Note of clarification of data on the association between CYP2E1 RsaI polymorphism and lung cancer risk
Keywords: Lung cancer; Risk; CYP2E1; Polymorphism;
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Excessive bile acid activated NF-kappa B and promoted the development of alcoholic steatohepatitis in farnesoid X receptor deficient mice
Keywords: Alcoholic liver disease; Alcoholic steatohepatitis; Farnesoid X receptor; Lieber-DeCarli ethanol diet; FXR; farnesoid X receptor; ALD; alcoholic liver disease; ASH; alcoholic steatohepatitis; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; CYP2E
Blueberry anthocyanins extract inhibits acrylamide-induced diverse toxicity in mice by preventing oxidative stress and cytochrome P450 2E1 activation
Keywords: AA; acrylamide; ALT; glutamic-pyruvic transaminase; AST; glutamic-oxalacetic transaminase; ALP; alkaline phosphatase; BAE; blueberry anthocyanins extract; CYP2E1; cytochrome P450 2E1; GA; glycidamide; GSH; glutathione; GPx; glutathione peroxidase; GST; gl
CYP17A1 and CYP2E1 variants associated with high altitude polycythemia in Tibetans at the Qinghai-Tibetan Plateau
Keywords: HAPC; high altitude polycythemia; CYP17A1 gene; cytochrome P450, family 17, subfamily A, polypeptide 1 gene; CYP2E1 gene; cytochrome P450, family 2, subfamily E, polypeptide 1 gene; SNP; single nucleotide polymorphism; H b; hemoglobin; HCT; hematocrit; HW
Dietary tomato powder inhibits alcohol-induced hepatic injury by suppressing cytochrome p450 2E1 induction in rodent models
Keywords: Tomato; Lycopene; CYP2E1; Alcohol; Liver disease;
Induction of CYP2E1 in testes of isoniazid-treated rats as possible cause of testicular disorders
Keywords: CYP2E1; Isoniazid; Rats; Spermatogenesis; Testes; Testosterone
Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures
Keywords: CYP2E1; Cooperativity; Acetaminophen; Styrene; Mixture
CYP2E1 epigenetic regulation in chronic, low-level toluene exposure: Relationship with oxidative stress and smoking habit
Keywords: Gene-specific DNA methylation; Toluene exposure; CYP2E1; GSTP1; SOD1; Smoking habit;
Subcellular localization of rat CYP2E1 impacts metabolic efficiency toward common substrates
Keywords: CYP; cytochrome P450 (specific isoforms); SDHA; succinate dehydrogenase; SERCA; sarco/endoplasmic reticulum Ca2+-ATPase; CYP2E1; Cooperativity; Styrene; Aniline; 4-Nitrophenol; Mitochondrial transport;
Platycodon grandiflorus - An Ethnopharmacological, phytochemical and pharmacological review
Keywords: (2R, 3R) taxifolin (Pubchem CID: 439533); quercetin-7-O-glucoside (Pubchem CID: 5282160); luteolin-7-O-glucoside (Pubchem CID: 5280637); apigenin-7-O-glucoside (Pubchem CID: 5280704); luteolin (Pubchem CID: 5280445); apigenin (Pubchem CID: 5280443); palmi
Activation of farnesoid X receptor attenuates hepatic injury in a murine model of alcoholic liver disease
Keywords: FXR; farnesoid X receptor; ALD; alcoholic liver disease; SHP; small heterodimer partner; BSEP; bile salt export pump; CYP7A1; cholesterol 7α-hydroxylase; CYP8B1; sterol 12α-hydroxylase; ADH; alcohol dehydrogenase; ALDH; aldehyde dehydrogenase; CYP2E1; c
Intestinal CYP2E1: A mediator of alcohol-induced gut leakiness
Keywords: Cyp2e1; Alcohol; Circadian rhythms; Intestinal permeability; Alcoholic steatohepatitis
The association between CYP2E1 polymorphisms and hepatotoxicity due to anti-tuberculosis drugs: A meta-analysis
Keywords: CYP2E1; Hepatotoxicity; Meta-analysis; ATDH;
Inhibitory potency of 4-carbon alkanes and alkenes toward CYP2E1 activity
Keywords: Butadiene; Epoxide; CYP2E1; Cytochrome P450
Human CYP2E1-dependent and human sulfotransferase 1A1-modulated induction of micronuclei by benzene and its hydroxylated metabolites in Chinese hamster V79-derived cells
Keywords: Benzene; CYP2E1; Micronuclei; Sulfotransferase (SULT);
Inhibition of cytochrome P450 by ethambutol in human liver microsomes
Keywords: Ethambutol; Drug-drug interaction; CYP1A2; CYP2E1; Theophylline;
Research ArticleProtective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice
Keywords: ALD; alcoholic liver disease; AST; aspartate amino transferase; CK18; cytokeratin 18; CO; carbon monoxide; CoPP; cobalt protoporphyrin; CORM; CO-releasing molecule; CYP2E1; cytochrome P450 2E1; EtOH; ethanol; FADD; Fas-associated protein with death domain
Scopoletin prevents alcohol-induced hepatic lipid accumulation by modulating the AMPK-SREBP pathway in diet-induced obese mice
Keywords: ACC; acetyl-CoA carboxylase; p-ACC; phosphorylated ACC; ADH; alcohol dehydrogenase; ALD; alcoholic liver disease; ALDH2; aldehyde dehydrogenase 2; ALP; alkaline phosphatase; ALT; alanine transaminase; AMPK; AMP-activated protein kinase; p-AMPK; phosphoryl
CYP2E1 induction leads to oxidative stress and cytotoxicity in glutathione-depleted cerebellar granule neurons
Keywords: CGNs; cerebellar granule neurons; CYP2E1; cytochrome P450 2E1; ROS; reactive oxygen species; GSH; glutathione; DIV; days in vitro; INH; isoniazid; BSO; l-buthionine sulfoximine; DAS; diallyl sulfide; EUKA; Eukarion-134; 8-oxodG; 8-oxo-7,8-dihydro-2-deoxyg
Curcumin and (â)-epigallocatechin-3-gallate attenuate acrylamide-induced proliferation in HepG2 cells
Keywords: Acrylamide; Proliferation; CYP2E1; Curcumin; EGCG;
Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway
Keywords: COX-2; cyclooxygenase-2; CYP2E1; cytochrome P450 2E1; ERK; the extracellular-receptor kinases; IL-1β; interleukin-1beta; JNK; the c-Jun N-terminal kinases; NF-κB; nuclear factor-κB; MAPKs; mitogen-activated protein kinases; UA; ursolic acid; ROS; react
Comparative transcriptomic analysis by RNA-seq to discern differential expression of genes in liver and muscle tissues of adult Berkshire and Jeju Native Pig
Keywords: DEGs; differentially expressed genes; JNP; Jeju Native Pig; GO; gene ontology; NGS; next generation sequencing; PE; paired-ends; CASAVA-v1.7; Consensus Assessment of Sequence and Variation v 1.7; UCSC; University of California Santa Cruz; EASE; Expression
CYP2E1 hydroxylation of aniline involves negative cooperativity
Keywords: HPLC, high performance liquid chromatographyCooperativity; Cytochrome P450; Metabolism; CYP2E1; Aniline
Binge alcohol promotes hypoxic liver injury through a CYP2E1-HIF-1α-dependent apoptosis pathway in mice and humans
Keywords: HIF-1α; hypoxia-inducible factor-1α; BAC; blood alcohol concentration; CYP2E1; cytochrome P450 2E1; ALD; alcoholic liver disease; NIAAA; National Institute on Alcohol Abuse and Alcoholism; iNOS; inducible nitric oxide synthase; ADH; alcohol dehydrogenas
Inhibition of cytochrome P450 2E1 and activation of transcription factor Nrf2 are renoprotective in myoglobinuric acute kidney injury
Keywords: acute kidney injury; CYP2E1; myoglobin; Nrf2; oxidative stress;
Structural and energetic analysis to provide insight residues of CYP2C9, 2C11 and 2E1 involved in valproic acid dehydrogenation selectivity
Keywords: Drug metabolism; CYP450 enzymes; Molecular dynamics simulations; Molecular mechanics generalized born surface area; CYP; cytochrome P-450; CYP2C9; cytochrome P-450 C9; CYP2C11; cytochrome P-450 C11; CYP2E1; cytochrome P-450 E1; MD; molecular dynamics; MM-
Berberine and S allyl cysteine mediated amelioration of DENÂ +Â CCl4 induced hepatocarcinoma
Keywords: ROS; reactive oxygen species; FACS; fluorescence activated cell sorter; DCFDA; 2â²,7â²-Dichlorofluorescein diacetate, TCA, tri choloro-acetic acid; HDAC1; histone deacetylase type1; pMdm2; phosphorylated Mdm2; PP2A; protein phosphatease 2A; MMP; mitocho
Clinical Application of Basic ScienceCYP2E1 and oxidant stress in alcoholic and non-alcoholic fatty liver disease
Keywords: OH; hydroxyl radical; ADH; alcohol dehydrogenase; ALD; alcoholic liver disease; CYP2E1; cytochrome P450 2E1; ER; endoplasmic reticulum; GSH; glutathione; H2O2; hydrogen peroxide; MEOS; microsomal ethanol-oxidizing system; NADPH; nicotinamide adenine dinuc
Protection of cyanidin-3-glucoside against oxidative stress induced by acrylamide in human MDA-MB-231 cells
Keywords: AA; acrylamide; Cy-3-glu; cyanidin-3-glucoside; CYP2E1; cytochrome P450 2E1; DCFH-DA; 2â²,7â²-dichlorofluoresceindiacetate; GA; glycidamide; γ-GCS; gamma-glutamyl cysteine synthase; GPx; glutathione peroxidase; GSH; glutathione; GST; glutathione S-tran
Relationship of NAT2, CYP2E1 and GSTM1/GSTT1 polymorphisms with mild elevation of liver enzymes in Brazilian individuals under anti-tuberculosis drug therapy
Keywords: NAT2; CYP2E1; GSTM1; GSTT1; Anti-tuberculosis drugs; Liver enzymes;
Effect of N-acetyl cysteine (NAC), an organosulfur compound from Allium plants, on experimentally induced hepatic prefibrogenic events in wistar rat
Keywords: AST; Alanine aminotransferase; ALT; Aspartate aminotransferase; ALP; Alkaline phosphatase; NAC; N-acetylcysteine; CCl4; Carbon tetrachloride; TAA; Thioacetamide; GPx; Glutathione peroxidase; GSH; Glutathione; CYP2E1; Cytochrome P450 2E1; LPO; Lipidperoxid
Structure of pyrazole derivatives impact their affinity, stoichiometry, and cooperative interactions for CYP2E1 complexes
Keywords: Cytochrome P450; CYP2E1; Allostery; Cooperativity; Azole; Structure-function;
Cellular steatosis in ethanol oxidizing-HepG2 cells is partially controlled by the transcription factor, early growth response-1
Keywords: ADH; alcohol dehydrogenase; CYP2E1; cytochrome P450 2E1; Egr-1; early growth response-1 protein; 4-MP; 4-methylpyrazole; DMEM; Dulbecco's modified Eagle's medium; CMZ; chlormethiazole; Suc-LLVY-AMC; succinyl-leucyl-leucyl-7-amido-4-methyl-coumarin; trolox
A novel upregulation of glutathione peroxidase 1 by knockout of liver-regenerating protein Reg3β aggravates acetaminophen-induced hepatic protein nitration
Keywords: Akt; protein kinase B; ALT; alanine aminotransferase; AP-1; activator protein 1; APAP; acetaminophen; CYP2E1; cytochrome P450 2E1; γ-GCS; γ-glutamylcysteine synthetase; GPX; glutathione peroxidase; GR; glutathione reductase; GS; glutathione synthetase;
Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis
Keywords: ACC; acetyl CoA carboxylase; ALD; alcoholic liver disease; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ACLY; ATP citrate lyase; ChREBP; carbohydrate response element binding protein; CYP2E1; cytochrome p450 2E1; ELOVL5; fatty acid e
Yerba-mate (Ilex paraguariensis) extract prevents ethanol-induced liver injury in rats
Keywords: Ethanol-induced liver injury; Yerba-mate tea; CYP2E1; Reactive oxygen species; Isolated hepatocytes; Alcohol dehydrogenase;
Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis
Keywords: 3-NT; 3-nitrotyrosine; 4-HNE; 4-hydroxynonenal; BUN; blood urea nitrogen; COX-2; cyclooxygenase-2; CP; cis-diamineplatinum(II) dichloride; CYP2E1; cytochrome P450 2E1; DMSO; dimethyl sulfoxide; FITC; fluorescein isothiocyanate; HE; hematoxylin and eosin;
Cytochrome P450 2E1 potentiates ethanol induction of hypoxia and HIF-1α in vivo
Keywords: AA; arachidonic acid; ALT; alanine aminotransferase; BSO; l-buthionine sulfoximine; CYP2E1; cytochrome P450 2E1; GSH; reduced glutathione; HE; hematoxylin-eosin; 4-HNE; 4-hydroxynonenal; HIF; hypoxia-inducible factor; HPH-2; HIF prolyl hydroxylase 2; IH
Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis
Keywords: CYP2E1; Cardiac function; Apoptosis; JNK; ASK-1; Stress signaling;
The sources of salidroside and its targeting for multiple chronic diseases
Keywords: 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid protein; MPTP; 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine; MPP+; N-methyl-4-phenylpyridine; AD; Alzheimer's disease; PD; Parkinson's disease; STZ; streptozotocin; PI3K; phosphatidylinositol 3-kinase; ROS; react
Quercetin suppressed CYP2E1-dependent ethanol hepatotoxicity via depleting heme pool and releasing CO
Keywords: Quercetin; Heme oxygenase-1 (HO-1); CYP2E1; Carbon monoxide (CO); Ethanol
Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma
Keywords: Hepatocellular carcinoma; Alcohol; Tobacco; Acetaldehyde; CYP2E1; Oxidative stress; Inflammation; Fibrosis
Differences in butadiene adduct formation between rats and mice not due to selective inhibition of CYP2E1 by butadiene metabolites
Keywords: CYP2E1; Butadiene; Cooperativity; Inactivation; Mouse; RatBD, 1,3-butadiene; EB, 1,2-epoxy-3-butene; EB-diol, 1,2-epoxy-3,4-butanediol; BD-diol, 3-butene-1,2-diol; LM, liver microsomes; HPLC, high-performance liquid chromatography
Ethanol self-administration and nicotine treatment induce brain levels of CYP2B6 and CYP2E1 in African green monkeys
Keywords: CYP2B6; CYP2E1; Nicotine; Ethanol; Monkey; Induction; BrainCYPs, cytochrome P450 enzymes; CYP2E1, cytochrome P450 2E1; CYP2B, cytochrome P450 2B; AGM, African green monkey
Chlorella vulgaris extract ameliorates carbon tetrachloride-induced acute hepatic injury in mice
Keywords: Chlorella vulgaris extract; Carbon tetrachloride; CYP2E1; Detoxification; Antioxidant
Genetic polymorphisms of CYP2E1, GST, and NAT2 enzymes are not associated with risk of breast cancer in a sample of Lebanese women
Keywords: Breast cancer; CYP2E1; GST; NAT2; Lebanese
CYP2E1-dependent elevation of serum cholesterol, triglycerides, and hepatic bile acids by isoniazid
Keywords: Isoniazid; CYP2E1; Metabolomics; Drug-induced hepatotoxicity
Inhibition of CYP2E1 leads to decreased malondialdehyde–acetaldehyde adduct formation in VL-17A cells under chronic alcohol exposure
Keywords: Alcohol; Liver cells; CYP2E1; Aldehyde-adducts
A comparison of Val81Met and other polymorphisms of alcohol metabolising genes in patients and controls in Northern Spain
Keywords: TH; ADH1B; ADH1C; ALDH2; CYP2E1; Alcohol; Alcoholism; Basque Country; Genetic; Polymorphism; Risk factor; SNP
Ethanol-induced oxidative stress is associated with EGF receptor phosphorylation in MCF-10A cells overexpressing CYP2E1
Keywords: Breast cancer; Ethanol; ROS; Oxidative stress; EGFR; CYP2E1