Keywords: CKD; Adaptation; Deterioration; MTORC/AKT; EGFR; ER stress; LCN2
مقالات ISI (ترجمه نشده)
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Keywords: NADPH oxidase; NOX/DUOX; EGFR; Tyrosine phosphatase; Tyrosine kinase; Cysteine oxidation
Keywords: BCR-ABL; breakpoint cluster region-Abelson tyrosine-protein kinase; CD95/FAS; cluster of differentiation 95/cell surface death receptor; DDR1; discoidin domain receptor tyrosine kinase 1; EGFR; epidermal growth factor receptor tyrosine kinase; EF1A2; euka
Keywords: AAV; adeno-associated viruses; Ad; adenovirus; CTGVT; cancer targeting gene-viro-therapy; EGFR; epidermal growth factor receptor; EPCs; endothelial precursor cells; GAOVT; gene armed oncolytic virus therapy; GCV; ganciclovir; HRE; hypoxia responsive eleme
Dual-mixed/CMC model for screening target components from traditional Chinese medicines simultaneously acting on EGFR & FGFR4 receptors
Keywords: TCM; traditional Chinese medicine; DS; Radix Salviae Miltiorrhiaeis; EGFR; epidermal growth factor receptor; FGFR4; fibroblast growth factor receptors 4; CMC; cell membrane chromatography; HPLC-ESI-IT-TOF-MSn; high performance liquid chromatography-electr
ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition
Keywords: Cataract; Fibrosis; Myofibroblast; Transforming growth factor-beta (TGFβ); Epithelial-mesenchymal transition (EMT); EGFR; ERK1/2; Smad;
T-cell receptor gene therapy - ready to go viral?
Keywords: T-cell receptor; Gene therapy; Cancer; Immunotherapy; T cell; ACT; adoptive cell therapy; allo-SCT; allogeneic stem cell transplantation; APC; antigen-presenting cell; BLAST; basic local alignment search tool; CAR; chimeric antigen receptor; CTL; cytotoxi
MicroRNA-218-5p inhibit the migration and proliferation of pterygium epithelial cells by targeting EGFR via PI3K/Akt/mTOR signaling pathway
Keywords: Pterygium; MiR-218-5p; EGFR; hPECs;
CDH17 alters MMP-2 expression via canonical NF-κB signalling in human gastric cancer
Keywords: GC; gastric cancer; CDH17; cadherin-17; CDH; cadherin; siRNA; short-interfering RNA; MMP2; matrix metallopeptidase 2; NF-κB; nuclear factor-kappaB; HER2; human epidermal growth factor receptor-2; EGFR; epidermal growth factor receptor; PI3K/AKT/mTOR; pho
Case Report: Osimertinib achieved remarkable and sustained disease control in an advanced non-small-cell lung cancer harboring EGFR H773L/V774M mutation complex
Keywords: EGFR; Complex mutations; Tyrosine kinase inhibitors; Non-small cell lung cancer; Osimertinib;
LncRNA HOXA-AS2 and its molecular mechanisms in human cancer
Keywords: lncRNA; HOXA-AS2; Diagnosis; Therapeutic target; Prognosis; APL; Acute promyelocytic leukemia; ATRA; All trans retinoic acid; Bax; BCL2-Associated X; BC; Breast cancer; Bcl-2; B-cell lymphoma-2; c-Myc; MYC proto-oncogene; CRC; Colorectal cancer; DDIT3; DN
Withanolide A extends the lifespan in human EGFR-driven cancerous Caenorhabditis elegans
Keywords: EGFR; Tumor; Lifespan; Fat deposition; Withanolide A; C. elegans;
Long-term outcomes with agalsidase alfa enzyme replacement therapy: Analysis using deconstructed composite events
Keywords: eGFR; estimated glomerular filtration rate; ERT; enzyme replacement therapy; FOS; Fabry Outcome Survey; LVH; left ventricular hypertrophy; NE; not estimable; Fabry disease; Enzyme replacement therapy; Agalsidase alfa; Long-term effectiveness;
EGFR and HER3 signaling blockade in invasive mucinous lung adenocarcinoma harboring an NRG1 fusion
Keywords: Invasive mucinous adenocarcinoma; NRG1; EGFR; HER3;
Percutaneous Cryoablation of Solitary, Sporadic Renal Cell Carcinoma: Outcome Analysis Based on Clear-Cell versus Papillary Subtypes
Keywords: AUA; American Urologic Association; ccRCC; clear-cell renal cell carcinoma; eGFR; estimated glomerular filtration rate; PCA; percutaneous cryoablation; pRCC; papillary renal cell carcinoma; RCC; renal cell carcinoma;
Impact of a comprehensive geriatric assessment to manage elderly patients with locally advanced non-small-cell lung cancers: An open phase II study using concurrent cisplatin-oral vinorelbine and radiotherapy (GFPC 08-06)
Keywords: ALK; anaplastic lymphoma kinase gene; CGA; comprehensive geriatric assessment; CT; computed-tomography scan; EGFR; epidermal growth-factor; ECOG PS; Eastern Cooperative Oncology Group performance status; La-NSCLC; locally advanced non-small-cell lung ca
Acquired EGFR L718V mutation mediates resistance to osimertinib in non-small cell lung cancer but retains sensitivity to afatinib
Keywords: EGFR; L718V; Osimertinib; Afatinib; Resistance; NSCLC;
Oncogenic DIRAS3 promotes malignant phenotypes of glioma by activating EGFR-AKT signaling
Keywords: DIRAS3; Glioma; EGFR; Akt;
The EUROpean and Chinese cardiac and renal Remote Ischemic Preconditioning Study (EURO-CRIPS CardioGroup I): A randomized controlled trial
Keywords: CIN; contrast-induced nephropathy; PCI; percutaneous coronary intervention; STEMI; ST segment elevation myocardial infarction; NAC; N-acetylcysteine; eGFR; estimated glomerular filtration rate; CRF; Case Report Form; CK-MB; creatine kinase-muscle brain; P
Predictors of 10-year changes in levels of N-terminal pro B-type natriuretic peptide and cardiac troponin I in the elderly
Keywords: cTnI; cardiac troponin I; CHS; Cardiovascular Health Study; CRP; C-reactive protein; CV; cardiovascular; eGFR; estimated glomerular filtration rate; LA; left-atrial; LV; left-ventricular; LVEF; left-ventricular ejection fraction; NT-proBNP; N-terminal pro
The effect on thrombin generation and anti-Xa levels of thromboprophylaxis dose adjustment in post-cesarean obese patients - A prospective cohort study
Keywords: EBL; estimated blood loss; eGFR; estimated glomerular filtration rate; ETP; endogenous thrombotic potential; BMI; body mass index; LMWH; low-molecular weight heparin; VTE; venous thromboembolism; Postpartum thromboprophylaxis; Obesity; Dose adjustment; Lo
MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression
Keywords: microRNA; OSCC; SHP2; EGFR; Proliferation; Apoptosis;
Graft immunologic events in deceased donor kidney transplant recipients with preformed HLA-donor specific antibodies
Keywords: Kidney transplant; Deceased donor; Acute rejection; Donor-specific antibodies; HLA-antibodies; %PRA; panel reactive antibody percentage; AMR; antibody mediated rejection; ACR; acute cellular rejection; AR; acute rejection; CDC; complement-dependent cytoto
Colorectal signet ring cell carcinoma: Influence of EGFR, E-cadherin and MMP-13 expression on clinicopathological features and prognosis
Keywords: Colorectal signet ring carcinoma; EGFR; E-cadherin; MMP-13; Prognosis;
Les thérapies ciblées per os
Keywords: angiogenèse; BCR/ABL; BRAF; EGFR; inhibiteur de kinase; MEK; thérapie ciblée; angiogenesis; BCR/ABL; BRAF; EGFR; kinase inhibitor; MEK; targeted therapy;
Assessment of EGFR mutation status in Tunisian patients with pulmonary adenocarcinoma
Keywords: EGFR; ALK; Non-small cell lung cancer; Adenocarcinoma; Real-time polymerase chain reaction;
Radiosynthesis and biological evaluation of 18F-labeled 4-anilinoquinazoline derivative (18F-FEA-Erlotinib) as a potential EGFR PET agent
Keywords: Fluorine-18; 4-Anilinoquinazolines; 18F-FEA-Erlotinib; EGFR; PET imaging;
Crystal structure of EGFR T790M/C797S/V948R in complex with EAI045
Keywords: EGFR; T790M; C797S; Drug-resistance; EAI045;
A phase I trial of afatinib and bevacizumab in chemo-naïve patients with advanced non-small-cell lung cancer harboring EGFR mutations: Okayama Lung Cancer Study Group Trial 1404
Keywords: Non-small-cell lung cancer; EGFR; Bevacizumab; Afatinib; EGFR-TKI; Phase Ib;
Balance between angiogenic and anti-angiogenic isoforms of VEGF-A is associated with the complexity and severity of coronary artery disease
Keywords: CAD; coronary artery disease; SS; Syntax Score; VEGF-A; vascular endothelial growth factor-A; PCI; percutaneous coronary intervention; AP; angina pectoris; ACS; acute coronary syndrome; HD; hemodialysis; HbA1c; glycosylated hemoglobin; eGFR; estimated glo
Tumor biomarker testing in non-small-cell lung cancer: A decade of change
Keywords: Lung cancer; Adenocarcinoma; Biomarker testing; Smoking history; EGFR; ALK;
PD-L1 expression according to the EGFR status in primary lung adenocarcinoma
Keywords: PD-L1; EGFR; Lung adenocarcinoma;
High ratio of T790M to EGFR activating mutations correlate with the osimertinib response in non-small-cell lung cancer
Keywords: EGFR; T790M; Osimertinib; ddPCR;
Clinical characteristics of T790M-positive lung adenocarcinoma after resistance to epidermal growth factor receptor-tyrosine kinase inhibitors with an emphasis on brain metastasis and survival
Keywords: Lung cancer; EGFR; T790M; Drug resistance; Osimertinib; Survival; Brain metastasis;
Hypoglycaemia in the over 75s: Understanding the predisposing factors in type 2 diabetes (T2DM)
Keywords: GP; general practitioner; EMIS; Egton Medical Information Systems; BMI; body mass index; HbA1c; glycated haemoglobin; eGFR; estimated glomerular filtration rate; DM; diabetes mellitus; IHD; ischaemic heart disease; (TIA); transient ischaemic attack; (DPP-
Circulating CD34+ and CD34+VEGFR2+ progenitor cells are associated with KLOTHO KL-VS polymorphism
Keywords: ARMS-PCR; amplification refractory mutation system-polymerase chain reaction; eGFR; estimated glomerular filtration rate; eNOS; endothelial nitric oxide synthase; EPCs; endothelial progenitor cells; FGFRs; fibroblast growth factor receptors; MnSOD; ma
Eps8 expression is significantly lower in p16+ head and neck squamous cell carcinomas (HNSCCs) compared with p16â HNSCCs
Keywords: EGFR; Eps8; Oropharyngeal squamous cell carcinoma; Oral cavity squamous cell carcinoma; p16;
Conformationally constrained peptides target the allosteric kinase dimer interface and inhibit EGFR activation
Keywords: Constrained peptide; EGFR; Allosteric inhibitor; Kinase dimerization; Stapled peptide;
Bile acid receptors in the biliary tree: TGR5 in physiology and disease
Keywords: AC; adenylate cyclase; BS; bile salt; BSEP; bile salt export pump (ABCB11); CA; cholic acid/cholate; cAMP; cyclic AMP; CBDL; common bile duct ligation; CCA; cholangiocarcinoma; CDCA; chenodeoxycholic acid/chenodeoxycholate; CD95L; CD95 ligand; CFTR; cysti
Induction of apoptosis by morusin in human non-small cell lung cancer cells by suppression of EGFR/STAT3 activation
Keywords: Morusin; Apoptosis; Non-small cell lung cancer; EGFR; STAT3;
Circadian rhythm of cardiac troponin I and its clinical impact on the diagnostic accuracy for acute myocardial infarction
Keywords: hs-cTnT; high-sensitivity cardiac troponin T; AMI; acute myocardial infarction; AUC; area under the curve; s-cTnI; sensitive cardiac troponin I; hs-cTnI; high-sensitivity cardiac troponin I; ECG; electrocardiography; APACE; Advantageous Predictors of Acut
Evaluation of the CKD-EPI creatinine based glomerular filtration rate estimating equation in Black African and Indian adults in KwaZulu-Natal, South Africa
Keywords: eGFR; CKD-EPI; MDRD; South Africa;
An extended phase Ib study of epertinib, an orally active reversible dual EGFR/HER2 tyrosine kinase inhibitor, in patients with solid tumours
Keywords: Epertinib; S-222611; EGFR; HER2; Tyrosine kinase inhibitor;
Factors associated with gene aberration test status and treatment decision in patients with unresectable Stage IIIB/IV nonsquamous non-small cell lung cancer: A multicenter survey in China (CTONG 1506)
Keywords: ALK; anaplastic lymphoma kinase; CI; confidence interval; CTONG; Chinese Thoracic Oncology Group; ECOG; Eastern Cooperative Oncology Group; EGFR; epidermal growth factor receptor; MERAF; Medical Record Abstraction Form; NSCLC; non-small cell lung cancer;
Phase II study of tailored S-1 monotherapy with a 1-week interval after a 2-week dosing period in elderly patients with advanced non-small cell lung cancer
Keywords: ALK; anaplastic lymphoma kinase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BSA; body surface area; Ccr; creatinine clearance; CI; confidence interval; CR; complete response; CTCAE; common terminology criteria for adverse events; DCR;
N-terminal pro B-Type natriuretic peptide is inversely correlated with low density lipoprotein cholesterol in the very elderly
Keywords: Natriuretic peptides; Lipid metabolism; LDL-cholesterol; Very elderly; Cardiovascular disease; ADL; activities of daily living; ANP; atrial natriuretic peptide; BMI; body mass index; BNP; B-type natriuretic peptide; BP; blood pressure; BSC-D; duration of
Triptolide inhibits pituitary adenoma cell viability, migration and invasion via ADAM12/EGFR signaling pathway
Keywords: Triptolide; Pituitary adenomas; ADAM12; EGFR;
MYC inhibition increases PD-L1 expression induced by IFN-γ in hepatocellular carcinoma cells
Keywords: CTL; cytotoxic T lymphocytes; EGFR; epidermal growth factor receptor; FACS; fluorescence-activated cell sorting; HCC; hepatocellular carcinomas; Inr; initiator; PD-1; programmed cell death protein-1; PD-L1; programmed cell death-ligand; T-ALL; T cell acut
Medaka igf1 identifies somatic cells and meiotic germ cells of both sexes
Keywords: aa; amino acid residues; igf; insulin-like growth factor; ISH; in situ hybridization; FISH; fluorescence ISH; nt; nucleotide; PGCs; primordial germ cells; cyp19a; P450 aromatase; egfr; epidermal growth factor receptor; cAMP; cyclic adenosine monophosphate
Malondialdehyde-modified LDL-related variables are associated with diabetic kidney disease in type 2 diabetes
Keywords: Malondialdehyde-modified low-density lipoprotein; Type 2 diabetes; Albuminuria; Estimated glomerular filtration rate; Dyslipidemia; AER; albumin excretion rate: BMI, body mass index; CKD; chronic kidney disease; CVD; cardiovascular disease; DPP-4; dipepti