کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6009825 | 1579829 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial
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کلمات کلیدی
AEDC-SSRSCbzSHBGCYP450HDLFT4LEVTSHhigh-density lipoprotein - HDL یا لیپوپروتئین با دانسیته بالا یا چگالی بالاTEAE - teaerandrogens - آندروژنCYP enzymes - آنزیم های CYPTriiodothyronine - تری یدوتیرونینThyroid - تیروئیدthyroxine - تیروکسینFree thyroxine - تیروکسین آزادantiepileptic drug - داروهای ضدصرعantiepileptic drugs - داروهای ضدصرع Cytochrome P450 - سیتوکروم پی۴۵۰adverse event - عارضه جانبی یا عوارض جانبیtreatment-emergent adverse event - عوارض جانبی ناگهانی درمانlevetiracetam - لوتیراستامLow-density lipoprotein - لیپوپروتئین کم چگالی یا الدیال LDL - لیپوپروتئین کم چگالی(کلسترول بد)Columbia Suicide Severity Rating Scale - مقیاس درجه بندی شدت خودکشی در کلمبیاThyroid-stimulating hormone - هورمون تحریک کننده تیروئیدcarbamazepine - کاربامازپینcholesterol - کلسترولsex-hormone-binding globulin - گلوبولین اتصال دهنده جنسی هورمون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial Changes in hormone and lipid levels in male patients with focal seizures when switched from carbamazepine to lacosamide as adjunctive treatment to levetiracetam: A small phase IIIb, prospective, multicenter, open-label trial](/preview/png/6009825.png)
چکیده انگلیسی
Treatment with enzyme-inducing antiepileptic drugs (AEDs) such as carbamazepine (CBZ) can lead to changes in reproductive, endocrine, and lipid parameters, resulting in clinical symptoms for some patients. Previous studies indicate that these changes can be reversed by switching to a nonenzyme-inducing AED. Lacosamide is a newer-generation AED, not known to induce or strongly inhibit cytochrome P450 (CYP450) enzymes. In this phase IIIb, prospective, multicenter, open-label, single-arm trial (NCT01375374), the serum concentrations of CYP-related reproductive hormones, thyroid hormones, and lipids were assessed in otherwise healthy male patients with focal seizures (N = 11), before and after a switch from CBZ (600-1200 mg/day at baseline) to lacosamide (target dose: 400 mg/day by the end of titration) as adjunctive treatment to the nonenzyme-inducing AED levetiracetam (LEV, stable dosage of > 1000 mg/day throughout). Cross titration took place over 4 weeks, followed by an 8-week maintenance period. Serum measurements were conducted at baseline and at the end of maintenance. The median serum sex-hormone-binding globulin (SHBG) concentration was towards the higher end of the normal range at baseline and decreased following the switch (61.7 to 47.5 nmol/L, N = 10, p = 0.027 by Wilcoxon signed-rank test). Free androgen index (100 Ã testosterone/SHBG) and free thyroxine serum concentration increased (25.4 to 36.4 and 13.0 to 14.9 pmol/L, respectively, both N = 10 and p = 0.002). At baseline, the median progesterone serum concentration was below the normal range (0.7 nmol/L), whereas median cholesterol and low-density lipoprotein concentrations were above the normal range (5.5 and 3.6 mmol/L, respectively). By the end of maintenance, all measured parameters were within the normal range. The safety and tolerability profile of lacosamide was consistent with that observed in previous studies. Furthermore, antiseizure efficacy appeared to be maintained, suggesting that deinduction of CYP enzymes following a switch from CBZ to lacosamide as adjunctive therapy to LEV is feasible within 8 weeks and is associated with normalization of serum parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Epilepsy & Behavior - Volume 62, September 2016, Pages 1-5
Journal: Epilepsy & Behavior - Volume 62, September 2016, Pages 1-5
نویسندگان
Christian E. Elger, Michael Rademacher, Christian Brandt, Sami Elmoufti, Peter Dedeken, Klaus Eckhardt, Frank Tennigkeit, Marc De Backer,