دانلود مقالات ISI درباره Drpla + ترجمه فارسی

شناسایی اهداف مشترک درمان برای اختلالات نورودژنراتیو انتخاب شده: یک رویکرد سیلیکا

Identification of common therapeutic targets for selected neurodegenerative disorders: An in silico approach

Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; ALS; amyotrophic lateral sclerosis; HD; Huntington's disease; DRPLA; Dentatorubral-pallidoluysian atrophy; NDs; neurodegenerative diseases; In silico study; STRING 9.1 program; Neurodegenerative diseas

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

افزایش تجمع پلی اکتین در مقایسه با پلی گلوامین در پروتئین آتروفی دنتاتوروبلرال-پالیدولیویسی

Increased aggregation of polyleucine compared with that of polyglutamine in dentatorubral-pallidoluysian atrophy protein

Keywords: ATN1; atrophin-1; CNS; central nervous system; DRPLA; dentatorubral-pallidoluysian atrophy; HD; Huntington's disease; polyQ; polyglutamine; polyL; polyleucine; SCA; spinocerebellar ataxia; TPEN; N,N,N′,N′-tetrakis (2-pyridylmethyl) ethylenediamine; Z-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Polyglutamine expansion diseases: More than simple repeats

Keywords: Neurodegenerative disease; Polyglutamine protein; Aggregation modulation; Post-translational modification; Molecular partner; Ataxin-3; APR; aggregation-prone region; αB-c; AlphaB-crystallin; AR; androgen receptor; Atx1; ataxin-1; Atx3; ataxin-3; Atn1; a

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

The c-Abl inhibitor, nilotinib, as a potential therapeutic agent for chronic cerebellar ataxia

Keywords: CA; cerebellar ataxia; PC; Purkinje cells; SCA; spinocerebellar ataxia; DRPLA; dentatorubral-pallidoluysian atrophy; MSA-C; multiple system atrophy-cerebellar type; MCP; middle cerebellar peduncles; CTCAE; Common Terminology Criteria for Adverse Events;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Striatal glucose hypometabolism in preadolescent-onset dentatorubral-pallidoluysian atrophy

Keywords: DRPLA; FDG-PET; Progressive myoclonus epilepsy; Striatal hypometabolism; Functional neuroimaging;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

RNA FISH for detecting expanded repeats in human diseases

Keywords: DM; myotonic dystrophy; HD; Huntington's disease; SCA; spinocerebellar ataxia; DRPLA; dentatorubral-pallidoluysian atrophy; HDL2; Huntington disease-like 2; ALS/FTD; amyotrophic lateral sclerosis/frontotemporal dementia; FXTAS; fragile X-associated trem

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

BIIB021, a synthetic Hsp90 inhibitor, induces mutant ataxin-1 degradation through the activation of heat shock factor 1

Keywords: 17-AAG; 17-allylamino-17-demethoxygeldanamycin; ALP; autophagy-lysosome pathway; AR; androgen receptor; ATXN1; ataxin-1; DMSO; dimethyl sulfoxide; DRPLA; dentatorubral pallidoluysian atrophy; HD; Huntington's disease; HSE; heat shock element; HSF1; heat

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Studying polyglutamine diseases in Drosophila

Keywords: Huntington's disease; HD; Huntingtin; HTT; Drosophila model; Polyglutamine diseases; PolyQ diseases; Dentatorubral-pallidoluysian atrophy; DRPLA; Spinobulbar muscular atrophy; SBMA; Spinocerebellar ataxia; Atrophin-1; Machado–Joseph disease; SCA1

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Toxic effects of expanded ataxin-1 involve mechanical instability of the nuclear membrane

Keywords: SCA1; spinocerebellar ataxia type 1; ATXN1; ataxin 1; polyglutamine; polyQ; SBMA; spinal bulbar muscular atrophy; HD; Huntington disease; DRPLA; dentatorubropallidoluysian atrophy; NLS; nuclear localization signal; RBM17; RNA-binding motif protein 17; AFM

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

DRPLA transgenic mouse substrains carrying single copy of full-length mutant human DRPLA gene with variable sizes of expanded CAG repeats exhibit CAG repeat length- and age-dependent changes in behavioral abnormalities and gene expression profiles

Keywords: ANOVA; analysis of variance; CDK; cyclin-dependent kinase; CREB; cAMP response element-binding protein; DRPLA; dentatorubral-pallidoluysian atrophy; GO; gene ontology; KO; knock-out; MAPK; mitogen-activated protein kinase; MJD; Machado-Joseph disease; N

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Autophagy and polyglutamine diseases

Keywords: HD; Huntington's disease; SCA; spinocerebellar ataxia; DRPLA; Denatorubral-pallidoluysian atrophy; SBMA; spinal and bulbar muscular atropy; Htt; Huntingtin; UPS; ubiquitin-proteasome system; HDL-2; Huntington's disease-like 2; IBs; inclusion bodies; RNA

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Alteration of protein folding and degradation in motor neuron diseases: Implications and protective functions of small heat shock proteins

Keywords: ALS; amyotrophic lateral sclerosis; AR; androgen receptor; ATG5; autophagy-related gene 5; Bag; Bcl-2 associated athanogene; CBP; CREB-binding protein; CMA; chaperone-mediated autophagy; CMT; Charcot-Marie-Tooth; DAO; d-amino acid oxidase; DCTN1; dynactin

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Toward understanding Machado-Joseph disease

Keywords: ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

Correlation of cerebral spinal fluid pH and HCO3- with disease progression in ALS

Keywords: ALS; amyotrophic lateral sclerosis; ALSFRS-R; ALS functional rating scale; CBD; corticobasal degeneration; CCA; cortical cerebellar atrophy; CS; cervical spondylosis; CSF; cerebrospinal fluid; DRPLA; dentatorubral-pallidoluysian atrophy; FALS; familial AL

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

14-3-3 proteins in neurodegeneration

Keywords: TH; tyrosine hydroxylase; 3′UTR; three prime untranslated region; CSF; cerebrospinal fluid; 2D-PAGE; two-dimensional polyacrylamide gel electrophoresis; PD; Parkinson disease; AD; Alzheimer disease; CJD; Creutzfeldt-Jakob disease; MSA; multiple system a

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Atrophin contributes to the negative regulation of epidermal growth factor receptor signaling in Drosophila

Keywords: Drosophila; Atrophin; DRPLA; EGFR signaling; Cell signaling; Yan

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Minimum prevalence of spinocerebellar ataxia 17 in the north east of England

Keywords: TBP; TATA-box binding protein; SCA17; Spinocerebellar ataxia type 17; TFIID; RNA polymerase II transcription factor D; HD; Huntington's disease; IT15 gene; important transcript 15 gene; DRPLA; dentatorubral-pallidoluysian atrophy; FTL; ferritin light ch

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2005 سفارش ترجمه

Interference with activity-dependent transcriptional activation of BDNF gene depending upon the expanded polyglutamines in neurons

Keywords: BDNF; PACAP; Calcium; Polyglutamine; Activity-dependent transcription; DRPLA;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

TATA-binding protein in neurodegenerative disease

Keywords: TBP; polyglutamine; SCA17; polyglutamine disorders; neurodegeneration; AD; Alzheimer's disease; CBP; cyclic AMP-responsive element-binding binding protein; CREB; cyclic AMP-responsive element-binding; DRPLA; dentatorubral-pallidoluysian atrophy; HD; Hun

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2005 سفارش ترجمه

Genetic Testing: Practical, Ethical, and Counseling Considerations

Keywords: CBAVD; congenital bilateral absence of the vas deferens; CF; cystic fibrosis; DRPLA; dentatorubropallidoluysian atrophy; EDS; Ehlers-Danlos syndrome; HD; Huntington disease; Hex A; hexosaminidase A; HH; hereditary hemochromatosis; HNPCC; hereditary nonpol

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1

Keywords: JAM; junctional adhesion molecule; MAGI-1; membrane-associated guanylate kinase inverted-1; MAGUK; membrane-associated guanylate kinase; SH3; Src homology 3; PTB; phosphotyrosine binding; PDZ; PSD-95/Dlg/ZO-1; YAP; Yes-associated protein; GuK; guanylate k

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه