Keywords: دوکس، داکسی سایکلین; T-box; Neural differentiation; Heart development; ES cells; Mesodermal differentiationmESCs, mouse ES cells; Eomes, eomesodermin; EBs, embryoid bodies; cTnT, cardiac troponin T; PBS, phosphate-buffered saline; dox, doxycycline; FBS, fetal bovine serum
مقالات ISI دوکس، داکسی سایکلین (ترجمه نشده)
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Keywords: دوکس، داکسی سایکلین; azadC, 5-aza-2′-deoxycytidine; DOX, doxycycline; EGFP, enhanced green fluorescent protein; ES cell, embryonic stem cell; ICE, inducible cassette exchangeInducible cells; Reporter genes; mCherry; Mouse embryonic stem cells; Transgenic cells
Therapeutic approaches for treating hemophilia A using embryonic stem cells
Keywords: دوکس، داکسی سایکلین; Bry, brachyury; CCl4, carbon tetrachloride; DAPI, 4′,6-diamidino-2-phenylindole; Dox, doxycycline; EB, embryoid body; ES, embryonic stem; FVIII, factor VIII; FVIII:Ag, factor VIII antigen; FVIII:C, factor VIII activity; FIX, factor IX; GFP, green fluoresc
Antibiotic transport across bronchial epithelial cells: Effects of molecular weight, LogP and apparent permeability
Keywords: دوکس، داکسی سایکلین; CIP, ciprofloxacin; CIP HCL, ciprofloxacin HCl; AZM, azithromycin; AZM dehydrate, azithromycin dehydrate; MXF, moxifloxacin; MXF HCl, moxifloxacin HCL; RFP, rifampicin; DOX, doxycycline; DOX HCL, doxycycline HCL; TOB, tobramycinAntibiotics; Lung delivery;
Pioglitazone significantly prevented decreased rate of neural differentiation of mouse embryonic stem cells which was reduced by Pex11β knock-down
Keywords: دوکس، داکسی سایکلین; Acox1, acyl-coenzyme A oxidase 1; Agps, alkylglycerole phosphate synthase; BSA, bovine serum albumin; DMSO, dimethyl-sulfoxide; Dox, Doxycycline; EBs, embryoid bodies; ES-FCS, embryonic stem cells qualified-FCS; FCS, fetal calf serum; GAPDH, glyceraldehyd
Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells
Keywords: دوکس، داکسی سایکلین; DOX, doxycycline; Egfp, enhanced green fluorescent protein; TACs, transit amplifying cells
Protein phosphatase PP1-NIPP1 activates mesenchymal genes in HeLa cells
Keywords: دوکس، داکسی سایکلین; Dox, doxycycline; NIPP1, nuclear inhibitor of PP1; PP1, protein phosphatase-1Nuclear inhibitor of PP1; Protein phosphatase-1; Mesenchymal lineage; HeLa cells
Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line
Keywords: دوکس، داکسی سایکلین; MEG3; Long non-coding RNA; p53; Pituitary tumor; Tumor suppressionNFA, clinically non-functioning pituitary adenoma; MEG3, maternally expressed gene 3; lncRNA, long non-coding RNA; HPV, human papillomavirus; Dox, doxycycline
Early activation of microglia and astrocytes in mouse models of spinocerebellar ataxia type 1
Keywords: دوکس، داکسی سایکلین; AD, Alzheimer’s disease; ALS, amyotrophic lateral sclerosis; ATXN1, ataxin-1; BG, Bergmann glia; DOX, doxycycline; GFAP, Glial Fibrilary Acidic Protein; HD, Parkinson’s disease; Iba1, ionized calcium-binding adapter molecule 1; IL6, Interleukin-6; SCA1, s
Anatomy of plasmid DNAs with anti-silencing elements
Keywords: دوکس، داکسی سایکلین; Dox, doxycycline; iALB, 3′ untranslated region of the human albumin gene; MAR, matrix attachment region; SEAP, secreted alkaline phosphatase; UTR, untranslated regionTransgene expression; Nonviral vector; Anti-silencing element; Hydrodynamics-based method
Brown adipose tissue derived VEGF-A modulates cold tolerance and energy expenditure
Keywords: دوکس، داکسی سایکلین; VEGF-A; BAT; Cold tolerance; Energy expenditureBAT, brown adipose tissue; WAT, white adipose tissue; UCP1, uncoupling protein1; Dox, doxycycline; HFD, high-fat diet; PGC-1α, PPARγ co-activator-1α; OCR, oxygen consumption rate; OGTT, oral glucose tolerance
From sheep to mice to cells: Tools for the study of the sphingolipidoses
Keywords: دوکس، داکسی سایکلین; α-Gal A, α-galactosidase A; ASA, arylsulfatase A; ASM, acid sphingomyelinase; β-Hex, β-hexosaminidase; CBE, conduritol-B-epoxide; CNS, central nervous system; DOX, doxycycline; GALC, galactosylceramidase; GD, Gaucher disease; GCase, glucosylceramidase; Gl
Induced expression of Fndc5 significantly increased cardiomyocyte differentiation rate of mouse embryonic stem cells
Keywords: دوکس، داکسی سایکلین; ANOVA, one-way analysis of variance; BSA, bovine serum albumin; cTnT, cardiac Troponin T2; Dkk1, dickkopf homolog 1; DMEM/F12, Dulbecco's modified Eagle medium/Ham's-Nutrient Mixture F-12; Dox, Doxycycline; EBs, embryoid bodies; ES-FCS, embryonic stem cel
The Circulating Level of FABP3 Is an Indirect Biomarker of MicroRNA-1
Keywords: دوکس، داکسی سایکلین; biomarker; cardiovascular diseases; FABP3; microRNA; miR-1ACRO, acromegaly; AS, aortic valve stenosis; cFABP3, cytosolic fatty acid-binding protein-3; CM, cardiomyocyte; dox, doxycycline; ELISA, enzyme-linked immunosorbent assay; FA, fatty acid; FABP3, fa
Human inducible nitric oxide synthase (iNOS) expression depends on chromosome region maintenance 1 (CRM1)- and eukaryotic translation initiation factor 4E (elF4E)-mediated nucleocytoplasmic mRNA transport
Keywords: دوکس، داکسی سایکلین; 3′-UTR, 3′-untranslated region; 5′-UTR, 5′-untranslated region; ARE, AU-rich element; ARE-BP, ARE binding protein; cds, coding sequence; CM, cytokine mixture; CRM1, chromosome region maintenance factor 1; Dox, doxycycline; eIF4E, eukaryotic translation in
Characterization of global metabolic responses of glucose-6-phosphate dehydrogenase-deficient hepatoma cells to diamide-induced oxidative stress
Keywords: دوکس، داکسی سایکلین; AMPK, AMP-activated protein kinase; Dox, Doxycycline; G6PD, Glucose-6-phosphate dehydrogenase; GCL, Glutamate cysteine ligase; Gi, shRNA against G6PD; GS, glutathione synthetase; GSH, Glutathione; GSR, Glutathione reductase; GSSG, Glutathione disulfide; L
Characterization of Dkk1 gene regulation by the osteoblast-specific transcription factor Osx
Keywords: دوکس، داکسی سایکلین; Osx, osterix; Dkk1, Dickkopf 1; OC, osteocalcin; E15.5, embryonic day 15.5; E18.5, embryonic day 18.5; ChIP, chromatin immunoprecipitation; Dox, Doxycycline; LRP, low-density lipoprotein receptor-related proteinOsx; Osterix; Dkk1; Osteoblast; Wnt signalin
Osteoblast-specific transcription factor Osterix (Osx) and HIF-1α cooperatively regulate gene expression of vascular endothelial growth factor (VEGF)
Keywords: دوکس، داکسی سایکلین; Osx, Osterix; VEGF, vascular endothelial growth factor; HIF-1α, Hypoxia-inducible factor-1α; PRR, proline-rich region; E18.5, embryonic day 18.5; Dox, doxycycline; BMP-2, bone morphogenetic protein 2; GAPDH, glyceraldehydes-3-phosphate dehydrogenaseOsx; O
Short-chain fatty acid receptor GPR41-mediated activation of sympathetic neurons involves synapsin 2b phosphorylation
Keywords: دوکس، داکسی سایکلین; SCFA, short-chain fatty acid; GPCR, G protein-coupled receptor; NE, norepinephrine; SNS, sympathetic nervous system; FFAs, free fatty acids; SCG, sympathetic cervical ganglion; P1, postnatal day 1; Dox, doxycycline; [3H]-NE, tritium-labeled norepinephrine
Expression of HIV-Tat protein is associated with learning and memory deficits in the mouse
Keywords: دوکس، داکسی سایکلین; ANOVA, analysis of variance; Dox, doxycycline; GFAP, glial fibrillary acidic protein; HIV, human immunodeficiency virus; HSD, Honestly Significant Difference; i.c.v., intracerebroventricular; i.p., intraperitoneal; ITI, inter-trial interval; LTP, long-ter
Peroxiredoxin 1 functions as a signal peroxidase to receive, transduce, and transmit peroxide signals in mammalian cells
Keywords: دوکس، داکسی سایکلین; ASK1, apoptosis signaling kinase 1; DTT, dithiothreitol; Dox, doxycycline; GPx, glutathione peroxidase; IB, immunoblot; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; NEM, N-ethylmaleimide; PBS, phosphate buffered saline; Prdx, pero
Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression
Keywords: دوکس، داکسی سایکلین; MAO-B, monoamine oxidase B; dox, doxycycline; PD, Parkinson's disease; SN, substantia nigra; CI, mitochondrial complex I; TH, tyrosine hydroxylase; ST, striatum; ROS, reactive oxygen species; DR, dox removal; DA, dopaminergic; NDA, non dopaminergicMonoami
Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism
Keywords: دوکس، داکسی سایکلین; PD, Parkinson's disease; ROS, reactive oxygen species; NGF, nerve growth factor; DCFDA, 2′,7′-dichlorofluorescein diacetate; FBS, fetal bovine serum; Dox, doxycycline; LDH, Lactate dehydrogenase; JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazo
Nuclear protein phosphatase-1: an epigenetic regulator of fear memory and amygdala long-term potentiation
Keywords: دوکس، داکسی سایکلین; PP1; histone posttranslational modifications; fear memory; LTP; epigenetic; amygdalaCREB, cAMP response element-binding protein; CREM, cAMP-responsive element modulator; dox, doxycycline; EGFP, enhanced green fluorescent protein; ERK/MAPK, extracellular s
Inducible dopaminergic glutathione depletion in an alpha-synuclein transgenic mouse model results in age-related olfactory dysfunction
Keywords: دوکس، داکسی سایکلین; Parkinson's disease; olfactory deficits; smell test; oxidative stress; neurodegeneration; mitochondrial dysfunctiona-syn, alpha-synuclein; DA, dopaminergic cells; Dox, doxycycline; DTg, dual transgenic; EPL, external plexiform layer; GCL, granule cell lay
Generation of stable reporter breast cancer cell lines for the identification of ER subtype selective ligands
Keywords: دوکس، داکسی سایکلین; BRET, bioluminescence resonance energy transfer; Cos, cosmosiin; Dox, doxycycline; DPN, diarylpropionitrile; E2, 17β-estradiol; ER, estrogen receptor; PPT, propyl pyrazole triol; ERE, estrogen response element; ICI, ICI 182,780; Liq, liquiritigeninEstroge
Mitochondrial reactive oxygen species generation by the SDHC V69E mutation causes low birth weight and neonatal growth retardation
Keywords: دوکس، داکسی سایکلین; SDHA, succinate dehydrogenase A subunit; SDHB, succinate dehydrogenase B subunit; SDHC, succinate dehydrogenase C subunit; SDHD, succinate dehydrogenase D subunit; PGLs, paragangliomas; SDH, succinate dehydrogenase; Dox, doxycycline; Tc, tetracycline; tTA
The coxsackie–adenovirus receptor induces an inflammatory cardiomyopathy independent of viral infection
Keywords: دوکس، داکسی سایکلین; CAR, coxsackie–adenovirus receptor; CVB, Group B coxsackieviruses; dox, doxycycline; IL, interleukin; IFN- γ, interferon-γ; TNF-α, tumor necrosis factor-α; MAPK, mitogen-activated protein kinase; P-MAPK, phosphorylated MAPK; MAPKKK, mitogen-activated prot
Ability to delay neuropathological events associated with astrocytic MAO-B increase in a Parkinsonian mouse model: Implications for early intervention on disease progression
Keywords: دوکس، داکسی سایکلین; MAO-B, monoamine oxidase B; dox, doxycycline; PD, Parkinson's disease; SN, substantia nigra; CI, mitochondrial complex I; TH, tyrosine hydroxylase; ST, striatum; ROS, reactive oxygen species; DR, dox removal; DA, dopaminergic; NDA, non dopaminergicMonoami
Nox1 is involved in p53 deacetylation and suppression of its transcriptional activity and apoptosis
Keywords: دوکس، داکسی سایکلین; HIPK2, homeodomain-interacting protein kinase-2; ADR, adriamycin; Dox, doxycycline; Nic, nicotinamide; Nox, NADPH oxidase; HEK-293, human embryo kidney; PARP, poly(ADP-ribose) polymerase; ROS, reactive oxygen species; RT-PCR, reverse transcriptase–polymer
Myocardial Remodeling Is Controlled by Myocyte-Targeted Gene Regulation of Phosphodiesterase Type 5
Keywords: دوکس، داکسی سایکلین; cyclic GMP; heart failure; phosphodiesterase-5; pressure overload; protein kinase G; transgenic mouse modelscGMP, cyclic guanosine monophosphate; DOX, doxycycline; ECM, extracellular matrix; LV, left ventricular; MHC, myosin heavy chain; PDE, phosphodiest
β-Catenin/TCF pathway plays a vital role in selenium induced-growth inhibition and apoptosis in esophageal squamous cell carcinoma (ESCC) cells
Keywords: دوکس، داکسی سایکلین; ESCC, esophageal squamous cell carcinoma; MSA, methylseleninic acid; CHX, cycloheximide; GSK-3β, glycogen synthase kinase 3β; DOX, doxycycline; AR, androgen receptor; EMSA, electrophoresis mobility shift assay; TUNEL, terminal deoxynucleotidyl transferase
Gambogic acid triggers DNA damage signaling that induces p53/p21Waf1/CIP1 activation through the ATR-Chk1 pathway
Keywords: دوکس، داکسی سایکلین; ATM, ataxia telangiectasia mutated; ATR, ataxia telangiectasia and Rad3-related; Adr, adriamycin; Caff, caffeine; DMSO, dimethyl sulfoxide; Dox, doxycycline; FBS, fetal bovine serum; FITC, fluorescein isothiocyanate; GA, gambogic acid; kd, kinase dead; PI
Inhibition of cellular Shp2 activity by a methyl ester analog of SPI-112
Keywords: دوکس، داکسی سایکلین; AO, acridine orange; DiFMUP, 6,8-difluoro-4-methylumbelliferyl phosphate; DiFMU, 6,8-difluoro-4-methylumbelliferone; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; dox, doxycycline; DTT, dithiothreitol; EB, Ethidium bromide; EGF, epid
The cell senescence inducing gene product MORF4 is regulated by degradation via the ubiquitin/proteasome pathway
Keywords: دوکس، داکسی سایکلین; CHX, cycloheximide; DMSO, dimethyl sulfoxide; dox, doxycycline; MORF4, mortality factor on chromosome 4; MRG15, MORF4 related gene on chromosome 15; MRGX, MORF4 related gene on chromosome X; NLS, nuclear localization signal; tet, tetracycline; Ub, ubiquit
Pyruvate kinase isoenzyme M2 is a glycolytic sensor differentially regulating cell proliferation, cell size and apoptotic cell death dependent on glucose supply
Keywords: دوکس، داکسی سایکلین; ADP, Adenosindiphosphat; ATP, Adenosintriphosphat; Dox, doxycycline; M2-PK or PKM2, pyruvate kinase M2; M1-PK, pyruvate kinase M1; MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NAD(P)H, Nicotinamidadenindinukleotid(phosphate); PDL, po
Prion protein protects against zinc-mediated cytotoxicity by modifying intracellular exchangeable zinc and inducing metallothionein expression
Keywords: دوکس، داکسی سایکلین; AD, Alzheimer disease; Dox, doxycycline; MT, metallothionein; PBS, phosphate buffer saline; PD, Parkinson disease; PrPC, cellular isoform of prion protein; PrPSc, scrapie isoform of prion protein; S.D., standard deviationPrion protein; Zinc ions; Metallot
Cellular responses to targeted genomic sequence modification using single-stranded oligonucleotides and zinc-finger nucleases
Keywords: دوکس، داکسی سایکلین; bp, base pairs; DSB, double-strand break; compl, complementary; ctr, control; dox, doxycycline; EGFP, enhanced green fluorescent protein; H2AX, variant of histone H2A; HR, homologous recombination; mEGFP, mutated enhanced green fluorescent protein; MMR, m
Properties of an Ezrin Mutant Defective in F-actin Binding
Keywords: دوکس، داکسی سایکلین; ERM, ezrin, radixin and moesin; FERM, four-point one ERM; RTK, receptor tyrosine kinase; GFP, green fluorescent protein; GST, glutathione-S-transferase; LPA, lysophosphatidic acid; ABPs, actin binding proteins; dox, doxycycline; abs, antibodies; WGA, whea
Glutamate-induced glioma cell proliferation is prevented by functional expression of the glutamate transporter GLT-1
Keywords: دوکس، داکسی سایکلین; C6-rtTA, transfected C6 cells expressing rtTA; C6-rtTA-GLT-1, transfected C6 cells with inducible expression of GLT-1; DHK, dihydrokainic acid; Dox, doxycycline; EAAC1, excitatory amino acid carrier 1; EAAT-2, excitatory amino acid transporter 2; GLAST, g
ER stress is the initial response to polyglutamine toxicity in PC12 cells
Keywords: دوکس، داکسی سایکلین; Dox, doxycycline; ER, endoplasmic reticulum; ERAD, ER-associated degradation of unfolded proteins; eIF2α, eukaryotic translational initiation factor 2; EYFP, yellow fluorescent protein; JNK, c-Jun N-terminal kinase; LDH, lactate dehydrogenase; MTT, 3-[4,5
Effects of mutant human Ki-rasG12C gene dosage on murine lung tumorigenesis and signaling to its downstream effectors
Keywords: دوکس، داکسی سایکلین; AC, adenocarcinomas; AD, adenomas; CCSP, Clara cell secretory protein; DOX, doxycycline; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; erk, extracellular regulated kinase; JNK, Jun kinase; MAPK, mitogen activated protein kinase; MEK, mitogen activated
The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin
Keywords: دوکس، داکسی سایکلین; ISC, iron sulfur cluster; FRDA, Friedreich's ataxia; Dox, doxycycline; MtF, mitochondrial ferritin; Mt53, HeLa cell clone expressing the MtF; FAC, ferric ammonium citrate; GAPDH, glyceradehyde-3-phosphate dehydrogenase; MTT, 3-(4,5-dimethylthiazol-2-yl)-2
Autotaxin and lysophosphatidic acid stimulate intestinal cell motility by redistribution of the actin modifying protein villin to the developing lamellipodia
Keywords: دوکس، داکسی سایکلین; ATX, autotaxin; LPA, lysophosphatidic acid; PLC-γ1, phospholipase C-γ1; PTX, pertussis toxin; VIL/FL, full-length human villin; VIL/AYFM, tyrosine phosphorylation site mutant of human villin; DOX, doxycycline; S1P1, sphingosine 1 phosphate 1; SEYFP, super
Gelsolin segment 5 inhibits HIV-induced T-cell apoptosis via Vpr-binding to VDAC
Keywords: دوکس، داکسی سایکلین; Cytoskeletal protein; AIDS; Mitochondria; Cell deathHIV-1, human immunodeficiency virus type 1; Vpr, viral protein R; VDAC, voltage-dependent anion channel; MMP, mitochondrial membrane permeabilization; IB, immunoblotting; Dox, doxycycline; PTPC, permeabi
Recombinant basic fibroblast growth factor inhibits the airway hyperresponsiveness, mucus production, and lung inflammation induced by an allergen challenge
Keywords: دوکس، داکسی سایکلین; Asthma; airway hyperresponsiveness; FGF2; mucus productionAHR, Airway hyperresponsiveness; BAL, Bronchoalveolar lavage; dox, Doxycycline; DPAS, Diastase-resistant periodic acid Schiff; FGF2, Basic fibroblast growth factor; L/N, Lymph nodes; OVA, LPS-deple
Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer
Keywords: دوکس، داکسی سایکلین; HCC, hepatocellular carcinoma; Dox, doxycycline; VEGF, vascular endothelial growth factor-A; Foxp3, forkhead box P3; IDO, indoleamine 2,3-dioxygenase; PD-1, programmed death 1; PD-L1, programmed death ligand 1; CTLA-4, cytotoxic T-lymphocyte antigen-4; o/
Parkinson's disease genetic mutations increase cell susceptibility to stress: Mutant α-synuclein enhances H2O2- and Sin-1-induced cell death
Keywords: دوکس، داکسی سایکلین; PD, Parkinson's disease; Dox, doxycycline; tTA, the tetracycline-controlled transactivator; TRE, tetracycline-responsive element; NGF, nerve growth factor; DTT, dithiothreitol; ROS, reactive oxygen species; H2O2, hydrogen peroxide; LDH, lactate dehydrogen
Optimedin induces expression of N-cadherin and stimulates aggregation of NGF-stimulated PC12 cells
Keywords: دوکس، داکسی سایکلین; DOX, doxycycline; NGF, nerve growth factorOlfactomedin; Optimedin; PC12; N-cadherin; β-Catenin; siRNA
A bidirectional Tet-dependent promotor construct regulating the expression of E1A for tight control of oncolytic adenovirus replication
Keywords: دوکس، داکسی سایکلین; oAdV, oncolytic adenovirus; Dox, doxycycline; TRE, tetracycline response element; rtTAs-M2, reverse tetracycline-controlled transactivator; SP-B, surfactant protein B; MOI, multiplicity of infection; Pfu, plaque-forming unitsTet-On system; Cancer gene the