The chloroethylating anticancer drug ACNU induces FRA1 that is involved in drug resistance of glioma cells

► Fra1 is activated by the anticancer drug nimustine. ► Downmodulation of FRA1 sensitizes glioma cells to nimustine. ► Downmodulation of FRA1 does not alter the regulation of the AP-1 targets ercc1, fasL, and xpf and does not impact DNA repair. ► Downmodulation of FRA1 impacts the G2/M cell cycle checkpoint.