Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes

► Vascular ablation of Id genes circumvents embryonic lethality. ► Mice develop postnatal cardiac phenotypes.► Expression patterns of vascular/fibrotic/hypertrophic markers are altered. ► IGFbp3 reverses vascular markers, like angiopoietin1 and thrombospondin1/4. ► IGFbp3 reverses fibrotic, but not hypertrophic markers.