Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell
Keywords: Ethanol; CYP2E1; Dopamine; Nucleus accumbens; Core; Shell;
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IP-10 protects while MIP-2 promotes experimental anesthetic hapten - induced hepatitis
Keywords: CYP2E1; Trifluoroacetyl chloride; TFA; DILI; MIP-2; IP-10; KC chemokinesAIH, autoimmune hepatitis; CYP2E1, cytochrome P450 2E1; DILI, drug-induced liver injury; IP-10, interferon gamma inducible protein-10; KC, keratinocyte-derived chemokine; KLH, keyhole
Protective effect of Acacia confusa bark extract and its active compound gallic acid against carbon tetrachloride-induced chronic liver injury in rats
Keywords: Acacia confusa; Gallic acid; Carbon tetrachloride; Hepatoprotective effect; CYP2E1;
Polyenephosphatidylcholine prevents alcoholic liver disease in PPARα-null mice through attenuation of increases in oxidative stress
Keywords: ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; AOX; acyl-coenzyme A oxidase; AP-1; activator protein-1; ASK1; apoptosis signal-regulating kinase 1; COL1A1; collagen type 1 α1; COX-2; cyclo-oxygenase 2; CYP2E1; cytochrome P450 2E1; GAPDH; glyce
The impact of CYP2E1 on the development of alcoholic liver disease as studied in a transgenic mouse model
Keywords: ALD; alcoholic liver disease; CYP2E1; cytochrome; EtOH; ethanol; MAP; mitogen activated protein; MDA; malondialdehyde; NTA; non-transgenic alcohol; NTD; non-transgenic dextrose; PCA; principal component analysis; TGA; transgenic alcohol; TGD; transgenic d
Benzene-induced hematopoietic toxicity transmitted by AhR in wild-type mouse and nullified by repopulation with AhR-deficient bone marrow cells: Time after benzene treatment and recovery
Keywords: Aryl hydrocarbon receptor; Benzene; CYP2E1; Hematotoxicity; Mice
Effect of chronic alcohol consumption on Hepatic SIRT1 and PGC-1α in rats
Keywords: Alcohol; CYP2E1; SIRT1; PGC-1α; Medium-chain triglycerides
Ethanol intoxication increases hepatic N-lysyl protein acetylation
Keywords: Sirtuin; Acetylation; Mitochondria; Ethanol; CYP2E1
Role of CYP2E1 in the mouse model of MPTP toxicity
Keywords: MPP+; Neurotoxicity; CYP2E1; DDC; DAS; PIC; Neurodegeneration; Parkinson's disease
Mutagenicity of N-nitrosodiethanolamine in a V79-derived cell line expressing two human biotransformation enzymes
Keywords: CYP2E1; Genetically engineered cell lines; Mutagenicity; 2-Nitropropane; N-Nitrosodiethanolamine; N-Nitrosodimethylamine; Sulphotransferase (SULT)
Protective effect of caffeic acid phenethyl ester against carbon tetrachloride-induced hepatotoxicity in mice
Keywords: Caffeic acid phenethyl ester; Hepatotoxicity; Carbon tetrachloride; Fas/FasL pathway; CYP2E1
Molecular mechanism of trichloroethylene-induced hepatotoxicity mediated by CYP2E1
Keywords: Trichloroethylene; CYP2E1; Metabolism; Hepatotoxicity; PPARα; NFκB
Protective effect of saponins derived from the roots of Platycodon grandiflorum against carbon tetrachloride induced hepatotoxicity in mice
Keywords: Platycodon grandiflorum; Carbon tetrachloride; Hepatotoxicity; Fas/FasL pathway; CYP2E1
Ethanol enhanced the genotoxicity of acrylamide in human, metabolically competent HepG2 cells by CYP2E1 induction and glutathione depletion
Keywords: Acrylamide; CYP2E1; Comet assay; SCGE; ssDNA apoptosis assay; Glutathione depletion; HepG2AA, acrylamide; BaP, benzo(a)pyrene; CYP2E1, cytochrome P4502E1; DMSO, dimethyl sulfoxide; EtOH, ethanol; GA, glycidamide; GSH, glutathione, reduced; HRP, horseradis
Prevention of alcoholic fatty liver and mitochondrial dysfunction in the rat by long-chain polyunsaturated fatty acids
Keywords: PUFA; polyunsaturated fatty acids; AA; arachidonic acid; DHA; docosahexaenoic acid; EFA; essential fatty acids; CYP2E1; ethanol-inducible cytochrome P450 2E1; iNOS; inducible nitric oxide synthase; MDA; malondialdehyde; ALT; alanine transaminase; AST; asp
The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury
Keywords: L-FABP; liver fatty acid binding protein; GST; glutathione S-transferase; CYP2E1; cytochrome P450 2E1; SAM; S-adenosylmethionine; SAH; S-adenosylhomocysteine; MCD; methionine and choline deficient; ROS; reactive oxygen species; PPARα; peroxisome prolifer
Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis
Keywords: Isoniazid; Hepatotoxicity; NAT2; CYP2E1; Korean
Effect of testicular steroids on catalytic activities of cytochrome P450 enzymes in porcine liver microsomes
Keywords: Androstenone; 17β-Oestradiol; Testosterone; Porcine microsomes; CYP2E1; CYP2A
Docosahexaenoic acid induces apoptosis in CYP2E1-containing HepG2 cells by activating the c-Jun N-terminal protein kinase related mitochondrial damage
Keywords: DHA; Apoptosis; HepG2 cells; CYP2E1; Lipid peroxides (LPOs); JNK activation; MAP kinases
Induction of CYP2B and CYP2E1 in precision-cut rat liver slices cultured in defined medium
Keywords: Precision-cut rat liver slices; Defined medium; CYP2B; CYP2E1
Distribution of alcohol-metabolizing enzyme genotypes in trauma patients with excessive alcohol consumption in the emergency department
Keywords: Alcohol-metabolizing enzyme; Trauma; ADH2; ALDH2; CYP2E1
A comparison of substrate dynamics in human CYP2E1 and CYP2A6
Keywords: CYP2E1; CYP2A6; Isotope effect; Cooperativity; Allosterism; Dynamics; P450; kH/kD; Xylene
Non-positive autoimmune responses against CYP2E1 in refrigeration mechanics exposed to halogenated hydrocarbons
Keywords: Autoimmune response; CYP2E1; Hydrochlorofluorocarbons (HCFCs); Hydrofluorocarbons (HFCs); Occupational exposure
Detection of auto-antibodies against cytochrome P4502E1 (CYP2E1) in chronic hepatitis C
Keywords: CHC; chronic hepatitis C; CYP2E1; cytochrome P450 2E1; ELISA; enzyme-linked immunosorbent assay; HCV; hepatitis C virus; LKM-1; liver kidney microsome type 1; PBS; phosphate-buffered saline; Auto-immunity; Cytochrome P450; Hepatitis C;
Hepatoprotective and antioxidant effects of the coffee diterpenes kahweol and cafestol on carbon tetrachloride-induced liver damage in mice
Keywords: Kahweol; Cafestol; Hepatoprotective effects; Carbon tetrachloride; CYP2E1; Antioxidant
Exposure assessment of benzene in Thai workers, DNA-repair capacity and influence of genetic polymorphisms
Keywords: Benzene; Occupational exposure; Trans,trans-muconic acid; DNA-repair capacity; CYP2E1; XRCC1
Skatole metabolism in the intact pre-pubescent male pig: The relationship between hepatic enzyme activity and skatole concentrations in plasma and fat
Keywords: Boar taint; Prepubescent; Pig; Steroid hormone; CYP2E1; CYP2A; Aldehyde oxidase; SULT1A1
Metabolic and genetic factors contributing to alcohol induced effects and fetal alcohol syndrome
Keywords: Alcohol; Ethanol metabolism; Biomarker of susceptibility; Genetic polymorphism; ADH; CYP2E1; FASD; FAS; Alcohol teratogenesis
Functional characterization of human and cynomolgus monkey cytochrome P450 2E1 enzymes
Keywords: Cytochrome P450 (CYP); CYP2E1; Chlorzoxazone 6-hydroxylation; 4-Nitrophenol 2-hydroxylation; Primates; Human; Cynomolgus monkey
Intestinal transport and metabolism of acrylamide
Keywords: Acrylamide; Caco-2 cells; Intestinal transport; Glutathione; CYP2E1
CYP2E1 active site residues in substrate recognition sequence 5 identified by photoaffinity labeling and homology modeling
Keywords: Cytochrome; P450 2E1; CYP2E1; Photoaffinity; Labeling; Modeling; Active site; Azido
Effects of diabetes on rabbit kidney and lung CYP2E1 and CYP2B4 expression and drug metabolism and potentiation of carcinogenic activity of N-nitrosodimethylamine in kidney and lung
Keywords: Diabetes; Rabbit liver; Lung; Kidney; CYP2E1; CYP2B4; NDMA; P-Nitrophenol; NDMA N-demethylase; p-Nitrophenol hydroxylase; Aniline 4-hydroxylase; Cytochrome P450 reductase; Benzphetamine N-demethylase
Geldanamycin, an inhibitor of Hsp90 increases cytochrome P450 2E1 mediated toxicity in HepG2 cells through sustained activation of the p38MAPK pathway
Keywords: CYP2E1; Hsp90; Geldanamycin; p38 MAPK; SB203580
Role of intracellular calcium and phospholipase A2 in arachidonic acid-induced toxicity in liver cells overexpressing CYP2E1
Keywords: Calcium; Arachidonic acid; CYP2E1; Hepatocytes; HepG2; Lipid peroxidation; Phospholipase A2; Mitochondria
Validation of a HPLC method for the determination of p-nitrophenol hydroxylase activity in rat hepatic microsomes
Keywords: p-Nitrophenol; CYP2E1; Microsomes; Metabolism; HPLC; Validation
Selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome P450 isozymes in rats
Keywords: Curcumin; Carbon tetrachloride; Free radicals; CYP2E1; Hepatotoxicity
Association of alcohol-metabolizing genes with alcoholism in a Mexican Indian (Otomi) population
Keywords: Alcoholism; Polymorphisms; Alcohol dehydrogenase; Aldehyde dehydrogenase; CYP2E1
Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients
Keywords: BMI; body mass index; CLZ; chlorzoxazone; CYP2E1; cytochrome P450 2E1; NAFLD; non-alcoholic fatty liver disease; ROS; reactive oxygen species; 6-OH-CLZ; 6-hydroxy-chlorzoxazone; Chlorzoxazone; Cytochrome P450 2E1; Non-alcoholic fatty liver disease; Obesit
Ageing is associated with increased expression but decreased activity of CYP2E1 in male Wistar rats
Keywords: CYP2E1; Ageing; Oxidative stress; HNF1α
Effects of glucose supplementation on the pharmacokinetics of intravenous chlorzoxazone in rats with water deprivation for 72 h
Keywords: Chlorzoxazone; Dehydration; Pharmacokinetics; Glucose supplementation; CYP2E1; Rats
Phenobarbital induces monkey brain CYP2E1 protein but not hepatic CYP2E1, in vitro or in vivo chlorzoxazone metabolism
Keywords: CYP2E1; Phenobarbital; Chlorzoxazone; Brain; Protein induction; (Monkey)
Regional and cellular distribution of CYP2E1 in monkey brain and its induction by chronic nicotine
Keywords: CYP2E1; Brain; Monkey; Nicotine; Smoker; Induction
Effects of sex, weight, diet and hCG administration on levels of skatole and indole in the liver and hepatic activities of cytochromes P4502E1 and P4502A6 in pigs
Keywords: Pigs; Liver; Skatole; Indole; CYP2E1; CYP2A6
Differences in sensitivity of cultured rat brain neuronal and glial cytochrome P450 2E1 to ethanol
Keywords: CYP2E1; Primary cultures; Neurons; Glia; Expression; Enzyme;
Gene–environmental interactions between alcohol-drinking behavior and ALDH2 and CYP2E1 polymorphisms and their impact on micronuclei frequency in human lymphocytes
Keywords: CA, chromosomal aberration; SCE, sister chromatid exchange; MN, micronuclei; ADH, alcohol dehydrogenase; ALDH2, aldehyde dehydrogenase 2; CYP2E1, cytochrome p4502E1ALDH2; CYP2E1; Ethanol; Micronuclei; Polymorphism
Status of antioxidant defense system and expression of toxicant responsive genes in striatum of maneb- and paraquat-induced Parkinson's disease phenotype in mouse: Mechanism of neurodegeneration
Keywords: Parkinson's disease phenotype; Pesticide; Maneb; Paraquat; CYP2E1; GSTA4-4
Modeling interchild differences in pharmacokinetics on the basis of subject-specific data on physiology and hepatic CYP2E1 levels: A case study with toluene
Keywords: PBPK model; Child; CYP2E1; Interindividual variability
Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer
Keywords: Genetic polymorphism; Colorectal cancer; Epoxide hydrolase; NAD(P)H:quinone oxidoreductase; CYP2E1; Alcohol dehydrogenase
Pharmacokinetics of Chlorzoxazone in Rats with Diabetes: Induction of CYP2E1 on 6-Hydroxychlorzoxazone Formation
Keywords: CZX and OH-CZX; rat model of diabetes induced by alloxan (DMIA) or streptozotocin (DMIS); pharmacokinetics; CYP2E1; rats; disease state; CYP enzymes; metabolism; intrinsic clearance; protein binding;
Hepatic Disposition of the Cytochrome P450 2E1 Marker Chlorzoxazone and its Hydroxylated Metabolite in Isolated Perfused Rat Livers
Keywords: cytochrome P450; CYP enzymes; CYP2E1; hepatic clearance; biliary clearance; hepatic metabolism; disposition; nonlinear metabolism; isolated rat liver perfusion; rats;