Role of Tau Protein in Neuronal Damage in Alzheimer's Disease and Down Syndrome
Keywords: Down syndrome; Alzheimer's disease; Tau protein; Amyloid precursor protein; Dyrk1A; Rcan
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Regulation of alternative splicing of tau exon 10 by 9G8 and Dyrk1A
Keywords: Tau; Alternative splicing; 9G8; Dyrk1A; Neurodegeneration;
Altered regulation of tau phosphorylation in a mouse model of down syndrome aging
Keywords: Alzheimer disease; Down syndrome; Tau; DYRK1A; GSK-3β; Phosphorylation;
Synthesis of chromeno[3,4-b]indoles as Lamellarin D analogues : A novel DYRK1A inhibitor class
Keywords: Lamellarin; Indoles; Kinase; DYRK1A; Topoisomerase inhibition
Potent and selective small molecule inhibitors of specific isoforms of Cdc2-like kinases (Clk) and dual specificity tyrosine-phosphorylation-regulated kinases (Dyrk)
Keywords: Clk1; Clk2; Clk3; Clk4; Dyrk1A; Dyrk1B; Pre-mRNA splicing; Kinase inhibition; Quinazoline
The small molecule harmine regulates NFATc1 and Id2 expression in osteoclast progenitor cells
Keywords: DYRK1A; Harmine; Id2; NFATc1; Osteoclast; Small molecule;
DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation
Keywords: DYRK; dual-specificity tyrosine-phosphorylation regulated protein kinase dual-specificity YAK1-related protein kinase; WDR; WD repeat; Hsp; heat shock protein; PARP; poly-ADP ribose polymerase; DYRK1A; WDR68; WD40-repeat; Down's syndrome; Nuclear transloc
Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3β
Keywords: NFTs; neurofibrillary tangles; AD; Alzheimer's disease; MAP; microtubule-associated protein; GSK3β; glycogen synthase kinase-3β; PP2A; protein phosphatase-2A; CDK5; cyclin-dependent kinase-5; DYRK1A; dual-specificity tyrosine-phosphorylation regulated
Neurodegeneration, Neuroprotection, and Disease-Oriented NeuroscienceResearch PaperForm of dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A nonphosphorylated at tyrosine 145 and 147 is enriched in the nuclei of astroglial cells, adult hip
Keywords: Down syndrome; Ts65Dn mice; DYRK1A; phosphorylation; brain tissue; BrdU; 5-bromo-2-deoxyuridine; ChAT; choline acetyltransferase; DS; Down syndrome; DYRK1A; dual-specificity tyrosine-(Y)-phosphorylation-regulated kinase 1A; ECL; enhanced chemiluminescence
Synthesis and biological evaluation of new 3-(6-hydroxyindol-2-yl)-5-(Phenyl) pyridine or pyrazine V-Shaped molecules as kinase inhibitors and cytotoxic agents
Keywords: Indole; Pyridine; Pyrazine; CDK; GSK3; DYRK1A; Cytotoxicity; Molecular modeling;
Effect of hyperhomocysteinemia on the protein kinase DYRK1A in liver of mice
Keywords: Homocysteine; Cystathionine beta synthase; Mice; DYRK1A; Calpains
Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)
Keywords: Kinase inhibition; Pre-mRNA splicing; Clk; Dyrk1A
Synthesis and kinase inhibitory activity of novel substituted indigoids
Keywords: Indirubin; Cyclin-dependent kinases; Glycogen synthase kinase-3; Casein kinase 1; DYRK1A; Alzheimer’s disease
Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
Keywords: DYRK1A; Aging; Visuo-spatial learning and memory; Motor dysfunction; Radial-arm water maze
Increased NR2A expression and prolonged decay of NMDA-induced calcium transient in cerebellum of TgDyrk1A mice, a mouse model of Down syndrome
Keywords: Down syndrome; DYRK1A; NMDA receptors; Cerebellum; Motor phenotype; Murine models; Microarrays
The down syndrome candidate dual-specificity tyrosine phosphorylation-regulated kinase 1A phosphorylates the neurodegeneration-related septin 4
Keywords: trisomy 21; scaffold; protein interaction; harmine; DYRK1A; SEPT4; AD; Alzheimer disease; CC; coiled-coil; DIG; digoxigenin; dox; doxycycline; DS; Down syndrome; DYRK1A; dual-specificity tyrosine phosphorylation-regulated kinase 1A; GST; glutathione S-tra
DYRK1A stabilizes HPV16E7 oncoprotein through phosphorylation of the threonine 5 and threonine 7 residues
Keywords: DYRK1A; Human papillomavirus; E7; Phosphorylation; Protein stability
Cloning and expression of PDK4, FOXO1A and DYRK1A from the hibernating greater horseshoe bat (Rhinolophus ferrumequinum)
Keywords: PDK4; FOXO1A; DYRK1A; Northern blot; Hibernate; Rhinolophus ferrumequinum
Dyrk1A overexpression in immortalized hippocampal cells produces the neuropathological features of Down syndrome
Keywords: Dyrk1A; Down syndrome; Alzheimer's disease; Amyloid precursor protein; Amyloid-β; Tau; Apoptosis; Neuronal differentiation
Putative therapeutic agents for the learning and memory deficits of people with Down syndrome
Keywords: Down syndrome; Learning and memory deficits; DYRK1A; Inhibitor; Pharmacophore
DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects
Keywords: Down syndrome; DYRK1A; Mental retardation; Learning and memory; Transgenic mice; Bacterial artificial chromosome
HAN11 binds mDia1 and controls GLI1 transcriptional activity
Keywords: Actin; DYRK1A; GLI1; HAN11; mDia1
Features and potentials of ATP-site directed CK2 inhibitors
Keywords: CK2; casein kinase 2; Dyrk1A; dual specificity tyrosine phosphorylation-regulated kinase; DMAT; 4,5,6,7-tetrabromo-2-(dimethylamino)benzimidazole; GSK3; glycogen synthase kinase 3; HSP90; heat shock protein; MNX; 1,8-dihydroxy-4-nitro-xanthen-9-one; PI3 k
Dual-specificity tyrosine-phosphorylated and regulated kinase 1A (DYRK1A) interacts with the phytanoyl-CoA α-hydroxylase associated protein 1 (PAHX-AP1), a brain specific protein
Keywords: CREB; c-AMP-response element binding protein; DS; Down syndrome; DSCR; Down syndrome critical region; DYRK1A; dual-specificity tyrosine-phosphorylated and regulated kinase 1A; eIF2BÉ; eukaryotic initiation factor 2B epsilon; FKHR; forkhead in rhabdomyosa