Keywords: آنزیم های CYP; paracellular transport; passive transport disease effects; pediatric; gastrointestinal transit; permeabiltiy; elderly; CYP enzymes; transporters; metabolism; solubility;
مقالات ISI آنزیم های CYP (ترجمه نشده)
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Keywords: آنزیم های CYP; glucosamine; paracetamol; bioavailability; metabolism; liver toxicity; pharmacokinetics; CYP enzymes;
Keywords: آنزیم های CYP; in vitro models; hepatocytes; membrane transport; CYP enzymes; passive diffusion/transport;
Keywords: آنزیم های CYP; pharmacokinetics; ADME; transporters; CYP enzymes; P-glycoprotein; microsomal stability
Keywords: آنزیم های CYP; physiologically based pharmacokinetic (PBPK) modeling; Cross-species extrapolation; Systems pharmacology; First-in-man; Virtual liver; Pharmacokinetic/pharmacodynamic models; Bioinformatics; CYP enzymes; Computational biology; Simulations
Keywords: آنزیم های CYP; Verapamil; Double-blind; Refractory epilepsy; P-gp inhibitor; Multidrug resistance-1; CYP enzymes;
Status Epilepticus Decreases Brain Cytochrome P450 2D4 Expression in Rats
Keywords: آنزیم های CYP; CYP enzymes; phase I metabolism; CNS; drug-metabolizing enzymes; mRNA; HDAC; histone deacetylase; KA; kainic acid; Oct-1; octamer transcription factor 1; SE; status epilepticus; YY1; yin yang 1;
Biopharmaceutical Characterization and Oral Efficacy of a New Rapid Acting Antidepressant Ro 25-6981
Keywords: آنزیم های CYP; oral absorption; caco-2 cells; gastrointestinal; permeability; CYP enzymes; microsomes; in vitro models; in silico modeling; metabolism; physicochemical;
LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity
Keywords: آنزیم های CYP; 1-OH-MDZ; 1-hydroxymidazolam; 4-OH-DCL; 4-hydroxydiclofenac; 5-OH-OME; 5-hydroxyomeprazole; CYP; cytochrome P450 enzymes; DXP; dextrorphan; ESI; electrospray ionization; EZE-Glc; ezetimibe glucuronide; LC-MS/MS; liquid chromatography tandem mass spectro
In vitro phase I metabolism of gamabufotalin and arenobufagin: Reveal the effect of substituent group on metabolic stability
Keywords: آنزیم های CYP; Gamabufotalin; Arenobufagin; CYP enzymes; Phase I metabolism; Human liver microsomes;
Concept: The Use of Targeted Immunoaffinity Proteomics for Routine Assessment of In Vitro Enzyme Induction
Keywords: آنزیم های CYP; drug interactions; cytochrome P450; CYP enzymes; induction; hepatocytes; in vitro models; in vitro-in vivo correlations (IVIVC); proteomics;
Population Approach to Efavirenz Therapy
Keywords: آنزیم های CYP; population pharmacokinetics; CYP enzymes; HIV/AIDS; therapeutic drug monitoring; pharmacogenetics;
Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data
Keywords: آنزیم های CYP; clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b
Estimation of Interindividual Variability of Pharmacokinetics of CYP2C9 Substrates in Humans
Keywords: آنزیم های CYP; CYP enzymes; pharmacokinetics; Monte Carlo simulation; pharmacogenetics; in silico modeling;
Cytochrome P450-derived eicosanoids and heart function
Keywords: آنزیم های CYP; AA; arachidonic acid; ACS; acute coronary syndrome; ALA; alpha-linolenic acid; AMI; acute myocardial infarction; AMPK; 5â² adenosine monophosphate-activated protein kinase; Ang II; angiotensin II; ANP; atrial natriuretic peptide; BaP; benzo(α)pyrene; BK
Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial
Keywords: آنزیم های CYP; AE; adverse event; AED; antiepileptic drug; CBZ; carbamazepine; C-SSRS; Columbia Suicide Severity Rating Scale; CYP450; cytochrome P450; fT4; free thyroxine; HDL; high-density lipoprotein; LDL; low-density lipoprotein; LEV; levetiracetam; SHBG; sex-hormon
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling
Keywords: آنزیم های CYP; clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm
A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients
Keywords: آنزیم های CYP; clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti
Characterization of Long-Lasting Oatp Inhibition by Typical Inhibitor Cyclosporine A and In Vitro-In Vivo Discrepancy in Its Drug Interaction Potential in Rats
Keywords: آنزیم های CYP; drug interactions; in vitro/in vivo correlations; pharmacokinetics; protein binding; transporters; CYP enzymes; hepatocytes; organic anion-transporting polypeptide transporters; multidrug resistance transporters; solute transporters; ABT; 1-aminobenzotr
An in vitro approach to assessing a potential drug interaction between MDMA (ecstasy) and caffeine
Keywords: آنزیم های CYP; MDMA; Caffeine; Cytotoxicity; CYP enzymes; SERT; Drug interaction;
Metabolism of the polycyclic musk galaxolide and its interference with endogenous and xenobiotic metabolizing enzymes in the European sea bass (Dicentrarchus labrax)
Keywords: آنزیم های CYP; HHCB; Cyp enzymes; C17,20-lyase; 11β-Hydroxylase; Ketoconazole; Fish;
Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat
Keywords: آنزیم های CYP; Atrazine; Antioxidant enzymes; CYP enzymes; Testicular steroidogenesis
Pharmacokinetic Interplay of Phase II Metabolism and Transport: A Theoretical Study
Keywords: آنزیم های CYP; phase II metabolism; interplay; efflux transporters; Caco-2 cells; PBPK; UGTs; glucuronidation; CYP enzymes;
A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes
Keywords: آنزیم های CYP; hepatic clearance; hepatic metabolism; hepatocytes; metabolic clearance; CYP enzymes; cytochrome P450; clearance; flavin monooxygenases (FMO);
Stereoselective Evasion of P-glycoprotein, Cytochrome P450 3A, and Hydrolases by Peptide Prodrug Modification of Saquinavir
Keywords: آنزیم های CYP; prodrugs; structure–activity relationship (SAR); P-glycoprotein; peptide transporters; metabolism; CYP enzymes; stability
Impact of CYP3A5*3 and CYP2C8-HapC on Paclitaxel/Carboplatin-Induced Myelosuppression in Patients with Ovarian Cancer
Keywords: آنزیم های CYP; CYP enzymes; pharmacogenetics; toxicity; polymorphism; drug metabolizing enzymes; cancer chemotherapy;
Effects of Uremic Toxins on Transport and Metabolism of Different Biopharmaceutics Drug Disposition Classification System Xenobiotics
Keywords: آنزیم های CYP; disease effects; BDDCS; organic anion-transporter polypeptide transporters; hepatocytes; CYP enzymes; microsomes; phase I metabolism
Simultaneous Absolute Quantification of 11 Cytochrome P450 Isoforms in Human Liver Microsomes by Liquid Chromatography Tandem Mass Spectrometry with In Silico Target Peptide Selection
Keywords: آنزیم های CYP; CYP enzymes; cytochrome P450; hepatic metabolism; LC-MS/MS; mass spectrometry; metabolism; microsomes; proteomics; quantification
Long-term cultivation of HepG2 liver cells encapsulated in alginate hydrogels: A study of cell viability, morphology and drug metabolism
Keywords: آنزیم های CYP; Cell encapsulation; 3D tissue models; Alginate; Hydrogels; CYP enzymes
The effect of CYP1A induction on amiodarone disposition in the rat
Keywords: آنزیم های CYP; CYP enzymes; induction; pharamcokinetics; phase I enzyme; distribution; clearance; metabolism;
The oxidative metabolism of dimemorfan by human cytochrome P450 enzymes
Keywords: آنزیم های CYP; dimemorfan; metabolism; microsomes; CYP enzymes; inhibition; kinetics;
Reversal of acetaminophen induced subchronic hepatorenal injury by propolis extract in rats
Keywords: آنزیم های CYP; Acetaminophen; CYP enzymes; Hepatoprotection; Lipid peroxidation; Liver function tests; Propolis; Reduced glutathione
Biotransformation of polycyclic aromatic hydrocarbons in marine polychaetes
Keywords: آنزیم های CYP; CYP enzymes; Metabolism; Phase I and phase II enzymes; PAH, Induction; Elimination; Trophic transfer
Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis
Keywords: آنزیم های CYP; POR; Retinoids; P450 cytochromes; CYP enzymes; Limb development; Brain patterning; Vasculogenesis
Pharmacokinetics of Oltipraz in Mutant Nagase Analbuminemic Rats
Keywords: آنزیم های CYP; oltipraz; mutant Nagase analbuminemic rats; CYP1A2; pharmacokinetics; protein binding; metabolism; CYP enzymes;
Effect of a PCB-based transformer oil on testicular steroidogenesis and xenobiotic-metabolizing enzymes
Keywords: آنزیم های CYP; Polychlorinated biphenyls; Pyralene; Testosterone; 17βHSD; EROD; PROD; CYP enzymes
Pharmacokinetics of Chlorzoxazone in Rats with Diabetes: Induction of CYP2E1 on 6-Hydroxychlorzoxazone Formation
Keywords: آنزیم های CYP; CZX and OH-CZX; rat model of diabetes induced by alloxan (DMIA) or streptozotocin (DMIS); pharmacokinetics; CYP2E1; rats; disease state; CYP enzymes; metabolism; intrinsic clearance; protein binding;
Hepatic Disposition of the Cytochrome P450 2E1 Marker Chlorzoxazone and its Hydroxylated Metabolite in Isolated Perfused Rat Livers
Keywords: آنزیم های CYP; cytochrome P450; CYP enzymes; CYP2E1; hepatic clearance; biliary clearance; hepatic metabolism; disposition; nonlinear metabolism; isolated rat liver perfusion; rats;
Pharmacokinetics and Therapeutic Effects of Oltipraz after Consecutive or Intermittent Oral Administration in Rats with Liver Cirrhosis Induced by Dimethylnitrosamine
Keywords: آنزیم های CYP; oltipraz; pharmacokinetics; CYP enzymes; therapeutic effects; consecutive or intermittent oral administration; liver cirrhosis; rats;
Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition
Keywords: آنزیم های CYP; oltipraz; protein-calorie malnutrition; cysteine; CYP enzymes; metabolic clearance; pharmacokinetics; rats;
NADPH-dependent metabolism of 17β-estradiol and estrone to polar and nonpolar metabolites by human tissues and cytochrome P450 isoforms
Keywords: آنزیم های CYP; E2; 17β-estradiol; E1; estrone; OH; hydroxy; CYP; cytochrome P450; NADPH; β-nicotinamide adenine dinucleotide phosphate (reduced form); HPLC; high-performance liquid chromatography; GC/MS; gas chromatography/mass spectrometry; TMS; trimethylsilyl; pmol/