Superiority of PLK-2 as α-synuclein phosphorylating agent relies on unique specificity determinants
Keywords: α-Synuclein; PLK2; PLK3; CK2; Parkinson's disease;
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Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells
Keywords: EGFR; CK2; Erlotinib; CX-4945
TiO2/MWNTs nanocomposites-based electrochemical strategy for label-free assay of casein kinase II activity and inhibition
Keywords: CK2; Electrochemical; TiO2/MWNTs; Phosphorylation; Inhibitor
Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking
Keywords: CK2; Bayesian categorization model; Pharmacophore model; Molecular docking; Virtual screening
Modified tetrahalogenated benzimidazoles with CK2 inhibitory activity are active against human prostate cancer cells LNCaP in vitro
Keywords: CK2; Tetrahalogenobenzimidazoles; Kinase inhibitors; Anticancer activity; Human prostate cancer cell line LCNaP
Identification of CK2 as the kinase that phosphorylates Pax3 at Ser209 in early myogenic differentiation
Keywords: Pax3; Myogenesis; CK2; Phosphorylation
Investigation on PLK2 and PLK3 substrate recognition
Keywords: PLK2; PLK3; CK2; PLK1; Kinase
TF - A novel cell-permeable and selective inhibitor of human protein kinase CK2 induces apoptosis in the prostate cancer cell line LNCaP
Keywords: Dibenzo[b,d]furan; CK2; LNCaP; Drug discovery; Inhibitor;
Indeno[1,2-b]indole derivatives as a novel class of potent human protein kinase CK2 inhibitors
Keywords: DGOKKNPUISUUGY-UHFFFAOYSA-N; Indeno[1,2-b]indoles; Inhibitors; Human protein kinase; CK2; Cancer;
Janus kinase 2 - A novel negative regulator of estrogen receptor α function
Keywords: CA; constitutive active; CDK2; Cyclin dependent kinase 2; CDK7; Cyclin dependent kinase 7; CK2; Casein kinase 2; DCC; dextran-coated charcoal-treated; DNA-PK; DNA-dependent protein kinase; E2; 17β-estradiol; EGFR; Epidermal growth factor receptor; ER; es
Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability
Keywords: CHX; cycloheximide; CK2; protein kinase CK2; DBD; DNA-binding domain; DCOH; dimerization cofactor for hepatocyte nuclear factor 1; GST; glutathione S-transferase; LBD; ligand-binding domain; Pin1; peptidyl-prolyl cis/trans isomerase 1; PPIase; Peptidyl-pr
Short CommunicationPromoter contribution to the testis-specific expression of Stellate gene family in Drosophila melanogaster
Keywords: CK2; protein kinase CK2 (casein kinase 2); PBS; phosphate buffered saline; DTT; dithiothreitol; DAPI; 4â²,6-diamidino-2-phenylindole; piRNAs; Piwi-interacting RNAs; DPE; downstream promoter element; TSS; transcriptional start site; CDS; coding sequence;
Nanoencapsulated anti-CK2 small molecule drug or siRNA specifically targets malignant cancer but not benign cells
Keywords: CK2; Prostate cancer; Nanocapsule; Nanoparticle; DMAT; TenfibgenCK2, official acronym for former casein kinase 2 or II; d, day(s); DMAT, 2-dimethylamino-4,5,6,7-tetrabromo-1H-benzimidazole; h, hour(s); HNSCC, head and neck squamous cell carcinoma; FBS, fe
Toward understanding Machado-Joseph disease
Keywords: ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind
Novel potent pyrimido[4,5-c]quinoline inhibitors of protein kinase CK2: SAR and preliminary assessment of their analgesic and anti-viral properties
Keywords: CK2; Kinase inhibitor; HIV; Inflammation; Pain
Protein kinase CK2 modulates IL-6 expression in inflammatory breast cancer
Keywords: CK2; IL-6; CX-4945; Inflammatory breast cancer
Determinants of voltage-gated sodium channel clustering in neurons
Keywords: Axon initial segment; Node de Ranvier; Ankyrin; CK2; Endocytosis
Structural basis of CX-4945 binding to human protein kinase CK2
Keywords: Cancer; CK2α; Protein kinase; Drug discovery; X-ray crystallography; CK2; protein kinase CK2; DMAT; 2-dimethylamino-4,5,6,7-tetrabromo-benzimidazole; ATP; adenosine-5â²-triphosphate; DMSO; dimethyl sulfoxide; HEPES; N-(2-hydroxyethyl) piperazine-Nâ²-(2
CK2 inhibitors increase the sensitivity of HSV-1 to interferon-β
Keywords: HSV-1; CK2; IFN; ICP0; Ad5; VSV
CK2 phosphorylation of XRCC1 facilitates dissociation from DNA and single-strand break formation during base excision repair
Keywords: CK2; XRCC1; Dimethyl sulfate; Mammalian cells; Base excision repair; Single-strand break; Chinese hamster ovary cells
Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins
Keywords: RDBGOPDIMUUTST-HSAZJEJNSA-N; Quercetin; Photoaffinity probe; Biotinylated pull down probe; Heat shock proteins; ATP binding proteins; Casein kinase 2; BSA; bovine serum albumin; CaMK2; Ca2+/calmodulin-dependent protein kinase II; CK2; casein kinase II; CO
Casein kinase 2 regulates in vivo bone formation through its interaction with bone morphogenetic protein receptor type Ia
Keywords: CK2; BMP2; Bone; BMP type Ia receptor; Smad
CIGB-300, a proapoptotic peptide, inhibits angiogenesis in vitro and in vivo
Keywords: Angiogenesis; CK2; HUVEC; CAM; Endothelial cells; CIGB-300
Regulation of nucleocytoplasmic trafficking of viral proteins: An integral role in pathogenesis?
Keywords: BPV; bovine papillomavirus; BRAP2; BRCA1-associated protein 2; CAV; chicken anaemia virus; CBP; CREB binding protein; Cdk; cyclin dependent kinase; CK1; protein kinase CK1; CK2; protein kinase CK2; Crm1; chromosome region maintenance protein 1; CTD; C-ter
Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3
Keywords: GST; glutathione S-transferase; ES; embryonic stem; PAGE; polyacrylamide gel electrophoresis; MALDI; matrix-assisted laser desorption-ionization; TOF; time-of-flight; CK2; casein kinase 2; CIAP; calf intestinal alkaline phosphatase; Epigenetics; Chromat
Phosphorylation of serine 392 in p53 is a common and integral event during p53 induction by diverse stimuli
Keywords: p53; CK2; p38; Phosphorylation; Serine 392;
Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation
Keywords: Diosgenin; Antiinflammation; NF-κB; AP-1; CK2; JNK
CK2 and GSK3 phosphorylation on S29 controls wild-type ATXN3 nuclear uptake
Keywords: ATXN3; Phosphorylation; CK2; GSK3; Subcellular localization; Mass spectrometry
Structural insight into human CK2α in complex with the potent inhibitor ellagic acid
Keywords: CK2; Crystal structure; Structure-based drug design; Ellagic acid
CK2β interacts with and regulates p21-activated kinases in Drosophila
Keywords: Drosophila; CK2; Regulatory β-subunit; p21-activated kinase;
The ER-membrane-resident Hsp40 ERj1 is a novel substrate for protein kinase CK2
Keywords: CK2; ERj1; Phosphorylation; Hsp40; Chaperone; Endoplasmic reticulum; Protein transport
Molecular networks and system-level properties
Keywords: Systems biology; Cell cycle; G1/S transition; Cki; Sic1; Far1; Cln3; CK2; Robustness; Emergent property; Network
Drosophila CK2 phosphorylates Hairy and regulates its activity in vivo
Keywords: Drosophila; Neurogenesis; CK2; Hairy; Repression;
Characterization of the InsP6-dependent interaction between CK2 and Nopp140
Keywords: CK2; Nopp140; InsP6; Protein interaction
Phosphorylation of the TGBp1 movement protein of Potato virus X by a Nicotiana tabacum CK2-like activity
Keywords: CK2; Phosphorylation; PVX; Triple gene block; Viral mobilization
APLF (C2orf13) facilitates nonhomologous end-joining and undergoes ATM-dependent hyperphosphorylation following ionizing radiation
Keywords: NHEJ; APLF; FHA domains; ATM; Phosphorylation; CK2
In CK2 inactivated cells the cyclin dependent kinase inhibitor Sic1 is involved in cell-cycle arrest before the onset of S phase
Keywords: Cell cycle; Saccharomyces cerevisiae; Cki; Sic1; CK2; G1/S transition
Nuclear localization of protein kinase CK2 catalytic subunit (CK2α) is associated with poor prognostic factors in human prostate cancer
Keywords: CK2; Nuclear localization; Biomarker; Prognostic factors; Prostate cancer;
Casein kinase 2 is the major enzyme in brain that phosphorylates Ser129 of human α-synuclein: Implication for α-synucleinopathies
Keywords: Aggregation; Parkinson’s disease; Lewy body; Heparin; Mutation; CK2
Heterogeneity of CK2 phosphorylation sites in the NS5A protein of different hepatitis C virus genotypes
Keywords: HCV; Hepatitis C virus; NS5A; Non structural 5A; CK2; Casein kinase 2; Phosphorylation
Induction of cell death in antiestrogen resistant human breast cancer cells by the protein kinase CK2 inhibitor DMAT
Keywords: CK2; DMAT; Breast cancer; Antiestrogen resistance; Apoptosis; Bcl-2
Biochemical characterization of a N-terminal fragment (p5) cleaved from fibroblast growth factor-binding protein (FGF-BP) in bovine milk in vitro
Keywords: CH-3S; cholesterol-3-sulfate; CK1δ; casein kinase 1δ; CK2; casein kinase 2; DTT; dithiothreitol; FGF; fibroblast growth factor; aFGF; acidic FGF; bFGF; basic FGF; FGF-BP; FGF-binding protein; FGFR; FGF receptor; bLF; bovine lactoferrin; bLF-BP; bLF-bind
Emodin negatively affects the phosphoinositide 3-kinase/AKT signalling pathway: A study on its mechanism of action
Keywords: CK2; AKT; mTOR; PI3K pathway; Emodin
Characterization of protein kinase CK2 from Trypanosoma brucei
Keywords: DRB; 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole; IR; infrared; mAb; monoclonal antibody; Tet; tetracycline; Casein kinase; CK2; Protein kinase; Trypanosoma; TAP-tag; Nucleolus; NOG1;
The role of volume-sensitive ion transport systems in regulation of epithelial transport
Keywords: NKCC; Na+, K+, 2Clâ; RVI; volume regulatory increase; EATC; Ehrlich ascites tumour cells; SK; K channels having small conductance; IK; intermediate conductance; BK; large conductance; 2P-4TM; four transmembrane-spanning segments; TASK-2; acid sensitive
Troglitazone inhibits endothelial cell proliferation through suppression of casein kinase 2 activity
Keywords: PPARγ; Troglitazone; HUVEC; Proliferation; Akt; PTEN; CK2
Synergistic activation of NF-κB by nontypeable H. influenzae and S. pneumoniae is mediated by CK2, IKKβ-IκBα, and p38 MAPK
Keywords: Synergistic activation; NF-κB; CK2; Polymicrobial infection
Sic1 is phosphorylated by CK2 on Ser201 in budding yeast cells
Keywords: Cell cycle; Saccharomyces cerevisiae; CK2; Sic1; Cki; 2-D Gel electrophoresis; Mass spectrometry analysis; Co-immunoprecipitation; Phosphorylation; Protein interaction