کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3203827 | 1202026 | 2006 | 7 صفحه PDF | دانلود رایگان |
The human β2-adrenoceptor is a member of the 7-transmembrane family of receptors, encoded by a gene on chromosome 5, and widely distributed in the respiratory tract. Intracellular signaling after β2-adrenoceptor activation is largely affected through cyclic adenosine monophosphate and protein kinase A. Differences in the mechanism of interaction of short- and long-acting β2-agonists and the β2-receptor are reflected in the kinetics of airway smooth muscle relaxation and the onset and duration of bronchodilation in asthmatic patients. β-Adrenoceptor desensitization associated with prolonged β2-agonist activation differs depending on the cell type and is reflected in different profiles of clinical tolerance to chronic β2-agonist therapy. A number of genetic polymorphisms of the β2-receptor have been described that appear to alter the behavior of the receptor, including the response to β2-agonists. The synergy between the β2-receptor and the glucocorticoid receptor functions has implications for the combined use of β2-agonists and corticosteroids in the treatment of respiratory disease.
Journal: Journal of Allergy and Clinical Immunology - Volume 117, Issue 1, January 2006, Pages 18–24