Keywords: آنزیم های متابولیسم دارو; Drug metabolizing enzymes; ontogeny; paediatric pharmacology; pharmacodynamics; pharmacogenetics; pharmacokinetics;
مقالات ISI آنزیم های متابولیسم دارو (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: آنزیم های متابولیسم دارو; Cancer; Resistance; Drug metabolizing enzymes; UGTs; GSTs; DPDs; TPMTs;
Keywords: آنزیم های متابولیسم دارو; proteomics; pharmacokinetic/pharmacodynamic models; physiologically based pharmacokinetic modeling; individualized drug therapy; drug metabolizing enzymes; transporters; population pharmacokinetics/pharmacodynamics;
Capillary electrophoresis in the context of drug discovery
Keywords: آنزیم های متابولیسم دارو; ACE; affinity capillary electrophoresis; AGP; α-acid glycoprotein; AH; adrenaline hydrochloride; AIμEA; automatic micro-enzyme assay; AL; amlodipine; AT; antithrombin III; Bag3; Bcl2-associated anthanogene 3; BGE; background electrolyte; CM; chylomicron
Keywords: آنزیم های متابولیسم دارو; in vitro/in vivo correlations (IVIVC); hepatic clearance; hepatic metabolism; hepatic transport; transporters; drug transport; drug metabolizing enzymes; HIV/AIDS; FBS; fetal bovine serum; HEPES; 4-(2-hydroxyethyl)-1- piperazine ethanesulfonic acid; HIV
Keywords: آنزیم های متابولیسم دارو; Astragali radix; Astragaloside IV; Calycosin; Formononetin; Drug metabolizing enzymes; Efflux transporters;
Keywords: آنزیم های متابولیسم دارو; Nonalcoholic fatty liver disease; Liver gene expression; Drug metabolizing enzymes; Cytochrome P450;
Keywords: آنزیم های متابولیسم دارو; Fruit and vegetables; Dietary guidance; Drug metabolizing enzymes; Antioxidant enzymes; Oxidative stress;
Keywords: آنزیم های متابولیسم دارو; ALT; alanine transferase; AST; aspartate transaminase; BMI; body mass index; CYP2E1; cytochrome P450 2E1; DIH; drug induced hepatotoxicity; DMEs; drug metabolizing enzymes; ETB; ethambutol; HRM; high resolution melting; INH; isoniazid; MDR1; multidrug res
Keywords: آنزیم های متابولیسم دارو; ADME; clinical pharmacokinetics; drug interactions; membrane transporter; drug metabolizing enzymes; cancer chemotherapy;
Keywords: آنزیم های متابولیسم دارو; Drug metabolizing enzymes; ontogeny; paediatric pharmacology; pharmacodynamics; pharmacogenetics; pharmacokinetics
Alisol B 23-acetate from the rhizomes of Alisma orientale is a natural agonist of the human pregnane X receptor
Keywords: آنزیم های متابولیسم دارو; Alisol B 23-acetate; Alisma orientale; Pregnane X receptor; Alisma rhizome; Nuclear receptor; CYP3A4; cytochrome P450 3A4; DMEs; drug metabolizing enzymes; HPH; human primary hepatocyte; ABA; alisol B 23-acetate; PXR; pregnane X receptor; SRC-1; steroid r
A systematic evaluation of microRNAs in regulating human hepatic CYP2E1
Keywords: آنزیم های متابولیسم دارو; microRNA, hsa-miR-214-3p; CYP2E1; Drug metabolizing enzymes; Pharmacogenomics; Inter-individual variability;
UDP-glucuronosyltransferases (UGTs) and their related metabolic cross-talk with internal homeostasis: A systematic review of UGT isoforms for precision medicine
Keywords: آنزیم های متابولیسم دارو; UGT; UDP glucuronosyltransferases; DDIs; drug-drug interactions; DMEs; drug metabolizing enzymes; LC-MS/MS; liquid chromatography coupled with tandem mass spectrometry; UDPGA; uridine diphosphate glucuronic acid; AA; arachidonic acid; HETEs; hydroxyeico
The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Keywords: آنزیم های متابولیسم دارو; CYP; cytochrome P450; miRNAs; microRNAs; DMETs; drug metabolizing enzymes and transporters; Ago; argonaute RISC catalytic component; RISC; RNA-induced silencing complex; FBS; fetal bovine serum; EMSA; electrophoretic mobility shift assay; HCC; hepatocellu
Rapid and ultra-rapid metabolizers with CYP2C19*17 polymorphism do not respond to standard therapy with proton pump inhibitors
Keywords: آنزیم های متابولیسم دارو; Pharmacogenomics; Drug metabolizing enzymes; Genotyping; Intragastric pH;
Clinical Exposure Boost Predictions by Integrating Cytochrome P450 3A4-Humanized Mouse Studies With PBPK Modeling
Keywords: آنزیم های متابولیسم دارو; clinical pharmacokinetics; CYP enzymes; drug interaction; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasm
Cytochrome P450 Activity in Ex Vivo Cornea Models and a Human Cornea Construct
Keywords: آنزیم های متابولیسم دارو; cell culture; cell lines; cytochrome P450; phase I metabolism; drug metabolizing enzymes; in vitro models; ophthalmic drug delivery; tissue engineering;
Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells
Keywords: آنزیم های متابولیسم دارو; cytochrome P450; dose-response; drug metabolizing enzymes; enzyme kinetics; enzymes; hepatic clearance; hepatic metabolism; kinetics;
A Physiologically Based Pharmacokinetic Model to Describe Artemether Pharmacokinetics in Adult and Pediatric Patients
Keywords: آنزیم های متابولیسم دارو; clinical pharmacokinetics; CYP enzymes; drug metabolizing enzymes; elimination; hepatic clearance; interspecies scaling; physiologically based pharmacokinetic modeling; preclinical pharmacokinetics; simulations; AUC; area under the plasma concentration-ti
Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism
Keywords: آنزیم های متابولیسم دارو; cytochrome P450; phenotype; drug metabolizing enzymes; pharmacokinetics; biopharmaceutics classification system;
Protective effect of Trigonella foenum-graecum on thioacetamide induced hepatotoxicity in rats
Keywords: آنزیم های متابولیسم دارو; Therapeutic agent; Thioacetamide; Cirrhosis; Biochemical markers; Trigonella foenum-graecum; Electron microscopy; Herbal drugs; Drug metabolizing enzymes
Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein
Keywords: آنزیم های متابولیسم دارو; drug design; CD13/APN-targeting; cancer; resistance; drug metabolizing enzymes; NGR motif-integrated apoprotein; pingyangmycin/bleomycin A5 conjugate;
Selective induction of glutathione S-transferases in round spermatids from the Brown-Norway rat by the chemotherapeutic regimen for testicular cancer
Keywords: آنزیم های متابولیسم دارو; Chemotherapeutic drugs; Testicular cancer; Drug metabolizing enzymes; Round spermatids; Glutathione S-transferases; DNA methylation
Pharmacokinetics of Vicagrel, a Promising Analog of Clopidogrel, in Rats and Beagle Dogs
Keywords: آنزیم های متابولیسم دارو; vicagrel; clopidogrel; prodrugs; 2-oxo-clopidogrel; drug resistance; active metabolite; pharmacokinetics; polymorphism; drug metabolizing enzymes;
Mass spectrometry-based proteomic analysis of human liver cytochrome(s) P450
Keywords: آنزیم های متابولیسم دارو; Cytochrome P450 expression; Human liver microsomes; Drug metabolizing enzymes; Proteomics; MALDI mass spectrometry; Pharmacoproteomics
Pharmacokinetic/Pharmacodynamic Modeling of 5-Fluorouracil by Using a Biomarker to Predict Tumor Growth in a Rat Model of Colorectal Cancer
Keywords: آنزیم های متابولیسم دارو; pharmacokinetics/pharmacodynamic models; cancer chemotherapy; individualized drug therapy; drug metabolizing enzymes; simulations; biomarker; dihydropyrimidine dehydrogenase; anticancer agent;
Utilizing In Vitro and PBPK Tools to Link ADME Characteristics to Plasma Profiles: Case Example Nifedipine Immediate Release Formulation
Keywords: آنزیم های متابولیسم دارو; absorption; bioavailability; computational ADME; cytochrome P450; dissolution; drug metabolizing enzymes; first-pass metabolism; pharmacokinetics; quality by design (QbD)
Species Difference of Esterase Expression and Hydrolase Activity in Plasma
Keywords: آنزیم های متابولیسم دارو; metabolism; prodrugs; drug metabolizing enzymes; albumin; enzymology;
Use of Enzyme Inhibitors to Evaluate the Conversion Pathways of Ester and Amide Prodrugs: A Case Study Example with the Prodrug Ceftobiprole Medocaril
Keywords: آنزیم های متابولیسم دارو; prodrug; drug metabolizing enzymes; in vitro models; inhibition; enzymology; hydrolysis; conversion; paraoxonase; esterase; ceftobiprole;
Summary of the National Institute of Child Health and Human Development-Best Pharmaceuticals for Children Act Pediatric Formulation Initiatives Workshop-Pediatric Biopharmaceutics Classification System Working Group
Keywords: آنزیم های متابولیسم دارو; pediatric biopharmaceutics classification system; ontogeny; drug metabolizing enzymes; gastroinestinal physiology; PBPK; biorepository;
Impact of CYP3A5*3 and CYP2C8-HapC on Paclitaxel/Carboplatin-Induced Myelosuppression in Patients with Ovarian Cancer
Keywords: آنزیم های متابولیسم دارو; CYP enzymes; pharmacogenetics; toxicity; polymorphism; drug metabolizing enzymes; cancer chemotherapy;
Molecular and Cellular PharmacologyEffect of pregnane X receptor (PXR) prototype agonists on chemoprotective and drug metabolizing enzymes in mice
Keywords: آنزیم های متابولیسم دارو; PXR; Dexamethasone; Spironolactone; Pregnenolone-16alpha-carbonitrile; Drug metabolizing enzymes;
An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir
Keywords: آنزیم های متابولیسم دارو; drug metabolizing enzymes; drug interactions; ADME; bioavailability; computational ADME; cytochrome P450;
An examination of the potential effect of lipids on the firstâpass metabolism of the lipophilic drug anethol trithione
Keywords: آنزیم های متابولیسم دارو; anethol trithione; medium chain triglycerides; firstâpass metabolism; hepatic metabolism; nonlinear pharmacokinetics; dose proportionality; drug metabolizing enzymes; inhibition; formulation; lipids;
Comparative Effects of Doxercalciferol (1α-Hydroxyvitamin D2) Versus Calcitriol (1α,25-Dihydroxyvitamin D3) on the Expression of Transporters and Enzymes in the Rat In Vivo
Keywords: آنزیم های متابولیسم دارو; doxercalciferol or Hectorol®; 1α,25-dihydroxyvitamin D3; vitamin D receptor; farnesoid X receptor; P-glycoprotein; membrane transporters; induction; drug transport; drug metabolizing enzymes; cytochrome P450;
Inhibition of NADPH-cytochrome P450 reductase by tannic acid in rat liver microsomes and primary hepatocytes: Methodological artifacts and application to ischemia-reperfusion injury
Keywords: آنزیم های متابولیسم دارو; tannic acid; NADPH-Cytochrome P450 reductase; microsomes; hepatocytes; inhibition; protein binding; simulated ischemia-reperfusion injury; cell culture; drug metabolizing enzymes;
ReviewBotanicals as medicinal food and their effects on drug metabolizing enzymes
Keywords: آنزیم های متابولیسم دارو; Cytochrome P450; Botanicals; Drug metabolizing enzymes; Inhibition; Induction; Herb-drug interaction;
Metabolic intervention of aflatoxin B1 toxicity by curcumin
Keywords: آنزیم های متابولیسم دارو; Aflatoxin B1; Curcumin; AFB1–DNA adduct; AFB1–N7-guanine adduct; AFB1–lysine adduct; Drug metabolizing enzymes
Regulation of gene expression of hepatic drug metabolizing enzymes and transporters by the Toll-like receptor 2 ligand, lipoteichoic acid
Keywords: آنزیم های متابولیسم دارو; Drug metabolizing enzymes; Liver; Nuclear receptors; Toll-like receptors; Inflammation; Lipoteichoic acid
A Combined Pharmacokinetic-Pharmacodynamic (PK-PD) Model for Tumor Growth in the Rat with UFT Administration
Keywords: آنزیم های متابولیسم دارو; pharmacokinetic-pharmacodynamic model; cancer chemotherapy; individualized drug therapy; drug metabolizing enzymes; hepatic metabolism;
Chemopreventive and therapeutic modulation of green tea polyphenols on drug metabolizing enzymes in 4-Nitroquinoline 1-oxide induced oral cancer
Keywords: آنزیم های متابولیسم دارو; Drug metabolizing enzymes; Oral cancer; Green tea polyphenols; 4-Nitroquinoline 1-oxide; Detoxification; Oral squamous cell carcinoma
Constitutive expression and inducibility of CYP1A1 in the H9c2 rat cardiomyoblast cells
Keywords: آنزیم های متابولیسم دارو; Cytochrome P450 1A1; H9c2 cells; Cardiomyocytes; Heart; Drug metabolizing enzymes
H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart
Keywords: آنزیم های متابولیسم دارو; H9c2 cells; Cytochrome P450s; Heart; Drug metabolizing enzymes; Cardiomyocytes
Zinc mediates normalization of hepatic drug metabolizing enzymes in chlorpyrifos-induced toxicity
Keywords: آنزیم های متابولیسم دارو; Zinc; Chlorpyrifos; Organophosphorus; Drug metabolizing enzymes; Cytochrome P450; Cytochrome b5
In vitro assessment of cytochrome P450 inhibition: Strategies for increasing LC/MSâbased assay throughput using a oneâpoint IC50 method and multiplexing highâperformance liquid chromatography
Keywords: آنزیم های متابولیسم دارو; cytochrome P450; drug-drug interactions; drug metabolizing enzymes; highâthroughput technologies; human liver microsomes; inhibition; mass spectrometry; mathematical model; oneâpoint IC50; probe substrates;
Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As3+, Cd2+ and Cr6+
Keywords: آنزیم های متابولیسم دارو; Aryl hydrocarbon receptor; Heavy metals; Oxidative stress; Drug metabolizing enzymes; Ascorbic acidALL, acute lymphocytic leukemia; AML, acute myelocytic leukemia; APL, acute promyelocytic leukemia; ARE, antioxidant response element; As3+, arsenite; AhR,
Genetics and variability in opioid response
Keywords: آنزیم های متابولیسم دارو; Pharmacogenetics; Drug metabolizing enzymes; Codeine; Tramadol; Opioid receptors;
Changes in hepatic drug metabolizing enzymes and lipid peroxidation by methanol extract and major compound of Orostachys japonicus
Keywords: آنزیم های متابولیسم دارو; Orostachys japonicus; Gallic acid; Bromobenzene; Drug metabolizing enzymes; Lipid peroxidation;
Gene expression of drug metabolizing enzymes in adult and aged mouse liver: A modulation by immobilization stress
Keywords: آنزیم های متابولیسم دارو; Ageing; Immobilization stress; Drug metabolizing enzymes; Cytochrome P450 1A; Catechol-O-methyltransferase; Mouse liver;