Therapeutic targeting of chemokine signaling in Multiple Sclerosis
Keywords: Multiple Sclerosis; Chemokines; EAE; T cells; Blood-brain barrier
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Radiobinding assay for detecting autoantibodies to single epitopes
Keywords: JM1; epitope corresponding to IA-2609-621; JM2; epitope corresponding to IA-2619-631; JM3; epitope corresponding to IA-2609-631; RBA; radiobinding assay; EAE; experimental allergic encephalitis; MOG; myelin oligodendrocyte glycoprotein; TrxA; thiore
Dendritic cell CD83: A therapeutic target or innocent bystander?
Keywords: BSA; bovine serum albumin; CD83-IgG1; extracellular domain of CD83 fused to Fc portion of human IgG1; CD83ext; CD83 extracellular domain; DCs; dendritic cells; EAE; experimental autoimmune encephalomyelitis; GST; glutathione S-transferase; hCD83; human CD
Expression of glutamate transporters GLT-1 and GLAST in different regions of rat brain during the course of experimental autoimmune encephalomyelitis
Keywords: EAE; excitatory amino acid transporters; glutamate excitotoxicity; multiple sclerosisANOVA, analysis of variance; bp, base pair; EAAT, excitatory amino acid transporter; EAE, experimental autoimmune encephalomyelitis; GAPDH, glyceraldehyde 3-phosphate deh
The Peyer's patch is a critical immunoregulatory site for mucosal tolerance in experimental autoimmune encephalomylelitis (EAE)
Keywords: Autoimmunity; EAE/MS; Tolerance; T cell receptors; Peyer's patch; EAE; experimental autoimmune encephalomyelitis; MS; multiple sclerosis; MBP; myelin basic protein; CNS; central nervous system; PP; Peyer's patches; CFSE; 5,6-carboxy-succinimidyl-fluorensc
Production and functions of IL-17 in microglia
Keywords: Cytokine; IL-17; EAE; MS; Microglia
Ribavirin ameliorates experimental autoimmune encephalomyelitis in rats and modulates cytokine production
Keywords: MS;; EAE;; Ribavirin;; Cytokines
Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis
Keywords: Multiple sclerosis; EAE; Metabotropic glutamate receptors; Purkinje cells
Targeting the tetraspanin CD81 blocks monocyte transmigration and ameliorates EAE
Keywords: Tetraspanins; CD81; Multiple sclerosis; Transendothelial migration; Therapeutic antibodies; EAE
Mannosylation of mutated MBP83–99 peptides diverts immune responses from Th1 to Th2
Keywords: MS; H2-As; Vaccine; Modeling; Binding motif; Mannan; MBP; EAE
Gene expression analysis of normal appearing brain tissue in an animal model for multiple sclerosis revealed grey matter alterations, but only minor white matter changes
Keywords: EAE; Neuroprotection; Inflammation; MS; NAWM; NAGM
Cellular responses in the spinal cord during development of hypomyelination in the mv rat
Keywords: EGF; epidermal growth factor; CNS; central nervous system; PLP; proteolipid protein; GFAP; glial fibrillary acidic protein; PCR; polymerase chain reaction; PFA; paraformaldehyde; PB; phosphate buffer; PBS; phosphate-buffered saline; CNPase; 2â², 3â²-cyc
Prevention of axonal injury using calpain inhibitor in chronic progressive experimental autoimmune encephalomyelitis
Keywords: Axon; Calpain; Calpain inhibitor; EAE; MS
Differential effects of decoy chemokine (7ND) gene therapy on acute, biphasic and chronic autoimmune encephalomyelitis: Implication for pathomechanisms of lesion formation
Keywords: EAE; experimental autoimmune encephalomyelitis; CNS; central nervous system; MBP; myelin basic protein; MO; monocyte; MOG; myelin oligodendrocyte glycoprotein; MP; macrophage; PI; post-immunization; RR; relapsing-remitting; SC; spinal cord; SP; secondar
Glial reactions and degeneration of myelinated processes in spinal cord gray matter in chronic experimental autoimmune encephalomyelitis
Keywords: multiple sclerosis; inflammation; mouse; degeneration; demyelination; AIF1; allograft inflammatory factor; APC-CC1; adenomatous polyposis coli gene clone CC1; CFA; complete Freund's adjuvant; ChAT; choline acetyl transferase; DAB; diaminobenzidine; EAE; e
IL-21 receptor expression determines the temporal phases of experimental autoimmune encephalomyelitis
Keywords: IL-21 receptor; EAE; Autoimmunity; CD4+CD25+ regulatory T cells; NK cells
Bowman–Birk inhibitor suppresses autoimmune inflammation and neuronal loss in a mouse model of multiple sclerosis
Keywords: Multiple sclerosis; EAE; Serine proteases; Bowman–Birk inhibitor; Neuroprotection; Neuroimmunology
MRI of optic neuritis in a rat model
Keywords: BBB; blood-brain barrier; BN; Brown Norway; CFA; complete Freund's adjuvant; EAE; experimental autoimmune encephalomyelitis; HE; hematoxylin and eosin; LFB; luxol fast blue; MOG; myelin oligodendrocyte glycoprotein; MRI; magnetic resonance imaging; MT;
Mast cell activation by myelin through scavenger receptor
Keywords: EAE; Myelin; Mast cells; Multiple sclerosis
Comparing the CNS morphology and immunobiology of different EAE models in C57BL/6 mice - A step towards understanding the complexity of multiple sclerosis
Keywords: Autoimmunity; C57BL/6 mice; EAE/MS; Histopathology; Immune response; Neuroimmunology; APC; antigen-presenting cell; B6; C57BL/6; CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; KO; knock-out; MBP; myelin basic protein; MOG; my
2,3-Benzodiazepine-type AMPA receptor antagonists and their neuroprotective effects
Keywords: ABP; AMPA receptor-binding protein; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; CAMK-II and IV; Ca2+-calmodulin kinase II and IV; EAE; experimental autoimmune encephalomyelitis; EGIS-8332; (±)-1-(4-aminophenyl)-3-acetyl-4-cyano-4-meth
Complement in experimental autoimmune encephalomyelitis revisited: C3 is required for development of maximal disease
Keywords: Complement; C3; EAE
Highlights From the Combined Society of Urodynamics and Female Urology, and International Society of Pelvic Neuromodulation Annual Meeting
Keywords: congress; urodynamics; urinary incontinence; female; prostate; AUR; acute urinary retention; AUS; artificial urinary sphincter; DO; detrusor overactivity; EAE; experimental autoimmune encephalitis; IC; interstitial cystitis; I-PSS; International Prostate
The role of poly(ADP-ribose) polymerase-1 in CNS disease
Keywords: DNA; transcription; inflammation; cell death; oxidative stress; AIF; apoptosis-inducing factor; DPQ 3; 4-dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone; EAE; experimental allergic encephalomyelitis; GPI 6150; 1,11b-dihydro-[2H]benzopyrano[4,3,2-
Elevation of matrix metalloproteinases (MMPs) in multiple sclerosis and impact of immunomodulators
Keywords: EAE; Interferon-beta; Metalloproteinases; Minocycline; Multiple sclerosis
CD8+ T cells in inflammatory demyelinating disease
Keywords: CD8; Interferon-gamma; Interleukin-17; MS; EAE; T cells
Short-term sPECAM-Fc treatment ameliorates EAE while chronic use hastens onset of symptoms
Keywords: PECAM-1; EAE; sPECAM-Fc; MS; Cellular migration
Disruption of the β2-integrin CD11d (αDβ2) gene fails to protect against experimental autoimmune encephalomyelitis
Keywords: Adhesion molecules; β2-integrins; EAE; Neuroimmunology
An interferon-γ-producing Th1 subset is the major source of IL-17 in experimental autoimmune encephalitis
Keywords: T cell differentiation; IL-17; Interferon-γ; EAE
A chimeric TCR-β chain confers increased susceptibility to EAE
Keywords: TCR; TH1/TH2; EAE;
CD4+CD25+ regulatory T cells contribute to the therapeutic effects of glatiramer acetate in experimental autoimmune encephalomyelitis
Keywords: EAE; CD4+CD25+ regulatory T cells; GA
Selective vulnerability of cerebral white matter in a murine model of multiple sclerosis detected using diffusion tensor imaging
Keywords: EAE; MOG; DTI; Visual pathway; Optic nerve; Optic tract; Mouse brain; Axonal damage; Myelin damage; Directional diffusivity
Control of experimental autoimmune encephalomyelitis by CD4+ suppressor T cells: Peripheral versus in situ immunoregulation
Keywords: EAE; Tolerance; Suppressor T cells; Autoimmunity; Epicutaneous immunization
Lipopolysaccharide pretreatment modulates the disease course in experimental autoimmune encephalomyelitis
Keywords: EAE; Multiple sclerosis; LPS; Anti-inflammatory mediators; Antigen presentation
Effects of progesterone in the spinal cord of a mouse model of multiple sclerosis
Keywords: EAE; Multiple sclerosis; Progesterone; Myelination; Neuroprotection
The contribution of nitric oxide and interferon gamma to the regulation of the neuro-inflammation in experimental autoimmune encephalomyelitis
Keywords: Nitric oxide; EAE; Interferon gamma; Regulation
Research reportFTY720 sustains and restores neuronal function in the DA rat model of MOG-induced experimental autoimmune encephalomyelitis
Keywords: EAE; Evoked potential; Fingolimod; FTY720; Multiple sclerosis; Sphingosine-1 phosphate;
Inflammation and dephosphorylation of the tight junction protein occludin in an experimental model of multiple sclerosis
Keywords: blood–brain barrier; experimental autoimmune encephalomyelitis; EAE; kinase; edema; signalingBBB, blood–brain barrier; d.p.i., days post-immunization; DTT, dithiothreitol; EAE, experimental autoimmune encephalomyelitis; Glut-1, glucose transporter-1; IGTP
CD44 variant DNA vaccination with virtual lymph node ameliorates experimental autoimmune encephalomyelitis through the induction of apoptosis
Keywords: EAE; Multiple sclerosis; Autoimmunity; CD44; DNA vaccination; Apoptosis
Neurodegeneration in autoimmune demyelination: Recent mechanistic insights reveal novel therapeutic targets
Keywords: MS; EAE; Neuronal damage; HMG-CoA reductase; EGCG; TRAIL
A model of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice for the characterisation of intervention therapies
Keywords: EAE; Multiple sclerosis; Model; Inflammation
Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency
Keywords: CD4+ T cell; CD8+ T cell; EAE; Immunoproteasome
Beta-interferon unbalances the peripheral T cell proinflammatory response in experimental autoimmune encephalomyelitis
Keywords: IFNβ; EAE; NFκB; Stat6; IL-4; IL-17
Effect of DAB389IL-2 immunotoxin on the course of experimental autoimmune encephalomyelitis in Lewis rats
Keywords: EAE; IL-2; DAB389IL-2; Immunotoxin; Immunotherapy
PD-1/PD-L1, but not PD-1/PD-L2, interactions regulate the severity of experimental autoimmune encephalomyelitis
Keywords: EAE; Multiple sclerosis; Costimulation; PD-1; PD-L1; PD-L2
Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS
Keywords: ATP; adenosine triphosphate; bHLH; basic helix-loop-helix; BMP; bone morphogenic protein; BrdU; bromodeoxy uridine; CD44; cell determinant-44; CNPase; 2â²,3â²-cyclic nucleotide 3â²-phosphodiesterase; CNTF; ciliary neurotrophic factor; CXCR4; receptor f
The PD-1/PD-L pathway is up-regulated during IL-12-induced suppression of EAE mediated by IFN-gamma
Keywords: EAE; Autoimmunity; PD-1/PD-L; Cytokines; Antigen presenting cells
Cross-reactivity between peptide mimics of the immunodominant myelin proteolipid protein epitope PLP139-151: Comparison of peptide priming in CFA vs. viral delivery
Keywords: Multiple sclerosis; T cell; Autoimmunity; EAE; Molecular mimicry;
Protease-activated receptors in the brain: Receptor expression, activation, and functions in neurodegeneration and neuroprotection
Keywords: 6-OHDA; 6-hydroxydopamine; AD; Alzheimer's disease; AP; activating peptide; EAE; experimental autoimmune encephalomyelitis; ERK1/2; extracellular signal-regulated kinase 1/2; GPX; glutathione peroxidase; GRO/CINC-1; growth-regulated oncogene/cytokine-indu
The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys
Keywords: Primate; CMV; Autoimmunity; EAE; ADEM; MS;