Keywords: Mitochondria; Ubiquitin; Neurodegeneration; E3 ligase; Mitochondria-derived vesicles; PD; Parkinson's disease; MDV; mitochondria-derived vesicle; DA; dopaminergic; SN; substantia nigra; GWAS; genome-wide association study; OMM; outer mitochondrial membran
مقالات ISI (ترجمه نشده)
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Keywords: PTM; post-translational modification; RBR; RING-between-RING; DUB; deubiquitinase; USP; ubiquitin-specific protease; SCF; Skp1-Cullin-F-box; CaMKII; Ca2Â +/calmodulin-dependent kinase 2; Cbl; Casitas B-lineage lymphoma; TKB; tyrosine kinase binding; RTK;
Keywords: Deubiquitinase; Interferon; Vaccine; EAV; PRRSV; Arterivirus;
Keywords: Cancer therapeutics; Small molecule inhibitors; Proteasome; Deubiquitinase; DUB; α,βâUnsaturated ketones; Apoptosis;
Keywords: AJ; adherens junction; APC; adenomatous polyposis coli; ARD; armadillo repeat domain; ARVC; arrhythmogenic right ventricular cardiomyopathy; Bsk; Basket; CaM; calmodulin; Cav-1; caveolin-1; CCM; cerebral cavernous malformations; Ccm3; cerebral cavernous m
Novel highly selective inhibitors of ubiquitin specific protease 30 (USP30) accelerate mitophagy
Keywords: USP; ubiquitin specific peptidase; DUB; deubiquitinase; biotin-UbVME; biotin-ubiquitin-vinylmethyl ester; BrdU; bromodeoxyuridine; Mitophagy; Deubiquitinase inhibitor; Parkin; USP30;
USP10 regulates the stability of the EMT-transcription factor Slug/SNAI2
Keywords: EMT; Deubiquitinase; DUB; Cancer; Slug; USP10;
Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine
Keywords: APAP; acetyl-para-aminophenol, acetaminophen; AMAP; acetyl-meta-aminophenol; CHX; cycloheximide; FTY720; fingolimod; HU; hydroxyurea; MMS; methyl methanesulfonate; Ubiquitin; Deubiquitinase; Toxicity; Tyrosine; Amino acids; Starvation; APAP;
YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity
Keywords: α-Synuclein; Cytotoxicity; Deubiquitinase; Huntington disease; Lysine residue; Parkinson's disease; Ubiquitin; YOD1;
Usp9x Promotes Survival in Human Pancreatic Cancer and Its Inhibition Suppresses Pancreatic Ductal Adenocarcinoma In Vivo Tumor Growth
Keywords: PDA; pancreatic ductal adenocarcinomas; PanIN; pancreatic epithelial lesions; GFR; growth factor reduced; DOX; doxycycline; 3D; three-dimensional; Usp9x-OV; Usp9x overexpression; DUB; deubiquitinase;
Identification of small-molecule inhibitors of USP2a
Keywords: Deubiquitinase; Ubiquitin; Small-molecular inhibitors; Heterocyclics; Anticancer;
K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B
Keywords: Dengue virus; NS1; NS4B; Ubiquitination; K48-linked polyubiquitin; Deubiquitinase; Proteasome;
Catalytic domain mutation in CYLD inactivates its enzyme function by structural perturbation and induces cell migration and proliferation
Keywords: CYLD; Cancer-associated mutants; Ubiquitin binding; Deubiquitinase;
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
Keywords: Proteasome; Deubiquitinase; VCP/p97 ATPase; Bis-benzylidine piperidones; Mitochondria;
Polyglutamine expansion diseases: More than simple repeats
Keywords: Neurodegenerative disease; Polyglutamine protein; Aggregation modulation; Post-translational modification; Molecular partner; Ataxin-3; APR; aggregation-prone region; αB-c; AlphaB-crystallin; AR; androgen receptor; Atx1; ataxin-1; Atx3; ataxin-3; Atn1; a
Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster
Keywords: AAA ATPase; Ataxia; Ataxin-3; Deubiquitinase; Machado-Joseph Disease; Neurodegeneration; Polyglutamine; Spinocerebellar Ataxia Type 3; VCP/p97;
PPPDE1 is a novel deubiquitinase belonging to a cysteine isopeptidase family
Keywords: Cysteine isopeptidase; Deubiquitinase; DUBs; PPPDE1; RPS7; DUBs; Deubiquitinating enzymes; PPPDE; after Permuted Papain fold Peptidases of DsRNA viruses and Eukaryotes;
The functional interplay between the HIF pathway and the ubiquitin system - more than a one-way road
Keywords: Hypoxia; PHD; FIH; Deubiquitinase; E3 ligase; Inflammation;
Ovarian tumor domain-containing protein 1 deubiquitinates and stabilizes p53
Keywords: Mdm2; mouse double minute 2 homolog; RING; really interesting new gene; DUB; deubiquitinase; USP; ubiquitin-specific protease; OTU; ovarian tumor proteases; OTUD1; ovarian tumor domain-containing protein 1; UIM; ubiquitin interacting motif; PI; propidium
The bad seed gardener: Deubiquitinases in the cancer stem-cell signaling network and therapeutic resistance
Keywords: BMP; bone morphogenetic protein; CSC; cancer stem cell; DUB; deubiquitinase; EIF; EMT-inducing transcriptional factor; EMT; epithelial-mesenchymal transition; GSC; glioma stem cell; HIF; hypoxia inducible factor; IAP; inhibitors of apoptosis; ID; inhibito
The substrate binding domains of human SIAH E3 ubiquitin ligases are now crystal clear
Keywords: DUB; Deubiquitinase; ERAD; endoplasmic-reticulum associated degradation; ESI; electrospray ionization; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; ITC; isothermal titration calorimetry; ML; maximum-likelihood; RING; really-interesting new g
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP
Keywords: NF-κB; Apoptosis; Ubiquitin; Deubiquitinase; Caspase; CHX; cycloheximide; E3; ubiquitin ligase; FADD; Fas-associated death domain protein; IKK; IκB kinase; LUBAC; linear ubiquitin chain assembly complex; NEMO; NF-κB-essential modulator; NF-κB; nuclear
Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells
Keywords: Hinokitiol; Copper; Proteasome; Deubiquitinase; Paraptosis; Cancer;
Neurotoxic mechanisms by which the USP14 inhibitor IU1 depletes ubiquitinated proteins and Tau in rat cerebral cortical neurons: Relevance to Alzheimer's disease
Keywords: AD; Alzheimer disease; BCA; bicinchoninic acid; Clp; calpeptin, calpain inhibitor Z-Leu-Nle-CHO; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; ECL; enhanced chemiluminescence; HAR; hexaammineruthenium; HA-Ub-VME;
Ubiquitin-specific protease 14 regulates cardiac hypertrophy progression by increasing GSK-3β phosphorylation
Keywords: Cardiac hypertrophy; Deubiquitinase; USP14; GSK-3β;
Regulation of the TGF-β pathway by deubiquitinases in cancer
Keywords: AMSH; Associated molecule with SH3 domain proteases; AMSH-LP; Associated molecule with SH3 domain-like proteases; ATXN3; ataxin-3; ATXN3L; ataxin 3-like; BMPs; bone morphogenetic proteins; BRCC36; BRCA1/BRCA2-containing complex subunit 36; CHIP; carboxy t
CSN-associated USP48 confers stability to nuclear NF-κB/RelA by trimming K48-linked Ub-chains
Keywords: NF-κB; COP9 signalosome; RelA; Deubiquitinase; CK2; Nuclear protein turnover;
Associate editor: B. TeicherDeubiquitinase inhibition as a cancer therapeutic strategy
Keywords: Cancer therapeutics; Small molecule inhibitors; Proteasome; Deubiquitinase; α,β-unsaturated ketones; Apoptosis; 19S RP; 19S regulatory particle; 20S CP; 20S core particle; ASK1; apoptosis signaling kinase 1; BRCA1; breast cancer type 1 susceptibility pr
Toward therapeutic targets for SCA3: Insight into the role of Machado–Joseph disease protein ataxin-3 in misfolded proteins clearance
Keywords: Machado–Joseph disease; Ataxin-3; Polyglutamine; Deubiquitinase; Misfolded protein clearance17-AAG, 17-N-allylamino-17-demethoxygeldanamycin; 17-DMAG, 17-dimethylaminoethylamino-17-demethoxy-geldanamycin; 3-NP, 3-nitropropionic acid; AD, Alzheimer's disea
USP22 is a positive regulator of NFATc2 on promoting IL2 expression
Keywords: T cell; IL2; NFATc2; USP22; Stability; Deubiquitinase;
The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development
Keywords: Deubiquitinase; Ubiquitin homeostasis; Drosophila development; Proteasome;
Message in a bottle: lessons learned from antagonism of STING signalling during RNA virus infection
Keywords: BiFC; bimolecular fluorescence complementation; CARD; caspase activation and recruitment domain; cGAMP; cyclic GMP-AMP; cGAS; cyclic GMP-AMP synthase; DC; dendritic cell; DUB; deubiquitinase; hSTING; human STING; IFN; interferon; IRF-3; interferon regulat
Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features
Keywords: MERS-CoV; Papain-like protease; Oxyanion hole; Zinc finger; Deubiquitinase; Antiviral drug design;
IKK regulates the deubiquitinase CYLD at the postsynaptic density
Keywords: PSD; postsynaptic density; DUB; deubiquitinase; EM; electron microscopy; IKK; inhibitor of κB kinase; NF-κB; nuclear factor κB; CaMKII; Ca2+/calmodulin-dependent protein kinase II; p-CYLD; CYLD phosphorylated at S-418; Ubiquitin; CYLD; Deubiquitinase;
CYLD, a deubiquitinase specific for lysine63-linked polyubiquitins, accumulates at the postsynaptic density in an activity-dependent manner
Keywords: CaMKII; Ca2+/calmodulin-dependent protein kinase II; PSD; postsynaptic density; UPS; ubiquitin proteasome system; Ubiquitin; CYLD; Deubiquitinase; K63-linked; PSD; Postsynaptic density;
Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth
Keywords: Ubiquitin-proteasome pathway; Deubiquitinase; ROS; Curcusone D; Bortezomib; Multiple myeloma;
Ubiquitination signals critical to regulatory T cell development and function
Keywords: Regulatory T cell; FOXP3; Ubiquitination; E3 ligase; Deubiquitinase; Treg cell therapy
A small-molecule inhibitor of deubiquitinating enzyme USP14 inhibits Dengue virus replication
Keywords: Flaviviruses; Proteasome; Deubiquitinase; Antiviral drug; Protein degradation; Deubiquitinase inhibitor;
Monocyte chemotactic protein-1-induced protein-1 (MCPIP1) is a novel multifunctional modulator of inflammatory reactions
Keywords: mRNA stability and decay; RNase; Proinflammatory cytokines; NF-kappaB signaling cascade; Ubiquitin-binding domains; Deubiquitinase;
Proteasome deubiquitinases as novel targets for cancer therapy
Keywords: AAA+ ATPases; ATPases associated with diverse cellular activities; AML; acute myeloid leukemia; Bcl-2; B cell lymphoma 2; Bcl-XL; B cell lymphoma extra large; CP; 20S proteasome core particle; DUB; deubiquitinase; ER; endoplasmic reticulum; HSP; heat shoc
Protein cross-linking as a novel mechanism of action of a ubiquitin-activating enzyme inhibitor with anti-tumor activity
Keywords: Ubiquitin-activating enzyme; Deubiquitinase; Inhibitor; Cross-linking
MDC1 is ubiquitylated on its tandem BRCT domain and directly binds RAP80 in a UBC13-dependent manner
Keywords: BRCT; BRCA1 C-terminus; DDR; DNA damage response; DSB; DNA double-strand break; DUB; deubiquitinase; FHA; forkhead associated; GST; glutathione S-transferase; a.a.; amino acids; NCS; neocarzinostatin; IP; immunoprecipitate; IR; ionizing radiation; PTM; po
A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination
Keywords: DUB; deubiquitinase; NEM; N-ethylmaleimide; Jak/Stat inhibitor; Deubiquitination; Signal transduction; Aggresome;
The deubiquitinase emperor's thumb is a regulator of apoptosis in Drosophila
Keywords: Apoptosis; emperor's thumb; Drosophila; Deubiquitinase
Multi-tasking on chromatin with the SAGA coactivator complexes
Keywords: SAGA; Acetyltransferase; Deubiquitinase; Transcription; Histone