Nicotinic receptor inactivation after acute and repeated in vivo nicotine exposures in rats
Keywords: کاهش حساسیت; Desensitization; Repeated dosing; Nicotine; Rat; Rubidium efflux
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Relationship between the G protein signaling and homologous desensitization of G protein-coupled receptors
Keywords: کاهش حساسیت; Signaling; Desensitization; GPCR; GRK; β-Arrestin; Dopamine D3 receptor; β2-Adrenergic receptor; Ste2p
Stevioside does not cause increased basal insulin secretion or β-cell desensitization as does the sulphonylurea, glibenclamide: Studies in vitro
Keywords: کاهش حساسیت; Stevioside; Basal insulin secretion (BIS); Glucose stimulated insulin secretion (GSIS); Desensitization; Glibenclamide; Glucagon-like peptide-1
Desensibilización de cotrimoxazol, rifampicina y penicilina G en nueve pacientes con hipersensibilidad previa
Keywords: کاهش حساسیت; Cotrimoxazol; Rifampicina; Penicilina G; Hipersensibilidad; Desensibilización; Cotrimoxazole; Rifampicin; Penicillin G; Hypersensitivity; Desensitization;
Mutation of the phosphorylatable residue Thr429 in Glu of the human VPAC1 led to a constitutively desensitized receptor
Keywords: کاهش حساسیت; VPAC1 receptors; Desensitization; Receptor mutation
Identification of P2X4 receptor-specific residues contributing to the ivermectin effects on channel deactivation
Keywords: کاهش حساسیت; Purinergic receptor-channels; P2X4; ATP; Ivermectin; Gating; Activation; Deactivation; Desensitization; Chimeras
Molecular mechanisms of β2-adrenergic receptor function, response, and regulation
Keywords: کاهش حساسیت; β2-Adrenergic receptor; β2-agonists; desensitization; polymorphismscAMP, Cyclic adenosine monophosphate; GR, Glucocorticoid receptor; GTP, Guanosine triphosphate; MAPK, Mitogen-activated protein kinase; PET, Positron emission tomography; PKA, Protein kina
Cellular mechanisms that determine selective RGS protein regulation of G protein-coupled receptor signaling
Keywords: کاهش حساسیت; RGS; GPCR; G protein; Desensitization; 7TM receptor
Characterization of the desensitization properties of five dopamine receptor subtypes and alternatively spliced variants of dopamine D2 and D4 receptors
Keywords: کاهش حساسیت; Signaling; Desensitization; GPCR; GRK; β-Arrestin; Dopamine receptor; SH3-binding domain
Downregulation of IgE antibody and allergic responses in the lung by epidermal biolistic microparticle delivery
Keywords: کاهش حساسیت; Desensitization; biolistic; Langerhans; IgE; eosinophilic; lung functionMCh, Methacholine; OVA, Ovalbumin; Raw, Newtonian resistance; Zrs, Respiratory input impedance
High-purity selection and maintenance of gene expression in human neuroblastoma cells stably over-expressing GFP fusion protein
Keywords: کاهش حساسیت; hDOR; human delta opioid receptor; FACS; fluorescence-activated cell sorting; β-arr1-GFP; β-arrestin1-GFP; FACS; GFP; SK-N-BE; hDOR; β-arrestin1; Desensitization;
Chronic violent video game exposure and desensitization to violence: Behavioral and event-related brain potential data
Keywords: کاهش حساسیت; Aggression; Desensitization; Violent media; Event-related potential ERP; Habituation; P300; Brain; Video games
Hypoxia-induced desensitization and internalization of adenosine A1 receptors in the rat hippocampus
Keywords: کاهش حساسیت; adenosine; A1 receptor; hypoxia; desensitization; internalization; hippocampusA1R, A1 receptor; CADO, 2-chloroadenosine; CPA, N6-cyclopentyladenosine; DPCPX, 1,3-dipropyl-8-cyclopentylxanthine; fEPSP, field excitatory post-synaptic potentials; SCH 58261,
Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons
Keywords: کاهش حساسیت; internalization; desensitization; trafficking; synthesis; mu opioid receptor; dorsal root ganglia neuronsANOVA, analysis of variance; CT, carboxyl-terminus; DAMGO, d-Ala2, N-MePhe4, Gly5-ol-enkephalin; DRG, dorsal root ganglia; EGFP, enhanced green fluore
μ-Opioid receptor internalization-dependent and -independent mechanisms of the development of tolerance to μ-opioid receptor agonists: Comparison between etorphine and morphine
Keywords: کاهش حساسیت; opioid tolerance; μ-opioid receptor; desensitization; astrocytes; morphine; spinal cordACM, astrocyte-conditioned medium; cPKC, conventional protein kinase C; DAMGO, [d-Ala2, N-Me-Phe4, Gly5-ol]enkephalin; DMEM, Dulbecco’s modified Eagle’s medium; GFAP, g
Frequency-dependent modulation of glycine receptor activation recorded from the zebrafish larvae hindbrain
Keywords: کاهش حساسیت; glycine receptors; patch-clamp; desensitization; frequency; synaptic activity; modulation; GABAAR; type A GABA receptor; GlyR; glycine receptor; M-cell; Mauthner cell; mIPSC; miniature inhibitory post-synaptic current; SSE; sum of squared error;
Underlying mechanism for NMDA receptor antagonism by the anti-inflammatory drug, sulfasalazine, in mouse cortical neurons
Keywords: کاهش حساسیت; Cortex; Desensitization; Glycine; Noncompetitive antagonism; Voltage-clamp; Whole-cell recording
Targeting G protein-coupled receptor signaling in asthma
Keywords: کاهش حساسیت; G protein-coupled receptor; Asthma; Airway; Airway smooth muscle; Allergy; Atopy; Inflammation; Beta-agonist; Desensitization; Contraction; Relaxation; Synthetic function; Airway remodeling; Beta-adrenergic receptor; Proliferation; G protein; Phospholipas
Homologous desensitization of signalling by the beta (β) isoform of the human thromboxane A2 receptor
Keywords: کاهش حساسیت; C-tail; carboxyl-terminal tail; [Ca2+]i; intracellular calcium; FBS; foetal bovine serum; GPCR; G protein-coupled receptor; GRK; G protein-coupled receptor kinase; HA; hemagglutinin; HEK; human embryonic kidney; IP; prostacyclin receptor; IP3; inositol 1,
Tracking the opioid receptors on the way of desensitization
Keywords: کاهش حساسیت; Opioid receptors; Desensitization; G-protein coupled receptors; Internalization; Phosphorylation; β-arrestins
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
Keywords: کاهش حساسیت; Arrestin; G-protein-coupled receptors; Desensitization; Structure; Conformational changeARF6, ADP ribosylation factor 6; ARNO, ARF nucleotide-binding site opener; AT1A, angiotensin II type 1A; b2AR, β2-adrenergic receptor; BRET, bioluminescence resonance
5-HT3A receptor kinetics: Agonist and anesthetic action
Keywords: کاهش حساسیت; Activation; Anesthetic; Deactivation; Desensitization; Electrophysiology; Isoflurane; Kinetics; Receptor;
Protein kinase C contributes to abnormal capsaicin responses in DRG neurons from cats with feline interstitial cystitis
Keywords: کاهش حساسیت; Dorsal root ganglia; Capsaicin; Nociception; Transient receptor potential vanilloid receptor 1; Protein kinase C; Phosphorylation; Desensitization; Interstitial cystitis; Diaryl piperazine;
Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic β-cells
Keywords: کاهش حساسیت; Pancreatic islets; MIN6 cells; Insulin secretion; Desensitization; Imidazolines; Efaroxan; BL11282;
Differential excitatory responses to oxytocin in sub-divisions of the bed nuclei of the stria terminalis
Keywords: کاهش حساسیت; Limbic; Desensitization; Septum; Oxytocin; Bed nuclei of the stria terminalis;
Okadaic acid increases the phosphorylation state of α1A-adrenoceptors and induces receptor desensitization
Keywords: کاهش حساسیت; α1-adrenoceptor; Receptor phosphorylation; Protein kinase C; Protein phosphatase; Desensitization; Phosphatidylinositol 3-kinase;
Subunit-dependent block by isoflurane of wild-type and mutant α1S270H GABAA receptor currents in Xenopus oocytes
Keywords: کاهش حساسیت; Anesthetic; GABA; Isoflurane; Desensitization; Inhibition; Open channel;
Norepinephrine reduces heat responses of cutaneous C-fiber nociceptors in Sprague-Dawley rats in vitro
Keywords: کاهش حساسیت; Sprague-Dawley rat; Norepinephrine; Bradykinin; Heat; Sensitization; Desensitization; In vitro; Cutaneous C-fiber nociceptor;
Urodynamic Effect of Intravesical Resiniferatoxin in Patients with Neurogenic Detrusor Overactivity of Spinal Origin: Results of a Double-Blind Randomized Placebo-Controlled Trial
Keywords: کاهش حساسیت; Resiniferatoxin; Neurogenic bladder; Neurogenic detrusor overactivity; Desensitization;
Rapid desensitization for hypersensitivity reactions to paclitaxel and docetaxel: a new standard protocol used in 77 successful treatments
Keywords: کاهش حساسیت; Paclitaxel and docetaxel hypersensitivity; Desensitization;
Glucosamine induces rapid desensitization of glucose transport in isolated adipocytes by increasing GlcN-6-P levels
Keywords: کاهش حساسیت; Glucosamine; GlcN-6-P; Hexosamine pathway; Desensitization; Adipocytes; Allosteric regulation; Hexokinase;
Effects of propofol on recombinant AMPA receptor channels
Keywords: کاهش حساسیت; Human AMPA-type receptor; Desensitization; Propofol; Patch-clamp; Fast solution exchange;
Prolonged exposure of canine coronary arteries to a nitric oxide donor desensitizes soluble guanylate cyclase
Keywords: کاهش حساسیت; coronary artery; guanylate cyclase; organic nitrate tolerance; desensitization; organ chambers; cyclic GMP;
Factors Associated With and Predictive of Persistence of Donor-Specific Antibody After Treatment With Plasmapheresis and Intravenous Immunoglobulin
Keywords: کاهش حساسیت; desensitization; plasmapheresis; IVIg; donor-specific antibody;
Molecular cloning and characterization of a new RGS protein of Medaka
Keywords: کاهش حساسیت; RGS; regulators of G protein signaling; G protein; heterotrimeric guanine nucleotide-binding proteins; RT-PCR; reverse transcriptase-PCR; MeRGS3L; Medaka RGS3-like protein; GIRK; G protein-gated inwardly rectifying K+ channel; G protein; Receptor; RGS; De
The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin1B receptor sensitivity and HPA axis activity
Keywords: کاهش حساسیت; ACTH; adrenocorticotropic hormone; dHC; dorsal hippocamus; HPA; hypothalamic-pituitary axis; 5-HT; serotonin; PFC; prefrontal cortex; SSRIs; selective serotonin reuptake inhibitors; Desensitization; HPA axis; Microdialysis; 5-HT 1B receptor; Serotonin;
The extracellular zinc-sensing receptor mediates intercellular communication by inducing ATP release
Keywords: کاهش حساسیت; Zinc-sensing receptor; Extracellular cation-sensing receptor; Desensitization; GPCR;
The function of the amino terminal domain in NMDA receptor modulation
Keywords: کاهش حساسیت; Glutamate; Receptors; NMDA; Glycine; Zinc; Spermine; Desensitization; Docking; Homology modelling; Inhibition;
Phosphorylation-dependent regulation of the guanylyl cyclase-linked natriuretic peptide receptors
Keywords: کاهش حساسیت; cGMP; Vasorelaxation; Heart failure; Desensitization; Phosphorylation;
Desensitization of nicotine acetylcholine receptors: Modulation by kinase activation and phosphatase inhibition
Keywords: کاهش حساسیت; Nicotine; Desensitization; Acetylcholine; Nicotinic receptor; Smoking; Phosphorylation;
Potentiation of β-adrenoceptor function in bovine tracheal smooth muscle by inhibition of protein kinase C
Keywords: کاهش حساسیت; GF 109203X; Airway smooth muscle; Protein kinase C; Desensitization; β-Adrenoceptor;
Î9-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture
Keywords: کاهش حساسیت; Cannabinoid; CB1; Desensitization; Hippocampus; Tetrahydrocannabinol; Win55,212-2;
Chronic caffeine or theophylline intake during pregnancy inhibits A1 receptor function in the rat brain
Keywords: کاهش حساسیت; adenosine A1 receptor; methylxanthines; gestation; Gi-proteins; desensitization; AC; adenylyl cyclase; ANOVA; analysis of variance; A1R; adenosine A1 receptors; CHA; N6-cyclohexyladenosine; GTPγS; guanosine-5â²-O(3-thiotriphosphate) tetralithium salt; S
Differential expression of genes coding for EGF-like factors and ADAMTS1 following gonadotropin stimulation in normal and transformed human granulosa cells
Keywords: کاهش حساسیت; Ovary; Metalloproteinase; Epiregulin; Amphiregulin; Desensitization; SV40 oncogene;
Acute and chronic administration of clorazepate modifies the cell surface regulation of μ opioid receptors induced by buprenorphine in specific regions of the rat brain
Keywords: کاهش حساسیت; Neurotransmitters, modulators, transporters, and receptors; Opioid receptors; Clorazepate; Buprenorphine; μ opioid receptor; Down-regulation; Desensitization; Rat brain; β-imager;
Role of specific protein kinase C isoforms in modulation of β1- and β2-adrenergic receptors
Keywords: کاهش حساسیت; Signalling; G protein-coupled receptors; Desensitization; Protein kinase; α1BAR; α1B-adrenergic receptor; CA; constitutively active; CYP; cyanopindolol; βAR; β-adrenergic receptor; βARK; β-adrenergic receptor kinase; GPCR; G protein-coupled receptor
Modulatory action of metabotropic glutamate receptor (mGluR) 5 on mGluR1 function in striatal cholinergic interneurons
Keywords: کاهش حساسیت; Metabotropic glutamate receptors; Striatum; Electrophysiology; Cholinergic interneurons; Desensitization; TANs;
Effects of chronic paroxetine pretreatment on (±)-8-hydroxy-2-(di-n-propyl-amino)tetralin induced c-fos expression following sexual behavior
Keywords: کاهش حساسیت; SSRI; ejaculation; 5-HT1A receptor; desensitization; oxytocin; locus coeruleus; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; PBS; phosphate-buffered saline; PBS-BT; phosphate-buffered saline containing 0.1% bovine serum albumin and 0.5% Triton X-100;
Pathophysiological roles of G-protein-coupled receptor kinases
Keywords: کاهش حساسیت; G-protein-coupled receptor (GPCR); G-protein-coupled receptor kinase (GRK); Signal transduction; desensitization; Transgenic mice; Human diseases;
Mechanisms of mu opioid receptor/G-protein desensitization in brain by chronic heroin administration
Keywords: کاهش حساسیت; Mu opioid; G-protein; Heroin; [35S]GTPγS; Desensitization;