Conditional deletions refine the embryonic requirement for Dlk1
Keywords: شکستن شرط; Dlk1; Conditional knockout; Pancreas; Pituitary; Endothelial cell;
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Chondrocyte BMP2 signaling plays an essential role in bone fracture healing
Keywords: شکستن شرط; BMP2, bone morphogenetic protein 2; cKO, conditional knockout; ROI, region of interest; OC, osteocalcin; BV, bone volume; TV, tissue volumeBMP2; Fracture healing; Fracture callus; Chondrocyte; Osteoblast; Conditional knockout
New Understandings on Folliculogenesis/Oogenesis Regulation in Mouse as Revealed by Conditional Knockout
Keywords: شکستن شرط; Conditional knockout; Folliculogenesis; Oogenesis; MouseGC, granulosa cell; PN, postnatal; PI3K, phosphatidylinositol 3-kinase; PIP2, phosphatidylinositol (4,5)-bisphosphate; PIP3, phosphatidylinositol (3,4,5)-trisphosphate; PTEN, phosphatase and tensin h
Bisphosphonates improve trabecular bone mass and normalize cortical thickness in ovariectomized, osteoblast connexin43 deficient mice
Keywords: شکستن شرط; Gap junctions; Conditional Knockout; Bisphosphonate
Conditional deletion of Tgfbr2 in hypertrophic chondrocytes delays terminal chondrocyte differentiation
Keywords: شکستن شرط; Tgfbr2; Conditional knockout; Hypertrophic chondrocyte; Indian hedgehog
Mcl-1 regulates the survival of adult neural precursor cells
Keywords: شکستن شرط; Bcl-2; B cell lymphoma 2; Bcl-xL; B cell lymphoma X large fragment; CKO; conditional knockout; BrdU; Bromodeoxyuridine; Cre; Cre recombinase; CMV; cytomegalovirus; Dcx; Doublecortin; DIV; days in vitro; FGF-2; fibroblast growth factor 2; GFAP; glial fibri
Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch
Keywords: شکستن شرط; Neural crest cell; Conditional knockout; Mouse; Endothelin; Craniofacial;
Mouse models for peroxisome biogenesis defects and β-oxidation enzyme deficiencies
Keywords: شکستن شرط; Peroxisome; Conditional knockout; neurodegeneration; PPARalpha; VLCFA; Bile acids
ReviewRodent models of TDP-43: Recent advances
Keywords: شکستن شرط; TDP-43; Transgenic; Conditional knockout;
CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice
Keywords: شکستن شرط; Immune Response; Signaling; Mouse Model; Chemokine; APC; antigen-presenting cell; BM; bone marrow; cDC; classical dendritic cells; cKO; conditional knockout; IL; interleukin; L-Arg; L-arginine; LPS; lipopolysaccharide; MDSC; myeloid-derived suppressor cel
Brief CommunicationPET imaging for attention deficit preclinical drug testing in neurofibromatosis-1 mice
Keywords: شکستن شرط; ADD; Attention Deficit Disorder; cAMP; cyclic adenosine monophosphate; CKO; conditional knockout; CT; computerized tomography; DA; dopamine; GEM; genetically-engineered mouse; MPH; methylphenidate; PET; positron emission tomography; Dopamine; Behavior; Ne
TGF-β signaling plays an essential role in the growth and maintenance of intervertebral disc tissue
Keywords: شکستن شرط; TGF-β; Col2a1-CreERT2; Intervertebral disc; Conditional knockout; MMP-13
Regulation of remyelination in multiple sclerosis
Keywords: شکستن شرط; Remyelination; Oligodendrocytes; Hyaluronan; Wnt; Notch1; Retinoid X receptor; 15d-PGJ(2); 15-deoxy-Î12,14-prostaglandin J2; CNP; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNS; central nervous system; cKO; conditional knockout; dpl; days post l
Long-term deficiency of circulating and hippocampal insulin-like growth factor I induces depressive behavior in adult mice: a potential model of geriatric depression
Keywords: شکستن شرط; insulin-like growth factor I; IGF-1; depression; conditional knockout; aging; hippocampusAAV, adeno-associated virus; ANOVA, analysis of variance; BDNF, brain-derived neurotrophic factor; CA1, cornu ammonis I; CMV, cytomegalovirus; DAPI, 4',6-diamidino-2-
A key role for Pak4 in proliferation and differentiation of neural progenitor cells
Keywords: شکستن شرط; Pak4; Neurogenesis; Conditional knockout; Nestin; Flox;
Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes
Keywords: شکستن شرط; Id1; Id3; IGFbp3; Thrombospondin; Angiopoietin; Conditional knockout; Angiogenesis; Fibrosis; Cardiomyopathy; Ventricular septal defects; Trabeculation;
Smad1 plays an essential role in bone development and postnatal bone formation
Keywords: شکستن شرط; Smad1; Conditional knockout; BMP signaling; Chondrocyte; Osteoblast
Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival
Keywords: شکستن شرط; Rac1 GTPase; Lens fibers; Conditional knockout; Migration; Cell adhesion
Pax3 is essential for normal cardiac neural crest morphogenesis but is not required during migration nor outflow tract septation
Keywords: شکستن شرط; Mouse embryo; Pax3; Cardiac neural crest; Congenital heart defects; Lineage mapping; Conditional knockout; Genetic cell ablation;
The activated aryl hydrocarbon receptor synergizes mitogen-induced murine liver hyperplasia
Keywords: شکستن شرط; AhR; Aryl hydrocarbon receptor; BrdU; bromodeoxyuridine; CKO; conditional knockout; CDK; cyclin-dependent kinase; PH; partial hepatectomy; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TCPOBOP; 1,4-bis[2-(3,5-dichloropyridyloxy)] benzene; TCPOBOP; TCDD; AhR;
Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesis
Keywords: شکستن شرط; bone morphogenetic protein; conditional knockout; d-glucuronyl C5-epimerase; loxP; N-deacetylase/N-sulfotransferase1; Smad
Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model
Keywords: شکستن شرط; adrenomedullin; complement factor H; conditional knockout; focal ischemia; infarct size; neuroprotectionAM, adrenomedullin; COX-2, cyclooxygenase-2; FH, complement factor H; iNOS, inducible nitric oxide synthase; KO, AM conditional knockout; MCA, middle c
Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels
Keywords: شکستن شرط; IGF-1 isoforms; Class 2 IGF-1; Conditional knockout; Circulating IGF-1
TGFβ signaling in male germ cells regulates gonocyte quiescence and fertility in mice
Keywords: شکستن شرط; TGFbeta; Conditional knockout; Germ line; Quiescence; Apoptosis; Fertility
Conditional knockout of fibronectin abrogates mouse mammary gland lobuloalveolar differentiation
Keywords: شکستن شرط; Fibronectin; Conditional knockout; Mammary epithelial cell proliferation; Lobuloalveolar differentiation
Thrombocytopenia Exacerbates Cholestasis-Induced Liver Fibrosis in Mice
Keywords: شکستن شرط; Bcl-2; Apoptosis; Cre; Conditional Knockout; ALP; alkaline phosphatase; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; BrdU; 5-bromo-2-deoxyuridine; ECM; extracellular matrix; HGF; hepatocyte growth factor; HSCs; hepatic stellate cells; MMP; mat
Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum
Keywords: شکستن شرط; Fibroblast growth factor; Receptor tyrosine kinase; Conditional knockout; Cerebellum development; Granule neuron; Bergmann glia; Mouse model
Impaired dendritic development and synaptic formation of postnatal-born dentate gyrus granular neurons in the absence of brain-derived neurotrophic factor signaling
Keywords: شکستن شرط; Mouse; Conditional knockout; Brain-derived neurotrophic factor; Postnatal-born granular neuron; Dentate gyrus; Dendrite; Spine; Synapse
Residual microRNA expression dictates the extent of inner ear development in conditional Dicer knockout mice
Keywords: شکستن شرط; RNA interference; MicroRNA; Sensory epithelium; Hair cell; Inner ear development; Conditional knockout; Floxed Dicer;
Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival
Keywords: شکستن شرط; Lens development; Cadherins; Cell adhesion; Lens vesicle separation; Conditional knockout;
Consequence of the loss of Sox2 in the developing brain of the mouse
Keywords: شکستن شرط; Sox2; Neural stem cells; Self-renewal; Multipotency; Conditional knockout
Adult neurogenesis is functionally associated with AD-like neurodegeneration
Keywords: شکستن شرط; Alzheimer's disease; Adult neurogenesis; Neuronal loss; Presenilin 1; Neurodegeneration; Conditional knockout; Mice
Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
Keywords: شکستن شرط; Apoptosis; Cell cycle; FGF receptor; Lens development; Lens fiber differentiation; Redundancy; Conditional knockout
Conditional mutant mice using tetracycline-controlled gene expression system in the brain
Keywords: شکستن شرط; Conditional knockout; tTA; Doxycycline; mGluR; Learning; Cerebellum; Inducible
Metabotropic glutamate receptor subtype-1 is essential for motor coordination in the adult cerebellum
Keywords: شکستن شرط; mGluR1; Conditional knockout; tTA; Tetracycline; Doxycycline; Motor coordination; Ataxia
DDB1 gene disruption causes a severe growth defect and apoptosis in chicken DT40 cells
Keywords: شکستن شرط; DDB1; DT40; Conditional knockout; Cell viability; Apoptosis; Cell cycle arrest
Selenoprotein expression is essential in endothelial cell development and cardiac muscle function
Keywords: شکستن شرط; Cardiovascular disease; Conditional knockout; Endothelial cells; Heart muscle; Selenocysteine; Selenocysteine tRNA; Selenoproteins
Generation of a conditional knockout of murine glucocerebrosidase: Utility for the study of Gaucher disease
Keywords: شکستن شرط; Gaucher disease; Glucocerebrosidase; Mouse model; Cre-lox; Flp-FRT; Conditional knockout; Hematopoietic cell; Tie2-Cre; Gaucher cell; Splenomegaly; GBA
Hand2 determines the noradrenergic phenotype in the mouse sympathetic nervous system
Keywords: شکستن شرط; Hand2; bHLH; Sympathetic nervous system; Conditional knockout; Neuronal differentiation; Catecholaminergic; Noradrenergic
Loss of HB-EGF in smooth muscle or endothelial cell lineages causes heart malformation
Keywords: شکستن شرط; Cardiac hypertrophy; Conditional knockout; HB-EGF; Heart valves; Heart failure
Conditional knockout of Mn superoxide dismutase in postnatal motor neurons reveals resistance to mitochondrial generated superoxide radicals
Keywords: شکستن شرط; Motor neurons; Oxidative stress; Mitochondria; Nerve injury; Conditional knockout; SOD2; Amyotrophic lateral sclerosis
BMP receptor type IA in limb bud mesenchyme regulates distal outgrowth and patterning
Keywords: شکستن شرط; Bone morphogenetic protein receptor; Limb development; Pattern formation; Conditional knockout; Prx1
Role of fibroblast growth factor receptors 1 and 2 in the metanephric mesenchyme
Keywords: شکستن شرط; Fibroblast growth factor receptor; Kidney development; Metanephric mesenchyme; Pax3 promoter; Conditional knockout
The BMP signaling and in vivo bone formation
Keywords: شکستن شرط; BMP; bone morphogenetic protein; TGFb; transforming growth factor b; BMPR; BMP receptor; Runx2; Runt-related gene 2; Smad; Sma/Mad; GDF; growth/differentiation factor; CKO; conditional knockout; Smurf1; Smad ubiquitin regulatory factor 1;
Conditional inactivation of the mouse Hus1 cell cycle checkpoint gene
Keywords: شکستن شرط; Mouse; Embryogenesis; Conditional knockout; Cell cycle checkpoint; Hus1; Genomic instability;
Listening to mutant mice: a spotlight on the role of CRF/CRF receptor systems in affective disorders
Keywords: شکستن شرط; CRF; Depression; Anxiety; CRF receptor antagonist; R121919; NBI 30775; CRF receptor type 1; CRF receptor type 2; Transgenic mice; Conditional knockout;