Keywords: سلول های گرانول مخچه; Cerebellar granule cells; Lanthionine; Neuritogenesis; CRMP2;
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Keywords: سلول های گرانول مخچه; 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Keywords: سلول های گرانول مخچه; Pleiotrophin; Neuromodulation; Hippocampus; Cerebellar granule cells; Gene expression; Caspase 6; AKT;
Keywords: سلول های گرانول مخچه; AD; Alzheimer's disease; ANT-1; adenine nucleotide translocator-1; Ap5A; P1,P5-di(adenosine-5â²)pentaphosphate; ATP D.S.; ATP detecting system; ATR; atractyloside; BME; basal medium Eagle; CGCs; cerebellar granule cells; COX; cytochrome c oxidase; DIDS
Keywords: سلول های گرانول مخچه; Preterm brain injury; Preterm cerebellar hemorrhage; Mouse model; Behavioral phenotype; Cerebellar granule cells; Gene expression; Cerebellar development
Time-dependent effects of perfluorinated compounds on viability in cerebellar granule neurons: Dependence on carbon chain length and functional group attached
Keywords: سلول های گرانول مخچه; Perfluoroalkyl and polyfluoroalkyl acids; Carbon chain length; Cytotoxicity; Cerebellar granule cells; Nano secondary ion mass spectrometry; Lipid peroxidation;
The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D
Keywords: سلول های گرانول مخچه; AIF; apoptosis inducing factor; A-T; ataxia telangiectasia syndrome; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and Rad3-related protein; CGC; cerebellar granule cells; DNA-PK; DNA-dependent protein kinase; Dox; doxorubicin; DSB; doubl
Pharmacological characterization of mGlu1 receptors in cerebellar granule cells reveals biased agonism
Keywords: سلول های گرانول مخچه; Metabotropic glutamate receptor 1; Biased agonism; Glutamate; Quisqualate; DHPG; Cerebellar granule cells; ACPD; 1-Aminocyclopentane-1,3-dicarboxylic acid; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium; DHPG; 3,5-dihydroxyphenylglycine; CPCCOE
Research ReportDevelopmental exposure to ethanol increases the neuronal vulnerability to oxygen-glucose deprivation in cerebellar granule cell cultures
Keywords: سلول های گرانول مخچه; BAL; blood alcohol level; CGCs; cerebellar granule cells; CT; cycle threshold; Ctr; control; EM+/âG; experimental medium with/without glucose; EtOH; ethanol; GO; gene ontology; OGD; oxygen-glucose deprivation; PI; propidium iodide; qPCR; quantitative
CYP2E1 induction leads to oxidative stress and cytotoxicity in glutathione-depleted cerebellar granule neurons
Keywords: سلول های گرانول مخچه; CGNs; cerebellar granule neurons; CYP2E1; cytochrome P450 2E1; ROS; reactive oxygen species; GSH; glutathione; DIV; days in vitro; INH; isoniazid; BSO; l-buthionine sulfoximine; DAS; diallyl sulfide; EUKA; Eukarion-134; 8-oxodG; 8-oxo-7,8-dihydro-2-deoxyg
Blockage of CR1 prevents activation of rodent microglia
Keywords: سلول های گرانول مخچه; Aβ; amyloid beta; AD; Alzheimer's disease; Apo; apocynin; APP; amyloid precursor protein; CGC; cerebellar granule cells; CR1; complement receptor 1; DIV; days in vitro; DHE; dihydroethidium; D-MEM; Dulbecco's modified eagle medium; EA; ethacrynic acid; E
Mitochondrial respiratory chain Complexes I and IV are impaired by β-amyloid via direct interaction and through Complex I-dependent ROS production, respectively
Keywords: سلول های گرانول مخچه; AA; antimycin A; Aβ; β-amyloid; AD; Alzheimer disease; ASC; ascorbate; CGCs; cerebellar granule cells; Co-IP; co-immunoprecipitation; COX; cytochrome oxidase; Cyt c; cytochrome c; DCIP; dichloroindophenol; DQH2; duroquinol reduced; DQox; duroquinone oxi
Perfluoroalkylated compounds induce cell death and formation of reactive oxygen species in cultured cerebellar granule cells
Keywords: سلول های گرانول مخچه; Perfluoroalkylated compounds (PFC); PFOS; FTOH; PFOA; PFOSA; Cerebellar granule cells; Reactive oxygen species (ROS); Cell death
Dissecting the molecular mechanism by which NH2htau and Aβ1-42 peptides impair mitochondrial ANT-1 in Alzheimer disease
Keywords: سلول های گرانول مخچه; AA; antimycin A; Aβ; β-amyloid; AD; Alzheimer disease; ANT-1; adenine nucleotide translocator-1; Ap5A; P1,P5-Di(adenosine-5â²)penta-phosphate; ATP D.S.; ATP detecting system; ATR; atractyloside; β-OH; β-hydroxybutyrate; CGCs; cerebellar granule cells
The effects of zolpidem treatment on GABAA receptors in cultured cerebellar granule cells: Changes in functional coupling
Keywords: سلول های گرانول مخچه; Zolpidem; Cerebellar granule cells; GABAA receptor; [3H]flunitrazepam binding; Gene expression; Tolerance;
Research reportAcute neuregulin-1 signaling influences AMPA receptor mediated responses in cultured cerebellar granule neurons
Keywords: سلول های گرانول مخچه; AMPA; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; CGCs; cerebellar granule cells; chemLTP; high-glycine/0 Mg2+-induced LTP; KA; kainate; LTP; long-term potentiation; mEPSC; miniature excitatory post-synaptic currents; NMDA; N-methyl-d-aspartic ac
An in vitro model for studying the effects of continuous ethanol exposure on N-methyl-d-aspartate receptor function
Keywords: سلول های گرانول مخچه; N-methyl-d-aspartate receptors; Cerebellar granule cells; Continuous ethanol exposure (CEE); Astrocytes; Confocal microscopy; Whole-cell patch clamp;
Positive allosteric modulation of metabotropic glutamate receptor 5 down-regulates fibrinogen-activated microglia providing neuronal protection
Keywords: سلول های گرانول مخچه; BBB; blood brain barrier; CDPPB; 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide; CGC; cerebellar granule cells; CNS; central nervous system; DCGIV; (2S,2â²R,3â²R)-2-(2â²,3â²-dicarboxycyclopropyl)glycine; ERK1/2; extracellular signal-regulated kinas
Altered energy status of primary cerebellar granule neuronal cultures from rats exposed to lead in the pre- and neonatal period
Keywords: سلول های گرانول مخچه; Lead (Pb); Cerebellar granule cells; ATP; Mitochondria; Energy status
Acute ethanol exposure prevents PMA-mediated augmentation of N-methyl-d-aspartate receptor function in primary cultured cerebellar granule cells
Keywords: سلول های گرانول مخچه; N-methyl-d-aspartate receptor; Cerebellar granule cells; Protein kinase C; Whole-cell patch-clamp; Phorbol 12-myristate 13-acetate; Ethanol;
SP protects cerebellar granule cells against β-amyloid-induced apoptosis by down-regulation and reduced activity of Kv4 potassium channels
Keywords: سلول های گرانول مخچه; Substance P; Apoptosis; Cerebellar granule cells; Aβ23–35; Voltage-gated K+channels; Kv4.2 and Kv4.3 subunitsAβ, β-amyloid peptide; Akt, serine/threonine protein kinase; AD, Alzheimer's disease; CGCs, cerebellar granule cells; DIV, days in vitro; IKA, fas
Cellular NeuroscienceResearch PaperRole for ionic fluxes on cell death and apoptotic volume decrease in cultured cerebellar granule neurons
Keywords: سلول های گرانول مخچه; apoptosis; low potassium; staurosporine; camptothecin; chloride fluxes; potassium fluxes; CGN; cerebellar granule cells; CPT; camptothecin; Cs+; cesium chloride; DIDS; 4,4â²-diisothiocyanato-stilbene-2,2â²-disulfonic acid; DIV; days in vitro; FDA; fluor
Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders
Keywords: سلول های گرانول مخچه; Apoptosis; Brain-derived neurotrophic factor (BDNF); Glycogen synthase kinase 3 (GSK-3); Lithium; Neurodegenerative diseases; Neuroprotection; 3-NP; 3-nitropropionic acid; Aβ; β-amyloid; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AP-1;
Homocysteine-induced acute excitotoxicity in cerebellar granule cells in vitro is accompanied by PP2A-mediated dephosphorylation of tau
Keywords: سلول های گرانول مخچه; Cerebellar granule cells; Excitotoxicity; Homocysteine; mGluRs; NMDA receptors; Phosphorylation; Tau protein; PP2A
The p38MAPK signaling pathway regulates neuronal apoptosis through the phosphorylation of the retinoblastoma protein
Keywords: سلول های گرانول مخچه; Cell cycle; Cerebellar granule cells; E2F-1; S/K deprivation
Hydroxylated polychlorinated biphenyls increase reactive oxygen species formation and induce cell death in cultured cerebellar granule cells
Keywords: سلول های گرانول مخچه; PCBs; Hydroxylated PCBs; Cell death; ERK1/2; Reactive oxygen species; Cerebellar granule cells; Cell toxicity
Neuroprotection by co-treatment and post-treating with calcitriol following the ischemic and excitotoxic insult in vivo and in vitro
Keywords: سلول های گرانول مخچه; Calcitriol; Cerebellar granule cells; Cortical neurons; Glutamate; Hippocampal neurons; Hypoxia-ischemia; Hypoxic preconditioning; Immature rats; Neurotoxicity; Perinatal asphyxia; Post-treatment;
Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons
Keywords: سلول های گرانول مخچه; Ryanodine; Calcium channels; Cerebellar granule cells; Bastadins; Diaryl ether
Neuroprotection of microglia conditioned media from apoptotic death induced by staurosporine and glutamate in cultures of rat cerebellar granule cells
Keywords: سلول های گرانول مخچه; Microglia; Cerebellar granule cells; Neurodegeneration; Neuroprotection; Neuron-microglia interactions;
The effects of glutamate receptor antagonists on cerebellar granule cell survival and development
Keywords: سلول های گرانول مخچه; NMDA receptor antagonist; Cerebellar granule cells; Development; Cell death
Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons
Keywords: سلول های گرانول مخچه; SB-415286; Lithium; B65 Neuroblastoma cells; Cerebellar granule cells; H2O2; Oxidative stress
Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation – Possible role as a dependence receptor
Keywords: سلول های گرانول مخچه; Cerebellar granule cells; Metabotropic glutamate receptor; Neurotoxicity; Neuroprotection; Trophic deprivation; Dependence receptors
Transcriptional cascade from Math1 to Mbh1 and Mbh2 is required for cerebellar granule cell differentiation
Keywords: سلول های گرانول مخچه; Cerebellar granule cells; Purkinje cells; Basic helix-loop-helix; Homeobox; Math1; Ptf1a; Mbh1; Mbh2; In vivo electroporation;
Protein biomarkers associated with growth and synaptogenesis in a cell culture model of neuronal development
Keywords: سلول های گرانول مخچه; Cerebellar granule cells; In vitro; Neurite growth; Synaptogenesis
A peptide containing residues 26-44 of tau protein impairs mitochondrial oxidative phosphorylation acting at the level of the adenine nucleotide translocator
Keywords: سلول های گرانول مخچه; AA; antimycin A; AD; Alzheimer Disease; ANT; adenine nucleotide translocator; Ap5A; P1,P5-Di(adenosine-5â²)penta-phosphate; ATP D.S.; ATP detecting system; ATR; atractyloside; BME; basal medium Eagle; β-OH,; β-hydroxybutyrate; CGC; cerebellar granule c
Glucosylceramide synthase decrease in frontal cortex of Alzheimer brain correlates with abnormal increase in endogenous ceramides: Consequences to morphology and viability on enzyme suppression in cultured primary neurons
Keywords: سلول های گرانول مخچه; Alzheimer's disease; Ceramide; Cerebellar granule cells; Glucosylceramide synthase; P4 inhibitor; Primary neurons
Actin depolymerization contributes to ethanol inhibition of NMDA receptors in primary cultured cerebellar granule cells
Keywords: سلول های گرانول مخچه; NMDA receptor; Cerebellar granule cells; Cytoskeleton; Ethanol pretreatment-enhanced inhibition; F-actin depolymerization; Confocal microscopy
Neuroprotective effect of melatonin against ischemia/reperfusion-induced neuronal apoptosis in mouse cerebellum
Keywords: سلول های گرانول مخچه; melatonin; cerebellar granule cells; ischemia/reperfusion; mitochondrium; cell apoptosis;
Mechanisms and modulation of neural cell damage induced by oxidative stress
Keywords: سلول های گرانول مخچه; Apoptosis; Oxidative stress; Methylmercury; Glucocorticoids; Cerebellar granule cells; Neural stem cells; Behavioral analysis
Measurements with fluorescent probes in primary neural cultures; improved multiwell techniques
Keywords: سلول های گرانول مخچه; Cerebellar granule cells; Drug discovery; Fluorescence; Methods; NMDA; Calcium; Rat; MK-801; Ion channel block; Fura-2
Cyclothiazide selectively inhibits mGluR1 receptors interacting with a common allosteric site for non-competitive antagonists
Keywords: سلول های گرانول مخچه; Metabotropic glutamate receptors; Cyclothiazide; Non-competitive antagonist; Cerebellar granule cells
Nitric oxide inhibits depolarization-evoked glutamate release from rat cerebellar granule cells
Keywords: سلول های گرانول مخچه; Nitric oxide; Neurotransmitter release; Cerebellar granule cells; Ca2+ channel; Redox modification
Comparative analysis of the effects of resveratrol in two apoptotic models: Inhibition of complex I and potassium deprivation in cerebellar neurons
Keywords: سلول های گرانول مخچه; cerebellar granule cells; resveratrol; sirtinol; SIRT1; MPP+; serum and potassium withdrawalCGN, cerebellar granule neuron; Ct, cycle threshold; H2DCFDA, 2,7-dichlorodihydrofluorescein diacetate; MPP+, 1-methyl-4-phenylpyridinium; PBS, phosphate buffered
Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor
Keywords: سلول های گرانول مخچه; Palytoxin; Ouabain; Resonant mirror; Na,K-ATPase; Sodium pump; Biosensor; Calcium; pH; Membrane potential; Cerebellar granule cells
Substance P provides neuroprotection in cerebellar granule cells through Akt and MAPK/Erk activation: Evidence for the involvement of the delayed rectifier potassium current
Keywords: سلول های گرانول مخچه; Substance P; Neuroprotection; Cerebellar granule cells; Tachykinin receptors
Glycogen synthase kinase-3 is involved in the regulation of the cell cycle in cerebellar granule cells
Keywords: سلول های گرانول مخچه; Apoptosis; Cell cycle; Serum and potassium withdrawal; Lithium; SB415286; GSK3β; Cerebellar granule cells
Mammalian Sir2-related protein (SIRT) 2–mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: A crucial role of tubulin deacetylation
Keywords: سلول های گرانول مخچه; cerebellar granule cells; NAD; nicotinamide; colchicine; sirtuin; developmentBSA, bovine serum albumin; DIV, days in vitro; FCS, fetal calf serum; GFP, green fluorescent protein; HDAC, histone deacetylase; HEK293T, human embryonic kidney 293T; HRP, horser
Inhibition of cyclin-dependent kinases is neuroprotective in 1-methyl-4-phenylpyridinium-induced apoptosis in neurons
Keywords: سلول های گرانول مخچه; cyclin dependent kinases; apoptosis; cerebellar granule cells; flavopiridol; vitamin EAIF, apoptosis-inducing factor; CGN, cerebellar granule neuron; FLAV, flavopiridol; H2DCFDA, 2,7-dichlorodihydrofluorescein diacetate; MPP+, 1-methyl-4-phenylpyridinium;
Excitotoxic neuronal injury in acute homocysteine neurotoxicity: Role of calcium and mitochondrial alterations
Keywords: سلول های گرانول مخچه; Calcium; Cerebellar granule cells; Cytochrome c; Homocysteine; Mitochondria
Differential development of vesicular glutamate transporters in brain: An in vitro study of cerebellar granule cells
Keywords: سلول های گرانول مخچه; Cerebellar granule cells; Co-culture; Development; Synapsin; Vesicular glutamate transporters