Keywords: CAR، گیرنده اصلی آندروستان; ADR, adverse drug reaction; ABC, ATP-binding cassette; AUC, area under plasma concentration versus time curve; BCRP, breast cancer resistance protein; CAR, constitutive androstane receptor; CE, capillary electrophoresis; CHM, Chinese herbal medicine; CL,
مقالات ISI CAR، گیرنده اصلی آندروستان (ترجمه نشده)
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Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; DNMTs, DNA methyltransferases; H3K4me1, histone 3 lysine 4 monomethylation; H3K4me2, histone 3 lysine 4 dimethylation; H3K4me3, histone 3 lysine 4 trimethylation; H3K9me2, histone 3 lysine 9 dimethylation; H3K9me3, h
Keywords: CAR، گیرنده اصلی آندروستان; Circadian rhythm; Liver; Metabolic syndrome; Type 2 diabetesARC, arcuate nucleus; BMAL1, brain and muscle ARNT-like 1; CAR, constitutive androstane receptor; CLOCK, circadian locomotor output cycles kaput; CRY, cryptochrome; CYP7A1, cholesterol 7α-hydroxy
Novel functions of PXR in cardiometabolic disease
Keywords: CAR، گیرنده اصلی آندروستان; ABCA, ATP-binding cassette transporter; Apo, Apolipoprotein; ARV, Anti-retroviral; BPA, Bisphenol A; CAR, Constitutive androstane receptor; CETP, Cholesteryl ester transfer protein; CPT1, Carnitine palmitoyltransferase 1; CREB, cAMP response element-bindi
PXR- and CAR-mediated herbal effect on human diseases
Keywords: CAR، گیرنده اصلی آندروستان; ABC, ATP-binding cassette; AD, Alzheimer's disease; AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; CARKO, CAR-knockout; CGD, cholesterol gallstone disease; CPT1, carnitine palmitoyltransferase 1; CYP, cytochrome P450; DBD, DNA-bind
Regulation of hepatic energy metabolism by the nuclear receptor PXR
Keywords: CAR، گیرنده اصلی آندروستان; ACAA2, acetyl-CoA acyltransferase 2; ACC1, acetyl-CoA carboxylase 1; ACL, adenosine triphosphate citrate lyase; ACOX1, acyl-coenzyme A oxidase 1; AKR1B10, aldo–keto reductase 1B10; CAR, constitutive androstane receptor; CD36, cluster of differentiation 36
Mechanisms of xenobiotic receptor activation: Direct vs. indirect
Keywords: CAR، گیرنده اصلی آندروستان; AhR, aryl hydrocarbon receptor; ARNT, aryl hydrocarbon nuclear translocator; CAR, constitutive androstane receptor; CCRP, cytoplasmic retention protein; CITCO, 6-(4-chlorophenyl)imidazo [2,1-beta][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime; D
Activation of the Constitutive Androstane Receptor induces hepatic lipogenesis and regulates Pnpla3 gene expression in a LXR-independent way
Keywords: CAR، گیرنده اصلی آندروستان; CAR, Constitutive Androstane Receptor; ChREBP, Carbohydrate Responsive Element-binding protein; CYP2B10, cytochrome P450, family 2, subfamily B, polypeptide 10; CYP2C29, cytochrome P450, family 2, subfamily C, polypeptide 29; CYP3A11, cytochrome P450, fam
Small-molecule modulators of PXR and CAR
Keywords: CAR، گیرنده اصلی آندروستان; AF-2, activation function 2; CAR, constitutive androstane receptor; CYP, cytochrome P450; DBD, DNA-binding domain; DDI, drug–drug interactions; DEHP, di(2-ethylhexyl) phthalate; DILI, drug-induced liver injury; DR4, direct repeat separated by 4 nucleotide
Disruption of HNF1α binding site causes inherited severe unconjugated hyperbilirubinemia
Keywords: CAR، گیرنده اصلی آندروستان; CAR, Constitutive androstane receptor; CNS, Crigler-Najjar syndrome; gtPBREM, phenobarbital-responsive enhancer module; HNF1α, Hepatic nuclear factor 1α; NT, nucleotide; PXR, Pregnane X Receptor; UCB, unconjugated bilirubin; UGT1A1, Uridine Diphosphate Gl
The HR96 activator, atrazine, reduces sensitivity of D. magna to triclosan and DHA
Keywords: CAR، گیرنده اصلی آندروستان; NR, nuclear receptor; PXR, pregnane-X-receptor; CAR, constitutive androstane receptor; TAG, triacylglycerol; GST, glutathione S-transferase; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; LA, linoleic acid; qPCR, quantitative real-time polymerase
MicroRNA hsa-miR-29a-3p modulates CYP2C19 in human liver cells
Keywords: CAR، گیرنده اصلی آندروستان; CYP, cytochrome P450; miRNA, microRNA; DMETs, drug metabolizing enzymes and transporters; PM, poor metabolizer; EM, extensive metabolizer; ERα, estrogen receptor α; CAR, constitutive androstane receptor; PXR, pregnane X receptor; RE, response element; 3′-
Genome-wide analysis of human constitutive androstane receptor (CAR) transcriptome in wild-type and CAR-knockout HepaRG cells
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime; CYP, cytochrome P450; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GPR56, G protein-coupled receptor 56; GPX2, glut
Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro
Keywords: CAR، گیرنده اصلی آندروستان; 1H NMR, proton nuclear magnetic resonance imaging; BSEP, Bile Salt Export Pump; CAR, constitutive androstane receptor; CsA, Cyclosporin A; DEG, differentially expressed gene; ER, endoplasmic reticulum; FC, fold change; FDR, False Discovery Rate; FXR, farn
Regulation of 3β-hydroxysteroid dehydrogenase and sulphotransferase 2A1 gene expression in primary porcine hepatocytes by selected sex-steroids and plant secondary metabolites from chicory (Cichorium intybus L.) and wormwood (Artemisia sp.)
Keywords: CAR، گیرنده اصلی آندروستان; 3β-HSD, 3β Hydroxysteroid dehydrogenase; AhR, aryl hydrocarbon receptor; ANOVA, analysis of variance; BSA, bovine serum albumin; CAR, constitutive androstane receptor; cDNA, complementary DNA; Ct, threshold cycle; DHEA, dehydroepiandrosterone; DMSO, dimet
Upregulation of COX-2 in the lung cancer promotes overexpression of multidrug resistance protein 4 (MRP4) via PGE2-dependent pathway
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; cAMP, cytosolic cyclic adenosine monophosphate; cGMP, cyclic guanosine monophosphate; COX-2, cyclooxygenase 2; BCA, bicinchoninic acid; BCRP, breast cancer resistance protein; MDR, multi-drug resistance; MRP4, multid
5β-Reduced steroids and human Δ4-3-ketosteroid 5β-reductase (AKR1D1)
Keywords: CAR، گیرنده اصلی آندروستان; AKR, aldo–keto reductase; AKR1C1–AKR1C4, human hydroxysteroid dehydrogenase; AKR1D1, human steroid 5β-reductase; AKR1D2, rat steroid 5β-reductase; CAR, constitutive androstane receptor; ERK, extracellular-signal regulated kinase; FXR, farnesoid X receptor
Fetal bovine serum and human constitutive androstane receptor: Evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; CAS, Chemical Abstracts Service; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime; CS-FBS, charcoal-stripped, dextran-treated fetal bovine serum; DEHP, di-(2-ethylhexyl)
Preclinical pharmacology of FL442, a novel nonsteroidal androgen receptor modulator
Keywords: CAR، گیرنده اصلی آندروستان; ADT, androgen-deprivation therapy; AF2, activation function 2; AhR, aryl hydrocarbon receptor; AR, androgen receptor; Bic, bicalutamide; CAR, constitutive androstane receptor; COS-1, African green monkey kidney cells; CRPC, castration resistant prostate c
Evaluation of Aroclor 1260 exposure in a mouse model of diet-induced obesity and non-alcoholic fatty liver disease
Keywords: CAR، گیرنده اصلی آندروستان; AhR, aryl hydrocarbon receptor; ALT, alanine transaminase; AST, aspartate transaminase; AUC, area under the curve; CAE, chloroacetate esterase; CAR, constitutive androstane receptor; CPT1A, carnitine palmitoyl transferase 1A; Cyp, cytochrome P450; DIO, di
Reduction of thyroid hormones triggers down-regulation of hepatic CYP2B through nuclear receptors CAR and TR in a rat model of acute stroke
Keywords: CAR، گیرنده اصلی آندروستان; ACTH, adrenocorticotropic hormone; ALT, alanine aminotransferase; AST, aspartate aminotransferase; CAR, constitutive androstane receptor; ChIP, chromatin immunoprecipitation; CYPs, cytochrome P450; CPR, cytochrome P450 reductase; DR4, a direct repeat sepa
Role of aldo–keto reductase family 1 (AKR1) enzymes in human steroid metabolism
Keywords: CAR، گیرنده اصلی آندروستان; AKR, aldo–keto reductase; AR, androgen receptor; CAR, constitutive androstane receptor; CRPC, castrate resistant prostate cancer; COMT, catechol-O-methyl transferase; CYP, cytochrome P450 superfamily; 3α/β-Diol, 5α-androstane-3α/β,17β-diol; 5α/β-DHT, 5α/β
Effects of artificial sweeteners on the AhR- and GR-dependent CYP1A1 expression in primary human hepatocytes and human cancer cells
Keywords: CAR، گیرنده اصلی آندروستان; AhR, Aryl hydrocarbon Receptor; CAR, Constitutive androstane receptor; ER, estrogen receptor; GR, glucocorticoid receptor; LXR, liver X receptor; PXR, pregnane X receptor; RXR, retinoic X receptor; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxinArtificial sweet
Time and dose-dependent effects of phenobarbital on the rat liver miRNAome
Keywords: CAR، گیرنده اصلی آندروستان; miRNA, microRNA; PB, phenobarbital; CAR, Constitutive Androstane Receptor; ppm, parts per million; pparα, peroxisome proliferator-activated receptorsmicroRNA; Xenobiotic; Dose; Temporal; Proliferation
Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression
Keywords: CAR، گیرنده اصلی آندروستان; AMPK, AMP-activated protein kinase; CAR, constitutive androstane receptor; CYP, cytochrome P450; epo, erythropoietin; HRE, hypoxia-responsive element; ho-1, heme oxygenase-1; HIF, hypoxia inducible factor; PHD, prolyl hydoxylase; PB, phenobarbital; PBREM,
The adverse outcome pathway concept: A pragmatic tool in toxicology
Keywords: CAR، گیرنده اصلی آندروستان; 5′-NT, 5′-nucleotidase; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AO(P)(s), adverse outcome (pathway(s)); AST, aspartate aminotransferase; BSEP, bile salt export pump; CAR, constitutive androstane receptor; CD36, fatty acid translocase; Ch
Polychlorinated biphenyl 153 is a diet-dependent obesogen that worsens nonalcoholic fatty liver disease in male C57BL6/J mice
Keywords: CAR، گیرنده اصلی آندروستان; AhR, aryl hydrocarbon receptor; ALT, alanine transaminase; AST, aspartate transaminase; AUC, area under the curve; CAR, constitutive androstane receptor; CPT1A, carnitine palmitoyl transferase 1A; CPT2, carnitine palmitoyl transferase; CD, control diet; F
Role of the nuclear xenobiotic receptors CAR and PXR in induction of cytochromes P450 by non-dioxinlike polychlorinated biphenyls in cultured rat hepatocytes
Keywords: CAR، گیرنده اصلی آندروستان; PCBs, polychlorinated biphenyls; DL, dioxinlike; NDL, non-dioxinlike; CAR, constitutive androstane receptor; PXR, pregnane X receptor; CYP, cytochrome P450; siRNA, small interfering RNA; OA, okadaic acid; PB, phenobarbital; Dex, dexamethasonePolychlorinat
Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio)
Keywords: CAR، گیرنده اصلی آندروستان; ABC transporters, ATP-binding cassette transporters; ARNT2, aryl hydrocarbon receptor nuclear translocator; CAR, constitutive androstane receptor; CLO, clotrimazole; CYP, cytochrome P450; DBD, DNA binding domain; DMSO, dimethylsulfoxide; EF1α, elongation
α-Methylacyl-CoA racemase (AMACR): Metabolic enzyme, drug metabolizer and cancer marker P504S
Keywords: CAR، گیرنده اصلی آندروستان; AMACR, α-methylacyl-CoA racemase (also known as P504S); 2-APA, 2-arylpropanoic acid (‘profen’); CAR, constitutive androstane receptor; CoA, coenzyme A; FXR, farnesoid X receptor; MCR, AMACR homolog from M. tuberculosis; NMR, nuclear magnetic resonance; NR
Evaluation of the utility of the lifetime mouse bioassay in the identification of cancer hazards for humans
Keywords: CAR، گیرنده اصلی آندروستان; BCP, o-benzyl-p-chlorophenol; CAR, constitutive androstane receptor; CPDB, Carcinogenic Potency Database; DNA, deoxyribonucleic acid; EAFUS, Everything Added to Food in the United States; EU, European Union; FDA, United States Food and Drug Administration
An ‘all-inclusive’ 96-well cytochrome P450 induction method: Measuring enzyme activity, mRNA levels, protein levels, and cytotoxicity from one well using cryopreserved human hepatocytes
Keywords: CAR، گیرنده اصلی آندروستان; AhR, Aryl hydrocarbon receptor; bDNA, branched DNA; CAR, constitutive androstane receptor; CHRM™, Cryopreserved Hepatocytes Recovery Medium; CYP, cytochrome P450; DMSO, dimethyl sulfoxide; DDI, drug–drug interactions; FDA, Food and Drug Administration; LD
ABC drug transporter and nuclear receptor expression in human cytotrophoblasts: Influence of spontaneous syncytialization and induction by glucocorticoids
Keywords: CAR، گیرنده اصلی آندروستان; ABC transporter; Nuclear receptor; Placenta; Cytotrophoblast; Glucocorticoid; SyncytializationABC, ATP binding cassette; BETA, betamethasone; CAR, constitutive androstane receptor; DEX, dexamethasone; GC, glucocorticoid; GR, glucocorticoid receptor; PRED,
Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; PXR, pregnane X receptor; PTU, propylthiouracil; WT, wild type; CYP, cytochrome P450; ND, normal diet; PTU/LI, propylthiouracil/low iodine; T4, tetraiodothyronine; CBZ, carbamazepine; MEM, minimal essential medium; W
Non-coplanar polychlorinated biphenyls (PCBs) are direct agonists for the human pregnane-X receptor and constitutive androstane receptor, and activate target gene expression in a tissue-specific manner
Keywords: CAR، گیرنده اصلی آندروستان; AhR, Aryl hydrocarbon receptor; CAR, constitutive androstane receptor; PCB, polychlorinated biphenyls; PXR, pregnane‐X receptorNuclear receptor; Gene expression; Drug metabolism; PXR; CAR
A tea catechin, epigallocatechin-3-gallate, is a unique modulator of the farnesoid X receptor
Keywords: CAR، گیرنده اصلی آندروستان; ALT, alanine aminotransferase; BSEP, bile salt efflux pump; CAR, constitutive androstane receptor; CDCA, chenodeoxycholic acid; EC, (−)-epicatechin; ECG, (−)-epicatechin-3-gallate; EGC, (−)-epigallocatechin; EGCG, (−)-epigallocatechins-3-gallate; Fgf15, f
Constitutive androstane receptor transactivates the hepatic expression of mouse Dhcr24 and human DHCR24 encoding a cholesterogenic enzyme 24-dehydrocholesterol reductase
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; PXR, pregnane X receptor; RXRα, retinoid X receptor α; DHCR24, 24-dehydrocholesterol reductase; TCPOBOP, 1,4-bis[(3,5-dichloropyridin-2-yl)oxy]benzene; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldeh
Renal efflux transporter expression in pregnant mice with Type I diabetes
Keywords: CAR، گیرنده اصلی آندروستان; Abc, ATP-binding cassette; Abca, ATP-binding cassette transporter; AhR, aryl hydrocarbon receptor; Bcrp, breast cancer resistance protein; CAR, constitutive androstane receptor; Cyp, cytochrome P450; HNF1α, hepatocyte nuclear factor 1α; Ho-1, heme oxygena
Transactivation of ABCG2 through a novel cis-element in the distal promoter by constitutive androstane receptor but not pregnane X receptor in human hepatocytes
Keywords: CAR، گیرنده اصلی آندروستان; ABC, ATP-binding cassette; AdhCAR, hCAR-expressing adenovirus; BCRP, breast cancer resistance protein; CAR, constitutive androstane receptor; ChIP, chromatin immunoprecipitation; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldeyde O-(3,4-di
Treatment with a constitutive androstane receptor ligand ameliorates the signs of preeclampsia in high-fat diet-induced obese pregnant mice
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; CD, control diet; GTT, glucose tolerance test; G6Pase, glucose-6-phosphatase; HFD, high-fat diet; HOMA-IR, homeostasis model assessment-insulin resistance; ITT, insulin tolerance test; SCD-1, stearoyl-CoA desaturase
Increased plasma thyroid hormone concentrations in LDL receptor deficient mice may be explained by inhibition of aryl hydrocarbon receptor-dependent expression of hepatic UDP-glucuronosyltransferases
Keywords: CAR، گیرنده اصلی آندروستان; AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; LDLR−/−, low density lipoprotein receptor deficient; UGT, UDP-glucuronosyltransferase; Mrp2, multidrug resistance-associated protein 2; SREBP-1, sterol regulatory element-binding prote
Liver X receptor α bidirectionally transactivates human CYP1A1 and CYP1A2 through two cis-elements common to both genes
Keywords: CAR، گیرنده اصلی آندروستان; LXR, liver X receptor; CAR, constitutive androstane receptor; RXR, retinoid X receptor; AhR, aryl hydrocarbon receptor; 24HC, 24(S)-hydroxycholesterol; 3MC, 3-methylcholanthrene; CITCO, 6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-d
Statins increase cytochrome P450 4F3-mediated eicosanoids production in human liver cells: A PXR dependent mechanism
Keywords: CAR، گیرنده اصلی آندروستان; 20-HETE, 20-hydroxyeicosatetraenoic acid; 25-OH chol, 25-hydroxycholesterol; ACS, acyl coenzyme A synthase; ApoAI, apoliprotein AI; CAR, constitutive androstane receptor; CYP, cytochrome P450; FAS, fatty acid synthase; GAPDH, glyceraldehyde-3-phosphate de
Characterization of human cytochrome P450 induction by pesticides
Keywords: CAR، گیرنده اصلی آندروستان; CYP, Cytochrome P450; PXR, Pregnane X receptor; CAR, Constitutive androstane receptor; XREM, Xenobiotic reponsive enhancer module; LBDs, Ligand-binding domains; AhR, Aryl hydrocarbon receptor; TCPOBOP, 1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene; TMPP, Tri
Ivermectin induces P-glycoprotein expression and function through mRNA stabilization in murine hepatocyte cell line
Keywords: CAR، گیرنده اصلی آندروستان; ABC, ATP-binding cassette; AhR, aryl-hydrocarbon receptor; CAR, constitutive androstane receptor; IVM, ivermectin; MLs, macrocyclic lactones; P-gp, P-glycoprotein; PXR, pregnane X receptorIvermectin; Macrocyclic lactones; P-glycoprotein; Mdr1; Hepatocytes
Oxazaphosphorine bioactivation and detoxification: the role of xenobiotic receptors
Keywords: CAR، گیرنده اصلی آندروستان; ALDH, aldehyde dehydrogenase; AKR, aldo-keto reductase; AhR, aryl hydrocarbon receptor; BCRP, breast cancer resistance protein; CAA, chloroacetaldehyde; CAR, constitutive androstane receptor; CPA, cyclophosphamide; CYP, cytochrome P450; CMF, cyclophospham
Drug–drug interactions by azole antifungals: Beyond a dogma of CYP3A4 enzyme activity inhibition
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; GR, glucocorticoid receptor; HNF4α, hepatocyte nuclear factor 4 alpha; PXR, pregnane X receptor; RXRα, retinoid X receptor alpha; SRC-1, steroid receptor co-activator 1Azoles; Cytochrome CYP3A4; Pregnane X receptor;
Simultaneous assessment of cytochrome P450 activity in cultured human hepatocytes for compound-mediated induction of CYP3A4, CYP2B6, and CYP1A2
Keywords: CAR، گیرنده اصلی آندروستان; AhR, aryl hydrocarbon receptor; CAR, constitutive androstane receptor; cDNA, complementary deoxyribonucleic acid; Ct, cycle threshold; CYP, cytochrome P450; CITCO, (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde-O-(3,4-dichlorobenzyl)oxime);
Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells
Keywords: CAR، گیرنده اصلی آندروستان; CAR, constitutive androstane receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; KTZ, ketoconazole; P-gp, P-glycoprotein; PXR, pregnane X receptor; Rh123, rhodamine 123; RIF, rifampicin; SL, spironolactoneHepG2 cells; Cytotoxicity; P-glycoprotein;
The HepaRG cell line is suitable for bioartificial liver application
Keywords: CAR، گیرنده اصلی آندروستان; DMSO, dimethylsulfoxide; CG, carbamoyl-glutamate; CPS, carbamoylphosphate synthetase; CYP, cytochrome P450; BAL, bioartificial liver; GS, glutamine synthetase; ARG, arginase; PHHs, primary human hepatocytes; CAR, constitutive androstane receptor; ALB, alb