کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10162393 | 1114328 | 2014 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
اکتشاف دارویی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein Preparation and Evaluation of a CD13/APN-Targeting and Hydrolase-Resistant Conjugate that Comprises Pingyangmycin and NGR Motif-Integrated Apoprotein](/preview/png/10162393.png)
چکیده انگلیسی
We have chemically synthesized NGR-LDP-PYM, a novel CD13/aminopeptidase (APN)-targeting and hydrolase-resistant conjugate by cross-linking of the antitumor antibiotic pingyangmycin (bleomycin A5, PYM) to an engineered NGR motif-integrated apoprotein (NGR-LDP) with a noncleavable linker. This protein-drug conjugate not only basically retains the original properties of PYM but also can specifically deliver PYM to the CD13/APN-expressing tumor cells. Furthermore, the resulting conjugate exhibits more resistance to hydrolysis of recombinant human bleomycin hydrolase than parental PYM. These results may be useful for improving the therapeutic efficacy of PYM and have implications in the treatment of PYM-refractory and CD13/APN-overexpressing tumors. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1204-1213, 2014
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1204-1213
Journal: Journal of Pharmaceutical Sciences - Volume 103, Issue 4, April 2014, Pages 1204-1213
نویسندگان
Bin Li, Yan-Bo Zheng, Dian-Dong Li, Yong-Su Zhen,