کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2547143 | 1124048 | 2009 | 7 صفحه PDF | دانلود رایگان |
Ethnopharmacological relevanceTotal saponins of Panax notoginseng (TSPN), main constituents extracted from Panax Notoginseng, a highly valued traditional Chinese medicine, have been shown to be an effective agent on cerebral infarction.Aim of the studyThe effects of TSPN on apoptosis and expressions of caspase-1, caspase-3 and caspase-8 were studied after cerebral ischemia for 2 h followed by reperfusion for 46 h in rats.Materials and methodsRats were subjected to transient middle cerebral artery occlusion (MCAO) model using the intraluminal thread. TSPN was administered intraperitoneally at 5 min before and 12 h, 24 h and 36 h after MCAO, respectively.ResultsTSPN (at the dose of 25 mg/kg) significantly attenuated TUNEL-positive cells and reduced the expression of caspase-1 and caspase-3 compared to the model group, while it had no obvious effect on the expression of caspase-8.ConclusionsThe neuroprotective effect of TSPN on focal ischemia may be related to inhibition of apoptosis and caspases activation.
Journal: Journal of Ethnopharmacology - Volume 121, Issue 3, 30 January 2009, Pages 412–418