دانلود مقالات ISI درباره مطالعه داکینگ + ترجمه فارسی

Molecular hybridization conceded exceptionally potent quinolinyl-oxadiazole hybrids through phenyl linked thiosemicarbazide antileishmanial scaffolds: In silico validation and SAR studies

Keywords: مطالعه داکینگ; Quinolinyl-oxadiazole; Antileishmanial; Docking study; Molecular hybridization;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of novel dual-specificity phosphatase 26 inhibitors by a hybrid virtual screening approach based on pharmacophore and molecular docking

Keywords: مطالعه داکینگ; DUSP26; Inhibitor; Homology modeling; Pharmacophore model; Docking study;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Isolation of isoflavones from Iris kashmiriana Baker as potential anti proliferative agents targeting NF-kappaB

Keywords: مطالعه داکینگ; Iris kashmiriana Baker; Iridaceae; Anticancer; Antioxidants; Cell cycle analysis; Docking study; G2/M phase; Isoflavonoid; NF-kappa B;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and characterization of novel imidazoquinoline based 2-azetidinones as potent antimicrobial and anticancer agents

Keywords: مطالعه داکینگ; Imidazoquinoline; Hydrazone; Azetidinone; Antimicrobial activity; Anticancer activity; β-Tubulin; Docking study;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and anticancer activity of new thiazolo[3,2-a]pyrimidines: DNA binding and molecular modeling study

Keywords: مطالعه داکینگ; Synthesis; Thiazolopyrimidines; Anticancer activity; DNA minor groove; Docking study;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Novel tacrine-1,2,3-triazole hybrids: In vitro, in vivo biological evaluation and docking study of cholinesterase inhibitors

Keywords: مطالعه داکینگ; Alzheimer's disease; Cholinesterase; Docking study; Dual binding; Morris water maze; Tacrine-1,2,3-triazole;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

2-Substituted-thio-N-(4-substituted-thiazol/1H-imidazol-2-yl)acetamides as BACE1 inhibitors: Synthesis, biological evaluation and docking studies

Keywords: مطالعه داکینگ; Alzheimer's disease; BACE-1 inhibitors; Docking study; BBB; Permeability; Surface Plasmon Resonance (SPR); PAMPA;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel pyrrolo-pyridine/pyrimidine derivatives bearing pyridazinone moiety as c-Met kinase inhibitors

Keywords: مطالعه داکینگ; Pyrrolo[2,3-b]pyridines; Pyrrolo[2,3-d]pyrimidines; Pyridazinone; c-Met; Antitumor activity; Docking study;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Novel 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors

Keywords: مطالعه داکینگ; Anticancer agents; 2-Aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridine; Antiproliferative activity; Docking study; Dual topoisomerase I and II inhibitors;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, anticancer, and docking studies of salicyl-hydrazone analogues: A novel series of small potent tropomyosin receptor kinase A inhibitors

Keywords: مطالعه داکینگ; Salicyl-hydrazones; Cytotoxicity; TrkA inhibitor; Docking study; Conformational analysis;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Substitution of PPh3+ as a lipophilic cation on new water-soluble Co(II) and Zn(II) Schiff base complexes: Effect of central metal and substitutional group of ligand on DNA-complex interaction

Keywords: مطالعه داکینگ; Water soluble; Schiff base complex; DNA; DFT; Docking study; Anticancer activity;

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

A detailed study on the interaction of a novel water-soluble glycine bridged zinc(II) Schiff base coordination polymer with BSA: Synthesis, crystal structure, molecular docking and cytotoxicity effect against A549, Jurkat and Raji cell lines

Keywords: مطالعه داکینگ; Water-soluble; Coordination polymer; BSA; Docking study; Anticancer activity;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Stabilization of the cyclodecadiene derivative isofuranodiene by silver (I) coordination. Mechanistic and biological aspects

Keywords: مطالعه داکینگ; Smyrnium olusatrum; Isofuranodiene; Silver adduct; DihydroFolateReductase; Docking study; Cytotoxicity;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of 3-substituted-6-(1-(1H-[1,2,3]triazolo[4,5-b]pyrazin-1-yl)ethyl)quinoline derivatives as highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitors via metabolite profiling-based structural optimization

Keywords: مطالعه داکینگ; c-Met; 3-Substituted quinolines; Triazolopyrazine; Metabolism; SAR; Docking study;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2017 سفارش ترجمه

New peptide deformylase inhibitors design, synthesis and pharmacokinetic assessment

Keywords: مطالعه داکینگ; PDF inhibitor; Antibacterial drug; Antibiotics resistance; MRSA; Docking study; Amide bioisosteres

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Pterin-7-carboxamides as a new class of aldose reductase inhibitors

Keywords: مطالعه داکینگ; Aldose reductase inhibitors; Pterin-7-carboxamide; Docking study; Quantitative structure-activity relationship; CGDYFAVFPXPHPZ-UHFFFAOYSA-M;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Novel tetrazoloquinoline–rhodanine conjugates: Highly efficient synthesis and biological evaluation

Keywords: مطالعه داکینگ; Antitubercular; Antifungal; Cytotoxicity; Docking study; Rhodanine derivatives

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, antitumor evaluation and molecular docking studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives

Keywords: مطالعه داکینگ; VQMBYCGKKNTCPS-UHFFFAOYSA-NTriazole; Tetrazine; X-ray diffraction; Antitumor activity; Docking study; Toxicity

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, antifungal activity and docking study of 2-amino-4H-benzochromene-3-carbonitrile derivatives

Keywords: مطالعه داکینگ; 2-Amino-4H-benzochromenes; Nano-TiCl4.SiO2; Docking study; Synthesis; Antifungal; Antibacterial

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Identification of novel VP35 inhibitors: Virtual screening driven new scaffolds

Keywords: مطالعه داکینگ; Ebola virus; Viral Protein 35; Pharmacophore; 3D QSAR; Docking study;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery and optimization of a series of imidazo[4,5-b]pyrazine derivatives as highly potent and exquisitely selective inhibitors of the mesenchymal–epithelial transition factor (c-Met) protein kinase

Keywords: مطالعه داکینگ; c-Met inhibitors; Imidazo[4,5-b]pyrazines; Docking study; Structure–activity relationship

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Anti-proliferative and computational studies of two new pregnane glycosides from Desmidorchis flava

Keywords: مطالعه داکینگ; Natural product; Desmidorchis flava; Pregnane glycoside; Anti-proliferative activity; Docking study

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibitory activity evaluation and mechanistic studies of tetracyclic oxindole derivatives as α-glucosidase inhibitors

Keywords: مطالعه داکینگ; Tetracyclic oxindole; α-Glucosidase inhibitors; Docking study; Kinetic analysis; Fluorescence spectra; RWBYYGQMJIRJRQ-UHFFFAOYSA-N; POWPDPUPJZTFIQ-UHFFFAOYSA-N; VTEIUYJSDHMOGY-UHFFFAOYSA-N; AAIDELZHTBZXGA-UHFFFAOYSA-N; DOTNCHNLYLAJHS-UHFFFAOYSA-N; ZJFWAM

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies

Keywords: مطالعه داکینگ; Synthesis; 4(3H)-Quinazolinone; Anti-inflammatory activity; COX-1/COX-2 inhibition assay; Docking study;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular docking studies, biological and toxicity evaluation of dihydroisoquinoline derivatives as potential anticancer agents

Keywords: مطالعه داکینگ; Leucine aminopeptidase; Antiproliferative activity; Docking study; Toxicity;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, cytotoxic activity, and tubulin polymerization inhibitory activity of new pyrrol-2(3H)-ones and pyridazin-3(2H)-ones

Keywords: مطالعه داکینگ; Pyrrolone; Pyridazinone; Cytotoxicity; Tubulin; Immunofluorescence; Docking study;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones

Keywords: مطالعه داکینگ; Synthesis; 2-Mercapto-4(3H)-quinazolinone; Anti-inflammatory activities; Cyclooxygenase-1/cyclooxygenase-2 inhibition assay; Docking study;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

Molecular mechanism of tanshinone IIA and cryptotanshinone in platelet anti-aggregating effects: an integrated study of pharmacology and computational analysis

Keywords: مطالعه داکینگ; Salvia miltiorrhiza Bunge; Tanshinones; Docking study; Platelet aggregation; P2Y receptors

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and docking study of novel tetracyclic oxindole derivatives as α-glucosidase inhibitors

Keywords: مطالعه داکینگ; Tetracyclic isatins; α-Glucosidase inhibitors; Docking study; Phenanthridine derivatives; SAR study

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

CAN catalyzed one-pot synthesis and docking study of some novel substituted imidazole coupled 1,2,4-triazole-5-carboxylic acids as antifungal agents

Keywords: مطالعه داکینگ; 1, 2, 4-Triazole; Imidazole; Ceric ammonium nitrate; Antifungal activity; Antibacterial activity; Docking study

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis, α-glucosidase inhibitory and molecular docking studies of prenylated and geranylated flavones, isoflavones and chalcones

Keywords: مطالعه داکینگ; α-Glucosidase inhibitors; Prenyl; Geranyl; Flavonoid; Docking study;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Design and synthesis of carborane-containing estrogen receptor-beta (ERβ)-selective ligands

Keywords: مطالعه داکینگ; Carborane; Estrogen receptor; Subtype selectivity; Docking study;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: Efficient synthesis, biological assessment and docking simulation study

Keywords: مطالعه داکینگ; Alzheimer's disease; Acetylcholinesterase; Docking study; Neuroprotective activity; Tacrine

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Design and synthesis of 11α-substituted bile acid derivatives as potential anti-tuberculosis agents

Keywords: مطالعه داکینگ; Cycloaddition; Bile acids; Antituberculosis; Docking study; In silico ADME;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Enhancing the cellular anti-proliferation activity of pyridazinones as c-met inhibitors using docking analysis

Keywords: مطالعه داکینگ; Pyridazinone; c-Met inhibitor; Anticancer; Docking study;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis, biological evaluation, and docking studies of novel thiourea derivatives of bisindolylmethane as carbonic anhydrase II inhibitor

Keywords: مطالعه داکینگ; Bisindolylmethane; Thiourea; Carbonic anhydrase II; Enzyme inhibition; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

In vitro cytotoxcity and interaction of new steroidal oxadiazinanones with calf thymus DNA using molecular docking, gel electrophoresis and spectroscopic techniques

Keywords: مطالعه داکینگ; Oxadiazinanone; Cyanoacetohydrazide; DNA binding; MTT assay; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Structure Based Library Design (SBLD) for new 1,4-dihydropyrimidine scaffold as simultaneous COX-1/COX-2 and 5-LOX inhibitors

Keywords: مطالعه داکینگ; COX-2; COX-1; 5-LOX; Structure Based Library Design (SBLD); Virtual Combinatorial Library Design; Virtual screening; Docking study; 1,4-Dihydropyrimidine;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2015 سفارش ترجمه

Synthesis and PGE2 production inhibition of s-triazine derivatives as a novel scaffold in RAW 264.7 macrophage cells

Keywords: مطالعه داکینگ; Inflammation; Prostaglandin E2; Cyanuric chloride; s-Triazine; Isostere; Docking study;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, biological evaluation and docking study of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives as 15-lipoxygenase inhibitors

Keywords: مطالعه داکینگ; Thiourea; Sulfonamides; Enzyme inhibitors; 15-Lipoxygenase; Antioxidant activity; Docking study

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, antileishmanial activity and docking study of N′-substitutedbenzylidene-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetohydrazides

Keywords: مطالعه داکینگ; Thieno[3,2-c]pyridine; Antileishmanial activity; L. donovani promastigotes; Antimicrobial activity; Docking study; ADME properties;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, docking and ADMET prediction of novel 5-((5-substituted-1-H-1,2,4-triazol-3-yl) methyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine as antifungal agents

Keywords: مطالعه داکینگ; 1,2,4-Triazole; Microwave irradiation; Antifungal activity; Docking study; ADMET properties

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

4-Oxo-1,4-dihydro-quinoline-3-carboxamides as BACE-1 inhibitors: Synthesis, biological evaluation and docking studies

Keywords: مطالعه داکینگ; Alzheimer's disease; BACE-1 inhibitors; 4-Oxo-1,4-dihydro-quinoline-3-carboxamide; Docking study

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and docking study of 5-(substituted benzylidene)thiazolidine-2,4-dione derivatives as inhibitors of protein tyrosine phosphatase 1B

Keywords: مطالعه داکینگ; Thiazolidinediones; PTP1B; Synthesis; Docking study;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: Synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity

Keywords: مطالعه داکینگ; 1,2,4-Triazole; Anti-inflammatory; Ulcerogenicity; Histopathological investigation; Cyclooxygenase activity; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis, antitumor activity, and structure–activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors

Keywords: مطالعه داکینگ; Trihydroxylated 2,4,6-triphenyl pyridines; Topoisomerase I; Topoisomerase II; Topo II inhibitory activity; Cytotoxicity; Anticancer agents; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Novel 1-[4-(Aminosulfonyl)phenyl]-1H-1,2,4-triazole derivatives with remarkable selective COX-2 inhibition: Design, synthesis, molecular docking, anti-inflammatory and ulcerogenicity studies

Keywords: مطالعه داکینگ; 1,2,4-Triazole; Anti-inflammatory; Ulcerogenicity; Cyclooxygenase selectivity; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and docking studies of some novel (R)-2-(4′-chlorophenyl)-3-(4′-nitrophenyl)-1,2,3,5-tetrahydrobenzo[4,5] imidazo [1,2-c]pyrimidin-4-ol derivatives as antitubercular agents

Keywords: مطالعه داکینگ; Tuberculosis; Docking study; Benzimidazole derivatives; In vitro antitubercular activity; Cytotoxicity assay; Structure–activity relationship (SAR)

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold

Keywords: مطالعه داکینگ; VEGFR-2; Kinase; Type-II; Quinoxaline; Docking study

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and structure–activity relationships of new carbonyl guanidine derivatives as novel dual 5-HT2B and 5-HT7 receptor antagonists. Part 2

Keywords: مطالعه داکینگ; Migraine; 5-HT2B receptor; 5-HT7 receptor; Dual antagonist; Carbonyl guanidine; Docking study

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه