RGS9-2 modulates nociceptive behaviour and opioid-mediated synaptic transmission in the spinal dorsal horn

► RGS9-2 plays a prominent role in spinal cord nociceptive reflexes. ► RGS9-2 is a positive modulator of morphine actions in the spinal cord. ► RGS9 modulates the hyperpolarizing actions of morphine in spinal cord lamina II neurons.