Cycloartane-type triterpenes from Euphorbia fischeriana stimulate human CYP3A4 promoter activity
Keywords: Euphorbia fischeriana; Cycloartane; CYP3A4; Promoter; Pregnane X receptor;
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Role of proinflammatory cytokines on expression of vitamin D metabolism and target genes in colon cancer cells
Keywords: IBD; inflammatory bowel disease; CYP24A1; 1,25-dihydroxyvitamin D3 24-hydroxylase; CYP27B1; 25-hydroxyvitamin D3 1α-hydroxylase; CYP3A4; cytochrome P450, family 3, subfamily A, polypeptide 4; TRPV6; transient receptor potential cation channel, subfamily
Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin
Keywords: Asafetida; Dextromethorphan; CYP3A4; CYP2D6; Microsomes; Metabolism; Interaction
VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke
Keywords: Vasodilator stimulated phosphoprotein; Clopidogrel resistance; CYP2C19; CYP3A4; Non-cardioembolic ischemic stroke;
Two surfaces of cytochrome b5 with major and minor contributions to CYP3A4-catalyzed steroid and nifedipine oxygenation chemistries
Keywords: Cytochrome b5; Testosterone; CYP3A4; Allostery; Cytochrome P450; Drug oxidation
Three new shRNA expression vectors targeting the CYP3A4 coding sequence to inhibit its expression
Keywords: RNAi; Cytochrome P450; CYP3A4; shRNA; Chemosensitivity
CYP-dependent Metabolism of Antitumor Pyrazolo[3,4-d]pyrimidine Derivatives Is Characterized by an Oxidative Dechlorination Reaction
Keywords: anticancer agents; cytochrome P450; CYP3A4; liver microsomes; metabolite kinetics; metabolite identification
Effect on metabolic enzymes and thyroid receptors induced by BDE-47 by activation the pregnane X receptor in HepG2, a human hepatoma cell line
Keywords: PXR; pregnane X receptor; hPXR; human pregnane X receptor; PBDE; polybrominated diphenyl ethers; BDE-47; 2,2â²,4,4â²-tetra-bromodiphenyl ether; CYP3A4; cytochrome P450 3A4; TRs; thyroid receptors; TREs; thyroid hormone response elements; UGTs; uridine d
Abiraterone inhibits 1α,25-dihydroxyvitamin D3 metabolism by CYP3A4 in human liver and intestine in vitro
Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; P450; cytochrome P450; VDR; vitamin D receptor; LC-MS/MS; liquid chromatography-tandem mass spectrometry; HLM; human liver microsomes; HIM; human intestinal microsomes; CRPC; castration-resistant prostate can
Investigating the contribution of CYP2J2 to ritonavir metabolism in vitro and in vivo
Keywords: CYP2J2; CYP2D6; CYP3A4; Time dependent inhibition; Ritonavir; In vivo; SimcypAUC, area under the plasma concentration–time curve; CYP, cytochrome P450 monooxygenase; EM, extensive metabolizer; IM, intermediate metabolizer; HLM, human liver microsomes; PM,
Combining metabolomic analysis and microarray gene expression analysis in the characterization of the medicinal plant Chelidonium majus L
Keywords: Chelidonii herba; Herbal safety; Gene expression profiling; 1H-NMR fingerprint; IPA; Ingenuity pathway analysis; PCA; Principal component analysis; qRT-PCR; quantitative real-time PCR; AhRR; Aryl-hydrocarbon receptor repressor; AKR1B10; Aldo-keto reductas
Influence of CYP3A4 Induction/Inhibition on the Pharmacokinetics of Vilazodone in Healthy Subjects
Keywords: carbamazepine; CYP3A4; depression; ketoconazole; pharmacokinetics; vilazodone;
Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1
Keywords: PXR; Metolazone; Drug metabolism; CYP3A4; MDR1
EASL Clinical Practice Guidelines: Management of hepatitis C virus infection
Keywords: AE; adverse event; ALT; alanine aminotransferase; BMI; body mass index; BOC; boceprevir; BT; viral breakthrough; CPGs; Clinical Practice Guidelines; CYP3A4; cytochrome p450 3A4; DAA; direct-acting antiviral; DVR; delayed virological response; EIA; enzyme
Grupo de Trabajo Conjunto sobre cirugÃa no cardiaca: Evaluación y manejo cardiovascular de la Sociedad Europea de CardiologÃa (ESC) y la European Society of Anesthesiology (ESA)
Keywords: GuÃas de Práctica ClÃnica; CirugÃa no cardiaca; Evaluación preoperatoria del riesgo cardiaco; Pruebas cardiacas preoperatorias; Revascularización arterial coronaria preoperatoria; Manejo cardiaco perioperatorio; Tratamiento antitrombótico; Bloquead
The cytotoxic effects of Scilla nervosa (Burch.) Jessop (Hyacinthaceae) aqueous extract on cultured HepG2 cells
Keywords: ÎΨm; mitochondrial membrane potential; CCM; complete culture medium; CYP3A4; cytochrome P450 3A4; IC50; concentration of extract that reduced cell viability to 50%; JC-1; 5,5â²,6,6â²-tetrachloro-1,1â²,3,3â²-tetraethylbenzimidazolcarbocyanine; MDA; m
Research ArticleA phase 2a trial of 12-week interferon-free therapy with two direct-acting antivirals (ABT-450/r, ABT-072) and ribavirin in IL28B C/C patients with chronic hepatitis C genotype 1
Keywords: HCV; hepatitis C virus; CYP3A4; cytochrome P450 isoform 3A4; RNA; ribonucleic acid; IL28B; interleukin-28B; LiPA; Versant® HCV Genotype Inno-LiPA Assay, version 2.0; MedDRA; Medical Dictionary for Regulatory Activities; OATP1B1; organic anion transportin
Effects of atorvastatin on CYP3A4 and CYP3A5 mRNA expression in mononuclear cells and CYP3A activity in hypercholeresterolemic patients
Keywords: Pharmacogenomics; Atorvastatin; CYP3A4; CYP3A5; mRNA expression; CYP3A activity;
Effect of Chinese herbs on CYP3A4 activity and expression in vitro
Keywords: TCM; Traditional Chinese Medicine; PK; pharmacokinetic; CYP3A4; cytochrome P450 3A4; PD; pharmacodynamic; hPXR; human pregnane X receptor; Herb-drug interactions; Pharmacokinetics; Traditional Chinese Medicine; Oldenlandia diffusa; Rehmannia glutinosa;
Liver, Pancreas and Biliary TractHepatitis B virus X protein co-activates pregnane X receptor to induce the cytochrome P450 3A4 enzyme, a potential implication in hepatocarcinogenesis
Keywords: ChIP; chromatin immunoprecipitation; CYP3A4; cytochrome P450 3A4; DMSO; dimethyl sulfoxide; GST; glutathione S-transferase; HBV; hepatitis B virus; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; PCN; pregnenolone 16α carbonitrile; PXR;
Human cytochrome P450-dependent differential metabolism among three 2α-substituted-1α,25-dihydroxyvitamin D3 analogs
Keywords: 25(OH)D3; 25-hydroxyvitamin D3; 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 1α,2α,25(OH)3D3; 1α,2α,25-trihydroxyvitamin D3; P450; cytochrome P450; UGT; UDP-glucuronosyltransferase; Glc-UA; glucuronic acid; HPLC; high-performance liquid chromatography;
In vitro evaluation of cytochrome P450 induction and the inhibition potential of mitragynine, a stimulant alkaloid
Keywords: Mitragynine; CYP1A2; CYP3A4; CYP450 induction assay; CYP450 inhibition assay; Drug-herb interactions;
Oxidase uncoupling in heme monooxygenases: Human cytochrome P450 CYP3A4 in Nanodiscs
Keywords: BC; bromocryptine; Cpd I; Compound I, Fe(IV)-oxo porphyrin pi-cation radical; POPC; 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine; POPS; 1-palmitoyl 2-oleoyl phosphatidylserine; TST; testosterone; Cytochrome P450; CYP3A4; Nanodiscs; P450 mechanism; Unc
In vitro metabolism of brucine by human liver microsomes and its interactions with CYP substrates
Keywords: Brucine; Human liver microsome; CYP3A4; Metabolism; Interaction
CYP3A4 and CYP2C19 genetic polymorphisms and zolpidem metabolism in the Chinese Han population: A pilot study
Keywords: CYP3A4; CYP2C19; Zolpidem metabolism
Cytotoxicity, antioxidant activity and an effect on CYP3A4 and CYP2D6 of Mutellina purpurea L. extracts
Keywords: ABTS; 2,2â²-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CYP2D6; cytochrome P450, isoenzyme 2D6; CYP3A4; cytochrome P450, isoenzyme 3A4; DMF; dimethylformamide; DMSO; dimethylsulphoxide; FBS; fetal bovine serum; MEM; eagle's minimal essential me
Effects of flavonoids derived from Taxus yunnanensis on p-glycoprotein and cytochrome P450 3A4
Keywords: Taxus yunnanensis; Flavonoid; P-glycoprotein; CYP3A4; Pregnane X receptor
Protective effects of triterpenoids from Ganoderma resinaceum on H2O2-induced toxicity in HepG2 cells
Keywords: Ganoderma resinaceum; Ganoderma triterpenoids; Hepatoprotective activities; CYP3A4; HepG2 cells
In-line capillary electrophoretic evaluation of the enantioselective metabolism of verapamil by cytochrome P3A4
Keywords: CYP3A4; EMMA; Enantioselective metabolism; Verapamil
Investigation of the Effect of the Uneven Distribution of CYP3A4 and P-Glycoprotein in the Intestine on the Barrier Function against Xenobiotics: A Simulation Study
Keywords: intestinal absorption; intestinal metabolism; P-glycoprotein; CYP3A4; pharmacokinetics; bioavailability
Effects of nifedipine on the pharmacokinetics of repaglinide in rats: Possible role of CYP3A4 and P-glycoprotein inhibition by nifedipine
Keywords: repaglinide; pharmacokinetics; bioavailability; nifedipine; CYP3A4; P-gp; rat
Sulforaphane is not an effective antagonist of the human pregnane X-receptor in vivo
Keywords: Sulforaphane; Cytochrome P450; CYP3A4; Midazolam; Pregnane X-receptor; NR1I2; Phase I clinical trial; Humanized PXR mice; Isolated hepatocytes
Pregnane X receptor dependent up-regulation of CYP2C9 and CYP3A4 in tumor cells by antitumor acridine agents, C-1748 and C-1305, selectively diminished under hypoxia
Keywords: Drug–drug interactions; Antitumor acridines; PXR receptor induction; Enzyme induction; CYP3A4; CYP2C9; UGT; P-gp induction; Cell hypoxia
Three-dimensional Quantitative Structure-Activity Relationship Analysis of Inhibitors of Human and Rat Cytochrome P4503A Enzymes
Keywords: 3D-QSAR; CYP3A1; CYP3A4; drug inhibition; drug-drug interaction; structure-based CoMFA;
Evaluation of in vitro cytochrome P450 induction and inhibition activity of deoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber L.
Keywords: Deoxyelephantopin; CYP3A4; Cytochrome P450 induction assay; Cytochrome P450 inhibition assay; Drug–herb interactions
Imidazopyridines as selective CYP3A4 inhibitors
Keywords: Cytochrome P450; CYP3A4; CYP3A5; Imidazopyridines
Characterization of urinary bile acids in a pediatric BRIC-1 patient: Effect of rifampicin treatment
Keywords: RFP; rifampicin; BRIC; benign recurrent intrahepatic cholestasis; GGT; γ-glutamyltransferase; PFIC-1; progressive familial intrahepatic cholestasis type 1; UGT; uridine diphosphate glucuronosyltransferase; CYP; cytochrome P450; AST; aspartate aminotransf
DP97, a DEAD box DNA/RNA helicase, is a target gene-selective co-regulator of the constitutive androstane receptor
Keywords: CAR; constitutive androstane receptor; UGT; UDP-glucuronosyltransferase; SRC-1; steroid receptor co-activator 1; PGC1α; peroxisome proliferator-activated receptor gamma, co-activator 1 alpha; CAR; CYP3A4; DP97; Nuclear receptor;
Oncology/EndocrineImpact of hepatic malignancy on CYP3A4 gene expression
Keywords: Liver; Malignancy; Hepatic metabolism; CYP3A4;
Andrographolide inhibits the expression and metabolic activity of cytochrome P450 3A4 in the modified Caco-2 cells
Keywords: Andrographolide; CYP3A4; Caco-2; 1α, 25-dihydroxyvitamin D3
Histone deacetylase 1 is required for Carbamazepine-induced CYP3A4 expression
Keywords: Carbamazepine; CYP3A4; Pregnane X receptor; Histone deacetylase 1
Cytochrome P450 inhibitory potential of selected Indian spices - possible food drug interaction
Keywords: Indian spices; Cytochrome P450; Standardization; CYP3A4; CYP2D6; CYP2C9; CYP1A2; Food-drug interaction;
Molecular imaging of cytochrome P450 activity in mice
Keywords: Liver metabolism; CYP3A4; Drug interaction; Reporter mice; Luciferase; Luminescent substrate
In vitro determination of the CYP 3A4 activity in rat hepatic microsomes by liquid-phase extraction and HPLC-photodiode array detection
Keywords: CYP3A4; HPLC; Testosterone; Salicylamid acid; NanoMOFs; MIL-100
Inductive modulation on P-glycoprotein and cytochrome 3A by resveratrol, a constituent of grapes
Keywords: CsA; cyclosporine; P-gp; P-glycoprotein; CYP3A4; cytochrome P450 3A4; RDS; resveratrol dietary supplement; HPLC; high-performance liquid chromatography; Cmax; the peak blood concentration; AUC0-t; the areas under the curves from time zero to last; MRT;
Evaluation of EROD and CYP3A4 activities in earthworm Eisenia fetida as biomarkers for soil heavy metal contamination
Keywords: Earthworm; CYP1A1; CYP3A4; Heavy metals; Biomarkers; ECm;
Assessment of the mutagenic, recombinagenic and carcinogenic potential of orlistat in somatic cells of Drosophila melanogaster
Keywords: BH; balanced heterozygote descendants; CYP3A4; cytochrome P450 3A4; DXR; doxorubicin; FAS; fatty acid synthase enzyme; FDA; Food and Drug Administration; GSH; glutathione; HB; high bioactivation cross; MH; marked trans heterozygous descendants; Sb; stubbl
Identification of pharmacogenetic predictors of lipid-lowering response to atorvastatin in Chilean subjects with hypercholesterolemia
Keywords: Polymorphisms; Hypercholesterolemia; Atorvastatin; CYP3A4;
Polysaccharide peptides from Coriolus versicolor competitively inhibit model cytochrome P450 enzyme probe substrates metabolism in human liver microsomes
Keywords: Polysaccharide peptide (PSP); Coriolus versicolor; Human CYP1A2; CYP2D6 CYP2E1; CYP3A4
Vitamin D 25-hydroxylase – Four decades of searching, are we there yet?
Keywords: Cytochrome P450 enzymes; CYP27A1; CYP2R1; CYP2J2/3; CYP3A4; CYP2D25; CYP2C11