کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8462827 | 1549041 | 2008 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparing the CNS morphology and immunobiology of different EAE models in C57BL/6 mice - A step towards understanding the complexity of multiple sclerosis
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کلمات کلیدی
EAEMP4PLPAPCMOGMBPC57BL/6 - C57BL / 6EAE/MS - EAE / MSProteolipid protein - Proteolipid پروتئینantigen-presenting cell - آنتیژن ارائه سلولexperimental autoimmune encephalomyelitis - آنسفالومیلیت خودایمنی تجربیautoimmunity - خودایمنیCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیNeuroimmunology - عصب شناسیC57BL/6 mice - موش C57BL / 6Multiple sclerosis - مولتیپل اسکلروزیس(ام اس)knock-out - ناک اوتwild type - نوع وحشیHistopathology - هیستوپاتولوژیImmune response - پاسخ یا واکنش ایمنیMyelin basic protein - پروتئین پایه میلینmyelin oligodendrocyte glycoprotein - گلیکوپروتئین الیگودندروسیت میلین
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Multiple sclerosis (MS) is a chronic neurodegenerative disease that causes central nervous system (CNS) inflammation and demyelination, affecting approximately two million people worldwide. In humans, different subtypes of the disease have been noted, characterized by distinct clinical courses and different histopathological manifestations. These disease variants likely result from the targeting of different neuroantigens in the CNS and possibly from the involvement of different effector arms of the immune system such as CD4+ and CD8+ T cells as well as autoantibodies. Mechanistic studies addressing the pathomechanisms of MS involve experimental autoimmune encephalomyelitis (EAE) in which immunization with neuroantigens is used to elicit the disease. Mechanism-oriented studies of EAE rely mostly on gene-modified mice on the C57BL/6 (B6) background. Here, we discuss how a systematic immuno- and histopathological comparison of the presently available EAE models on the B6 background, i.e. myelin basic protein-proteolipid protein (MBP-PLP) fusion protein (MP4)-, myelin oligodendrocyte glycoprotein (MOG) peptide 35-55- and PLP peptide 178-191-induced EAE, can facilitate our understanding of the complexity of MS. We point out how the development of further models on this basis can help cover the plethora of disease manifestations seen in MS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 190, Issue 1, 28 February 2008, Pages 1-15
Journal: Annals of Anatomy - Anatomischer Anzeiger - Volume 190, Issue 1, 28 February 2008, Pages 1-15
نویسندگان
Stefanie Kuerten, Doychin N. Angelov,