Keywords: شاخ پشتی; antinociception; dorsal horn; intracisternal; intrathecal; substance P;
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Keywords: شاخ پشتی; Spinal cord injury; Neuropathic pain; Dorsal horn; Spinal cord stimulation;
Keywords: شاخ پشتی; ABC; avidin-biotin-peroxidase-complex; Ax; axon; CNBr; cyanogen bromide; CNS; central nervous system; den; dendrite; DH; dorsal horn; E; embryonic day; Ex; excitatory terminal; GABA; γ-amino butyric acid; GAD; glutamic acid decarboxylase; GAT; GABA tra
Keywords: شاخ پشتی; Clonidine; Dexmedetomidine; Alpha-2 adrenoreceptors; Pons; Locus coeruleus; Medullospinal tracts; Dorsal horn; Premedication;
Keywords: شاخ پشتی; AF; anterior funiculus; CGRP; calcitonin gene-related peptide; cc; central canal; cu; cuneate fasciculus; DH; dorsal horn; DRG; dorsal root ganglion; E; embryonic day; gr; gracile fasciculus; IL; immunolabeling; LF; lateral funiculus; P; postnatal day; PB
Keywords: شاخ پشتی; Neonatal; Paediatric; Peripheral nerve; Neuroimmune; Microglia; Neuropathic pain; Adolescent; Dorsal horn; Pro-inflammatory; Anti-inflammatory; Somatosensory; Plasticity;
Keywords: شاخ پشتی; Neonatal; Surgical incision; Inflammation; Microglia; Pain; Spinal cord; Dorsal horn; Synapse; Patch clamp; DRG; Primary afferent; Glutamate; GABA; Glycine; Membrane excitability;
Keywords: شاخ پشتی; CVLM; caudal ventrolateral medulla; DAC; deep axon cells; DH; dorsal horn; GAD; glutamate decarboxylase; HTM; high-threshold mechanoreceptors; LAC; local axon cells; mEPSCs; miniature excitatory postsynaptic currents; NTS; nucleus tractus solitarius; PAD;
Keywords: شاخ پشتی; Dorsal horn; Dorsal root potentials; Gate theory; Nociceptor; Presynaptic inhibition; Substantia gelatinosa; TENS;
Keywords: شاخ پشتی; GSK3β; GSK3beta; IL-1β; Interleukin-1beta; Glutamate transporter; Dorsal horn; Pain; Nociception
Keywords: شاخ پشتی; μ-Opioid receptors; Development; Neonate; Periaqueductal grey; Dorsal horn;
Keywords: شاخ پشتی; aCSF; artificial cerebrospinal fluid; 4-AP; 4-aminopyridine; DH; dorsal horn; SG; substantia gelatinosa; VH; ventral horn; Dorsal horn; Oscillatory activity; KCNQ; Nociception; Potassium channels; M-current;
Keywords: شاخ پشتی; ALS; amyotrophic lateral sclerosis; CB; calbindin; ChAT; choline acetyl transferase; CR; calretinin; CST; corticospinal tract; DH; dorsal horn; EMG; electromyogram; GFAP; glial fibrillary acidic protein; 5-HT; serotonin; NF200; neurofilament 200; NMJ; neu
Enhanced Postsynaptic GABAB Receptor Signaling in Adult Spinal Projection Neurons after Neonatal Injury
Keywords: شاخ پشتی; SDH; superficial dorsal horn; P; postnatal day; GIRK; G protein-coupled inward-rectifying potassium channel; NICU; neonatal intensive care unit; GABABR; GABAB receptor; eGFP; enhanced green fluorescent protein; GAD67; glutamic acid decarboxylase 67; PB; p
Antinociceptive Effects of the Antidepressant Phenelzine are Mediated by Context-Dependent Inhibition of Neuronal Responses in the Dorsal Horn
Keywords: شاخ پشتی; 5-HT; 5-hydroxytryptamine (serotonin); 5-HT1AR; 5-HT1A receptor; aCFS; artificial cerebrospinal fluid; ANOVA; analysis of variance; CNS; central nervous system; DA; dopamine; EAE; experimental autoimmune encephalomyelitis; GABA; gamma-aminobutyric acid; G
EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function
Keywords: شاخ پشتی; βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI
The histology, physiology, neurochemistry and circuitry of the substantia gelatinosa Rolandi (lamina II) in mammalian spinal cord
Keywords: شاخ پشتی; [Ca2+]i; intracellular Ca2+ concentration; 5-HT; serotonin; Ach; acetylcholine; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptor; BDNF; brain-derived neurotrophic factor; CCK; cholecystokinin;
Research articlePax2 is persistently expressed by GABAergic neurons throughout the adult rat dorsal horn
Keywords: شاخ پشتی; GABA; γ-aminobutyric acid; GAD; glutamate decarboxylase; GAD67; glutamate decarboxylase 67; Pax2; paired box 2; PBS; phosphate-buffered saline; Dorsal horn; Spinal cord; Inhibitory neuron; GABA; Pax2;
[3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement
Keywords: شاخ پشتی; Adaptor-associated kinase 1; Neuropathic pain; Dorsal horn; Central nervous system; Radioligand binding; Occupancy; Rodent; Non-human primate;
UVB irradiation induces rapid changes in galanin, substance P and c-fos immunoreactivity in rat dorsal root ganglia and spinal cord
Keywords: شاخ پشتی; Lateral spinal nucleus; Dorsal horn; Inflammation; Neuropeptides; Pain translational model; Immunoreactivity;
Spontaneous and Bite-Evoked Muscle Pain Are Mediated by a Common Nociceptive Pathway With Differential Contribution by TRPV1
Keywords: شاخ پشتی; Muscle pain; nociceptors; inflammation; transient receptor potential vanilloid 1; dorsal horn; vanilloids; orofacial pain;
Slow Intrathecal Injection of rAAVrh10 Enhances its Transduction of Spinal Cord and Therapeutic Efficacy in a Mutant SOD1 Model of ALS
Keywords: شاخ پشتی; ALS; amyotrophic lateral sclerosis; IT; intrathecal; rAAV; recombinant adeno-associated virus; CNS; central nervous system; DRG; dorsal root ganglia; IV; intravenous; qPCR; quantitative Polymerase Chain Reaction; DH; dorsal horn; PF; posterior funiculus;
Small molecule inhibitors of PSD95-nNOS protein-protein interactions suppress formalin-evoked Fos protein expression and nociceptive behavior in rats
Keywords: شاخ پشتی; AUC; area under the curve; CNS; central nervous system; CPS; composite pain scores; eNOS; endothelial nitric oxide synthase; FLI; Fos-like immunoreactive; i.p.; intraperitoneal; NMDAR; N-methyl-d-aspartate receptor; nNOS; neuronal nitric oxide synthase; N
Transcriptional expression of inflammatory mediators in various somatosensory relay centers in the brain of rat models of peripheral mononeuropathy and local inflammation
Keywords: شاخ پشتی; NGF; nerve growth factor; DRG; dorsal root ganglia; ET; endotoxin; ELISA; enzyme-linked immunosorbent assay; DH; dorsal horn; SNI; spared nerve injury; CCI; chronic constriction injury; ET; endotoxin; LPS; lipopolysaccharide; VF; Von Frey; PW; paw withdra
Distinct forms of synaptic inhibition and neuromodulation regulate calretinin-positive neuron excitability in the spinal cord dorsal horn
Keywords: شاخ پشتی; ACSF; artificial cerebrospinal fluid; DH; dorsal horn; HC; holding current; mIPSCs; miniature inhibitory postsynaptic currents; PBS; phosphate-buffered saline; RMS; root mean square; sIPSCs; spontaneous inhibitory postsynaptic currents; glycine; GABA; nor
Increase of transcription factor EB (TFEB) and lysosomes in rat DRG neurons and their transportation to the central nerve terminal in dorsal horn after nerve injury
Keywords: شاخ پشتی; DH; dorsal horn; DRG; dorsal root ganglion; IB4; Isolectin B4; Iba1; ionized calcium binding adapter molecule 1; IHC; immunohistochemistry; Neu-1; neuramidase-1; PB; phosphate buffer; PBS; phosphate-buffered saline; PFA; paraformaldehyde; RT; room tempera
Are presynaptic GABA-CÏ2 receptors involved in anti-nociception?
Keywords: شاخ پشتی; GABA-C receptors; Spinal cord; Pain; Anti-nociception; Substantia gelatinosa; Dorsal horn;
Electrophysiological characterization of activation state-dependent Cav2 channel antagonist TROX-1 in spinal nerve injured rats
Keywords: شاخ پشتی; ANOVA; analysis of variance; APs; action potentials; Ctrl; control; DMSO; dimethylsulfoxide; DRG; dorsal root ganglia; EGTA; ethylene glycol tetraacetic acid; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; I; input; PD; post-discharge; RM; rep
Neuroscience Forefront ReviewCircuitry and plasticity of the dorsal horn - Toward a better understanding of neuropathic pain
Keywords: شاخ پشتی; 5HT; 5-hydroxytryptamine; AMPA; alpha-amino3-hydroxy-5-methyl-4-isoxazoleproprionic acid; BDNF; brain-derived neurotrophic factor; CGRP; calcitonin gene related peptide; CVLM; caudal ventrolateral medulla; DH; dorsal horn; DRG; dorsal root ganglion; GABA;
The expression of calcium/calmodulin-dependent protein kinase II in the dorsal horns of rats with type 1 and type 2 diabetes
Keywords: شاخ پشتی; Diabetes mellitus; CaMKII; Dorsal horn; Rat; Neuropathic pain;
Selective innervation of NK1 receptor-lacking lamina I spinoparabrachial neurons by presumed nonpeptidergic Aδ nociceptors in the rat
Keywords: شاخ پشتی; Cholera toxin B subunit; Dorsal horn; Lamina I projection neuron; Spinal cord; Transganglionic tracing;
Anti-hyperalgesic effects of a novel TRPM8 agonist in neuropathic rats: A comparison with topical menthol
Keywords: شاخ پشتی; In vivo electrophysiology; Dorsal horn; TRPM8; Neuropathy; Cold hyperalgesia; Menthol;
Characteristic development of the GABA-removal system in the mouse spinal cord
Keywords: شاخ پشتی; ABC; avidin-biotin-peroxidase-complex; AF; anterior funiculus; As; astrocyte; Ax; axon; cc; central canal; CNS; central nervous system; DH; dorsal horn; E; embryonic day; f; presynapse containing flat vesicles; GABA; gamma-amino butyric acid; GAT; GAB
Research ReportSpinal expression of Hippo signaling components YAP and TAZ following peripheral nerve injury in rats
Keywords: شاخ پشتی; Neuropathic pain; Hippo signaling pathway; Spinal cord; Dorsal horn; Proliferation; Dendrite; Synaptic plasticity; Structural plasticity;
Original ResearchFull Report: Basic and Translational-Alimentary TractLinaclotide Inhibits Colonic Nociceptors and Relieves Abdominal Pain via Guanylate Cyclase-C and Extracellular Cyclic Guanosine 3â²,5â²-Monophosphate
Keywords: شاخ پشتی; CVH; CRD; Signaling Transduction; Analgesia; cGMP; cyclic guanosine-3â²,5â²-monophosphate; CRD; colorectal distention; CVH; chronic visceral hypersensitivity; DH; dorsal horn; GC-C; guanylate cyclase-C; IBS; irritable bowel syndrome; IBS-C; irritable bo
Restoring ionotropic inhibition as an analgesic strategy
Keywords: شاخ پشتی; Dorsal horn; KCC2; Chloride; GABA; Glycine; Analgesia;
Extrasynaptic AMPA receptors in the dorsal horn: Evidence and functional significance
Keywords: شاخ پشتی; Extrasynaptic AMPA receptors; AMPAR trafficking; AMPAR subunits; Dorsal horn; Inflammatory pain
Unexpected association of the “inhibitory” neuroligin 2 with excitatory PSD95 in neuropathic pain
Keywords: شاخ پشتی; Dorsal horn; Neuroligin; Neuropathic pain; Painful sensitization; Spinal cord;
The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice
Keywords: شاخ پشتی; CERS; ceramide synthase; DMSO; dimethyl sulfoxide; FB1; Fumonisin B1; IL-1β; interleukin-1β; i.t.; intrathecal; PBS; phosphate buffered saline; PSL; partial sciatic nerve ligation; SCN; sciatic nerve; SMase; sphingomyelinase; TNF-α; tumor necrosis fact
Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat
Keywords: شاخ پشتی; IL-18; interleukin-18; Vc; trigeminal spinal subnucleus caudalis; IANT; inferior alveolar nerve transection; DH; dorsal horn; IL-1β; interleukin-1β; TNF-α; tumor necrosis factor-α; IAN; inferior alveolar nerve; Iba1; ionized calcium-binding adapter mo
Mast cell degranulation distinctly activates trigemino-cervical and lumbosacral pain pathways and elicits widespread tactile pain hypersensitivity
Keywords: شاخ پشتی; Mast cell; Pain; Dorsal horn; Fos; Dura; Viscera; Headache; Visceral pain; Allodynia
Pain and immunity
Keywords: شاخ پشتی; Nociceptors; Neuropathic pain; Allodynia; Sensitization; Neuron; Glial cell; Matrophage; T cell; T cell receptor; Dorsal root ganglion; Dorsal horn; Plasticity; Integrated network; Reciprocal communication; IL-1β; TNF-α; Resolvins; Neuroimmune synapse
Spinal Cord NMDA Receptor-Mediated Activation of Mammalian Target of Rapamycin Is Required for the Development and Maintenance of Bone Cancer-Induced Pain Hypersensitivities in Rats
Keywords: شاخ پشتی; mTOR; NMDA receptors; activation; dorsal horn; cancer pain
Distinct development of GABA system in the ventral and dorsal horns in the embryonic mouse spinal cord
Keywords: شاخ پشتی; ABC; Avidin-biotin-peroxidase-complex; AF; Anterior funiculus; CC; Central canal; CNS; Central nervous system; de; Dendrite; DH; Dorsal horn; E; Embryonic day; G1-G4; GABAergic neuronal group 1-4; GABA; γ-Amino butyric acid; GAD; Glutamic acid decarb
RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn
Keywords: شاخ پشتی; Tail immersion test; Spinal cord; Knockout mice; DAMGO; Dorsal horn;
Contribution of peripheral versus central EP1 prostaglandin receptors to inflammatory pain
Keywords: شاخ پشتی; Hyperalgesia; Spinal cord; Dorsal horn; Pain relief; Intrathecal; NSAIDs
HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain
Keywords: شاخ پشتی; γ-aminobutyric acid; Dorsal horn; Disinhibition; Hyperalgesia; Chronic constriction injury; Analgesia
Attenuation of pain-related behavior evoked by injury through blockade of neuropeptide Y Y2 receptor
Keywords: شاخ پشتی; Neuropathic pain; Spinal nerve ligation; Dorsal root ganglia; Dorsal horn; Neuropeptide Y; BIBO3304; BIIE0246; Gliosis; Inflammation; GFAP;
The somatostatin analogue octreotide inhibits capsaicin-mediated activation of nociceptive primary afferent fibres in spinal cord lamina II (substantia gelatinosa)
Keywords: شاخ پشتی; Capsaicin; Octreotide; SST2 receptors; Dorsal horn; Nociception;
Pharmacological enhancement of δ-subunit-containing GABAA receptors that generate a tonic inhibitory conductance in spinal neurons attenuates acute nociception in mice
Keywords: شاخ پشتی; Dorsal horn; GABA; Inhibition; Nociception; Sensitization;