دانلود مقالات ISI درباره Ema + ترجمه فارسی

Clinical data supporting a 2-dose schedule of MenB-FHbp, a bivalent meningococcal serogroup B vaccine, in adolescents and young adults

Keywords: ACIP; Advisory Committee on Immunization Practices; EMA; European Medicines Agency; FDA; US Food and Drug Administration; FHbp; factor H binding protein; GMT; geometric mean titer; HPV; human papillomavirus; hSBA; serum bactericidal assay using human comp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Loss of C/EBP-β LIP drives cisplatin resistance in malignant pleural mesothelioma

Keywords: ANOVA; analysis of variance; ATF6; activating transcription factor 6; C/EBP; CAAT/enhancer binding protein; IRE1; inositol-requiring enzyme 1; CHOP/GADD153; C/EBP homologous protein/growth arrest/DNA damage inducible 153; CEA; carcino-embrionic antigen; C

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Integrated DR and reconfiguration scheduling for optimal operation of microgrids using Hong's point estimate method

Keywords: Microgrids operation; Demand response; Reconfiguration; Hong's PEM; EMA;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2018 سفارش ترجمه

Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives

Keywords: NNSCLC; non-small cell lung cancer; OS; overall survival; EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; ALK; Anaplastic lymphoma kinase; MET; mesenchymal epithelial transition factor; PFS; progression free survival; HER2; human e

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

Quantitative evaluation of the matrix effect in bioanalytical methods based on LC-MS: A comparison of two approaches

Keywords: AAPS; American Association of Pharmaceutical Scientists; CV(%); coefficient of variation; EMA; European Medicines Agency; FDA; U.S. Food and Drug Administration; GLP; good laboratory practice; IS; internal standard; IS-norm; internal standard normalized;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Clinicopathological features of low-grade malignant endolymphatic sac tumors

Keywords: ELST; endolymphatic sac tumor; CK; cytokeratin; EMA; epithelial membrane antigen; Vim; vimentin; CgA; chromogranin A; TTF-1; thyroid transcription factor-1; TG; thyroglobulin; NSE; neuron specific enolase; GFAP; glial fibrillary acidic protein; Syn; synap

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

The construal of experience in HCI: Understanding self-reports

Keywords: Self report; User experience; Design; EMA; Experiencing self; Remembering self; Future self; Behaviour change; Wellbeing; Decision making;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2018 سفارش ترجمه

Automatic segmentation of speech articulators from real-time midsagittal MRI based on supervised learning

Keywords: Real-time MRI; Speech articulation; Articulator segmentation; Multiple Linear Regression; Active Shape Models; Shape Particle Filtering; AAM; Active Appearance Models; ASM; Active Shape Models; EMA; ElectroMagnetic Articulography; fps; frames per second (

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

General model of Photovoltaic (PV) integration into existing public high-rise residential buildings in Singapore - Challenges and benefits

Keywords: PV; Photovoltaic; HDB; Housing & Development Board; MCDM; Multi-Criteria Decision-Making; USEP; Uniform Singapore Energy Price; RES; Renewable energy source; SCBB; Solar Capability Building Programme; DM; Decision Maker; BIPV; Building integrated Photovol

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2018 سفارش ترجمه

High throughput routine determination of 17 tyrosine kinase inhibitors by LC-MS/MS

Keywords: ALL; Acute Lymphoid Leukemia; CML; Chronic Myeloid Leukaemia; CV; Coefficient of Variation; EGFR; Endothelial derived growth factor Receptor; EMA; European Medicines Agency; ER; Extraction Recovery; FDA; Food and Drug Administration; GIST; Gastro Intestin

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial

Keywords: CM; complementary medicine; CT; computerized tomography; DCR; disease control rate; ECOG PS; Eastern Cooperative Oncology Group performance status; EMA; European Medicines Agency; EORTC QLQ-C30; European Organization for Research and Treatment of Cancer Q

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits

Keywords: BW; body weight; CpG; unmethylated 2′ deoxyribo (cytidine-phosphate-guanosine); EFD; embryo-fetal development; EMA; European Medicines Agency; FDA; Food and Drug Administration; G0; day 0 of gestation; GSK; GlaxoSmithKline; HLS; Huntington Life Sciences

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro

Keywords: 95%CI; 95% confidential interval; AB; apical-to-basolateral; ABC; ATP-binding cassette; Abcb1; canine P-glycoprotein; ABCB1; human P-glycoprotein; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; BA; basolateral-t

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Relative potency of fifteen pyrrolizidine alkaloids to induce DNA damage as measured by micronucleus induction in HepaRG human liver cells

Keywords: Pyrrolizidine alkaloids; HepaRG; Genetic toxicology; Micronucleus test; Relative potency factor; Risk assessment; BMD; benchmark dose; CEF; critical effect size; CEDL; lower confidence interval of the critical effect dose; CEDU; upper confidence interval

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma

Keywords: AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; EDTA; ethylenediaminetetraacetic acid; EMA; European Medicines Agency; ESI; electrospray ionization; H1, H2, H3, H4; the thiol metabolite isomers of clopidogrel; HPLC; hig

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Implementing the additional strength biowaiver for generics: EMA recommended approaches and challenges for a US-FDA submission

Keywords: Strength; Biowaiver; EMA; US-FDA;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro models for immunogenicity prediction of therapeutic proteins

Keywords: Therapeutic protein; Immunogenicity assessment; In vitro model; Subcutaneous injection; Injection site reactions; ADAs; antidrug antibodies; ALN; artificial lymph node; APCs; antigen presenting cells; ASCs; adipose-derived stem/stromal cells; DCs; dendrit

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

Keywords: 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Microfluidics contribution to pharmaceutical sciences: From drug discovery to post marketing product management

Keywords: ALS; amyotrophic lateral sclerosis; BBB; blood-brain barrier; CE; capillary electrophoresis; CL; chemiluminescence; CMC; capillary microsampling; CSF; cerebrospinal fluid; CTC; circulating cancer cells; CYP; cytochrome P; DBS; dried blood spots; DDS; drug

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Dry powder inhalers: An overview of the in vitro dissolution methodologies and their correlation with the biopharmaceutical aspects of the drug products

Keywords: Pulmonary delivery; Dry powder inhalation; Solubility; Dissolution methods; Biopharmaceutical classification; API; Active pharmaceutical ingredient; ACI; Andersen cascade impactor; ALF; alveolar lung fluid; BCS; Biopharmaceutics Classification System; iBC

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Pituitary Ependymoma: A Case Report and Review of the Literature

Keywords: Ependymoma; Pituitary ependymoma; Sellar; EMA; Epithelial membrane antigen; GFAP; Glial fibrillary acidic protein; H&E; Hematoxylin-eosin; MRI; Magnetic resonance imaging; PRL; Prolactin; WHO; World Health Organization;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Consenso Mexicano para el Tratamiento de la Hepatitis C

Keywords: Consenso; Agentes antivirales de acción directa; Regímenes libres de interferón; Ribavirina; Consensus; Direct-acting antiviral agents; Interferon-free regimens; Ribavirin; AAD; antivirales de acción directa; AASLD; Asociación Americana para el Estud

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

The Mexican consensus on the treatment of hepatitis C

Keywords: Consensus; Direct-acting antiviral agents; Interferon-free regimens; Ribavirin; Consenso; Agentes antivirales de acción directa; Regímenes libres de interferón; Ribavirina; AASLD; American Association for the Study of Liver Diseases; AFP; alpha-fetopro

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Safety evaluation of a mixture of the human-identical milk oligosaccharides 2′-fucosyllactose and difucosyllactose

Keywords: 2′-fucosyllactose; Difucosyllactose; Lactodifucotetraose; Human-identical milk oligosaccharide; Infant formula; Safety; 2-AA; 2-aminoanthracene; 2′-FL; 2′-fucosyllactose; 2′-FL/DFL; 2′-fucosyllactose/difucosyllactose mixture; 2-NF; 2-nitroflouri

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Bispecific antibodies for cancer therapy: A review

Keywords: ADCC; antibody-dependent cell-mediated cytotoxicity; AE; adverse events; ALL; acute lymphoblastic leukemia; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; B-ALL; B-cell acute lymphoblastic leukemia; BiTES; Bi-sp

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments

Keywords: ACR; American College of Radiology; AD; Alzheimer disease; ADNI; Alzheimer's Disease Neuroimaging Initiative; ALS; Amyotrophic Lateral Sclerosis; ASD; Autism Spectrum Disorder; BBB; Blood-Brain-Barrier; BEST; Biomarkers, Endpoints and other Tools; BLA; Bi

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2018 سفارش ترجمه

Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

Keywords: Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Causes and solutions to “globesity”: The new fa(s)t alarming global epidemic

Keywords: Obesity; Chronic low-grade inflammation; Pharmacotherapy; Novel targets; Medicinal plants; Clinical studies; Contents; 5HT2CR; Serotonin receptors subtype 2C; ACC; Acetyl-CoA carboxylase (EC 6.4.1.2); ACTH; Adrenocorticotropic hormone; AgRP; Agouti-relate

دانلود رایگان متن کامل مقاله ISI 84 صفحه سال انتشار : 2018 سفارش ترجمه

Nanopharmaceuticals for wound healing - Lost in translation?

Keywords: Nanomaterials; Biomaterials; Advanced wound healing therapies; Current regulatory perspective; ASTM; American Society for Testing and Materials; CQA; critical quality attributes; ECM; extracellular matrix; EGF; epidermal growth factor; EMA; European medic

دانلود رایگان متن کامل مقاله ISI 95 صفحه سال انتشار : 2018 سفارش ترجمه

Case ReportBK virus nephropathy, collecting duct cell proliferation and malignancy in a renal allograft: Case history and review of the literature

Keywords: BKV; BK virus; CD; collecting duct; CD10; cluster of differentiation 10; CK5/6; cytokeratin 5/6; CK7; cytokeratin 7; CK19; cytokeratin 19; CK-HMW; high molecular weight cytokeratin; CT-scan; computed tomography scan; E-cadherin; epithelial cadherin; EMA;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Spindle cell oncocytoma of the adenohypophysis: 2 case reports of unusual radiological and intra-operative findings

Keywords: Spindle cell oncocytoma; Endoscopy; Transsphenoidal; Pituitary; Meningioma; Extended transtuberculum; SCO; Spindle Cell Oncocytoma; EMA; Epithelial Membrane Antigen (EMA); GFAP; Glial Fibrillary Acid Protein; MRI; Magnetic Resonance Imaging; T1w; T1 weigh

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Endoneurial-CD34 positive cells define an intermediate layer in human digital Pacinian corpuscles

Keywords: EMA; epithelial membrane antigen; Glut1; glucose transporter 1; NSE; neuron specific enolase; NFP; neurofilament; CD34 antigen; Endoneurium; Immunohistochemistry; Pacinian corpuscles; Human;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

The spatial accuracy of geographic ecological momentary assessment (GEMA): Error and bias due to subject and environmental characteristics

Keywords: Ecological momentary assessment; EMA; Location; Ecology; Environment; Neighborhood; Accuracy; Data quality;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

A simple HPLC-UV method for quantification of enzalutamide and its active metabolite N-desmethyl enzalutamide in patients with metastatic castration-resistant prostate cancer

Keywords: Enzalutamide; Prostate; Cancer; Therapeutic drug monitoring; HPLC-UV; AR-V7; androgen receptor splice variant-7; Ctrough; steady-state trough plasma concentration; CV; coefficient of variation; CYP; cytochrome P450; DMSO; dimethylsulfoxide; EMA; European

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Legionella jordanis inactivation in water by solar driven processes: EMA-qPCR versus culture-based analyses for new mechanistic insights

Keywords: EMA; Legionella jordanis; Real time qPCR; TiO2; Hydrogen peroxide;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Is a deuterated internal standard appropriate for the reliable determination of olmesartan in human plasma?

Keywords: CI; confidence interval; EMA; European Medicines Agency; FDA; US Food and Drug Administration; IS; internal standard; LLOQ; lower limit of quantification; OLM; olmesartan; SIL; stable isotopically labelled; Olmesartan; Liquid chromatography/mass spectrome

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Development and validation of an ELISA method for the quantification of nivolumab in plasma from non-small-cell lung cancer patients

Keywords: ALP; Alkaline Phosphatase; ALT; alanine transaminase; AST; aspartate aminotransferase; BSA; Bovine Serum Albumin; CRP; C-Reactive Protein; CV; Coefficient of Variation; ECOG; Eastern Cooperative Oncology Group; EMA; European Medicines Agency; FDA; Food an

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of the virus clearance capacity and robustness of the manufacturing process for the recombinant factor VIII protein, turoctocog alfa

Keywords: Turoctocog alfa; Manufacture; Virus clearance; rFVIII; Virus safety; Virus clearance evaluation; BEV; Bovine enterovirus; CHO; Chinese hamster ovary; EMA; European Medicines Agency; eMuLV; Ecotropic murine leukaemia virus; FDA; US Food and Drug Administra

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperIn-line monitoring of multi-layered film-coating on pellets using Raman spectroscopy by MCR and PLS analyses

Keywords: PAT; process analytical technology; EMA; European medicines agency; FDA; food and drug administration; ICH; international conference for harmonization of technical requirements for registration of pharmaceuticals for human use; PLS; partial least squares;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of human percutaneous absorption from in vitro and in vivo animal experiments

Keywords: PK; pharmacokinetic; Vd; steady-state volume of distribution; CL; total body clearance; OECD; the Organization for Economic Co-operation and Development; FDA; U.S. Food and Drug Administration; EMA; European Medicines Agency; IV; intravenous; LC-MS/MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS

Keywords: ACN; acetonitrile; allo-THE; 5α-tetrahydrocortisone, allo-tetrahydrocortisone; alloTHF; 5α-tetrahydrocortisol, allo-tetrahydrocortisol; AME; apparent mineralocorticoid excess; DCM; dichloromethane; E; cortisone; EMA; European Medicines Agency; F; cortis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method

Keywords: CV; coefficient of variation; EMA; European Medicines Agency; ESI; electrospray ionization; HSCT; hematopoietic stem cell transplantation; IS; internal standard; LLOQ; lower limit of quantitation; MF; matrix effect; RID; refractive index detector; r.t.; r

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of a primary course of H9N2 vaccine with or without AS03 adjuvant in adults: A phase I/II randomized trial

Keywords: AE; adverse event; AESI; adverse event of specific interest; AS; adjuvant system; CBER; Center for Biologics Evaluation and Research; CHMP; Committee for Medicinal Products for Human Use; CI; confidence interval; EMA; European Medicines Agency; GMT; geome

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Liquid chromatography-tandem mass spectrometry assay for the quantification of niraparib and its metabolite M1 in human plasma and urine

Keywords: ACN; acetonitrile; BER; base excision repair; C.V.; coefficient of variation; DMSO; dimethylsulfoxide; DSB; double strand break; EMA; European Medicine Agency; FDA; Food and Drug Administration; GLP; Good Laboratory Practice; HRR; homologous recombination

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Genotoxic evaluation of poly(anhydride) nanoparticles in the gastrointestinal tract of mice

Keywords: ALS; alkali-labile sites; DAPI; 4,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ECVAM; european centre for the validation of alternative methods; EMA; european medicines agency; EMS; ethyl methanesulfonate; Fpg; formamidopyridine DNA glycosilase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ULTEMAT: A mobile framework for smart ecological momentary assessments and interventions

Keywords: EMA; In the moment assessments; Experience sampling; Context awareness;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Dosing considerations for rufinamide in patients with Lennox-Gastaut syndrome: Phase III trial results and real-world clinical data

Keywords: Rufinamide; Dosing; Antiepileptic drug; Lennox-Gastaut syndrome; Epilepsy; AE; adverse event; AED; antiepileptic drug; AUC; area under the curve; BID; twice daily; Cmax; peak plasma concentration; ECG; electrocardiogram; EEG; electroencephalogram; EMA;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Changing paradigms in bioequivalence trials submitted to the EMA for evaluation - A clinical and regulatory perspective

Keywords: EU; European Union; MA; marketing authorisation; BE; bioequivalence; BCS; Biopharmaceutics Classification System (BCS); CHMP; Committee for Medicinal Products for Human Use; NHS; National Health System; API; active pharmaceutical ingredient; EMA; European

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts

Keywords: HE; n-hexanic extract; EE; ethanolic extract; AE; aqueous extract; EMSA; electrophoretic mobility shift assay; qRT-PCR; quantitative real-time polymerase chain reaction; EMA; European Medicines Agency; HMPC; Committee on Herbal Medicinal Products; THF; te

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original Research ArticleMetabolic engineering of Saccharomyces cerevisiae for de novo production of dihydrochalcones with known antioxidant, antidiabetic, and sweet tasting properties

Keywords: CHI; chalcone isomerase; CHS; chalcone synthase; CH3H; chalcone 3-hydroxylase; CPR; cytochrome P450 reductase; CYP; cytochrome P450; C4H; cinnamate 4-hydroxylase; DBR; double bond reductase; DHC; dihydrochalcone; EMA; European Medicine Agency; FDA; Food a

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه