Keywords: COMT، catechol-O-methyltransferase; AD, Alzheimer's disease; Bcl-2, B-cell lymphoma 2 protein; BDNF, brain-derived neurotrophic factor; CNS, central nervous system; COMT, catechol-O-methyltransferase; CREB, cAMP response element-binding protein; DAOA, gene for d-amino acid oxidase activator
مقالات ISI COMT، catechol-O-methyltransferase (ترجمه نشده)
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Keywords: COMT، catechol-O-methyltransferase; α-Syn, α-synuclein; 3-MT, 3-methoxytyramine; 6-OHDA, 6-hydroxydopamine; Ach, acetylcholine; ANOVA, analysis of variance; COMT, catechol-O-methyltransferase; DA, dopamine; DAT, dopamine transporter; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanilic a
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; D1R, dopamine D1 receptor; D2R, dopamine D2 receptor; DAT, dopamine transporter; DMT1, divalent metal transporter 1; EPM, elevated plus maze; ICP-MS, inductively coupled plasma mass spectrometry; Mn, manganese; NET, nor
Keywords: COMT، catechol-O-methyltransferase; PND, post natal day; PPI, pre-pulse inhibition; THC, delta9-tetrahydrocannabinol; PCP, phencyclidine; COMT, catechol-O-methyltransferase; CB1, cannabinoid receptor 1; 5-HT2A serotonin 2A receptor, NMDA N-methyl-D-aspartate receptor; mGluR5, metabotropic g
Keywords: COMT، catechol-O-methyltransferase; AKT1, V-akt murine thymoma viral oncogene homolog 1; BDNF, Brain-derived neurotrophic factor; CB1R, Cannabinoid receptor 1; COMT, Catechol-o-methyltransferase; CNV, Copy number variation; CPT, Continuous performance test; DA, Dopamine; DAT, Dopamine trans
Keywords: COMT، catechol-O-methyltransferase; AP, antipsychotic; CD, cluster of differentiation; CNS, central nervous system; COMT, catechol-O-methyltransferase; COX, cyclooxygenase; CSF, cerebrospinal fluid; CSF2RA, colony stimulator factor receptor 2 alpha; DISC, disrupted in schizophrenia; GWAS, g
Keywords: COMT، catechol-O-methyltransferase; APOE, apolipoprotein E; BOLD, blood oxygenation level dependent; CACT, computer-assisted cognitive training; cTBS, continuous theta burst stimulation; COMT, catechol-O-methyltransferase; CRUNCH, compensation-related utilization of neural circuits hypothes
Keywords: COMT، catechol-O-methyltransferase; ACC, anterior cingulate cortex; BDNF, brain-derived neurotrophic factor; CCK, cholecystokinin; COMT, catechol-O-methyltransferase; DBH, dopamine beta-hydroxylase; DLPFC, dorsolateral prefrontal cortex; DRD3, dopamine receptor D3; FA, fractional anisotroph
The role of monoamine oxidase A in aggression: Current translational developments and future challenges
Keywords: COMT، catechol-O-methyltransferase; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, serotonin; COMT, catechol-O-methyltransferase; CSF, cerebro-spinal fluid; DSM-5, diagnostic and statistical manual of mental disorders, fifth edition; GxE, gene × environment; HVA, homovanillic acid; KO, knockout;
Methylenetetrahydrofolate reductase deficiency alters levels of glutamate and γ-aminobutyric acid in brain tissue
Keywords: COMT، catechol-O-methyltransferase; 5-HIAA, 5-hydroxyindoleacetic acid; 5-methylTHF, 5-methyltetrahydrofolate; COMT, catechol-O-methyltransferase; HPLC, high performance liquid chromatography; MTHFR, methylenetetrahydrofolate reductase; SAM, S-adenosylmethionine; GABA, γ-aminobutyric acid;
Association between catechol-O-methyltransferase Val158Met polymorphism and configural mode of face processing
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; Val, valine; Met, methionine; STS, superior temporal sulcus; SNP, single nucleotide polymorphism; RT, reaction timeFace configuration; Genetic polymorphism; COMT
The endometrial cancer cell lines Ishikawa and HEC-1A, and the control cell line HIEEC, differ in expression of estrogen biosynthetic and metabolic genes, and in androstenedione and estrone-sulfate metabolism
Keywords: COMT، catechol-O-methyltransferase; AKR, aldo–keto reductase; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; DHEA, dehydroepiandrosterone; E1, estrone; E2, estradiol; E1S, estrone-sulfate; EC, endometrial cancer; ER, estrogen receptor; FBS, fetal bovine serum; GPER, membrane-boun
Gene × gene × gender interaction of BDNF and COMT genotypes associated with panic disorder
Keywords: COMT، catechol-O-methyltransferase; BDNF, brain-derived neurotrophic factor; COMT, catechol-O-methyltransferase; DSM-IV, Diagnostic and Statistical Manual of Mental Disorders, 4th edition; HA, harm avoidance; MANCOVA, multivariate analysis of covariance; Met, methionine; MINI 24, Mini Inter
Enhanced inhibition of prostate cancer xenograft tumor growth by combining quercetin and green tea
Keywords: COMT، catechol-O-methyltransferase; AR, androgen receptor; COMT, catechol-O-methyltransferase; GT, green tea; GTPs, green tea polyphenols; EC, (−)-epicatechin, ECG, (−)-epicatechin-3-gallate; EGC, epigallocatechin; EGCG, (−), epigallocatechin-3-gallate; HD, high dose; HPLC, high-performance
From Pavlov to PTSD: The extinction of conditioned fear in rodents, humans, and anxiety disorders
Keywords: COMT، catechol-O-methyltransferase; 5-HTTLPR, serotonin transporter gene linked polymorphic region; BDNF, brain-derived neurotropic factor; BNST, bed nucleus of the stria terminalis; COMT, catechol-O-methyltransferase; CR, conditioned response; CS+ or CS, conditioned stimulus; CS−, never-co
Pathomechanisms and compensatory efforts related to Parkinsonian speech
Keywords: COMT، catechol-O-methyltransferase; AC, auditory cortex; CN, caudate nucleus; COMT, catechol-O-methyltransferase; CON, control participant; DAT1, dopamine transporter; DLPFC, dorsolateral prefrontal cortex; dPMC, dorsal premotor cortex; dstriatum, dorsal striatum; EPI, echo-planar imaging;
The catechol-o-methyltransferase Val158Met polymorphism modulates organization of regional cerebral blood flow response to working memory in adults
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-o-methyltransferase; DLPFC, dorsolateral prefrontal cortex; AH, amygdala/hippocampus; WM, working memory; DA, dopamine; ROI, region of interestCatechol-o-methyltransferase (COMT); Dopamine; Working memory; PET
Effects of COMT genotype on sensory gating and its modulation by nicotine: Differences in low and high P50 suppressors
Keywords: COMT، catechol-O-methyltransferase; ANOVA, analysis of variances; COMT, catechol-O-methyltransferase; D1, dopamine D1 receptor; D2, dopamine D2 receptor; DA, dopamine; DAT1, gene coding for the dopamine transporter; dP50, P50 difference score index of sensory gating; DRD2, gene encoding for
Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration
Keywords: COMT، catechol-O-methyltransferase; L-DOPA, levodopa; PD, Parkinson disease; COMT, catechol-O-methyltransferase; 3-OMD, 3-O-methyldopa; CNS, central nervous system; H2-DCF-DA, 2′,7′-dichlorofluorescein diacetate; AdoMet, S-adenosyl-L-methionine; ROS, reactive oxygen species; MTT, 3-(4,5-dim
Increased vulnerability of parkin knock down PC12 cells to hydrogen peroxide toxicity: The role of salsolinol and NM-salsolinol
Keywords: COMT، catechol-O-methyltransferase; AR-JP, autosomal recessive juvenile Parkinson’s disease; COMT, catechol-O-methyltransferase; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; MAO, monoamine oxidase; MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; MTT, methylthiazol tetr
Stress and neurodevelopmental processes in the emergence of psychosis
Keywords: COMT، catechol-O-methyltransferase; ACTH, adrenocorticotrophic hormone; AST, associative striatum; BDNF, brain-derived neurotrophic factor; CHR, clinical high-risk; COMT, catechol-O-methyltransferase; CRH, corticotrophin-releasing hormone; DA, dopamine; DEX, dexamethasone; DST, dexamethason
Endogenous morphine and its metabolites in mammals: History, synthesis, localization and perspectives
Keywords: COMT، catechol-O-methyltransferase; 4-HPAA, 4-hydroxyphenylacetaldehyde; 4-HPP, 4-hydroxyphenylpyruvate; AADC, aromatic l-amino acid decarboxylase; COMT, catechol-O-methyltransferase; CSF, cerebrospinal fluid; CYP2D6, cytochrome P450 2D6; DOPAL, 3,4-dihydroxyphenylacetaldehyde; DOR, delta o
Association between the catechol-O-methyltransferase (rs4680: Val158Met) polymorphism and serum alanine aminotransferase activity
Keywords: COMT، catechol-O-methyltransferase; J-MICC, Japan Multi-Institutional Collaborative Cohort; COMT, catechol-O-methyltransferase; AST, aspartate aminotransferase; ALT, alanine aminotransferase; γ-GT, gamma-glutamyl transpeptidase; 95% CI, 95% confidence interval; HCC, hepatocellular carcinoma
Catechol metabolites of zeranol and 17β-estradiol: A comparative in vitro study on the induction of oxidative DNA damage and methylation by catechol-O-methyltransferase
Keywords: COMT، catechol-O-methyltransferase; amu, atomic mass units; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; DAD, diode array detector; DMSO, dimethylsulfoxide; E1, estrone; E2, 17β-estradiol; ESI, electrospray ionization; HO, hydroxy; IBX, ortho-iodoxybenzoic acid; LC, liquid chro
Evaluation of serum estrogen-DNA adducts as potential biomarkers for breast cancer risk
Keywords: COMT، catechol-O-methyltransferase; CE, catechol estrogens; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; UPLC/MS–MS, ultraperformance liquid chromatography/tandem mass spectrometryBreast cancer; Depurinating estrogen-DNA adducts; Biomarker; Breast cancer prevention
Optimization of fermentation conditions for the production of human soluble catechol-O-methyltransferase by Escherichia coli using artificial neural network
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; E. coli, Escherichia coli; hSCOMT, human soluble catechol-O-methyltransferase; CCD, Central composite design; ANN, predictive artificial neural network; MBCOMT, membrane-bound catechol-O-methyltransferase; SAM, S-adenos
CYP1B1 and hormone-induced cancer
Keywords: COMT، catechol-O-methyltransferase; AhR, aryl hydrocarbon receptor; ARNT, aryl hydrocarbon receptor nuclear translocator; bp, base pair; CaP, prostate adenocarcinoma; CE, catechol oestrogen; COMT, catechol-O-methyltransferase; CYP1B1, cytochrome P450 1B1; DRE, dioxin-responsive element; E1,
Genetically engineered mouse models of Parkinson's disease
Keywords: COMT، catechol-O-methyltransferase; MPTP, 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine; MPP+, 1-methyl-4-phenylpyridinium; 6-OHDA, 6-hydroxydopamine; COMT, catechol-O-methyltransferase; DA, dopamine; DAT, dopamine transporter; L-DOPA, levodopa; LB, Lewy body; LPS, lipopolysaccharride; MAOB,
A novel prokaryotic expression system for biosynthesis of recombinant human membrane-bound catechol-O-methyltransferase
Keywords: COMT، catechol-O-methyltransferase; B. choshinensis, Brevibacillus choshinensis; CHAPS, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonate; CMC, critic micellar concentration; COMT, catechol-O-methyltransferase; E. coli, Escherichia coli; hMBCOMT, human membrane-bound catechol-O-meth
Formation of diethylstilbestrol–DNA adducts in human breast epithelial cells and inhibition by resveratrol
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; DES, diethylstilbestrol; HPLC-ECD, high performance liquid chromatography with electrochemical detection; MTT, 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltrazolium bromide; NQO1, NAD(P)H quinone oxi
Inhibition of 17β-estradiol activation by CYP1A1: Genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols
Keywords: COMT، catechol-O-methyltransferase; CYP, cytochrome P450; CYP1A1, human cytochrome P450 1A1; P450 reductase, NADPH-cytochrome P450 reductase; COMT, catechol-O-methyltransferase; E2, 17β-estradiol; 2-MeO-E2, 2-methoxyestradiol; TMS, tetramethoxy-stilbene; SJW, St. John's Wort (Hypericum perf
Gene–environment interactions and construct validity in preclinical models of psychiatric disorders
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; THC, Delta-9-tetrahydrocannabinol; HD, Huntington's disease; SNPs, single nucleotide polymorphisms; GWA, genome-wide association; TRPs, tandem repeat polymorphisms; SSRIs, selective serotonin reuptake inhibitorsAnimal m
Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cells
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; E2-3,4-Q, estradiol-3,4-quinone; GSH, glutathione; HPLC-ECD, high-performance liquid chromatography with electrochemical detection; MTT, 3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromid
Expression of estrogen and progesterone receptors and estrogen metabolizing enzymes in different breast cancer cell lines
Keywords: COMT، catechol-O-methyltransferase; E1, estrone; E2, estradiol; ER, estrogen receptor; PR, progesterone receptor; DHEA, dehydroepiandrosterone; DHEA-S, DHEA-sulfate; E1-S, estrone-sulfate; E2-S, estradiol-sulfate; COMT, catechol-O-methyltransferase; SULT, sulfotransferase; UGT, UDP glucuron
Identification of novel circulating coffee metabolites in human plasma by liquid chromatography–mass spectrometry
Keywords: COMT، catechol-O-methyltransferase; ACN, acetonitrile; CA, caffeic acid; CE, collision energy; CID, collision induced dissociation; Cmax, maximum plasma concentration; COMT, catechol-O-methyltransferase; CGA, chlorogenic acid; CoA, coumaric acid; CQA, caffeoylquinic acid; CQAL, caffeoylquin
Different effects of intranigral and intrastriatal administration of the proteasome inhibitor lactacystin on typical neurochemical and histological markers of Parkinson's disease in rats
Keywords: COMT، catechol-O-methyltransferase; ANOVA, analysis of variance; COMT, catechol-O-methyltransferase; CV, cresyl violet; DA, dopamine; DAT, dopamine transporter; DOPAC, 3,4-dihydroxyphenylacetic acid; DOPAL, 3,4-dihydroxyphenylacetaldehyde; DOPET, 3,4-dihydroxyphenylethanol; HPLC, high-press
Unbalanced metabolism of endogenous estrogens in the etiology and prevention of human cancer
Keywords: COMT، catechol-O-methyltransferase; BB, Big Blue; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; CYP19, aromatase; DA-Q, dopamine quinone; DES, diethylstilbestrol; E1, estrone; E2, estradiol; E1(E2)-Q, estrone(estradiol) quinone; ERKO, estrogen receptor-α knocked out; GSH, glutat
Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia
Keywords: COMT، catechol-O-methyltransferase; LMX1A, LIM homeobox transcription factor 1 alpha; LMX1B, LIM homeobox transcription factor 1 beta; PITX3, Paired-like homeodomain 3; BDNF, Brain-derived neurotrophic factor; COMT, Catechol-O-methyltransferase; DRD1/2/4, Dopamine receptor D1/2/4; DAT1, Dop
Met158 variant of the catechol-O-methyltransferase genotype is associated with thicker cortex in adult brain
Keywords: COMT، catechol-O-methyltransferase; COMT Val158Met polymorphism; cortical thickness; superior temporal sulcus; inferior prefrontal sulcus; imaging geneticsBDNF, brain derived neurotrophic factor; COMT, catechol-O-methyltransferase; fMRI, functional magnetic resonance imaging; GLM, general l
The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells
Keywords: COMT، catechol-O-methyltransferase; BA, baicalein; BET, betanin; COMT, catechol-O-methyltransferase; CYA, cyanidin; DAC, decitabine; DNMTs, DNA methyltransferases; EA, ellagic acid; EGCG, (−)-epigallocatechin-3-gallate; GAL, galangin; MYR, myricetin; PCA, protocatechuic acid; PHR, phloretin
Aromatic hydroxylation and catechol formation: A novel metabolic pathway of the growth promotor zeranol
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; CYP, cytochrome P450; DAD, diode array detector; E1, estrone; E2, 17β-estradiol; ESI, electrospray ionization; GC, gas chromatography; hCYP, human CYP; LC, liquid chromatography; MS, mass spectrometry; MSn, daughter ion
Hepatotoxicity of high oral dose (−)-epigallocatechin-3-gallate in mice
Keywords: COMT، catechol-O-methyltransferase; Green tea; (−)-Epigallocatechin-3-gallate; Hepatotoxicity; Mouse; Oxidative stress4-HNE, 4-hydroxynonenal; ALT, alanine aminotransferase; COMT, catechol-O-methyltransferase; EGCG, (−)-epigallocatechin-3-gallate; γH2AX, phosphorylated histone 2AX; IHC, imm
Protective effect of simple phenols from extravirgin olive oil against lipid peroxidation in intestinal Caco-2 cells
Keywords: COMT، catechol-O-methyltransferase; HP, fatty acid hydroperoxides; HT, hydroxytyrosol; HVA, homovanillic alcohol; TYR, tyrosol; TBH, tert-butyl hydroperoxide; UFA, unsaturated fatty acids; COMT, catechol-O-methyltransferase; HPODE, hydroperoxy-octadecadienoic acidHydroxytyrosol; Homovanilli
Gonadectomy and hormone replacement exert region- and enzyme isoform-specific effects on monoamine oxidase and catechol-O-methyltransferase activity in prefrontal cortex and neostriatum of adult male rats
Keywords: COMT، catechol-O-methyltransferase; estrogen; androgen; schizophrenia; depression/anxiety; monoamines; indolaminesANOVA, analysis of variance; BSM, bulbospongiosus muscles; COMT, catechol-O-methyltransferase; COMT-mb, catechol-O-methyltransferase, membrane-bound isoform; COMT-s, catechol-O-
The Interface of Pain and Mood Disturbances in the Rheumatic Diseases
Keywords: COMT، catechol-O-methyltransferase; depression; fibromyalgia; rheumatoid arthritis; osteoarthritisBDNF, Brain-derived neurotrophic factor; CBT, Cognitive behavioral therapy; CNS, Central nervous system; COMT, Catechol-O-methyltransferase; CRH, Corticotropin-releasing hormone; CRP, C-reactiv
Depression and the role of genes involved in dopamine metabolism and signalling
Keywords: COMT، catechol-O-methyltransferase; bp, base pair; COMT, catechol-O-methyltransferase; DAT, dopamine transporter; DBH, dopamine-β-hydroxylase; DDC, dopa decarboxylase; HVA, homovanillic acid; MAO, monoamine oxidase; MDD, major depressive disorder; MDE, major depressive episode; RFLP, restri
Mind–body interactions in pain: the neurophysiology of anxious and catastrophic pain-related thoughts
Keywords: COMT، catechol-O-methyltransferase; COMT, catechol-O-methyltransferase; fMRI, functional magnetic resonance imaging; IL-6, interleukin-6; NFR, nociceptive flexion reflex
Association of genetic polymorphisms in the type II deiodinase gene with bipolar disorder in a subset of Chinese population
Keywords: COMT، catechol-O-methyltransferase; 5-HTT, 5-hydroxytryptamine transporter; BDNF, brain-derived neurotrophic factor; BPAD, bipolar disorder; CI, confidence interval; COMT, catechol-O-methyltransferase; DAT, dopamine transporter; DIO2, Type II deiodinase; DNA, deoxyribonucleic acid; DSM-IV,
The leukocytes expressing DARPP-32 are reduced in patients with schizophrenia and bipolar disorder
Keywords: COMT، catechol-O-methyltransferase; BPD, Bipolar disorder; CD, Cluster of differentiation; CNS, Central nervous system; COMT, Catechol-O-Methyltransferase; CY, Cychrome; DARPP-32, Dopamine and cyclic adenosine 3′:5′-monophosphate-regulated phosphoprotein of relative molecular mass 32,000; D
Concerted action of the cytosolic sulfotransferase, SULT1A3, and catechol-O-methyltransferase in the metabolism of dopamine in SK-N-MC human neuroblastoma cells
Keywords: COMT، catechol-O-methyltransferase; SULT, sulfotransferase; COMT, catechol-O-methyltransferase; PAPS, 3′-phosphoadenosine-5′-phosphosulfate; AdoMet, S-adenosyl-l-methionineDopamine; 3-Methyldopamine; Sulfotransferase; SULT1A3; Catechol-O-methyltransferase; Tropolone