Keywords: DREAM; Biphalin; Opioid receptors; MOR/DOR/KOR agonist; Synergistic analgesic effect; Cyclic peptides; Acm; acetamidomethyl; ACN; acetonitrile; BBB; blood brain barrier; Boc; t-butyloxycarbonyl; BOP; (benzotriazol-1-yloxytris(dimethylamino)phosphonium hexafluoro
مقالات ISI DREAM (ترجمه نشده)
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Keywords: DREAM; 4HNE; 4-Hydroxy-2-nonenal; AC; Adenylyl cyclase; AD; Alzheimer's disease; AMP; Adenosine monophosphate; AMPK; AMP-activated protein kinase; cAMP; Cyclic adenosine 3â²,5â²-monophosphate; CB; Cannabinoid receptor; CHO; Chinese hamster ovary; DAL; Dehydro-
Keywords: DREAM; Ach; acetylcholine; ADHD; attention-deficit hyperactivity disorder; BDNF; brain-derived neurotrophic factor; BEND; beta-endorphin; BFNA; beta-funaltrexamine; Ca(2+); calcium; CAMK; calmodulin-dependent protein kinase II; cAMP; cyclic adenosine monophospha
Keywords: DREAM; DAMGO; [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; dyn-DN; dominant negative dynamin inhibitory peptide; ERK1/2; extracellular signal-regulated kinase 1 and 2; PTX; pertussis toxin; scr-dyn; scrambled control peptide; vlPAG; ventrolateral periaqueductal gray;
Keywords: DREAM; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-(1-piperidyl)pyrazo-le-3-carboxamide; BSA; bovine serum albumin; DAMGO; [d-Ala2, N-MePhe4, Gly-ol]-enkephalin; DIEA; diisopropylethylamine; DMF; dimethylformamide; EGTA; ethylene glycol-bis(2-amino
Keywords: DREAM; β-Cells; DAMGO; Islets; Glucose metabolism; DAMGO (PubChem CID: 5462471); U-50.488 (PubChem CID: 6604724); SNC-80 (PubChem CID: 123924); β-FNA (PubChem CID: 57339687);
Keywords: DREAM; DAMGO; [D-Ala2, N-MePhe4, Gly5-ol]-enkephalin; DOR; delta opioid receptor; DPDPE; [D-Pen2,5]-enkephalin; IC; insular cortex; IOR; insular oral region; KOR; kappa opioid receptor; MCA; middle cerebral artery; MOR; mu opioid receptor; Pyr; pyramidal cells;
Keywords: DREAM; ACC; anterior cingulate; ACSF; artificial cerebrospinal fluid; AI; agranular region; DAMGO; [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin acetate salt; DPDPE; [D-Pen2,5]-Enkephalin hydrate; FS; fast-spiking; IC; insular cortex; Pyr; pyramidal; uIPSCs; unitary inh
Keywords: DREAM; Ach; acetylcholine; ACTH; adrenocorticotrophic hormone; BDNF; brain-derived neurotrophic factor; BEND; beta-endorphin; BFNA; beta-funaltrexamine; BNST; bed nucleus of the stria terminalis; Ca(2+); calcium; CaMKII; calcium/calmodulin-dependent protein kina
Keywords: DREAM; ANOVA; analysis of variance; CPR; cytochrome P450 reductase; DAMGO; [D-Ala2, N-Me-Phe4, Gly5-ol]-enkephalin acetate; GTPγS; guanosine 5â²-O-(3-thiotriphosphate) tetralithium salt; icv; intracerebroventricular; Null; neuronal cytochrome P450 reductase de
Keywords: DREAM; BBB; blood-brain barrier; Boc; tert-butyloxycarbonyl; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; DAMGO; H-Tyr-d-Ala-Gly-NMePhe-Gly-ol; DCM; dichloromethane; DIEA; N,N-diisopropylethylamine; DOR; δ-opioid receptor; DPDPE; Tyr-c(d
Keywords: DREAM; NAc; nucleus accumbens; COS; cream, oil, and sugar emulsion; Î-FNA; β-funaltrexamine; nor-BNI; nor-binaltorphimine; DAMGO; [D-Ala2,N-MePhe4,Gly-ol]-enkephalin; CTAP; D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2; M-W-F; Monday-Wednesday-Friday; IA; in
Keywords: DREAM; DAMGO; Feeding; High-fat diet; Central amygdala; Nucleus accumbens; Food deprivation
Keywords: DREAM; WLS; Wntless; MOR; mu-opioid receptor; LC; locus coeruleus; NE; norepinephrine; DAMGO; [d-Ala2, N-Me-Phe4, Gly-ol5]-enkephalin; TH; tyrosine hydroxylase; GPCR; G-protein coupled receptor; GIP; G-protein interacting protein; MORIP; mu-opioid receptor inter
Keywords: DREAM; IBS; Irritable Bowel Syndrome; IBS-D; IBS diarrhea predominant; IBS-C; IBS constipation predominant; IBS-A; IBS alternating; PBMC; peripheral blood mononuclear cell; MALDI-TOF; matrix-assisted laser desorption/ionization-time of flight; MOR; μ-opioid rec
Keywords: DREAM; Ach; acetylcholine; AchE; acetylcholine esterease; ACTH; adrenocorticotrophic hormone; ADHD; attention deficit/hyperactivity disorder; AIDS; autoimmune deficiency syndrome; AMSH; alpha-melanocyte-stimulating hormone; BAM; bovine adrenal medulla peptide; B
Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene
Keywords: DREAM; NMYR; N-methyl-l-tyrosine-l-arginine; PENK; preproenkephalin; POMC; proopiomelanocortin; Leu-Arg; l-leucine-l-arginine; NMLR; N-methyl-l-Leucine-l-arginine; WT; wild-type; KO; knockout; DAMGO; [D-Ala2, N-Methyl-Phe4, Gly5-ol] enkephalin; MOPr; μ opioid r
Up-regulation of μ-, δ- and κ-opioid receptors in concanavalin A-stimulated rat spleen lymphocytes
Keywords: DREAM; Opioids receptors; Up-regulation; Concanavalin A; Rat spleen lymphocytes; G proteins; β-arrestin-1/2; Ab; antibodies; Bt, Bnsp, Bsp; total, non-specific and specific radioligand binding; Con A; Concanavalin A; DAMGO; [(2-D-alanine-2-4-methylphenylalanine
Mu Opioid Receptor Agonist DAMGO Produces Place Conditioning, Abstinence-induced Withdrawal, and Naltrexone-Dependent Locomotor Activation in Planarians
Keywords: DREAM; Mu opioid; DAMGO; Planarians; Withdrawal; Addiction; Place preference;
Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace
Keywords: DREAM; Analgesia; Butyrylfentanyl; Mu-opioid receptor; MT-45; U-47700; DAMGO; [D-Ala2,N-MePhe4,Gly-ol]-enkephalin; DPDPE; [D-Pen2, D-Pen5]-enkephalin; DOR-1; delta-opioid receptor; GTPγS; guanosine 5â²-O-[gamma-thio]triphosphate; KOR-1; kappa-opioid receptor;
Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum
Keywords: DREAM; KYNA; Opioid receptor; [35S]GTPγS binding; G-protein; MK-801; 3-NLT; 3-nitro-l-tyrosine; CNS; central nerve system; CSF; cerebrospinal fluid; BBB; blood-brain barrier; DAMGO; Tyr-D-Ala-Gly-(NMe)Phe-Gly-ol; DOPr; δ opioid peptide receptor; EGTA; ethylene
Research reportActivation of mu-opioid receptors in the ventral pallidum decreases the negative hedonic evaluation of a conditioned aversive taste in rats
Keywords: DREAM; CS; conditioned stimulus; CTA; conditioned taste aversion; DAMGO; [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; LiCl; lithium chloride; MOR; mu-opioid receptor; NAc; nucleus accumbens; VP; ventral pallidum; Ventral pallidum; Mu-opioid receptor; DAMGO; Hedonic ev
Marked sexual dimorphism in 5-HT1 receptors mediating pronociceptive effects of sumatriptan
Keywords: DREAM; 5-HT; 5-hydroxytryptamine; 5-HT1B; 5-hydroxytryptamine receptor subtype 1B; 5-HT1D; 5-hydroxytryptamine receptor subtype 1D; PKA; protein kinase A; GPCR; G-protein-coupled receptor; GPR30; G-protein-coupled estrogen receptor 30; ANOVA; analysis of varianc
Residues W320 and Y328 within the binding site of the μ-opioid receptor influence opiate ligand bias
Keywords: DREAM; GPCR; μ-opioid receptor; Ligand bias; Opioid; cAMP; β-arrestin; ANOVA; analysis of variance; BSA; bovine serum albumin; cAMP; 3â²,5'-cyclic adenosine monophosphate; CI; confidence intervals; DAMGO; D-Ala2,N-MePhe4,Gly-ol]-enkephalin; E/[A]; concentra
Effect of cannabinoids on CGRP release in the isolated rat lumbar spinal cord
Keywords: DREAM; Cannabinoid; CGRP; Spinal cord; DAMGO; WIN 55,; 212-2;
Research reportPeripheral interactions between cannabinoid and opioid receptor agonists in a model of inflammatory mechanical hyperalgesia
Keywords: DREAM; DAMGO; ACPA; μ Opioid receptor; CB1; Dorsal root ganglia; Isobologram; Complete freund's adjuvant;
Proteomic analysis of protein composition of rat forebrain cortex exposed to morphine for 10Â days; comparison with animals exposed to morphine and subsequently nurtured for 20Â days in the absence of this drug
Keywords: DREAM; ABC; ammonium bicarbonate; ACN; acetonitrile; AC; adenylyl cyclase; CBB; Coomassie Brilliant Blue; CNS; central nervous system; DAMGO; [(2-d-alanine2-4-methylphenylalanine-5-glycineol)-enkefalin]; DADLE; [(2-d-alanine-5-d-leucine)-enkefalin]; 2D-ELFO; t
Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and β-arrestin 2 activity in the forebrain
Keywords: DREAM; Amyg; Amygdala; β-Arr2; β-arrestin-2; BSA; bovine serum albumin; CNS; central nervous system; Co-IP; co-immunoprecipitation; CPu; caudate-putamen; [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DAMGO; DOX; doxycycline; EC50; ligand concentration causing half-
Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier
Keywords: DREAM; (4-6): drug delivery; microRNA; Peripheral nerve; Biocompatibility; In vivo test; In vitro test; BBB; blood-brain barrier; BNB; blood-nerve barrier; CLDN1; claudin-1 gene; DAMGO; [d-Ala2,N-Me-Phe4,Gly5-ol]enkephalin; miR; microRNA; GSK-3; glycogen s
Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia
Keywords: DREAM; G-protein stimulation; [35S]GTPγS binding; Brain membranes; Opioid receptors; DAMGO; Schizophrenia animal model;
ReviewOpioid-induced hyperalgesia: Cellular and molecular mechanisms
Keywords: DREAM; 5-HT; serotonin; β2-AR; β2-adrenergic receptor; β-FNA; β-funaltrexamine; BDNF; brain derived neurotrophic factor; CCK; cholecystokinin; CNS; central nervous system; CxCR; chemokine receptor; CxCL; chemokine; DAMGO; Tyr-D-Ala-Gly-NMe-Phe-Gly-ol; DOR; d
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres
Keywords: DREAM; [35S]GTPγS; sulfur-35 guanosine-5â²-O-(3-thio)triphosphate; DAMGO; [D-Ala2,MePhe4,Gly-ol5]enkephalin; DPDPE; [D-Pen2,D-Pen5]enkephalin; U69,593; (5α,7α,8β)-(â)-N-methyl-N-[7-(1-pyrrolidinyl)-1-oxaspiro[4,5]dec-8-yl]benzeneacetamide; JDTic; Opioids;
Systematic analysis of factors influencing observations of biased agonism at the mu-opioid receptor
Keywords: DREAM; AC; adenylyl cyclase; α-neo; α-neoendorphin; β-arr1 and β-arr2; β-arrestin 1 and 2; BRET; bioluminescence resonance energy transfer; CHO; Chinese hamster ovary; DAMGO; d-Ala2-N-MePhe4-Gly-ol enkephalin; endo; endomorphin; pERK; extracellular signal r
Design and synthesis of novel bivalent ligands (MOR and DOR) by conjugation of enkephalin analogues with 4-anilidopiperidine derivatives
Keywords: DREAM; ACN; Acetonitrile; Boc; tert-butyloxycarbonyl; CHO; Chinese hamster ovary; DCM; Dichloromethane; DIPEA; N,N-Diisopropylethylamine; DALEA; [D-Ala2, Leu5] enkephalin amide; DAMGO; [D-Ala2,NMePhe4,Gly5-ol]enkephalin; Dmt; 2,6-dimethyltyrosine; DPDPE; c[D-Pen
Research ReportEffects of co-administration of 2-arachidonylglycerol (2-AG) and a selective µ-opioid receptor agonist into the nucleus accumbens on high-fat feeding behaviors in the rat
Keywords: DREAM; Nucleus accumbens; 2-arachidonylglycerol; Palatable food; Cannabinoid; DAMGO; Opioid; Approach; Consumption; Reward; Feeding; High fat;
Regional differences in mu and kappa opioid receptor G-protein activation in brain in male and female prairie voles
Keywords: DREAM; [35S]GTPγS; guanosine 5â²-O[γ-35S] triphosphate; DAMGO; [d-Ala2,NMe-Phe4,Gly-ol5]-enkephalin; EGAT; ethylene glycol tetraacetic acid); NAc; nucleus accumbens; nor-BNI; nor-binaltorphimine; PBS; phosphate-buffered saline; second messenger; signaling; au
DAMGO depresses inhibitory synaptic transmission via different downstream pathways of μ opioid receptors in ventral tegmental area and periaqueductal gray
Keywords: DREAM; 4-AP; 4-aminopyridine; AA; arachidonic acid; AACOCF3; arachidonyl trifluoromethyl ketone; AC; adenylyl cyclase; BIS I; bisindolylmaleimide I; DA; dopamine; DAMGO; [D-Ala2,N-Me-Phe4,Gly5-ol]-enkephalin; DL-AP 5; DL-2-amino-5-phosphonopentanoic acid; DNQX;
The inhibition of high-voltage-activated calcium current by activation of MrgC11 involves phospholipase C-dependent mechanisms
Keywords: DREAM; CTX; cholera toxin; DAMGO; [D-Ala2, N-methyl-Phe4, Gly-ol5]-enkephalin; DMEM; dulbecco's modified eagle medium; DRG; dorsal root ganglion; EGTA; ethylene glycol tetraacetic acid; FBS; fetal bovine serum; HBSS; hank's balanced salt solution; HEPES; 4-(2-hy
RGS2 and RGS4 proteins: New modulators of the κ-opioid receptor signaling
Keywords: DREAM; 293Â F; cell line of human embryonic kidney origin; 6ÃÂ His; hexahistidine; aa; amino acids; AC; adenylyl cyclase; AR; adrenergic receptors; AT1; Angiotensin Receptor 1; CT; carboxyl terminus; ÎÎRGS4; RGS4 lacking its N-terminal domain; DAMGO; [d-Ala2,
Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins
Keywords: DREAM; Blood-brain barrier (BBB) transport (influx/efflux); Antinociceptive activity; Linear/cyclic enkephalin analogs; In vivo mouse models; AUC; area under the curve; Alloc; allyloxycarbonyl; BBB; blood-brain barrier; Boc; tertButyloxycarbonyl; BSA; bovine
Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting
Keywords: DREAM; Dynorphin; Kappa opioid receptor; [35S]GTPγS binding; Mouse striatum; Selectivity; Drug discovery; KOR antagonist; CTOP; D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2; DAMGO; [D-Ala2, NMe-Phe4, Gly-ol5]-enkephalin; Dyn; dynorphin; DOR; delta opioid receptor; [
μ-Opioid receptor 6-transmembrane isoform: A potential therapeutic target for new effective opioids
Keywords: DREAM; MOR; μ-opioid receptor; 6TM MOR; six transmembrane helices μ-opioid receptor; 7TM MOR; seven transmembrane helices μ-opioid receptor; OIH; opioid induced hyperalgesia; VGCC; voltage-gated Ca2 + channels; cAMP; cyclic adenosine monophosphate; AC; adeny
[Dmt1]DALDA analogues with enhanced μ opioid agonist potency and with a mixed μ/κ opioid activity profile
Keywords: DREAM; Boc; tert-butyloxycarbonyl; DAMGO; H-Tyr-d-Ala-Gly-Phe(NMe)-Gly-ol; Dmp; 2â²,6â²-dimethylphenylalanine; Dmt; 2â²,6â²-dimethyltyrosine; [Dmt1]DALDA; H-Dmt-d-Arg-Phe-Lys-NH2; DSLET; H-Tyr-d-Ser-Gly-Phe-Leu-Thr-OH; EDT; 1,2-ethanediol; Emp; 2â²-ethyl-6â
Research reportManipulation of GABA in the ventral pallidum, but not the nucleus accumbens, induces intense, preferential, fat consumption in rats
Keywords: DREAM; Macronutrient; Carbohydrate; Feeding; Food deprivation; DAMGO; Bicuculline;
Natriorexigenic effect of DAMGO is decreased by blocking AT1 receptors in the central nucleus of the amygdala
Keywords: DREAM; μ-ORs; μ-opioid receptors; AHA; anterior hypothalamic area; ANOVA; analysis of variance; ANG II; angiotensin II; AT1; ANG II type 1; CAP; angiotensin-converting enzyme inhibitor captopril; CeA; central nucleus of the amygdala; DAMGO; [D-Ala2, N-Me-Phe4,
LY2456302 is a novel, potent, orally-bioavailable small molecule kappa-selective antagonist with activity in animal models predictive of efficacy in mood and addictive disorders
Keywords: DREAM; Opioid receptors; Kappa opioid antagonist; Antidepressant; Addiction; Alcohol dependence; Dynorphin; CREB; cyclic adenosine monophosphate-response element binding protein; DAMGO; [D-Ala2, N-MePhe4, Gly-ol]-enkephalin; DPDPE; [d-Pen2,d-Pen5]-enkephalin; ER
N-terminal guanidinylation of TIPP (Tyr-Tic-Phe-Phe) peptides results in major changes of the opioid activity profile
Keywords: DREAM; BBB; blood-brain barrier; Boc; tert-butyloxycarbonyl; Cl-HOBt; 6-chloro-1-hydroxybenzotriazole; DAMGO; H-Tyr-D-Ala-Gly-Phe(NMe)-Gly-ol; DIC; 1,3-diisopropylcarbodiimide; DIPP; H-Dmt-Tic-Phe-Phe-OH; DIPP-NH2; H-Dmt-Tic-Phe-Phe-NH2; DIPP-NH2[Ψ]; H-Dmt-Ti
Research reportSpinal interaction between the highly selective μ agonist DAMGO and several δ opioid receptor ligands in naive and morphine-tolerant mice
Keywords: DREAM; Opioid receptors; Receptor interaction; Tolerance; Heterodimers; DAMGO; TIPP;
Sweetened-Fat Intake Sensitizes Gamma-Aminobutyric Acid-Mediated Feeding Responses Elicited from the Nucleus Accumbens Shell
Keywords: DREAM; DAMGO; feeding behavior; GABAA receptor; musimol; opioid; sensitization;
Hybrid peptides endomorphin-2/DAMGO: Design, synthesis and biological evaluation
Keywords: DREAM; Analgesics; DAMGO; Endomorphins; Hot plate; Nociception; Opioid; Tail flick;