Evidence for involvement of the CD40/CD40L system in post-stroke epilepsy
Keywords: Ischemic stroke (IS); Post-stroke epilepsy (PSE); CD40; CD40L; Genetic polymorphism;
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Investigation of gene–gene interactions between CD40 and CD40L in Polish multiple sclerosis patients
Keywords: SNP, Single nucleotide polymorphism; MS, multiple sclerosis; RR, relapsing-remitting multiple sclerosis; SP, secondary-progressive multiple sclerosisMultiple sclerosis; CD40; CD40L; Gene–gene interactions
X-linked hyper IgM syndrome: Clinical, immunological and molecular features in patients from India
Keywords: X-linked hyper-IgM syndrome (XHIM); CD40L gene; CD40L; CD154; T-cell and B-cell immunodeficiency
Soluble CD40 ligand-activated B cells from patients with chronic hepatitis B virus infection as antigen presenting cells to induce hepatitis B virus specific cytotoxic T lymphocytes
Keywords: APCs; antigen presenting cells; CD40L; CD40 ligand; CD40-B; CD40L-activated B; CHB; chronic hepatitis B; CTLs; cytotoxic T lymphocytes; DCs; dendritic cells; HBcAg; hepatitis B core antigen; HBsAg; hepatitis B surface antigen; HBV; hepatitis B virus; HCC;
Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway
Keywords: CLL; ZAP-70; Microenvironment; IL-6; IL-8; CD40L; IL-4; PI3K pathway;
Signals from activation of B-cell receptor with anti-IgD can override the stimulatory effects of excess BAFF on mature B cells in vivo
Keywords: BAFF; B-cell activating factor; BAFF-receptor; BAFF-R or BR3; BCMA; B cell maturation antigen; BCR; B-cell receptor; CD40L; CD40 ligand; CLL; chronic lymphocytic leukaemia; FcγRβII; Fc gamma receptor beta isoform II; HRP; horseradish peroxidase; mIgM; m
A multimerized form of recombinant human CD40 ligand supports long-term activation and proliferation of B cells
Keywords: antigen presentation; APC; B cells; CD40L; immunotherapy; proliferation
Research ArticleCharacterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection
Keywords: OSM; oncostatin M; LIFR; leukemia inhibitory factor receptor; OSMRβ; OSM receptor beta subunit; APC; antigen presenting cells; DCs; dendritic cells; TLR; toll-like receptors; IFN; interferon; CD40L; CD40 ligand; CHC; chronic hepatitis C; HCV; hepatitis C
Clinical, molecular, and T cell subset analyses in a small cohort of Chinese patients with hyper-IgM syndrome type 1
Keywords: HIGM1; CD40L; Th1; Th17; Treg
Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets
Keywords: Ginkgolide B; Platelets; Syk; p38MAPK; PF4; CD40L;
Safety and immunogenicity of an adjuvanted protein therapeutic HIV-1 vaccine in subjects with HIV-1 infection: A randomised placebo-controlled study
Keywords: AE; adverse event; ANOVA; analysis of variance; ANCOVA; analysis of covariance; ART; antiretroviral therapy; ATP; according-to-protocol; CD40L; CD40-ligand; CI; confidence interval; DAIDS; National Institute of Allergy and Infectious Diseases Division of
Regulation of platelet responses triggered by Toll-like receptor 2 and 4 ligands is another non-genomic role of nuclear factor-kappaB
Keywords: Abs; Antibodies; ADP; Adenosine diphosphate; ATP; Adenosine triphosphate; BAY 11-7082; (E)-3-[4-methylphenylsulfonyl]-2-propenenitrile; Ca2Â +; Calcium; CD40L; CD40 ligand; cGMP/PKG; Cyclic guanosine monophosphate/Dependent protein kinase G; ERK1/2; Extra
Processing of blood samples influences PBMC viability and outcome of cell-mediated immune responses in antiretroviral therapy-naïve HIV-1-infected patients
Keywords: ANOVA; Analysis of Variance; ART; antiretroviral therapy; ARTâ HIV+; ART-naïve HIV-1-infected patients; ART+ HIV+; ART-experienced HIV-1-infected patients; CD40L; CD40-ligand; CMI; cell mediated immunity; DAIDS; Division of Acquired Immunodeficiency Sy
The NF-κB family member RelB regulates microRNA miR-146a to suppress cigarette smoke-induced COX-2 protein expression in lung fibroblasts
Keywords: CD40L; CD40 ligand; COPD; chronic obstructive pulmonary disease; COX-2; cyclooxygenase-2; CSE; cigarette smoke extract; miRNA; microRNA; NF-κB; nuclear factor-κB; RLU; relative luciferase units; TNF-α; tumor necrosis factor-α; MicroRNA; Cyclooxygenase
Effects of varying antigens and adjuvant systems on the immunogenicity and safety of investigational tetravalent human oncogenic papillomavirus vaccines: Results from two randomized trials
Keywords: AE; adverse event; ANOVA; analysis of variance; ATP; according-to-protocol; CD40L; CD40 ligand; CI; confidence interval; CIN; cervical intraepithelial neoplasia; Ctrl; control; ELISA; enzyme-linked immunosorbent assay; EU; ELISA units; GMT; geometric mean
Immune deficiencies, infection, and systemic immune disordersHigh-content cytometry and transcriptomic biomarker profiling of human B-cell activation
Keywords: Primary immunodeficiency; primary antibody deficiency; B-cell immunology; chip cytometry; AID; Activation-induced cytidine deaminase; CD40L; CD40 ligand; CSR; Class-switch recombination; CVID; Common variable immunodeficiency; MACS; Magnetic-activated cel
Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
Keywords: Food allergy; allergy; oral immunotherapy; peanut; TÂ regulatory cells; desensitization; tolerance; epigenetics; forkhead box protein 3; ai-Treg; Antigen-induced regulatory T; APC; Antigen-presenting cell; CD40L; CD40 ligand; CFSE; Carboxyfluorescein succ
Single nucleotide polymorphism of CD40 in the 5â²-untranslated region is associated with ischemic stroke
Keywords: SNP; single nucleotide polymorphism; PCR-RFLP; polymerase chain reaction-restriction fragment length polymorphism; TNFR; tumor necrosis factor receptor; CD40L; CD40 ligand; CNS; central nervous system; 5â²-UTR; 5â²-untranslated region; ICD-9-CM; Interna
Association of CD40 â 1C/T polymorphism with cerebral infarction susceptibility and its effect on sCD40L in Chinese population
Keywords: Cerebral infarction (CI); CD40; CD40L; Genetic polymorphism; Peripheral blood mononuclear cells (PBMCs);
Polyfunctional CD4+ T cell responses in HIV-1-infected viral controllers compared with those in healthy recipients of an adjuvanted polyprotein HIV-1 vaccine
Keywords: AIDS; acquired immune deficiency syndrome; ARC; AIDS Reference Center; ART; antiretroviral therapy; AS; adjuvant system; CD40L; CD40-ligand; F4; recombinant fusion protein comprised of HIV-1 p17, p24, RT and Nef; HCV; hepatitis C virus; HIV; human immunod
Hypomorphic Janus kinase 3 mutations result in a spectrum of immune defects, including partial maternal T-cell engraftment
Keywords: Severe combined immunodeficiency; cytokine signaling; maternal engraftment; B-LCL; B-lymphoblast cell line; BMT; Bone marrow transplantation; CD40L; CD40 ligand; CFSE; Carboxyfluorescein diacetate succinimidyl ester; GVHD; Graft-versus-host disease; JAK3;
Optimization of a human IgG B-cell ELISpot assay for the analysis of vaccine-induced B-cell responses
Keywords: ASC; antibody-secreting cells; CD40L; CD40 ligand; FCS; fetal calf serum; FHA; filamentous hemagglutinin; CMI; cell-mediated immunity; DT; diphtheria toxin; IL; interleukin; mAb; monoclonal antibody; ON; over night; PBMC; peripheral blood mononuclear cell
Impaired NFAT and NFκB activation are involved in suppression of CD40 ligand expression by Î9-tetrahydrocannabinol in human CD4+ T cells
Keywords: Î9-tetrahydrocannabinol (Î9-THC); T cell-receptor signaling; Intracellular calcium; NFAT; NFκB; CD40L;
Blood CD4+CD45RO+CXCR5+ T cells are decreased but partially functional in signal transducer and activator of transcription 3 deficiency
Keywords: Human; T cells; signal transducer and activator of transcription 3 deficiency; cell activation; naive B cells; Bcl6; B-cell lymphoma 6; CD40L; CD40 ligand; CD62L; L-selectin; CSR; Class-switch recombination; GC; Germinal center; ICOS; Inducible costimulat
B-lymphocyte lineage cells and the respiratory system
Keywords: B cells; plasma cells; plasmablasts; respiratory diseases; AID; Activation-induced cytidine deaminase; APRIL; A proliferation-inducing ligand; BAFF; B cell-activating factor of the TNF family; BAL; Bronchoalveolar lavage; BCMA; B-cell maturation antigen
E4BP4 overexpression: A protective mechanism in CD4+ T cells from SLE patients
Keywords: Systemic lupus erythematosus; E4BP4; T cells; CD40L; Histone modifications
Deficiency of caspase recruitment domain family, member 11 (CARD11), causes profound combined immunodeficiency in human subjects
Keywords: CARD11; human; combined immunodeficiency; hypogammaglobulinemia; profound combined immunodeficiency disorder; transitional B cell; nuclear factor κB; B cell-activating factor receptor; inducible T-cell costimulator; germinal center; APC; Allophycocyanin;
T cells stimulate catabolic gene expression by the stromal cells from giant cell tumor of bone
Keywords: Giant cell tumor; CD40; CD40L; PTHrP; MMP-13; RANKL;
Platelets and cytokines: How and why?
Keywords: Platelets; Transfusion; Transfusion hazards; Inflammation; Innate immunity; Cytokines; CD40L; Biological response modifiersPlaquettes; Transfusion; Effets indésirables transfusionnels; Inflammation; Immunité innée; Cytokines; CD40L; Modificateurs du compo
CD40L demethylation in CD4+ T cells from women with rheumatoid arthritis
Keywords: Rheumatoid arthritis; CD40L; DNA methylation; CD4+ T cells
Prevention and synergistic control of Ph+ ALL by a DNA vaccine and 6-mercaptopurine
Keywords: ALL; acute lymphoblastic leukemia; CD40L; CD40-ligand; CpG; cytosine-guanine dinucleotide; dSLIM; double stem-loop immunomodulator; GM-CSF; granulocyte-macrophage colony-stimulating factor; IL; interleukin; IFN-γ; interferon gamma; 6-MP; 6-mercapto
Immune responses elicited by a fourth dose of the HPV-16/18 AS04-adjuvanted vaccine in previously vaccinated adult women
Keywords: AE; adverse event; ATP; according-to-protocol; CD40L; CD40 ligand; CI; confidence interval; CMI; cell-mediated immune; CVS; cervico-vaginal secretion; DNA; deoxyribonucleic acid; ELISA; enzyme-linked immunosorbent assay; Gmean; geometric mean; GMT; geomet
Protective effect of IgM against colonization of the respiratory tract by nontypeable Haemophilus influenzae in patients with hypogammaglobulinemia
Keywords: Haemophilus influenzae; infections; immunoglobulins; IgM; immunodeficiency; AID; Activation-induced deaminase; BTK; Bruton tyrosine kinase; CD40L; CD40 ligand; HIgM; Hyper-IgM; NTHi; Nontypeable Haemophilus influenzae; PHG; Panhypogammaglobulinemia; RR; R
CD205 antigen targeting combined with dendritic cell recruitment factors and antigen-linked CD40L activation primes and expands significant antigen-specific antibody and CD4+ T cell responses following DNA vaccination of outbred animals
Keywords: Dendritic cell; Antigen-targeting; CD40L; Linked activation; CD4 T cells; DNA vaccine; Intradermal; Outbred species;
Clinical, molecular, and cellular immunologic findings in patients with SP110-associated veno-occlusive disease with immunodeficiency syndrome
Keywords: Veno-occlusive disease with immunodeficiency; hypogammaglobulinemia; SP110; B-cell development; BMT; Bone marrow transplantation; CD40L; CD40 ligand; CMV; Cytomegalovirus; DAVID; Database for Annotation, Visualization and Integrated Discovery; hVOD; Hepat
Warts and all: Human papillomavirus in primary immunodeficiencies
Keywords: Immunodeficiency; human papillomavirus; warts; squamous; carcinoma; dysplastic; ADA; Adenosine deaminase; A-T; Ataxia-telangiectasia; ATM; Ataxia-telangiectasia mutated gene; CD40L; CD40 ligand; CMV; Cytomegalovirus; CVID; Common variable immunodeficiency
Review ArticlePlatelet CD40L at the interface of adaptive immunity
Keywords: CD40L; CD40 Ligand (also CD154); SLE; systemic lupus erythematosus; DC; dendritic cell; IFNγ; interferon gamma; CTL; cytotoxic T lymphocyte; GC; germinal center; RANTES; regulated upon activation normal T cell expressed and secreted; Ad5mOVA; adenovirus
CD40L-null NKT cells provide B cell help for specific antibody responses
Keywords: NKT; natural killer T cell; α-GC; alpha-galactosylceramide; KLH; keyhole limpet hemocyanin; NP; nitrophenol; Antibody; B lymphocyte; CD40L; NKT cell;
Transplant long-surviving induced by CD40-CD40 ligand costimulation blockade is dependent on IFN-γ through its effect on CD4+CD25+ regulatory T cells
Keywords: CD40L; CD40 ligand; CTL; cytotoxic T lymphocyte; E/T ratios; effector to target ratios; FACS; fluorescence-activated cell sorter; GVHD; graft versus host disease; i.p.; intraperitoneally; i.v.; intravenously; mAb; monoclonal antibody; MACS; magnetic-activ
MicroRNA-146a regulates the maturation process and pro-inflammatory cytokine secretion by targeting CD40L in oxLDL-stimulated dendritic cells
Keywords: microRNA-146a; oxLDL; Dendritic cell; CD40L; Immuno-inflammationDC, dendritic cell; MiRNA, microRNA; OxLDL, oxidized low density lipoprotein; TNF-α, tumor necrosis factor-α; IL, interleukin; UTR, untranslated regions
IDO expression by human B lymphocytes in response to T lymphocyte stimuli and TLR engagement is biologically inactive
Keywords: 1MT; 1-methyl-tryptophan; Ab; antibody; APC; antigen-presenting cells; CD40L; CD40-ligand; CTLA4-Ig; cytotoxic T lymphocyte antigen-4-immunoglobulin; DAPI; 4â²,6â²-diamidino-2-phenylindole; DC; dendritic cells; FBS; fetal bovine serum; FITC; fluorescein
Functional expression of chimeric Fab of an anti-CD40L mAb: Vector design and culture condition optimization
Keywords: CD40L; Fab; E. coli expression
CD154 Expression Is Associated with Neutralizing Antibody Titer Levels Postinfluenza Vaccination in Stem Cell Transplant Patients and Healthy Adults
Keywords: CD154; CD40L; Influenza; Vaccination; Stem cell transplant
Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation
Keywords: Toll-like receptor 9; CD40; transmembrane activator and calcium-modulating cyclophilin ligand interactor; class-switch recombination; plasma cell; immunoglobulin; B cells; AICDA; Activation-induced cytidine deaminase; APRIL; A proliferation inducing ligan
CD40 ligand-triggered human dendritic cells mount interleukin-23 responses that are further enhanced by danger signals
Keywords: Dendritic cells; IL-12; IL-23; Tumor vaccination; CD40L;
Comparative analysis of MVA-CD40L and MVA-TRICOM vectors for enhancing the immunogenicity of chronic lymphocytic leukemia (CLL) cells
Keywords: Immunotherapy; CLL; TRICOM; CD40L; Vaccine
Regulation of CD40L (CD154) and CD62P (p-selectin) Surface Expression upon GPIIb-IIIa Blockade of Platelets from Stable Coronary Artery Disease Patients
Keywords: Platelets; Coronary artery disease; Eptifibatide; CD40L; CD62P
CD40 ligand expressed in adenovirus can improve the immunogenicity of the GP3 and GP5 of porcine reproductive and respiratory syndrome virus in swine
Keywords: CD40L; PRRSV; GP3; GP5; Immune responses
A novel allergen-specific therapy for allergy using CD40-silenced dendritic cells
Keywords: Allergy; CD40; small interfering RN; dendritic cells; regulatory T cells; CD40L; CD40 ligand; DC; Dendritic cell; Foxp3; Forkhead box protein 3; KLH; Keyhole limpet hemocyanin; OVA; Ovalbumin; shRNA; Short hairpin RNA; siRNA; Small interfering RNA; Treg;
IFN-γ activated JAK1 shifts CD40-induced cytokine profiles in human antigen-presenting cells toward high IL-12p70 and low IL-10 production
Keywords: Dendritic cells; Monocytes; B-cells; Endothelial cells; CD40; CD40L; JAK; Tyk2; STAT; NF-κB; IRF-1; IRF-8; IL-12; IL-10