise and fall; LVSP; left ventricula
مقالات ISI (ترجمه نشده)
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Keywords: TNF-α; tumor necrosis factor-α; IL-6; interleukin-6; IL-1β; interleukin-1β; MAPKs; mitogen-activated protein kinases; ERKs; extracellular signal-regulated kinases; JNK; c-Jun NH2-terminal kinase; DCFH-DA; dichlorofluorescein diacetate; PI; propidium i
Keywords: AMPK-GLUT1; AMP-activated protein kinase-glucose transporter 1; Bax; bcl-2 associated X protein; Bcl-2; B-cell lymphoma gene 2; Bim; bcl-2-like 4; BRAF; v-raf murine sarcoma viral oncogene homolog B1; Cdk; cyclin-dependent kinase; CIMP; CpG island methyla
Keywords: Anticancer activity; Apoptosis; DNA repair; Glioblastoma; Seaweed compounds; Temozolomide; AIC; 5-aminoimidazole-4-carboxamide; Akt; Protein kinase B (PKB); AP site; apurinic/apyrimidinic site; AP-1; activator protein-1; APE-1; AP endonuclease; Bax; Bcl-2
Keywords: Atherosclerosis; Cardiovascular diseases; Cell cycle; Proliferation; Pulmonary hypertension; Restenosis; Signaling pathway; Vascular smooth muscle cells; ACE; angiotensin converting enzyme; aFGF; acidic FGF; Ang II; angiotensin II; AP-1; activating protei
Keywords: AP-1; activator protein-1; BAL; bronchoalveolar lavage; BSA; bovine serum albumin; cpm; counts per minute; ERK; extracellular signaling-regulated kinase; HMGB1; high-mobility group box 1; IL; interleukin; IR; ischemia-reperfusion; JNK; c-Jun NH2-terminal
Keywords: AbA; Aureobasidin A; ABC; ATP-binding cassette; AMPK; AMP-activated protein kinase; ATG; Autophagy-related; ATP; Adenosine triphosphate; C1P; Ceramide-1-phosphate; CERS; Ceramide synthase; CK2; Casein kinase II; CLS; Chronological lifespan; CMA; Chaperone
Keywords: mAb; monoclonal antibody; BPD; benzoporphyrin derivative; PDT; photodynamic therapy; nanoPAL; nanophotoactivatable liposomes; PDAC; pancreatic ductal adenocarcinoma; VEGF; vascular endothelial growth factor; MAPK; mitogen activated protein kinases; HIF; h
Keywords: AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ATRA; all-trans retinoic acid; BHA; butylated hydroxyanisole; C/EBP; CCAAT/enhancer binding proteins; CREB; cyclic AMP response element-binding proteins; CSF; cerebrospinal fluid; DUOX; dual
Keywords: ATF6; activating transcription factor 6; CHOP; C/EBP homologous protein; CNS; central nervous system; ER; endoplasmic reticulum; ERS; endoplasmic reticulum stress; GRP78; 78-kDa glucose-regulated protein; IRE1; inositol-requiring enzyme 1; JNK; c-JUN NH2-
Keywords: COPD; chronic obstructive pulmonary disorder; FACTp140; FACT complex subunit SPT16; K18; keratin type 1 cytoskeletal 18; AFABP; adipocyte fatty acid-binding protein; OSF3; peroxiredoxin-1; SPTBN1; spectrin β chain brain 1; STAT; signal transducer and act
Keywords: EGF; epidermal growth factor; DPBS; dulbecco's phosphate-buffered saline; DMEM; dulbecco's modified eagle medium; TBST; Tween 20/Tris-buffered saline; TGF-β1; transforming growth factor beta1; MAPK; mitogen-activated protein kinases; ERK; extracellular r
Keywords: AC; adenylyl cyclase; cAMP; adenosine 3â²,5â²-cyclic monophosphate; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular-signal-regulated kinase; F2-IsoP; F2-isoprostane; FSK; forskolin; HSC; hepatic stellate cell; I-BOP; [1S-[1α,2α(Z),3β(1E,
Keywords: PRDX; peroxiredoxin; Tg; transgenic; iPLA2; calcium-independent phospholipase 2; AP-1; activating protein-1; MAPK; mitogen-activated protein kinase; JNK; c-Jun NH2-terminal kinase; SAPK2, p38; stress-activated protein kinase 2; ERK1/2; p44/p42, extracellu
Keywords: Bcl-2; B cell lymphoma 2; Bcl-xL; B cell lymphoma-extra large; ARE; antioxidant-response element; Cul3; cullin 3; Cyt c; cytochrome c; Drp1; dynamin-related protein 1; ERK; extracellular signal-regulated kinase; GSH; glutathione; GST; glutathione S-tran
JLP-JNK signaling protects cancer cells from reactive oxygen species-induced cell death
Keywords: Oxidative stress; ROS; Cell death; Scaffold protein; JNK; DHE; dihydroethidium; FBS; fetal bovine serum; GST; glutathione S-transferase; HA; hemagglutinin; HCC; hepatocellular carcinoma; H2O2; hydrogen peroxide; JBD; JNK-binding domain; JLP; JNK-associate
Anti-neuroinflammatory effects of 20C from Gastrodia elata via regulating autophagy in LPS-activated BV-2 cells through MAPKs and TLR4/Akt/mTOR signaling pathways
Keywords: Akt; protein kinase B; Atg; autophagy related gene; CNS; central nervous system; COX-2; cyclooxygenase-2; CQ; chloroquine; ERK; extracellular signal-regulated kinase; IL-1β; interleukin-1β; iNOS; inducible nitric oxide synthase; JNK; c-jun NH2-terminal
Lipophilic ester and amide derivatives of rosmarinic acid protect cells against H2O2-induced DNA damage and apoptosis: The potential role of intracellular accumulation and labile iron chelation
Keywords: ACN; acetonitrile; DTT; dithiothreitol; FBS; fetal bovine serum; FITC; fluorescein isothiocynate; G.O.; glucose oxidase; JNK; c-Jun NH2-terminal kinase; MAPKs; mitogen activated protein kinases; PI; propidium iodide; ROS; reactive oxygen species; RosA; ro
Topical administration of reversible SAHH inhibitor ameliorates imiquimod-induced psoriasis-like skin lesions in mice via suppression of TNF-α/IFN-γ-induced inflammatory response in keratinocytes and T cell-derived IL-17
Keywords: SAHH; S-adenosyl-l-homocysteine hydrolase; IMQ; imiquimod; KC; keratinocytes; IL; interleukin; ICAM-1; intercellular adhesion molecule-1; EGFR; epidermal growth factor receptor; MAPKs; mitogen activated protein kinases; ERK; extracellular signal-regulated
Mechanisms controlling the anti-neoplastic functions of FoxO proteins
Keywords: ATM; ataxia telangiectasia mutated; cHL; classical hodgkin lymphoma; CML; chronic myelogenous leukemia; CSC; cancer stem cell; ERK; the extracellular signal-regulated kinase; ERα; the nuclear receptor estrogen receptor α; FoxO; forkhead box O; G6PC; glu
KRIT1 loss-of-function induces a chronic Nrf2-mediated adaptive homeostasis that sensitizes cells to oxidative stress: Implication for Cerebral Cavernous Malformation disease
Keywords: AGEs; advanced glycation end-products; ARE; antioxidant-response element; AP; argpyrimidine (Náº-(5-hydroxy-4,6-dimethylpyrimidine-2-yl)-l-ornithine); BBB; blood-brain barrier; Casp-3; Caspase-3; CCM; Cerebral Cavernous Malformation; CNS; central nervous
Anti-inflammatory effect of Calycosin glycoside on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells
Keywords: CG; Calycosin glycoside; LPS; lipopolysaccharide; TNF-α; factor α; IL-6; interleukin 6; IL-1β; interleukin 1β; NO; nitric oxide; PGE2; prostaglandin E2; MAPKs; mitogen-activated protein kinases; NF-κB; nuclear transcription factor Kappa-B; IκBs; inh
Peroxiredoxin 2 regulates PGF2α-induced corpus luteum regression in mice by inhibiting ROS-dependent JNK activation
Keywords: 20α-HSD; 20α-Hydroxysteroid Dehydrogenase; 3β-HSD; 3β-Hydroxysteroid Dehydrogenase; CL; Corpus Luteum; ERK; Extracellular Signal-Regulated Kinase; hCG; Human Chorionic Gonadotropin; JNK; c-Jun NH2-Terminal Kinase; MAPK; Mitogen-Activated Protein Kinas
Research reportInhibition on the S-nitrosylation of MKK4 can protect hippocampal CA1 neurons in rat cerebral ischemia/reperfusion
Keywords: eNOS; endothelial nitric oxide synthase; GSNO; S-nitrosoglutathione; iNOS; inducible nitric oxide synthase; I/R; ischemia/reperfusion; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MKK4; mitogen-activated protein kinase kinase 4;
Nrf2 antioxidant defense is involved in survival signaling elicited by 27-hydroxycholesterol in human promonocytic cells
Keywords: ARE; antioxidant response element; CYP27A1; 27-hydroxylase; DAPI; 4,6-diamidino-2-phenylindole; DPI; diphenyleneiodonium chloride; ERK; extracellular signal-regulated kinase; GPx; glutathione peroxidase; GSR; glutathione reductase; HO-1; heme oxygenase-1;
Targeting heme oxygenase-1 and carbon monoxide for therapeutic modulation of inflammation
Keywords: ALI; acute lung injury; APCs; antigen-presenting cells; ARE; antioxidant responsive element; Bach1; Broad complex-Tramtrack-Bric-a-brac (BNB) and Cap'n'collar (CNC) homolog 1; BAL; bronchoalveolar lavage; BR; bilirubin-IXα; BV; biliverdin-IXα; BVR;
Intracellular labile iron determines H2O2-induced apoptotic signaling via sustained activation of ASK1/JNK-p38 axis
Keywords: Trx; thioredoxin; Prx; peroxiredoxin; GPx; glutathione peroxidase; LIP; labile iron pool; MAPK; mitogen activated protein kinases; ASK1; apoptosis signal-regulating kinase 1; JNK; c-Jun NH2-terminal kinase; HUVECs; human umbilical vein endothelial cells;
Regulation of the TGF-β pathway by deubiquitinases in cancer
Keywords: AMSH; Associated molecule with SH3 domain proteases; AMSH-LP; Associated molecule with SH3 domain-like proteases; ATXN3; ataxin-3; ATXN3L; ataxin 3-like; BMPs; bone morphogenetic proteins; BRCC36; BRCA1/BRCA2-containing complex subunit 36; CHIP; carboxy t
Glyoxalase I drives epithelial-to-mesenchymal transition via argpyrimidine-modified Hsp70, miR-21 and SMAD signalling in human bronchial cells BEAS-2B chronically exposed to crystalline silica Min-U-Sil 5: Transformation into a neoplastic-like phenotype
Keywords: Glo1; Glyoxalase I; MG; Methylglyoxal; AGEs; Advanced glycation end products; AP; Argpyrimidine; MS5; Min-U-Sil 5; EMT; Epithelial to mesenchymal transition; E-cad; E-cadherin; ZO-1; Zonula occludens-1; α-SMA; α-smooth muscle actin; ROS; Reactive Oxygen
Sphingosine-1-phosphate stimulated connective tissue growth factor expression in human buccal fibroblasts: Inhibition by epigallocatechin-3-gallate
Keywords: c-Jun NH2-terminal kinase; connective tissue growth factor; epigallocatechin-3-gallate; oral submucous fibrosis; sphingosine-1-phosphate
Human endotoxin tolerance is associated with enrichment of the CD14+ CD16+ monocyte subset
Keywords: IκBα; I-kappa-B-alpha; IRF; IFN regulatory factor; JNK; c-Jun NH2-terminal kinase; LPS; lipopolysaccharide; MyD88; myeloid differentiation factor 88; PBMC; peripheral blood mononuclear cells; TLR4; toll-like receptor 4; TRIF; TIR domain containing adapt
Critical role of JSAP1 and JLP in axonal transport in the cerebellar Purkinje cells of mice
Keywords: APP; amyloid precursor protein; cDKO; conditional double KO; cKO; conditional KO; cTKO; conditional triple KO; Cyt c; cytochrome c; DAPI; 4,6-diamidino-2-phenylindole; DCN; deep cerebellar nuclei; floxed; loxP-flanked; GFAP; glial fibrillary acidic protei
Anti-inflammatory effect of desoxo-narchinol-A isolated from Nardostachys jatamansi against lipopolysaccharide
Keywords: COX-2; cyclooxygenase-2; DN; desoxo-narchinol-A; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular signal-regulated kinase; EtOAc; ethyl acetate; FBS; fetal bovine serum; H&E; hematoxylin and eosin; HPRT; hypoxanthine guanine phosphoribosyl-tra
Lead decreases cell survival, proliferation, and neuronal differentiation of primary cultured adult neural precursor cells through activation of the JNK and p38 MAP kinases
Keywords: aNPC; adult neural precursor cells; SGZ; subgranular zone; DG; dentate gyrus; JNK; c-Jun NH2-terminal kinase; MAP; mitogen activated protein; DMSO; dimethyl sulfoxide; BrdU; 5-bromo-2â²-deoxyuridine; EGF; epidermal growth factor; bFGF; basic fibroblast g
Let-7g induces granulosa cell apoptosis by targeting MAP3K1 in the porcine ovary
Keywords: Let-7g; MAP3K1; FoxO1; Granulosa cell; Apoptosis; miRNAs; mircoRNAs; 3â² UTR; 3â²-untranslated regions; GCs; granulosa cells; PTEN; phosphatase and tensin homolog; PBS; phosphate buffered saline; PI; propidium iodide; BSA; bovine serum albumin; DAPI; AT
A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-Akt dependent pathways
Keywords: BrdU; bromodeoxyuridine; DG; dentate gyrus; DIV; day in vitro; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; MAPK/ERK kinase; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetr
β-Arrestin-1 protects against endoplasmic reticulum stress/p53-upregulated modulator of apoptosis-mediated apoptosis via repressing p-p65/inducible nitric oxide synthase in portal hypertensive gastropathy
Keywords: PHG; portal hypertensive gastropathy; PVL; partial portal vein ligation; SO; sham operation; PUMA; p53-upregulated modulator of apoptosis; ER; endoplasmic reticulum; GPCR; G-protein-coupled receptors; iNOS; inducible nitric oxide synthase; NF-κB; nuclear
Plumbagin inhibits LPS-induced inflammation through the inactivation of the nuclear factor-kappa B and mitogen activated protein kinase signaling pathways in RAW 264.7 cells
Keywords: ANOVA; one-way analysis of variance; ERK1/2; extracellular signal-regulated kinase 1/2; Iκ-B; inhibitor κB; IKK; Iκ-B kinase; iNOS; inducible nitric oxide synthase; JNK; c-Jun NH2-terminal kinase; LPS; lipopolysaccharide; MAPK; mitogen-activated protei
Role of Bcl-xL/Beclin-1 in interplay between apoptosis and autophagy in oxaliplatin and bortezomib-induced cell death
Keywords: JNK; c-Jun NH2-terminal kinase; Bcl-xL; B-cell lymphoma-extra large; BAX; Bcl-2-associated X protein; PARP; Poly (ADP-ribose) polymerase; COX; Cyclooxygenase; SDS; Sodium dodecyl sulfate; PAGE; Polyacrylamide gel electrophoresis; BH3; Bcl-2 homology domai
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives
Keywords: Heart; MAPK; Cardiac diseases; Mitochondria; Cell signaling; AngII; angiotensin II; CA; constitutively active; CHIP; C terminus of Hsc70-interacting protein; CT-1; cardiotrophin-1; ÎΨmit; mitochondrial membrane potential; DN; dominant negative; ERK1/2;
Zinc chloride exposure increases heme oxygenase-1 expression in MDPC-23 odontoblast-like cells
Keywords: Akt; amino kinase terminal; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated protein kinase; HO-1; heme oxygenase-1; JNK; c-Jun NH2-terminal kinase; MAPKs; mitogen-activated protein kinases; MK-2; MAPK-activated protein kinase-2; NF-κB; nucl
NOD2 triggers PGE2 synthesis leading to IL-8 activation in Staphylococcus aureus-infected human conjunctival epithelial cells
Keywords: Conjunctival epithelial cells; Staphylococcus aureus; NOD2; c-jun NH2-terminal kinase; COX-2; IL-8;
Butein protects human dental pulp cells from hydrogen peroxide-induced oxidative toxicity via Nrf2 pathway-dependent heme oxygenase-1 expressions
Keywords: Butein; Human dental pulp cells; Hydrogen peroxide; Heme oxygenase-1; Nuclear factor-E2-related factor 2; C-Jun NH2-terminal kinase;
Melatonin receptor activation suppresses adrenocorticotropin production via BMP-4 action by pituitary AtT20 cells
Keywords: ACTH; adrenocorticotropin; ActRÐÐ; activin type ÐÐ receptor; ALK; activin receptor-like kinase; BMP; bone morphogenetic protein; BMPRÐÐ; BMP type ÐÐ receptor; CRH; corticotropin-releasing hormone; ERK; extracellular signal-regulated kinase; JNK; c
In vitro and in vivo immunostimulatory effects of hot water extracts from the leaves of Artemisia princeps Pampanini cv. Sajabal
Keywords: ERK1/2; extracellular signal-regulated kinase1/2; iNOS; inducible nitric oxide synthase; IκB-α; inhibitory kappa B-α; JNK; c-Jun NH2-terminal kinase; NF-κB; nuclear factor-κB; NO; nitric oxide; qRT-PCR; quantitative reverse-transcriptase polymerase c
Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes
Keywords: CaMKK; Ca2+/calmodulin-dependent protein kinase kinase; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; ER; endoplasmic reticulum; PERK; double stranded RNA-activated protein kinase-like ER-associated kinase; IRE-1; inositol requiring ER-
Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells
Keywords: MOR; mu opioid receptor; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein/extracellular signal-regulated kinase; NF-κB; nuclear factor-kappaB; DP; distal promoter; PP; proximal promoter; Oct-1; octame
Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways
Keywords: Cmax; maximum plasma concentration; COX-2; cyclooxygenase-2; Erk1/2; extracellular signal-regulated kinase 1/2; IκB; inhibitor κB; IL-6; interleukin-6; iNOS; inducible nitric oxide synthase; JNK; c-Jun NH2-terminal kinase; LDH; lactate dehydrogenase; LP
Crystal and solution structures disclose a putative transient state of mitogen-activated protein kinase kinase 4
Keywords: JNK; c-Jun NH2-terminal kinase; MAP; mitogen-activated protein; MAP2K; MAP kinase kinase; MAP3K; MAP kinase kinase kinase; npMAP2K4; non-phosphorylated MAP2K4; IPTG; isopropyl-β-d-thiogalactopyranoside; ANP; adenylyl-imidodiphosphate; ATP; adenosine trip
Protein kinases participate in the contraction in response to levobupivacaine in the rat aorta
Keywords: Levobupivacaine; Contraction; Protein kinase C; Rho-kinase; Ca2+ sensitivity; c-Jun NH2-terminal kinase