
Probing the catalytic mechanism of bovine CD38/NAD+glycohydrolase by site directed mutagenesis of key active site residues
Keywords: cADPR، cyclic ADP-ribose; bCD38, bovine CD38/NAD+glycohydrolase; hCD38, human CD38/NAD+glycohydrolase; wt, wild type enzyme; cADPR, cyclic ADP-ribose; rFNAD, 2′-deoxy-2′-β-d-fluororibofuranoside NAD+; aFNAD, 2′-deoxy-2′-β-d-fluoroarabinofuranoside NAD+; Nic, nicotinamide; INH, iso