Keywords: DXR; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; DXS; 1-deoxy-D-xylulose 5-phosphate-synthase; GGPS; Geranylgeranyl diphosphate synthase; PDS; Phytoene desaturase; ZDS; ζ-carotene desaturase; CRTISO; Carotenoid isomerase; LCYB; Lycopene β-cyclase;
مقالات ISI (ترجمه نشده)
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Keywords: RT-PCR; reverse transcription polymerase chain reaction; MEP; methylerthiol 4-phosphate; IDP; isopentenyl diphosphate; DMADP; dimethylallyl diphosphate; GPP; geranyl diphosphate; FDP; farnesyl diphosphate; GGPPS; geranylgeranyl diphosphate synthesis; DXR;
Keywords: Intestinal failure; Parenteral nutrition; Bone mineral density; Dual energy X-ray absorptiometry; Digital X-ray radiogrammetry; BHI; bone health index; BMAD; bone mineral apparent density; BMD; bone mineral density; DXA; dual energy X-ray absorptiometry;
Keywords: DCM; dilated cardiomyopathy; DXR; doxorubicin; HF; heart failure, ST group short-term doxorubicin injection; LT group; long-term doxorubicin injection; LV; left ventricle, LVEF left ventricle ejection function; LVDd; LV end-diastolic dimension; LVDs; end-
Keywords: TNBC; triple negative breast cancer; ROS; reactive oxygen species; H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; MTT; 3-[4,5-dimethyl-2-thiazolyl]-2,5-diphenyl-2H-tetrazolium bromide; CI value; combination index value; DXR; doxorubicin; 3-MA; 3
Keywords: W. somnifera; Withanolides; Bioreactor; P. indica; Cell suspension cultures; CAS; Cycloaretenol synthase; DW; Dry weight; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; FPPS; Farnesyl pyrophosphate sy
Keywords: A/G; albumin/globulin ratio; ALT; alanine transaminase; ALP; alkaline phosphatase; AST; aspartate transaminase; BSA; bovine serum albumin; BUN; blood urea nitrogen; CHOL; cholesterol; CK; cytokeratin; Cre; creatinine; DiI; 1,1â²-dioctadecyl-3,3,3â²3'-
Keywords: ABEI; N-(4-aminobutyl)-N-ethylisoluminol; Ab; Antibody; ADM; Adriamycin; AFP; Alpha fetoprotein; Ag; Antigen; ALP; Alkaline phosphatase; ATP; Adenosine triphosphate; bbc-DL-DNA; bio-bar-code dendrimer-like DNA; BPE; Biophoton emission; CA; Carcinoma antig
Keywords: AACT; acetoacetyl-CoA thiolase; ADP; adenosine diphosphate; APC; allophycocyanin; ATP; adenosine triphosphate; BChl; bacteriochlorophyll; CAR; carotenoid; CDP-ME2P; 4-(citidine 5â²-diphospho)-2-C-methyl-d-erythritol; Chl; chlorophyll; CHYβ; β-hydroxyla
Structural characterization of 1-deoxy-D-xylulose 5-phosphate Reductoisomerase from Vibrio vulnificus
Keywords: 1-deoxy-D-xylulose-5-phosphate reductoisomerase; 2-C-methylerythritol 4-phosphate; Dxr; Vibrio vulnificus;
Doxorubicin resistance in breast cancer: A novel role for the human protein AHNAK
Keywords: cCasp7; cleaved caspase 7; cPARP; cleaved PARP; CRU; central repeated unit; DMEM; Dulbecco's Modified Eagle Medium; DXR; doxorubicin; EMT; epithelial-mesenchymal transition; FITC; fluorescein isothiocyanate; HBSS; Hank's Balanced Salt Solution; HD-DXR
Effect of methyl jasmonate on the aroma of Sangiovese grapes and wines
Keywords: CCD; carotenoid cleavage dioxygenases; DOX/MEP; 1-deoxy-d-xylulose/2-C-methyl-d-erythritol 4-phosphate; DXS; Deoxyxylulose phosphate synthase; DXR; Deoxyxylylose phosphate reductoisomerase; E-L; Eichhorn-Lorenz; GC-MS; Gas chromatography - mass spec
Elevation of sensitivity to anticancer agents of human lung adenocarcinoma A549 cells by knockdown of claudin-2 expression in monolayer and spheroid culture models
Keywords: ABC; ATP-binding cassette; AJs; adherens junctions; CMFDA; 5-chloromethylfluorescein diacetate; Ct; threshold cycle; DXR; doxorubicin; Dox; doxycycline; HBSS; Hank's balanced salt solution; HNF-1; hepatocyte nuclear factor-1; LY; lucifer yellow; Nfr2; NF-
Diverse responses of tanshinone biosynthesis to biotic and abiotic elicitors in hairy root cultures of Salvia miltiorrhiza and Salvia castanea Diels f. tomentosa
Keywords: AACT; acetyl-CoA C-acetyltransferase; CPS; copalyl diphosphate synthase; CT; cryptotanshinone; CYPs; cytochromes P450; DMAPP; dimethylallyl diphosphate; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulo
Diverse specialized metabolism and their responses to lactalbumin hydrolysate in hairy root cultures of Salvia miltiorrhiza Bunge and Salvia castanea Diels f. tomentosa Stib
Keywords: CA; caffeic acid; CT; cryptotanshinone; CYP76AH1; cytochrome P450 dependent monooxygenase; CYPs; cytochromes P450; DT-I; dihydrotanshinone I; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DW; dry weigh
Toxicogenetic study of Persea americana fruit pulp oil and its effect on genomic instability
Keywords: Persea americana; Antioxidant; Cytotoxicity; Genotoxicity; Chemoprevention; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSTFA; N,O-bis(trimethylsilyl)trifluoroacetamide; DDPH; 2,2-diphenyl-1-picrylhydrazyl; DMSO; dimethylsulfoxide; DXR
Antimicrobial mechanism of epigallocatechin gallate and gallocatechin gallate: They target 1-deoxy-d-xylulose 5-phosphate reductoisomerase, the key enzyme of the MEP terpenoid biosynthetic pathway
Keywords: EGCG; GCG; Mode of antimicrobial action; 1-Deoxy-d-xylulose 5-phosphate reductoisomerase; MEP pathway; Specific inhibition; CIAP; Calf intestine alkaline phosphatase; DLS; Dynamic light scattering; DNPH; 2,4-Dinitrophenylhydrazine; DXP; 1-Deoxy-d-xylulose
Original ArticleDoxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells
Keywords: Cancer stem cells; Drug resistance; Mitophagy; BNIP3L; Autophagy; ATG7; autophagy related 7; BNIP3L; BCL2/adenovirus E1B 19Â kDa protein-interacting protein 3-like; CSCs; cancer stem cells; DXR; doxorubicin; DAPK1; death-associated protein kinase 1; DNA;
Research articleTissue-specific gene-expression patterns of genes associated with thymol/carvacrol biosynthesis in thyme (Thymus vulgaris L.) and their differential changes upon treatment with abiotic elicitors
Keywords: Thymus vulgaris; Thymol; Carvacrol; Trichome; Terpene; Biosynthesis; CYP; Cytochrome P450; DMADP; dimethylallyl diphosphate; DXP; 1-deoxy-D-xylulose-5-phosphate; DXR; 1-deoxy-D-xylulose-5-phosphate reductoisomerase; GDP; Geranyl diphosphate; GDS; geranyl
Synthesis and evaluation of antitumor, anti-inflammatory and analgesic activity of novel deoxycholic acid derivatives bearing aryl- or hetarylsulfanyl moieties at the C-3 position
Keywords: BAs; bile acids; DCA; deoxycholic acid; DXR; doxorubicin hydrochloride; IFNγ; interferon γ; i.p.; intraperitoneally; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NOS; NO synthases; eNOS; endothelial NO synthase; iNOS; inducible NO
Synthesis and biological evaluation of phosphate isosters of fosmidomycin and analogs as inhibitors of Escherichia coli and Mycobacterium smegmatis 1-deoxyxylulose 5-phosphate reductoisomerases
Keywords: DXP; 1-deoxy-d-xylulose 5-phosphate; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; MEP; 2-C-methyl-d-erythritol 4-phosphate; GlpT; glycerol-3-phosphate transporter; UhpT; hexose-6-phosphate transporter; FosR; fosmidomycin resistant strain of E. co
Digital X-ray radiogrammetry in the study of osteoporotic fractures: Comparison to dual energy X-ray absorptiometry and FRAX
Keywords: AUC; area under curve; BMD; bone mineral density; DXA; dual energy X-ray absorptiometry; DXR; digital X-ray radiogrammetry; FN; femoral neck; MOF; major osteoporotic fracture; SD; standard deviation; SOF; the Study of Osteoporotic Fractures; VPA; volume p
Deletion of carotenoid cleavage dioxygenase 4a (CmCCD4a) and global up-regulation of plastid protein-coding genes in a mutant chrysanthemum cultivar producing yellow petals
Keywords: CCD; carotenoid cleavage dioxygenase; NCED; 9-cis epoxycarotenoid dioxygenases; ABA; abscisic acid; ZDS; ζ-carotene desaturase; DEG; differentially expressed genes; DXS; 1-deoxyxylulose 5-phosphate synthase; DXR; 1-deoxyxylulose 5-phosphate reductoisomer
Isoprenoid generating systems in plants - A handy toolbox how to assess contribution of the mevalonate and methylerythritol phosphate pathways to the biosynthetic process
Keywords: Ac-CoA; acetyl CoA; AACT; AcAC-CoA thiolase; CLM; clomazone (2-[(2-chlorophenyl)methyl]-4,4-dimethyl-3-isoxazolidinone); DMAPP; dimethylallyl diphosphate; DMNT; (3E)-4,8-dimethyl-1,3,7-nonatriene; DOXP; deoxyxylulose phosphate; DX; 1-deoxy-d-xylulose; DXK
Tumour stromal morphology impacts nanomedicine cytotoxicity in patient-derived xenografts
Keywords: DXR; doxorubicin; EPR; enhanced permeability and retention; MVD; microvessel density; PDTX; patient-derived tumour xenograft (also referred to as: explant tumour); SCID; severe combined immunodeficiency; SDARS; Spatial Distribution of Apoptosis Relative t
Research articleEnvironmental cues induce changes of steviol glycosides contents and transcription of corresponding biosynthetic genes in Stevia rebaudiana
Keywords: Stevia rebaudiana Bertoni; Steviol glycosides; Transcription; Environmental cues; SGs; steviol glycosides; ST; stevioside; RA; rebaudioside A; MEP; 2-C-methyl-d-erythritol-4 phosphate; DXP; 1-deoxy-d-xylulose 5-phosphate; DXS; DXP synthase; DXR; DXP reduc
Modulating effect of synthetic statins against damage induced by doxorubicin in somatic cells of Drosophila melanogaster
Keywords: Atorvastatin; Rosuvastatin; Modulatory effect; Smart; Drosophila melanogaster; BH; balancer heterozygote descendants; CYP; cytochrome P450; CYP2C9; cytochrome P450 2C9; CYP 2C19; cytochrome P450 2C19; DXR; doxorubicin; eNOS; endothelial nitric oxide synth
Novel insights into structure–function mechanism and tissue-specific expression profiling of full-length dxr gene from Cymbopogon winterianus
Keywords: Citronella; DXR; Molecular modelling; Molecular dynamics simulation; Docking
Medicinal uses, phytochemistry and pharmacology of the genus Uncaria
Keywords: U1; Uncaria acida (Hunter) Roxb; U2; Uncaria africana G. Don; U3; Uncaria attenuate Korth; U4; Uncaria barbata Merr; U5; Uncaria bernaysii F. Muell; U6; Uncaria borneensis Havil; U7; Uncaria callophylla Blume ex Korth; U8; Uncaria canescens Korth; U9; Unc
The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs
Keywords: Mycobacterium tuberculosis; Nonmevalonate pathway; Dxr; Antibiotic;
Organically produced coffee exerts protective effects against the micronuclei induction by mutagens in mouse gut and bone marrow
Keywords: DXR; doxorubicin; bw; body weight; i.p.; Intraperitoneally; DMH; 1,2-dimethylhydrazine dihydrochloride; MN; micronuclei; PS; physiological saline; BMG; body mass gain; SGR; specific growth rate; FCR; feed conversion ratio; OC; organic coffee; CC; conventi
In vivo assessment of the cytotoxic, genotoxic and antigenotoxic potential of maná-cubiu (Solanum sessiliflorum Dunal) fruit
Keywords: DXR; doxorubicin; GSH; reduced glutathione; MNPCE; micronucleated polychromatic erythrocyte; MNRET; micronucleated reticulocytes; NCE; normochromatic erythrocyte; PCE; polychromatic erythrocyte; RNS; reactive nitrogen species; ROS; reactive oxygen species
Catechol–rhodanine derivatives: Specific and promiscuous inhibitors of Escherichia coli deoxyxylulose phosphate reductoisomerase (DXR)
Keywords: Catechol–rhodanines; DXR; False positives; Isoprenoid; Promiscuous inhibitors
Energy adaptive response during parthanatos is enhanced by PD98059 and involves mitochondrial function but not autophagy induction
Keywords: 3AB; 3-aminobenzamide; 7AAD; 7-aminoactinomycin D; AIF; apoptosis-inducing factor; AMPK; AMP-activated protein kinase; DPI; diphenyliodonium; DXR; doxorubicin; FACS; fluorescence-activated cell sorting; FCCP; trifluorocarbonylcyanide phenylhydrazone; LC3;
Lack of mutagenic effect by multi-walled functionalized carbon nanotubes in the somatic cells of Drosophila melanogaster
Keywords: BH; balanced heterozygote descendants; DXR; doxorubicin; HB; high bioactivation cross; CNTs; carbon nanotubes; SWCNTs; single walled carbon nanotubes; DWCNTs; double walled carbon nanotubes; MWCNT; multi-walled carbon nanotubes; MH; marked trans heterozyg
Pharmaceutical nanotechnologyUse of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration
Keywords: ABC; accelerated blood clearance; AUC; area under the blood concentration-time curve; CHOL; cholesterol; DMEM; Dulbecco's modified Eagle's medium; DXR; doxorubicin; ELISA; enzyme-linked immunosorbent assay; FBS; fetal bovine serum; HEPC; hydrogenated eg
Cloning and expression analysis of ten genes associated with picrosides biosynthesis in Picrorhiza kurrooa
Keywords: MVA; mevalonate; MEP; 2-C-methyl-d-erythritol 4-phosphate; DXS; 1-deoxy-d-xylulose-5-phosphate synthase; DXR; 1-deoxy-d-xylulose-5-phosphate reductoisomerase; MCT; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; CMK; 4-diphosphocytidyl-2-C-methy
Cloning, molecular characterization and functional analysis of 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR) gene for diterpenoid tanshinone biosynthesis in Salvia miltiorrhiza Bge. f. alba
Keywords: Salvia miltiorrhiza Bge. f. alba; SmHDR1; Expression profiling; Tanshinones; Hairy root; CTAB; cetyltrimethylammonium bromide; DMAPP; dimethylallyl diphosphate; DXR; 1-deoxy-d-xylulose 5-phosphate reductoisomerase; DXS; 1-deoxy-d-xylulose 5-phosphate synt
Methylerythritol phosphate pathway to isoprenoids: Kinetic modeling and in silico enzyme inhibitions in Plasmodium falciparum
Keywords: BLAST; basic local alignment search tool; BLAST-P; protein BLAST; CCC; concentration control coefficient; CDPME; 4-(cytidine 5â²-diphospho)-2-C-methyl-d-erythritol; CDPMEK; 4-(cytidine 5â²-diphospho)-2-C-methyl-d-erythritol kinase; CDPMES; 4-(cytidine 5
Contents of therapeutic metabolites in Swertia chirayita correlate with the expression profiles of multiple genes in corresponding biosynthesis pathways
Keywords: 7-DLGT; 7-deoxyloganetic acid glucosyl transferase; 8-HGO; 8-hydroxygeraniol oxidoreductase; AAC; acetyl-CoA carboxylase; AACT; acetoacetyl-CoA thiolase; ADH; arogenate dehydrogenase; ADT; prephenate dehydratase; C3H; p-coumarate 3-hydroxylase; C4H; trans
Assessment of the mutagenic, recombinagenic and carcinogenic potential of orlistat in somatic cells of Drosophila melanogaster
Keywords: BH; balanced heterozygote descendants; CYP3A4; cytochrome P450 3A4; DXR; doxorubicin; FAS; fatty acid synthase enzyme; FDA; Food and Drug Administration; GSH; glutathione; HB; high bioactivation cross; MH; marked trans heterozygous descendants; Sb; stubbl
The single cellular green microalga Botryococcus braunii, race B possesses three distinct 1-deoxy-d-xylulose 5-phosphate synthases
Keywords: MEP; methylerythritol 4-phosphate; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; IPP; isopentenyl diphosphate; DMAPP; dimethylally diphosphate; MVA; mevalonate; DXP; 1-deoxy-d-xylulose 5-phosphate; NTR; non-translated region; TLC; thin-layer chromatograph
A raison d'être for two distinct pathways in the early steps of plant isoprenoid biosynthesis?
Keywords: AACT; acetoacetyl-coenzyme A thiolase; Ac-CoA; acetyl-coenzyme A; AcAc-CoA; acetoacetyl-coenzyme A; ADP; adenosine diphosphate; ATP; adenosine triphosphate; CDP-ME; 4-diphosphocytidyl-2C-methyl-d-erythritol; CDP-MEP; 4-diphosphocytidyl-2C-methyl-d-erythri
Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs
Keywords: Nonmevalonate pathway; Dxr; Antibiotic; Mycobacterium tuberculosis
Substitution of the phosphonic acid and hydroxamic acid functionalities of the DXR inhibitor FR900098: An attempt to improve the activity against Mycobacterium tuberculosis
Keywords: Tuberculosis; DXR; Enzyme inhibitor; Fosmidomycin; FR900098;
Foliar application of chitosan activates artemisinin biosynthesis in Artemisia annua L.
Keywords: ADS; amorpha-4,11-diene synthase; APX; ascorbate peroxidase; CAT; catalase; CPY71AV1; cytochrome P450 monooxygenase; DBR2; artemisinic aldehyde reductase; DMAPP; dimethylallyl diphosphate; DW; dry weight; DXS; 1-deoxy-d-xylulose 5-phosphate synthase; DXR;
Different roles of p53 in the regulation of DNA damage caused by 1,2-heteroannelated anthraquinones and doxorubicin
Keywords: DXR; doxorubicin; DNMT; DNA methyltransferase; HDAC1; histone deacetylase 1; NCI 60; National Cancer Institute 60; NSC number; the NCI's internal ID number; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; FACS; fluorescence activated ce
Functional genetic analysis of the Plasmodium falciparum deoxyxylulose 5-phosphate reductoisomerase gene
Keywords: DXP; deoxyxylulose 5-phosphate; DXR; deoxyxylulose phosphate reductoisomerase; MEP; 2C-methyl-d-erythritol 5-phosphate; PCR; polymerase chain reaction; Malaria; Isoprenoid biosynthesis; Drug targets;
Crystal structure of 1-deoxy-d-xylulose 5-phosphate reductoisomerase from the hyperthermophile Thermotoga maritima for insights into the coordination of conformational changes and an inhibitor binding
Keywords: Conformational changes; DXR; Fosmidomycin; Kinetics; The MEP pathway; Protein crystal structure
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.
Keywords: AAR; artemisinic aldehyde Î11(13) reductase; ADS; amorpha-4,11-diene synthase; CYP71AV1; amorpha-4,11-diene hydroxylase; DXR; 1-deoxy-d-xylulose-5-phosphate reductoisomerase; FPP; farnesyl diphosphate; FPPS; farnesyl diphosphate synthase; GST; glandular