دانلود مقالات ISI درباره Cyp3A4 + ترجمه فارسی

PXR-mediated transcriptional activation of CYP3A4 by cryptotanshinone and tanshinone IIA

Keywords: PXR, pregnane X receptor; CAR, constitutive androstane receptor; GR, glucocorticoid receptor; PXRE, PXR response element; hPXR, human PXR; PCR, polymerase chain reaction; wt, wild-typeCryptotanshinone; Tanshinone IIA; PXR; CYP3A4; Induction

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide

Keywords: Budesonide; Dexamethasone; Cytochrome P450; CYP3A4; Cyp3a11; PXR

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Arsenite and its metabolites, MMAIII and DMAIII, modify CYP3A4, PXR and RXR alpha expression in the small intestine of CYP3A4 transgenic mice

Keywords: Sodium arsenite; CYP3A4; PXR; RXR alpha; Ubiquitin-proteasome pathway; Transgenic mice;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

CYP1A1 and CYP3A4 modulation by dietary flavonoids in human intestinal Caco-2 cells

Keywords: Polyphenols; Human intestinal Caco-2 cells; CYP1A1; CYP3A4; Food and drug interactions; EROD assay;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases

Keywords: CYP3A4; Cytochrome P450 ubiquitination; ERAD; E3 ubiquitin ligases; E3s; UBC7; gp78; CHIP; HRD1; TEB4

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

Establishment of knockdown of superoxide dismutase 2 and expression of CYP3A4 cell system to evaluate drug-induced cytotoxicity

Keywords: Superoxide dismutase 2; CYP3A4; Cytotoxicity; RNA interference; Reactive oxygen species

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2009 سفارش ترجمه

In vitro assessment of P450 induction potential of novel chemopreventive agents SR13668, 9-cis-UAB30, and pentamethychromanol in primary cultures of human hepatocytes

Keywords: Chemoprevention; SR13668; 9-cis-UAB30; Pentamethylchromanol; Human hepatocytes; CYP1A2; CYP2B6; CYP3A4

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Novel CYP17 inhibitors: Synthesis, biological evaluation, structure–activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls

Keywords: Prostate cancer; Androgens; 17α-Hydroxylase-17,20-lyase (CYP17) inhibitors; Steroidomimetics; CYP3A4; CYP11B1

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Drug-metabolising enzymes are down-regulated by hypoxia in differentiated human hepatoma HepaRG cells: HIF-1α involvement in CYP3A4 repression

Keywords: Hypoxia; HIF-1α; Cytochrome P450; CYP3A4; Hepatocellular carcinoma; HepaRG; Chemoresistance;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2009 سفارش ترجمه

Methodology for development of a physiological model incorporating CYP3A and P-glycoprotein for the prediction of intestinal drug absorption

Keywords: physiologically based pharmacokinetics; CYP3A4; P-glycoprotein; Intestinal absorption; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2009 سفارش ترجمه

Detection of ABCC2, CYP2B6 and CYP3A4 in human peripheral blood mononuclear cells using flow cytometry

Keywords: ABCC2 (MRP2); CYP2B6; CYP3A4; PBMC; Lymphocyte; Flow cytometry;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties

Keywords: Gonadotropin-releasing hormone; Antagonist; Non-peptide; Uracil; Zwitterions; CYP3A4

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity

Keywords: Zwitterion; Gonadotropin-releasing hormone; Receptor; Antagonist; CYP3A4; Inhibition; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2008 سفارش ترجمه

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

Keywords: IGF-IR inhibitor; Cyp3A4; Cytochrome 3A4; Oral exposure; Oral bioavailability; Malonate; Methyl anion synthon; SNAr reaction; Decarboxylation; pKa

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium

Keywords: CYP3A4; Endometrial carcinoma; Genotoxic; Selective oestrogen receptor modulator; SULT2A1; Tamoxifen;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2008 سفارش ترجمه

Inhibition of oxidative metabolism of tocopherols with ω-N-heterocyclic derivatives of vitamin E

Keywords: Tocopherol; Tocotrienol; Vitamin E; Oxidative metabolism; CYP4F2; CYP3A4; Enzyme inhibition

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Development of immobilized enzyme reactors based on human recombinant cytochrome P450 enzymes for phase I drug metabolism studies

Keywords: Immobilized enzyme reactors; CYP2D6; CYP3A4; Monolithic minidisks; LC–MS/MS; On-line drug metabolism

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Discovery of sulfonylalkylamides: A new class of orally active factor Xa inhibitors

Keywords: Factor Xa inhibitor; Anticoagulant; Sulfonylalkylamide; CYP3A4

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2008 سفارش ترجمه

Genetic polymorphisms of CYP3A4: CYP3A4⁎18 allele is found in five healthy Malaysian subjects

Keywords: CYP3A4; Genetic polymorphism; PCR–RFLP; Malaysian

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

The Effect of Single-Dose Tramadol on Oxycodone Clearance

Keywords: tramadol; oxycodone; drug interaction; pharmacokinetics; CYP2D6; CYP3A4

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Pharmacokinetics for psychiatrists

Keywords: absorption; CYP2D6; CYP3A4; drugs; elderly; inhibition; interaction; lithium; metabolism; pharmacokinetics; psychotropic drugs

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Polychlorinated biphenyl (PCB) induction of CYP3A4 enzyme activity in healthy Faroese adults

Keywords: CYP3A4; 6β-Hydroxycortisol/cortisol ratio; Polychlorinated biphenyls; Persistent organohalogen pollutants; Faroe Islands

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes

Keywords: Tetrahydrocannabinol; Cannabinol; CYP2C9; CYP3A4; Human hepatic microsomes; Oxidative metabolism

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Rifampicin-induced CYP3A4 activation in CTX patients cannot replace chenodeoxycholic acid treatment

Keywords: Cerebrotendinous Xanthomatosis; CYP3A4; Rifampicin; Cholestanol;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

An improved HPLC assay with fluorescence detection for the determination of domperidone and three major metabolites for application to in vitro drug metabolism studies

Keywords: HPLC; Domperidone; CYP3A4; Cytochrome P450; Metabolites; Drug metabolism

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Regulation of CYP3A4 and CYP2B6 expression by liver X receptor agonists

Keywords: Liver X receptor agonists; Pregnane X receptor; T0901317; CYP3A4; CYP2B6; Human hepatocytes

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit

Keywords: HPLC, high-performance liquid chromatography; CYP P450, cytochrome P450; NMR, nuclear magnetic resonance; MS, mass spectrometryGrapefruit juice–drug interaction; Furocoumarin; Coumarin; Antioxidant activity; CYP3A4

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Synthesis and structure–activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1)

Keywords: MCH; MCH-R1; MCH antagonists; Melanin-concentrating hormone receptor-1 antagonists; Spirohydantion; CYP3A4; Obesity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Examination of Glucocorticoid Receptor α-Mediated Transcriptional Regulation of P-glycoprotein, CYP3A4, and CYP2C9 Genes in Placental Trophoblast Cell Lines

Keywords: Glucocorticoid receptor; Transcriptional regulation; P-glycoprotein; CYP3A4; Placenta; Cell lines; Placental barrier

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery

Keywords: In vitro cytochrome P450 inhibition assay; LC–MS/MS; DDI; Cocktail DDI analysis; Bioanalysis; CYP3A4; CYP2D6; CYP2C19; CYP2C9; CYP1A2; High-throughput analysis; Drug discovery

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

P-glycoprotein and cytochrome P450 3A4 involvement in risperidone transport using an in vitro Caco-2/TC7 model and an in vivo model

Keywords: ab; apical to basolateral; AQ; absorptive quotient; AUCT; area under the curve; ba; basolateral to apical; ClR; renal clearance; Cmax; maximum plasma concentration; CYP; cytochrome P450; ER; efflux ratio; F; fraction not metabolised; FA; fraction absorbed

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

The chimpanzee cytochrome P450 3A subfamily: Is our closest related species really that similar?

Keywords: CYP3A4; CYP3A5; CYP3A7; CYP3A43; CYP3A67; Chimpanzee; Human

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

Energetics of heterotropic cooperativity between α-naphthoflavone and testosterone binding to CYP3A4

Keywords: Binding; Thermodynamics; CYP; Allosterism; Drug-interactions; CYP3A4; EPR; Cooperativity plot; Testosterone; α-Naphthoflavone

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Evidences for CYP3A4 autoactivation in the desulfuration of dimethoate by the human liver

Keywords: Dimethoate; Omethoate; Organophosphorothionate pesticides; CYP1A2; CYP3A4; Autoactivation; Atypical kinetics

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Could steroids mask the diagnosis of cerebrotendinous xanthomatosis?

Keywords: Achilles tendon; Cerebellar ataxia; Cerebrotendinous xanthomatosis; Cholestanol; CYP3A4; Steroids;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Ketopiperazine-based renin inhibitors: Optimization of the “C” ring

Keywords: Renin inhibitor; Hypertension; Ketopiperazine; CYP3A4;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Neonicotinoid metabolic activation and inactivation established with coupled nicotinic receptor-CYP3A4 and -aldehyde oxidase systems

Keywords: Aldehyde oxidase; CYP3A4; Metabolism; Neonicotinoid; Nicotinic receptor

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants

Keywords: Cytochrome P450; Jamu; Drug interaction; Inhibition; CYP3A4; CYP2D6

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants

Keywords: CYP, cytochrome P450; CYP3A4, cytochrome P450 3A4; CYP2D6, cytochrome P450 2D6; NADPH, nicotinamide adenine dinucleotide phosphate; HLM, human liver microsomesIndonesian medicinal plants; Mechanism-based inhibition; Cytochrome P450; CYP3A4; CYP2D6

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4

Keywords: Furanocoumarins; Grapefruit juice; Cytochrome P450; CYP3A4

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2006 سفارش ترجمه

MDR- and CYP3A4-mediated drug–herbal interactions

Keywords: P-gp; CYP3A4; Drug; Herbs; Biovailability; Drug-resistance

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2006 سفارش ترجمه

Effect of fluvoxamine on plasma risperidone concentrations in patients with schizophrenia

Keywords: Risperidone; 9-Hydroxyrisperidone; Fluvoxamine; Drug interaction; CYP2D6; CYP3A4;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Effect of age and gender on citalopram and desmethylcitalopram steady-state plasma concentrations in adults and elderly depressed patients

Keywords: ALAT; alanine amino transferase; ASAT; aspartate aminotransferase; BMI; body mass index; CIT; citalopram; CYP2D6; cytochrome P4502D6; CYP3A4; cytochrome P4503A4; CYP2C19; cytochrome P4502C19; DCIT; N-desmethylcitalopram; γ-GT; gamma-glutamyl transferase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

High vulnerability to acute dystonic reactions: A case of antipsychotic exposure and uncontrolled seizure activity

Keywords: AIMS; Abnormal Involuntary Movement Scale; CT; computed tomography; CYP2D6; cytochrome P450 2D6; CYP3A4; cytochrome P450 3A4; D2; dopamine 2; DRD2 gene; dopamine D2 receptor gene; DRD3 gene; dopamine D3 receptor gene; EEG; electroencephalogram; EPS; extra

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Association study of four activity SNPs of CYP3A4 with the precocious puberty in Chinese girls

Keywords: Precocious puberty; CYP3A4; Genetic variation;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Kinetic study of cytochrome P450 3A4 activity on warfarin by capillary electrophoresis with fluorescence detection

Keywords: Kinetic study; Michaelis-Menten analysis; Enzyme; CYP3A4;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Study of urinary 6β-hydroxycortisol/cortisol ratio in spot urine sample as a biomarker of 3A4 enzyme activity in healthy and epileptic subjects of Egyptian population

Keywords: 6β-Hydroxycortisol/cortisol ratio; CYP3A4; Carbamazepine;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin

Keywords: CsA; Cyclosporin; Th1; T helper 1; CYP3A4; cytochrome P450 IIIA4; P-gp; P-glycoprotein; Morin; Cyclosporin; Pharmacodynamics; T cells; B cells; Macrophages; Th1/Th2 cytokines;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

A highly sensitive LC-MS-MS assay for analysis of midazolam and its major metabolite in human plasma: Applications to drug metabolism

Keywords: Midazolam; LC-MS-MS; Plasma; Pharmacokinetics; CYP3A4;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه

Induction of Human CYP1A2 and CYP3A4 in Primary Culture of Hepatocytes from Chimeric Mice with Humanized Liver

Keywords: chimeric mouse liver; human hepatocytes; CYP1A2; CYP3A4; induction; real-time RT-PCR;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2005 سفارش ترجمه