Restoring ionotropic inhibition as an analgesic strategy

- Ionotropic GABAA and glycine receptors in the dorsal horn regulate nociception.
- Ionotropic inhibition requires KCC2 activity to maintain low intracellular Cl−.
- A loss of inhibition via GABAA or glycine can cause hyperalgesia and allodynia.
- Increasing the activity of GABAA receptors or KCC2 restores normal nociception.