From DNA damage to chromosome aberrations: Joining the break
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Chromosome aberrations; Resection;
مقالات ISI DNA دو رشته شکسته (ترجمه نشده)
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Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; MRN/MRX; ATM/Tel1; ATR/Mec1; Checkpoint; Resection
Adaptation of the neutral bacterial comet assay to assess antimicrobial-mediated DNA double-strand breaks in Escherichia coli
Keywords: DNA دو رشته شکسته; E. coli; Neutral comet assay; Single cell gel electrophoresis; DNA double-strand breaks; Antibacterial mineral leachate; Antibiotic;
Repair rates of DNA double-strand breaks under different doses of proton and γ-ray irradiation
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Ionizing radiation; γ-Ray; Proton
Assessing LINE-1 retrotransposition activity in neuroblastoma cells exposed to extremely low-frequency pulsed magnetic fields
Keywords: DNA دو رشته شکسته; ELF-MF; extremely low-frequency magnetic fields; PMF; pulsed magnetic field; DNA-DSB; DNA double-strand breaks; LINE-1 or L1; Long Interspersed Elements type 1; EGFP; enhanced green fluorescent protein; GAPDH; d-glyceraldehyde-3-phosphate dehydrogenase; T
X-ray induced DNA double-strand breaks in coronary CT angiography: Comparison of sequential, low-pitch helical and high-pitch helical data acquisition
Keywords: DNA دو رشته شکسته; Cardiac-CT; DNA double-strand breaks; Biological X-ray effects; High-pitch spiral data acquisition
No Evidence for DNA Double-strand Breaks Caused by Endodontic Sealers
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; endodontic sealers; epoxy resin; gamma H2AX assay; methacrylate-based; resin-based; root canal sealer
Vaginal cells of smokers are more resistant to human papillomavirus infection than that of non-smokers
Keywords: DNA دو رشته شکسته; Cigarette smoking; Comet assay; DNA double-strand breaks; HPV infection; Vaginal abnormalities
Dynamics of γH2AX formation and elimination in mammalian cells after X-irradiation
Keywords: DNA دو رشته شکسته; Ionizing radiation; Histone H2AX phosphorylation; DNA double-strand breaks; Bystander effect; Non-proliferating mammalian tissues; γH2AX; histone H2AX with phosphorylated C-terminal serine; DSB; double-strand DNA break; IR; X-irradiation;
The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells
Keywords: DNA دو رشته شکسته; AP-1; activator protein 1; FRA1; Fos-related antigen 1; DSB; DNA double-strand breaks; SSB; DNA single-strand breaks; ACNU; nimustine, (1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride; FRA1; ACNU; Glioma; Sensitivit
Accumulation of DNA damage in complex normal tissues after protracted low-dose radiation
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Low-dose radiation; Tissue-specific stem cells; 53BP1 foci; Non-homologous end-joining;
Homologous recombination and non-homologous end-joining repair pathways in bovine embryos with different developmental competence
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; DNA repair; Embryo development; Bovine
PCNA-dependent accumulation of CDKN1A into nuclear foci after ionizing irradiation
Keywords: DNA دو رشته شکسته; LET; linear energy transfer; DSBs; DNA double-strand breaks; SSBs; DNA single-strand breaks; CPD; cumulative population doublings; NHDF; neonatal human dermal fibroblasts; TLC; thin-layer cellulose; ICQ; Intensity Correlation Quotient; ICA; Image Correlat
Mre11–Rad50 complex crystals suggest molecular calisthenics
Keywords: DNA دو رشته شکسته; Genome maintenance; DNA double-strand breaks; DNA repair
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
Keywords: DNA دو رشته شکسته; Review; Homologous recombination; Stalled replication fork; DNA double-strand breaks; Poly(ADP-ribose) polymerase; BRCA1; BRCA2; Synthetic lethality; Cancer
Inhibition of REV3 Expression Induces Persistent DNA Damage and Growth Arrest in Cancer Cells
Keywords: DNA دو رشته شکسته; TLS; DNA translesion synthesis; Pol ζ; DNA translesion synthesis polymerase ζ; REV3; the mammalian REV3L gene; MEF; mouse embryonic fibroblast; DDR; DNA damage response; DSBs; DNA double-strand breaks; ATM; ataxia-telangiectasia mutated; γH2AX; phospho
Mechanism of elimination of phosphorylated histone H2AX from chromatin after repair of DNA double-strand breaks
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Histone phosphorylation; DNA repair; Histone dephosphorylation
Suberoylanilide Hydroxyamic Acid Modification of Chromatin Architecture Affects DNA Break Formation and Repair
Keywords: DNA دو رشته شکسته; SAHA; Sublethal damage repair; DNA double-strand breaks; DNA rearrangements; Radiosensitizer;
Accumulation of DNA Double-Strand Breaks in Normal Tissues After Fractionated Irradiation
Keywords: DNA دو رشته شکسته; DNA repair; DNA double-strand breaks; Normal tissues; Fractionated irradiation;
Assembly and function of DNA double-strand break repair foci in mammalian cells
Keywords: DNA دو رشته شکسته; DNA damage response; DNA double-strand breaks; Ionizing Radiation-Induced Foci; Ubiquitin; Phosphorylation; DNA repair
DNA Repair Alterations in Children With Pediatric Malignancies: Novel Opportunities to Identify Patients at Risk for High-Grade Toxicities
Keywords: DNA دو رشته شکسته; DNA repair; DNA double-strand breaks; Normal tissue toxicity; Predictive assay; Childhood cancer;
Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; DNA repair; Alkylating agents; S-phase; Damage response; Sensitivity; Homologous recombination;
Intracellular chromosome breaks on silicon surface
Keywords: DNA دو رشته شکسته; Silicon; Reactive oxygen/nitrogen species; Micronuclei; DNA double-strand breaks; Biocompatibility
Up-regulation of ROS by mitochondria-dependent bystander signaling contributes to genotoxicity of bystander effects
Keywords: DNA دو رشته شکسته; RIBE; radiation-induced bystander effect; RIGI; radiation-induced genomic instability; ICCM; irradiated cells conditioned medium; ICCM10Â min; ICCM harvested at 10Â min time point post-irradiation; DSBs; DNA double-strand breaks; ROS; reactive oxygen spec
Analysis of chromatin remodeling during formation of a DNA double-strand break at the yeast mating type locus
Keywords: DNA دو رشته شکسته; Yeast; DNA double-strand breaks; Chromatin remodeling
Histone H2AX participates the DNA damage-induced ATM activation through interaction with NBS1
Keywords: DNA دو رشته شکسته; Histone H2AX; ATM; NBS1; DNA double-strand breaks; Cell cycle checkpoint;
Regulatory ubiquitylation in response to DNA double-strand breaks
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Ubiquitin; RNF8; RNF168; BRCA1; UBC13; RIDDLE syndrome; DNA repair; Checkpoint
Induction of DNA Double-Strand Breaks and Cellular Migration Through Bystander Effects in Cells Irradiated With the Slit-Type Microplanar Beam of the Spring-8 Synchrotron
Keywords: DNA دو رشته شکسته; Bystander effect; Slit microbeam; Radiotherapy; DNA double-strand breaks; Cellular migration;
Fluoroquinolones lower constitutive H2AX and ATM phosphorylation in TK6 lymphoblastoid cells via modulation of the intracellular redox status
Keywords: DNA دو رشته شکسته; fluoroquinolones; DNA double-strand breaks; constitutive histone H2AX phosphorylation; constitutive activation of ATM; ROS scavenging; cell cycle
In utero and acute exposure to benzene: Investigation of DNA double-strand breaks and DNA recombination in mice
Keywords: DNA دو رشته شکسته; DSB, double-strand break; GD, gestational day; i.p., intraperitoneal; V(D)J, variable diversity joining; X-gal, 5-bromo-4-chloro-3-indolyl-β-d-galactosideChildhood leukemia; Benzene; DNA double-strand breaks; Micronuclei; Genotoxicity tests
Dynamic localization of human RAD18 during the cell cycle and a functional connection with DNA double-strand break repair
Keywords: DNA دو رشته شکسته; Cell cycle; DNA double-strand breaks; PCNA; RAD18;
Brca2/Xrcc2 dependent HR, but not NHEJ, is required for protection against O6-methylguanine triggered apoptosis, DSBs and chromosomal aberrations by a process leading to SCEs
Keywords: DNA دو رشته شکسته; Apoptosis; DNA double-strand breaks; Aberrations; SCEs; Brca2; XRCC2; NHEJ; MGMT; Homologous recombination; Temozolomide
Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: Separation of checkpoint and repair functions in 53BP1
Keywords: DNA دو رشته شکسته; Ionizing radiation; Checkpoint; DNA damage repair; DNA double-strand breaks; X-ray sensitivity; Colon cancer; SW48
Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Topoisomerase II; Etoposide; Mitoxantrone; Neutral comet assay; γH2AX; Genotoxicity thresholds
Cell sorting analysis of cell cycle-dependent X-ray sensitivity in end joining-deficient human cells
Keywords: DNA دو رشته شکسته; Flow cytometry; Cell sorter; Cell cycle; DNA double-strand breaks; Nonhomologous end joining; X-ray sensitivity; DT40; Nalm-6
DNA Double-Strand Break Rejoining in Complex Normal Tissues
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; DSB rejoining; DNA repair; γH2AX; Normal tissue; Radiosensitivity;
Accumulation of Ku80 proteins at DNA double-strand breaks in living cells
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; γ-H2AX; Irradiation; Ku70; Ku80
Toxicity and mutagenicity of selenium compounds in Saccharomyces cerevisiae
Keywords: DNA دو رشته شکسته; Saccharomoces cerevisiae; Selenium compounds; Sodium selenite; Toxicity; Mutagenicity; DNA double-strand breaks
Two distinctly altered cellular responses to DNA double-strand breaks in human neuroblastoma
Keywords: DNA دو رشته شکسته; Neuroblastoma; DNA double-strand breaks; Chk2; p21; VimentinNB, neuroblastoma; MNA, MYCN amplification; DSB, double-strand break; ATM, ataxia telangiectasia mutated; NSE, neuron-specific enolase; NCS, neocarzinostatin; IR, ionizing radiation
NK314, a novel topoisomerase II inhibitor, induces rapid DNA double-strand breaks and exhibits superior antitumor effects against tumors resistant to other topoisomerase II inhibitors
Keywords: DNA دو رشته شکسته; NK314; DNA double-strand breaks; Topoisomerase II; Etoposide
Induction and repair rate of DNA damage: A unified model for describing effects of external and internal irradiation and contamination with heavy metals
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; DNA repair; Biostatistical models; Ionizing radiation; Heavy metals;
Radiosensitization effect of zidovudine on human malignant glioma cells
Keywords: DNA دو رشته شکسته; AZT; Zidovudine, 3â²-azido-3â²-deoxythymidine; TA; telomerase activity; SSBs; DNA single-strand breaks; DSBs; DNA double-strand breaks; SER; sensitization enhancement ratio; TM; tail moment; TRF; mean terminal restriction fragments length; Telomere; Tel
Chemosensitivity of primary human fibroblasts with defective unhooking of DNA interstrand cross-links
Keywords: DNA دو رشته شکسته; Human XP-F fibroblasts; HN2 sensitivity; DNA repair; Interstrand cross-links; DNA double-strand breaks
Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs
Keywords: DNA دو رشته شکسته; Nonhomologous end joining; Rag-1; DNA double-strand breaks; V(D)J recombination; Opportunistic infection
Protein trafficking in response to DNA damage
Keywords: DNA دو رشته شکسته; ARF; alternative reading frame; ATM; ataxia telangiectasia mutated kinase; ATR; ataxia telangiectasia RAD3-related kinase; DSB; DNA double-strand breaks; Mdm2; murine double minute; MMC; mitomycin C; MDC1; Mediator of DNA damage checkpoint protein 1; PARP
Involvement of Ku80 in microhomology-mediated end joining for DNA double-strand breaks in vivo
Keywords: DNA دو رشته شکسته; Non-homologous end joining; Microhomology-mediated end joining; DNA double-strand breaks; Ku
Homologous recombination and prostate cancer: A model for novel DNA repair targets and therapies
Keywords: DNA دو رشته شکسته; Hypoxia; Prostate cancer; DNA repair; DNA double-strand breaks; End-joining; Homologous recombination; Cell cycle; Biomarkers; RAD51; ATM; ATR; Carcinogenesis; Chemotherapy; Radiotherapy; Androgen deprivation
Analysis of DNA double-strand break repair pathways in mice
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Ionizing radiation; Homologous recombination; Nonhomologous end-joining; Embryonic stem cells; Mouse embryonic fibroblasts; Cell survival
Radiation-induced DNA double-strand breaks in dependence on protein concentration and under aerobic and anaerobic conditions
Keywords: DNA دو رشته شکسته; Radiolysis of DNA; DNA double-strand breaks; Radiation protection by proteins; Oxygen enhancement; Protein peroxyl radicals;
γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
Keywords: DNA دو رشته شکسته; DNA double-strand breaks; Chromatin; Histone H2AX; MDC1; DNA damage checkpoint; DNA repair; Foci; Genome stability