Prevention and synergistic control of Ph+ ALL by a DNA vaccine and 6-mercaptopurine

► The DNA vaccine BCR-ABL/GM-CSF/IL-12/dSLIM prevents Ph+ ALL in syngeneic mice. ► DNA vaccination induces an innate and adaptive immune response. ► DNA vaccination eliminates minimal residual disease of Ph+ ALL in syngeneic mice. ► Compared to 6-MP the DNA vaccine led to a significantly longer leukemia-free survival. ► Synergistic treatment of minimal residual disease with DNA vaccination and 6-MP.