Inhibition of CYP2E1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction and apoptosis

► We examine the effect of CYP2E1 inhibition against alcoholic cardiomyopathy. ► Diallyl sulfide alleviates ethanol intake-induced cardiac defect and apoptosis. ► CYP2E1 inhibition inhibits oxidative stress, activation of ASK-1 and JNK.