The 'complexities' of life and death: Death receptor signalling platforms
Keywords: کاسپاز-8; Apoptosis; Necroptosis; DISC; FADD; Caspase-8; RIPK; cFLIP;
مقالات ISI کاسپاز-8 (ترجمه نشده)
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Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes
Keywords: کاسپاز-8; AIF; apoptosis-inducing factor, mitochondrion-associated, 1; Apaf-1; apoptotic peptidase activating factor 1; Bax; BCL2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl-extra large; Bid; BH3 interacting domain death agonist; CASP3; caspase-3; C
IFN-γ combined with targeting of XIAP leads to increased apoptosis-sensitisation of TRAIL resistant pancreatic carcinoma cells
Keywords: کاسپاز-8; Apoptosis; TRAIL; XIAP; Pancreatic cancer; Interferon; Caspase-8
Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein
Keywords: کاسپاز-8; Caspase-8; High-throughput screening; Medicinal chemistry; Amyloid precursor protein; Alzheimer's disease; Neurodegeneration;
Selective induction of apoptosis through activation of caspase-8 in human leukemia cells (Jurkat) by dandelion root extract
Keywords: کاسپاز-8; Dandelion root extract; Caspase-8; Apoptosis; Mitochondria; Human leukemia
Stratified corneal limbal epithelial cells are protected from UVB-induced apoptosis by elevated extracellular K+
Keywords: کاسپاز-8; apoptosis; caspase-3; caspase-8; cornea; corneal epithelium; tear film; potassium; ultraviolet
Caspase-8 and Bid: Caught in the act between death receptors and mitochondria
Keywords: کاسپاز-8; Caspase-8; Mitochondria; Bid; Type II cells; Death inducing signalling complex; XIAP;
Caspase-8 cleavage of the interleukin-21 (IL-21) receptor is a negative feedback regulator of IL-21 signaling
Keywords: کاسپاز-8; Bid; BH3 interacting domain death agonist; CA14; carbonic anhydrase XIV; CASP8; caspase-8; ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; IL-21; interleukin-21; IL21R; interleukin-21 receptor; IL2RG; interleukin 2 receptor, gamma; NCtag
Expressions of apoptosis-regulating factors in bovine retained placenta
Keywords: کاسپاز-8; Apoptosis; Caspases; Cattle; Placenta; Retained placenta; RFM; retained fetal membrane; cFLIP; cellular FLICE-like inhibiting protein; FLICE; FADD-like ICE; FADD; FAS-associating protein with death domain; ICE; interleukin-1β converting enzyme; CASP8; ca
Molecular and Cellular PharmacologyRecombinant TFPI-2 enhances macrophage apoptosis through upregulation of Fas/FasL
Keywords: کاسپاز-8; Tissue factor pathway inhibitor-2; Atherosclerosis; Apoptosis; Fas/FasL; Caspase-8;
Comparing different physical factors on serum TNF-α levels, chondrocyte apoptosis, caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits
Keywords: کاسپاز-8; OA; TNF-α; Chondrocyte apoptosis; Caspase-3; Caspase-8
Tissue Factor/ FVIIa prevents the extrinsic pathway of apoptosis by regulation of the tumor suppressor Death-Associated Protein Kinase 1 (DAPK1)
Keywords: کاسپاز-8; Tissue factor; FVIIa; Apoptosis; DAPK1; PAR2; Caspase-8
Research ArticleAblation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo
Keywords: کاسپاز-8; c-FLIP; CD95; d-Galactosamine/LPS; Concanavalin A; JNK; Bid; Apoptosis; Caspase-8; Liver injury; Cell death; ALT; alanine aminotransferase; c-FLIP; cellular FLICE-inhibitory protein; ConA; concanavalin A; DED; death effector domain; DISC; death-inducing s
Combined treatment with the Cox-2 inhibitor niflumic acid and PPARγ ligand ciglitazone induces ER stress/caspase-8-mediated apoptosis in human lung cancer cells
Keywords: کاسپاز-8; Niflumic acid; Ciglitazone; Apoptosis; Caspase-8; ER stress; CHOP
Tumor necrosis factor alpha pathways develops liver apoptosis in type 1 diabetes mellitus
Keywords: کاسپاز-8; DM, diabetes mellitus; STZ, streptozotocin; AG, aminoguanidine; SID, streptozotocin-induced diabetes; ALT, alanine aminotransferase; AST, aspartate aminotransferaseTNF-α; Caspase-8; NFκB; iNOS; JNK; Insulin; Caspase-3; Apoptosis; Liver; Diabetes
Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs
Keywords: کاسپاز-8; Proteasome inhibitors; Leukemia; Apoptosis; Caspase-8; Oxidative stress
Physiological significance of selective degradation of p62 by autophagy
Keywords: کاسپاز-8; Autophagy; Ubiquitin; p62; Neighbor of BRCA1 gene 1; TRAF6; Caspase-8; Keap1Atg, autophagy-related; DISC, death-inducing signaling complex; LC3, microtubule-associated protein 1 light chain 3; LIR, LC3-interacting region; LRS, LC3 recognition sequence; Nb
Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway
Keywords: کاسپاز-8; ISA, irciniastatin A; JNK, c-Jun N-terminal kinase; NAC, N-acetyl-l-cysteine; ROS, reactive oxygen speciesIrciniastatin A; Ribotoxic stress; Apoptosis; Caspase-8; JNK
Molecular cloning of sea bass (Dicentrarchus labrax L.) caspase-8 gene and its involvement in Photobacterium damselae ssp. piscicida triggered apoptosis
Keywords: کاسپاز-8; Sea bass; Dicentrarchus labrax; Caspase-8; Apoptosis; Photobacterium damselae ssp. piscicida
A functional RNAi screen identifies hexokinase 1 as a modifier of type II apoptosis
Keywords: کاسپاز-8; Apoptosis; Hexokinase 1; Caspase-8; DISC; TNF
Malt1 and cIAP2-Malt1 as effectors of NF-κB activation: Kissing cousins or distant relatives?
Keywords: کاسپاز-8; MALT; mucosa associated lymphoid tissue; cIAP2; cellular inhibitor of apoptosis 2; IKK complex; inhibitor of κB kinase; TCR; T cell receptor; BCR; B cell receptor; Bcl10; B cell lymphoma 10; CARD; caspase associated recruitment domain; BIR; baculovirus I
Kinetic and structural characterization of caspase-3 and caspase-8 inhibition by a novel class of irreversible inhibitors
Keywords: کاسپاز-8; AMC, 7-amino-4-methyl-coumarin; DMSO, dimethyl sulfoxide; DTT, dithiothreitol; fmk, flouromethyl ketone; MMX, Molecumetics Company, Ltd; RMSD, root mean squared deviationCaspase-3; Caspase-8; Peptidomimetic inhibitors; Irreversible inhibition; Urazole; Cr
Involvement of caspase-8, -9, and -3 in high glucose-induced apoptosis in PC12 cells
Keywords: کاسپاز-8; PC12; High glucose; Apoptosis; Caspase-3; Caspase-8; Caspase-9
Caspase inhibitors increase the rate of recovery of neural stem/progenitor cells from post-mortem rat brains stored at room temperature
Keywords: کاسپاز-8; Neural stem cell; Caspase inhibitor; Caspase-8; Apoptosis; Cell transplantation therapy
Titanium dioxide nanoparticles induce apoptosis through the JNK/p38-caspase-8-Bid pathway in phytohemagglutinin-stimulated human lymphocytes
Keywords: کاسپاز-8; Titanium dioxide nanoparticles; Apoptosis; Caspase-8; Mitogen-activated protein kinases; Inhibitors; RNA interference;
Caspase-8 in cancer biology and therapy
Keywords: کاسپاز-8; Apoptosis; Caspase-8; Cancer
Total saponins of Panax Notoginseng modulate the expression of caspases and attenuate apoptosis in rats following focal cerebral ischemia-reperfusion
Keywords: کاسپاز-8; Total saponins of Panax notoginseng; Cerebral ischemia-reperfusion; TUNEL; Caspase-1; Caspase-3; Caspase-8
KAAD-cyclopamine augmented TRAIL-mediated apoptosis in malignant glioma cells by modulating the intrinsic and extrinsic apoptotic pathway
Keywords: کاسپاز-8; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; IAP; Inhibitor of apoptosis proteins; DR4; death receptor 4; DR5; death receptor 5; XIAP; X-linked inhibitor of apoptosis protein; ph-Akt; phosphorylated Akt; Glioma; TRAIL/Apo2L; KAAD-cyclop
N,N-dimethyl phytosphingosine induces caspase-8-dependent cytochrome c release and apoptosis through ROS generation in human leukemia cells
Keywords: کاسپاز-8; N,N-dimethyl phytosphingosine (DMPS); Cell death mechanisms; Inhibitors; Reactive oxygen species (ROS); Caspase-8
Evidence for a pro-apoptotic phenotype in skeletal muscle of hypertensive rats
Keywords: کاسپاز-8; Apoptosis; ARC; XIAP; Caspase-8; Smac; Oxidative stress; Skeletal muscle; Hypertension;
Bcl-2 and caspase-8 related anoikis resistance in human osteosarcoma MG-63 cells
Keywords: کاسپاز-8; Anoikis; Osteosarcoma; Bcl-2; Caspase-8; PI3K; β-catenin;
Non-apoptotic functions of caspase-8
Keywords: کاسپاز-8; NF-κB; Caspase-8; Monocyte differentiation; Apoptosis; Proliferation
Cell-autonomous and non-cell-autonomous functions of caspase-8
Keywords: کاسپاز-8; CY, cyclophosphamide; GdCl, gadolinium chloride; PHx, partial hepatectomy; KO, knockout; WT, wild-typeApoptosis; Caspase-8; Cell-autonomous; Therapy; TNF
Expression and localization of Fas-associated proteins following focal cerebral ischemia in rats
Keywords: کاسپاز-8; Brain ischemia; Reperfusion; Apoptosis; Rat; FADD; DAXX; Fap-1; Caspase-8
Cytotoxic effects of dimethyl sulphoxide (DMSO) on cochlear organotypic cultures
Keywords: کاسپاز-8; Dimethyl sulphoxide, DMSO; Hensen cell, HnC; Outer hair cell, OHC; Inner hair cell, IHC; Terminal deoxynucleotidyl transferase biotin-dUTP nick end labeling, TUNELDimethyl sulphoxide; Hair cells; Cochlear organotypic culture; Apoptosis; Caspase-8; Caspase
Cannabidiol-induced apoptosis in primary lymphocytes is associated with oxidative stress-dependent activation of caspase-8
Keywords: کاسپاز-8; Cannabidiol; Apoptosis; Lymphocyte; Oxidative stress; Reactive oxygen species; Caspase-8
Leukocyte Elastase Inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation
Keywords: کاسپاز-8; LEI, Leukocyte Elastase Inhibitor; L-DNase II, LEI-derived DNase II; HMA, Hexa-methylene-amiloride; Crm A, cytokine response modifier A; TNFα, tumor necrosis factor α; PAI-2, plasminogen activator inhibitor 2; PI-9, Proteinase Inhibitor-9; AP24, Apoptot
Simple computational models of type I/type II cells in Fas signaling-induced apoptosis
Keywords: کاسپاز-8; Computational cell biology; Model reduction; Caspase-8; Caspase-9; DISC
Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells
Keywords: کاسپاز-8; Caspase-8; Neuroblastoma; Medulloblastoma; Small cell lung carcinoma; Retinoid; Retinoic acid; CREB; Apoptosis; Transcription;
Characterisation of cDNAs of key genes involved in apoptosis in common carp (Cyprinus carpio L.)
Keywords: کاسپاز-8; Common carp (Cyprinus carpio L.); Apoptosis; Apaf-1; Bcl-2; Caspase-8; Mcl-1
hMTH1 depletion promotes oxidative-stress-induced apoptosis through a Noxa- and caspase-3/7-mediated signaling pathway
Keywords: کاسپاز-8; siRNA; small interfering RNA; ROS; reactive oxygen species; 8-oxoG; 8-oxoguanine; 8-oxo-dGTP; 2â²-deoxy-8-oxoguanosine triphosphate; 2-OH-dATP; 2â²-deoxy-2-hydroxyadenosine triphosphate; γ-H2AX; phosphorylated-H2AX; hMTH1; Hydrogen peroxide; p53; Noxa;
Hypoxia/reoxygenation induces apoptosis through a ROS-mediated caspase-8/Bid/Bax pathway in human lymphocytes
Keywords: کاسپاز-8; Hypoxia/reoxygenation (H/R); Apoptosis; Reactive oxygen species (ROS); Mitochondrial membrane potential (MMP); Caspase-8; Bid; Bax
Caspase-8 dependent osteosarcoma cell apoptosis induced by proteasome inhibitor MG132
Keywords: کاسپاز-8; Proteasome inhibitor; Osteosarcoma; Apoptosis; p27Kip1; Bcl-2; Caspase-8;
Interferon-γ mediated up-regulation of caspase-8 sensitises medulloblastoma cells to radio- and chemotherapy
Keywords: کاسپاز-8; Brain tumour; Medulloblastoma; Caspase-8; Apoptosis; Novel therapies; Interferon
Time-of-day affects expression of hippocampal markers for ischemic damage induced by global ischemia
Keywords: کاسپاز-8; Circadian rhythms; Ischemia; Per1; Caspase-3; Caspase-8; Caspase-9; Calbindin
Neuroprotective effects of echinacoside in the mouse MPTP model of Parkinson's disease
Keywords: کاسپاز-8; Echinacoside; Parkinson's disease; MPTP; MPP+; Apoptosis; Caspase-3; Caspase-8
Nonylphenol induces apoptosis of Jurkat cells by a caspase-8 dependent mechanism
Keywords: کاسپاز-8; Nonylphenol; Jurkat cells; Apoptosis; Caspase-8
Membrane expression of DR4, DR5 and caspase-8 levels, but not Mcl-1, determine sensitivity of human myeloma cells to Apo2L/TRAIL
Keywords: کاسپاز-8; TRAIL; Death receptors; Mcl-1; Caspase-8; Apoptosis; Myeloma; Valproic acid; Histone deacetylase inhibitor; Lipid rafts
Cytotoxicity of diacetoxyscirpenol is associated with apoptosis by activation of caspase-8 and interruption of cell cycle progression by down-regulation of cdk4 and cyclin B1 in human Jurkat T cells
Keywords: کاسپاز-8; Diacetoxyscirpenol; Trichothecene mycotoxin; T-cell toxicity; Apoptosis; Caspase-8; Bid; Caspase cascade; Mitochondrial cytochrome c release; Cell cycle arrest
The p75 neurotrophin receptor is essential for neuronal cell survival and improvement of functional recovery after spinal cord injury
Keywords: کاسپاز-8; spinal cord injury; p75 neurotrophin receptor; caspase-3; caspase-9; caspase-8; caspase-6; BBB; Basso, Beattie, Bresnahan; H&E; hematoxylin and eosin; LFB; Luxul Fast Blue; Map2; microtubule-associated protein 2; p75NTR; p75 neurotrophin receptor; SCI; sp