دانلود مقالات ISI درباره وضع + ترجمه فارسی

Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS

Keywords: وضع; BDDCS; flip-flop pharmacokinetics; half-life; oral drug absorption; transporters; absorption; pharmacokinetics; intestinal absorption; disposition

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Use of Minipig Skin Biopsy Model as an Innovative Tool to Design Topical Formulation to Achieve Desired Pharmacokinetics in Humans

Keywords: وضع; skin penetration; biopsy; minipig; topical; pharmacokinetics; human; absorption; disposition; skin; clinical pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Effect of Repeated Injections of Adenosine Diphosphate-Encapsulated Liposomes Coated with a Fibrinogen γ-Chain Dodecapeptide Developed as a Synthetic Platelet Substitute on Accelerated Blood Clearance in a Healthy and an Anticancer Drug-Induced Thrombocyt

Keywords: وضع; liposome; adenosine-diphosphate; dodecapeptide; accelerated blood clearance phenomenon; thrombocytopenia; platelet substitute; pegylation; disposition; clearance; pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

A Spreadsheet-Based Method for Simultaneously Estimating the Disposition of Multiple Ingredients Applied to Skin

Keywords: وضع; diffusion; thermodynamics; transdermal drug delivery; percutaneous; absorption; activity coefficient; mathematical model; excipients; disposition;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Drug Distribution to Human Tissues: Prediction and Examination of the Basic Assumption in In Vivo Pharmacokinetics-Pharmacodynamics (PK/PD) Research

Keywords: وضع; ADME; clinical pharmacokinetics; disposition; distribution; partition coefficients; pharmacokinetics; PKPD; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Subacute nicotine co-exposure has no effect on 2,2′,3,5′,6- pentachlorobiphenyl disposition but alters hepatic cytochrome P450 expression in the male rat

Keywords: وضع; Ct; fractional amplification (cycle number at which fluorescence exceeds a user-defined threshold); d; day; b.w.; body weight; DE; diatomaceous earth; EF; enantiomeric fraction; qPCR; quantitative (real-time) polymerase chain reaction; PCBs; polychlorinat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

A Paradigm Shift in Pharmacokinetic-Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design

Keywords: وضع; ADME; unbound fraction; pharmacokinetics; pharmacodynamics; disposition; distribution; partition coefficients; PBPK; PKPD;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Utilizing Physiologically Based Pharmacokinetic Modeling to Inform Formulation and Clinical Development for a Compound with pH-Dependent Solubility

Keywords: وضع; absorption; disposition; pharmacokinetics; ADME; physiological model;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor

Keywords: وضع; ADME; antiinfectives; in vitro/in vivo correlations (IVIVC); disposition; hepatic clearance; clearance; metabolism; P-glycoprotein; pharmacokinetics; bioavailability

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs

Keywords: وضع; ADME; chemotherapy; oncology; disposition; distribution; partition coefficients; pharmacokinetics; PBPK modeling; tumor; xenograft;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Organic Cation Transporter/Solute Carrier Family 22a is Involved in Drug Transfer into Milk in Mice

Keywords: وضع; drug transfer into milk; lactation; organic cation transporter/solute carrier 22a; pediatric; mammary transport/secretion; disposition;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacokinetic Interactions Between the Orexin Receptor Antagonist Almorexant and the CYP3A4 Inhibitors Ketoconazole and Diltiazem

Keywords: وضع; drug interaction; pharmacokinetics; cytochrome P450 3A4; almorexant; ketoconazole; diltiazem; orexin receptor antagonist; healthy subjects; metabolism; disposition;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Disposition and kinetics of tetrabromobisphenol A in female Wistar Han rats

Keywords: وضع; Tetrabromobisphenol A (PubChem CID: 6618)Disposition; Tetrabromobisphenol A; TBBPA; Brominated flame retardant; Persistent organic pollutants; Toxicokinetics; Disposition; Female rat

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

The metrics of MWCNT-induced pulmonary inflammation are dependent on the selected testing regimen

Keywords: وضع; Nanoparticles; Multi-walled carbon nanotubes; Repeated inhalation exposure; Disposition; Aggregates; Volume displacement lung overload;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Intramuscular Administration of Paliperidone Palmitate Extended-Release Injectable Microsuspension Induces a Subclinical Inflammatory Reaction Modulating the Pharmacokinetics in Rats

Keywords: وضع; prodrugs; nanoparticles; muscle; disposition; biocompatibility; pharmacokinetics; paliperidone palmitate; sustained release; histopathology; inflammation; API; active pharmaceutical ingredient; AUC; area under the (plasma concentration vs. time) curve; CL

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacokinetic Study of Adenosine Diphosphate-Encapsulated Liposomes Coated with Fibrinogen γ-Chain Dodecapeptide as a Synthetic Platelet Substitute in an Anticancer Drug-Induced Thrombocytopenia Rat Model

Keywords: وضع; liposome; adenosine-diphosphate; dodecapeptide; disposition; thrombocytopenia; platelet substitute; biocompatibility; disease state; cancer chemothrapy;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Domoic acid toxicokinetics in Dungeness crabs: New insights into mechanisms that regulate bioaccumulation

Keywords: وضع; Transporters; Disposition; Extracellular; Hepatopancreas;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

The comparison of disposal attitudes towards forensic psychiatric patients among police officers, psychiatrists and community members in China

Keywords: وضع; Forensic psychiatric patient; Attitude; Disposition; Community members; Police officers; Psychiatrists; Questionnaire

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics of florfenicol after intravenous and intramuscular dosing in llamas

Keywords: وضع; Llama; Florfenicol; Disposition; Pharmacokinetic analysis; Bioavailability

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry

Keywords: وضع; Osthole; Metabolism; Disposition; UPLC; QTOF/MS

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Studies on pharmacokinetic mechanism of phenytoin resistance in refractory epilepsy

Keywords: وضع; genetic polymorphisms; P-glycoprotein; pharamcokinetics; bioavailability; haplotype; drug transport; efflux pumps; high-performance/pressure liquid chromatography (HPLC); disposition; absorption

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The Inhibitory Effects of the Bioactive Components Isolated from Scutellaria Baicalensis on the Cellular Uptake Mediated by the Essential Solute Carrier Transporters

Keywords: وضع; Scutellaria baicalensis; solute carrier transporters; baicalein; baicalin; wogonin; disposition; drug interactions; organic anion transporters; organic anion-transporting polypeptide transporters; organic cation transporters;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Evaluation of the pharmacokinetics and cardiotoxicity of doxorubicin in rat receiving nilotinib

Keywords: وضع; Doxorubicin; Nilotinib; P-Glycoprotein; Cardiotoxicity; Pharmacokinetic; Disposition

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Disposition Kinetics of Diclofenac in the Dual Perfused Rat Liver

Keywords: وضع; albumin; biopharmaceutics classification system (BCS); disposition; hepatic clearance; pharmacokinetics; protein binding; diclofenac; dual liver perfusion; hepatic artery; portal vein

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

In vitro inhibition of metabolism but not transport of gliclazide and repaglinide by Cree medicinal plant extracts

Keywords: وضع; Traditional medicine; Disposition; Drug interaction; Caco-2; Cytochrome P450

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Estrogen Receptor α Induction by Mitoxantrone Increases Abcg2 Expression in Placental Trophoblast Cells

Keywords: وضع; membrane transporter; ABC transporter; placenta; disposition; cell culture

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Disposition of ON 01210.Na (Ex-RAD(R)), a Novel Radioprotectant, in the Isolated Perfused Rat Liver: Probing Metabolic Inhibition to Increase Systemic Exposure

Keywords: وضع; metabolic clearance; disposition; drug interactions; hepatic metabolism; glutathione-S-transferases; preclinical pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Biodistribution and Excretion of Radiolabeled 40 kDa Polyethylene Glycol Following Intravenous Administration in Mice

Keywords: وضع; preclinical pharmacokinetics; distribution; disposition; excretion; pegylation;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Investigation of the effect of active efflux at the blood–brain barrier on the distribution of nonsteroidal aromatase inhibitors in the central nervous system

Keywords: وضع; blood–brain barrier; CNS; disposition; efflux pumps; P-glycoprotein; endothelial; transporters

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Time-Dependent Interaction of Ritonavir in Chronic Use: The Power Balance Between Inhibition and Induction of P-Glycoprotein and Cytochrome P450 3A

Keywords: وضع; ADME; bioavailability; cytochrome P450; disposition; drug interaction; intestinal absorption; P-glycoprotein; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

The Impact of Lymphatic Transport on the Systemic Disposition of Lipophilic Drugs

Keywords: وضع; absorption; clearance; disposition; distribution; lipids; lipoproteins; lymphatic transport; oral absorption; pharmacokinetics; intravenous;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Correlation of Tissue-Plasma Partition Coefficients Between Normal Tissues and Subcutaneous Xenografts of Human Tumor Cell Lines in Mouse as a Prediction Tool of Drug Penetration in Tumors

Keywords: وضع; ADME; chemotherapy; oncology; disposition; distribution; partition coefficients; pharmacokinetics; PBPK modeling; xenograft;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics and disposition study of calf thymus DNA in rats by applying 3H-labeling method

Keywords: وضع; Calf thymus DNA; Radioisotope labeling; Tritium; Pharmacokinetics; Disposition

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

The impaired disposition of probe drugs is due to both liver and kidney dysfunctions in CCl4-model rats

Keywords: وضع; Carbon tetrachloride; Disposition; Probe drugs; Model rats; Sprague-Dawley rats;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Regulatory Review of Acetaminophen Clinical Pharmacology in Young Pediatric Patients

Keywords: وضع; ADME; clinical pharmacokinetics; disposition; metabolism; pediatric; pharamcokinetics; pharmacodynamics; pharmacokinetics/pharmacodynamics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Viral Meningitis: Which Patients Can Be Discharged from the Emergency Department?

Keywords: وضع; viral meningitis; bacterial meningitis; prediction model; disposition; admission

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Case studies combined with or without concept maps improve critical thinking in hospital-based nurses: A randomized-controlled trial

Keywords: وضع; Critical thinking; Skill; Disposition; Concept map; Case study; Randomized-controlled trial

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Absorption and disposition of bromate in F344 rats

Keywords: وضع; Bromate; Absorption; Disposition; Reaction products; Rat

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Probing a Potential In Vivo Drug–Excipient Interaction: Temporal Effects of a Modified β-Cyclodextrin on the Intravenous Pharmacokinetics of a Model High-Affinity Drug Ligand

Keywords: وضع; cyclodextrins; ozonide; clearance; distribution; disposition; interactions; excipient; renal excretion; pharmacokinetics; LC–MS

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Ocular Pharmacokinetics of a Novel Tetrahydroquinoline Analog in Rabbit: Compartmental Analysis and PK-PD Evaluation

Keywords: وضع; pharmacokinetics; ocular PK; topical infusion; elimination; compartmental modeling; pharmacokinetic/pharmacodynamic models; Link model; effect compartment model; pharmacodynamics; disposition;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Therapeutic Drug Monitoring in Interstitial Fluid: A Feasibility Study Using a Comprehensive Panel of Drugs

Keywords: وضع; therapeutic drug monitoring; pharmacokinetics; disposition; distribution; clinical pharmacokinetics; interstitial fluid; rabbit model; ultrafiltration probe; vancomycin; methotrexate;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method

Keywords: وضع; animal alternative; ADME; disposition; distribution; volume of distribution; pharmacokinetics; protein binding; unbound fraction; PBPK; first-time-in-human;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmaceutical Aspects of the Recombinant Human Serum Albumin Dimer: Structural Characteristics, Biological Properties, and Medical Applications

Keywords: وضع; albumin; biomaterials; disposition; drug delivery systems; nanotechnology; physicochemical properties; polymeric biomaterials

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Clearance: Modeling Hepatic Metabolic Clearance of Highly Bound Drugs and Comparative Assessment with Existing Calculation Methods

Keywords: وضع; disposition; microsomes; hepatic clearance; metabolic clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Pharmacokinetics of Vandetanib: Three Phase I Studies in Healthy Subjects

Keywords: وضع; disposition; metabolism; pharmacokinetics; vandetanib

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

Comparative Assessment of In Vitro-In Vivo Extrapolation Methods used for Predicting Hepatic Metabolic Clearance of Drugs

Keywords: وضع; disposition; microsomes; clearance; unbound fraction; computational ADME; in vitro-in vivo extrapolation; in vitro-in vivo correlation; IVIVE; pharmacokinetics; PBPK modeling;

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Poloxamer 407 Increases the Recovery of Paracetamol in the Isolated Perfused Rat Liver

Keywords: وضع; disposition; elimination; endothelial; protein binding; surfactants; pharmacokinetics/pharmacodynamics; hepatocytes; hepatic metabolism; hepatic clearance; disposition

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Ocular Pharmacokinetics of a Novel Tetrahydroquinoline Analog in Rabbit: Absorption, Disposition, and Non-compartmental Analysis

Keywords: وضع; ocular PK; pharmacokinetics; disposition; corneal and conjunctival-scleral routes; absorption; topical infusion; distribution; elimination; non-compartmental analysis; rabbits;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Seasonal and spatial distribution patterns of atmospheric phosphorus deposition to Lake Simcoe, ON

Keywords: وضع; Lake Simcoe; Phosphorus; Atmospheric; Disposition; Radar;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Interrelating the acute and chronic mode of action of inhaled methylenediphenyl diisocyanate (MDI) in rats assisted by computational toxicology

Keywords: وضع; Diisocyanates; Aerosol; Irritation; Oxidative stress; Repeated inhalation exposure; Disposition; Particle clearance; Pulmonary toxicity; Lung overload;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه