کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3070818 1580754 2006 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
پیش نمایش صفحه اول مقاله
DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defects
چکیده انگلیسی

Among the various phenotypes seen in Down syndrome (DS), mental retardation is the most common and most debilitating condition suffered by individuals with DS. The DYRK1A gene on human chromosome 21q22.2 encodes a subfamily of protein kinases that displays dual substrate specificities and is known to play a critical role in neurodevelopment. To study DS mental retardation, we have generated transgenic mice that contain only one copy of the complete human DYRK1A gene in a bacterial artificial chromosome. The transgenic mice showed significant impairment in hippocampal-dependent memory tasks in a Morris water maze. Interestingly, we observed shifts in both long-term potentiation and long-term depression, which suggests a role for DYRK1A in bidirectional synaptic plasticity. These mice represent the most clinically relevant DYRK1A mouse model to date and provide us a valuable tool for the in vivo study of mechanisms that underlie the learning and memory deficit in DS.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 22, Issue 3, June 2006, Pages 463–472
نویسندگان
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