Keywords: ERK، kinase regulated extracellular; l-THP, levo-tetrahydropalmatine; ERK, extracellular-regulated kinase; CREB, cAMP responsive element binding protein; Hip, hippocampus; CPu, caudate putamen; PFc, prefrontal cortex; CPP, conditioned place preference; PCP, phencyclidine; NMDA, N-methyl-d-as
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SRPK2 promotes the growth and migration of the colon cancer cells
Keywords: ERK، kinase regulated extracellular; SRPK, serine–arginine protein kinase; ERK, extracellular-regulated kinase; RAF, Ras-associated factor; RT-PCR, Real-time PCR; PBS, phosphate-buffered saline; RNAi, RNA interferenceColon cancer; SRPK2; ERK; Cell growth and migration
Redox signaling in cardiovascular pathophysiology: A focus on hydrogen peroxide and vascular smooth muscle cells
Keywords: ERK، kinase regulated extracellular; AAA, abdominal aortic aneurysms; AGEs, advanced glycation end products; AKT, protein kinase B; Ang II, angiotensin II; CREB, cyclic AMP response element–binding protein; eNOS, endothelial NO synthase; ERK, extracellular-regulated kinase; GPx, glutathione
Kinetics and Signal Activation Properties of Circulating Factor(s) From Healthy Volunteers Undergoing Remote Ischemic Pre-Conditioning
Keywords: ERK، kinase regulated extracellular; cardioprotection; human; humoral factor; kinetics; remote ischemic pre-conditioning; signalingAKT, protein kinase B; ERK, extracellular-regulated kinase; IQR, interquartile range; LV+RV, left and right ventricular; LVDP, left ventricular developed pressur
Both prolactin (PRL) and a molecular mimic of phosphorylated PRL, S179D-PRL, protect the hippocampus of female rats against excitotoxicity
Keywords: ERK، kinase regulated extracellular; ERK, extracellular-regulated kinase; hPRL, human prolactin; KA, kainic acid; Neu-N, neuronal nuclei; oPRL, ovine prolactin; OVX, ovariectomized; PRL, prolactin; S179D-PRL, human prolactin in which the normally phosphorylated serine at position 179 is repl
Dual contribution of MAPK and PI3K in epidermal growth factor-induced destabilization of thyroid follicular integrity and invasion of cells into extracellular matrix
Keywords: ERK، kinase regulated extracellular; TSH, thyroid stimulating hormone; EGF, epidermal growth factor; TGF-β, transforming growth factor-beta; MAPK, mitogen activated protein kinase; ERK, extracellular-regulated kinase; MEK, MAPK/ERK kinase; PI3K, phosphoinositide 3-kinase; EMT, epithelial–mes
Interleukin-1β inhibits the differentiation of hippocampal neural precursor cells into serotonergic neurons
Keywords: ERK، kinase regulated extracellular; 5-HT, serotonin; bFGF, basic fibroblast growth factor; DIV, days in vitro; DMEM, Dulbecco's modified eagle's medium; DMSO, dimethyl sulphoxide; EGF, epidermal growth factor; ERK, extracellular-regulated kinase; FBS, fetal bovine serum; GFAP, glial fibrill
Mechanism of interleukin-1α transcriptional regulation of S100A9 in a human epidermal keratinocyte cell line
Keywords: ERK، kinase regulated extracellular; ERK, extracellular-regulated kinase; JNK, c-JUN N-terminal kinase; p38, p38 kinase; IL-1R1, IL-1 receptor; siRNA, small interfering RNA; TLR5, Toll-like receptor 5S100A9; IL-1α; Keratinocytes; p38; C/EBPβ
Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia
Keywords: ERK، kinase regulated extracellular; 4αPDD, 4α-phorbol 12,13-didecanoate; COX, cyclooxygenase; DRG, dorsal root ganglion; ERK, extracellular-regulated kinase; IL-17A, interleukin-17A; IL-17RA, interleukin-17A receptor; IL-17RA-like IR, interleukin-17A receptor-like immunoreactivity; NFκB, nu
Activation of Akt through 5-HT2A receptor ameliorates serotonin-induced degradation of insulin receptor substrate-1 in adipocytes
Keywords: ERK، kinase regulated extracellular; T2DM, type 2 diabetes mellitus; 5-HT, 5-hydroxytryptamine (Serotonin); IRS-1, insulin receptor substrate-1; LDM, low density microsome; PI3 K, phosphatidylinositol-3 kinase; CHX, cycloheximide; Erk, extracellular-regulated kinase; mTOR, mammalian target o
CB2: Therapeutic target-in-waiting
Keywords: ERK، kinase regulated extracellular; CHO, Chinese hamster ovary; CNS, central nervous system; ERK, extracellular-regulated kinase; GPCR, G protein-coupled receptor; GRK, G protein receptor kinase; HEK, human embryonic kidney; JNK, c-jun N terminal kinase; MAP kinase, mitogen-activated protei
Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I
Keywords: ERK، kinase regulated extracellular; AP, alkylphenol; Ab, antibody; BPA, bisphenol A; GPR30 or GPER, G protein-coupled estrogen receptor; E1, estrone; E2, estradiol; E3, estriol; ERK, extracellular-regulated kinase; mERα, membrane estrogen receptor-α; mERβ, membrane estrogen receptor-β; MAPK
(E,Z)-3-(3′,5′-Dimethoxy-4′-hydroxy-benzylidene)-2-indolinone blocks mast cell degranulation
Keywords: ERK، kinase regulated extracellular; BMMC, murine bone marrow derived mast cells; DNP, dinitrophenyl; MAPK, mitogen-activated protein kinase; ERK, extracellular-regulated kinase; PI3-K, phosphatidylinositol 3-kinase; PKB, protein kinase B; SNARE, soluble N-ethylmaleimide-sensitive-factor att
Apigenin protects HT22 murine hippocampal neuronal cells against endoplasmic reticulum stress-induced apoptosis
Keywords: ERK، kinase regulated extracellular; ATF6, activating transcription factor 6; BFA, brefeldin A; CHOP, C/EBP homologous protein; eIF2α, eukaryotic initiation factor 2α; ER, endoplasmic reticulum; ERK, extracellular-regulated kinase; GRP, glucose-regulated protein; GSH, glutathione; IRE1, inos
Brain-derived neurotrophic factor and cocaine addiction
Keywords: ERK، kinase regulated extracellular; BDNF, brain-derived neurotrophic factor; CREB, cAmp response element binding protein; DA, dopamine; ERK, extracellular-regulated kinase; MAPK, mitogen-activated protein kinase; MEK, mitogen-activated extracellular-regulated protein kinase; GDNF, glial cel
Src redox regulation: Again in the front line
Keywords: ERK، kinase regulated extracellular; Csk, C-terminal Src kinase; Chk, Csk homology kinase; COX, cyclooxygenase; Duox, dual oxidase; ECM, extracellular matrix; EGFR, epidermal growth factor receptor; ERK, extracellular-regulated kinase; GF, growth factor; HIF-1, hypoxia-inducible factor-1; Li
Inhibition of vascular smooth muscle cell proliferation by the vitamin E derivative pentamethylhydroxychromane in an in vitro and in vivo study: pivotal role of hydroxyl radical-mediated PLCγ1 and JAK2 phosphorylation
Keywords: ERK، kinase regulated extracellular; CCA, common carotid artery; DCF-DA, 2,7-dichlorofluorescin diacetate; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; ECL, enhanced chemiluminescence; EEL, external elastic lamina; ERK, extracellular-regulated kinase; ESR, electron spi
Time-course regulation of survival pathways by epicatechin on HepG2 cells
Keywords: ERK، kinase regulated extracellular; AKT/PKB, protein kinase B; EGCG, epigallocatechin-3-gallate; ERK, extracellular-regulated kinase; FBS, fetal bovine serum; JNK, c-jun N-amino-terminal kinase; MAPK, mitogen-activated protein kinase; PI, phosphatidylinositol; PI3K, phosphatidylinositol-3-k
Regulation Of Brn-3a N-terminal transcriptional activity by MEK1/2-ERK1/2 signalling in neural differentiation
Keywords: ERK، kinase regulated extracellular; RA, all-trans retinoic acid; MEK, MAPK–ERK kinase; ERK, extracellular-regulated kinase; MAPK, mitogen-activated protein kinase; POU, pit-oct-unc; TG, trigeminal ganglia; DRG, dorsal root ganglia; TAD, transcriptional activation domain; Bcl-XL, B-cell cll/
Oxidative stress in the pathogenesis of psoriasis
Keywords: ERK، kinase regulated extracellular; AP-1, activator protein 1; ASK1, apoptosis signal-regulating kinase-1; ATF, activating transcription factor; CD, cluster of differentiation; DC, dendritic cell; DMF, dimethylfumarate; ERK, extracellular-regulated kinase; GSH, glutathione; IFN-γ, interfero
Harnessing the tumour-derived cytokine, CSF-1, to co-stimulate T-cell growth and activation
Keywords: ERK، kinase regulated extracellular; CAR, chimeric antigen receptor; CSF-1(R), colony-stimulating factor-1 (receptor); CTL, cytotoxic T-lymphocyte; (e)GFP, (enhanced) Green fluorescent protein; EMCV, Encephalomyocarditis virus; Erk, extracellular-regulated kinase; FGF(1R), fibroblast growth
17β-Estradiol rapidly mobilizes intracellular calcium from ryanodine-receptor-gated stores via a PKC–PKA–Erk-dependent pathway in the human eccrine sweat gland cell line NCL-SG3
Keywords: ERK، kinase regulated extracellular; E2, 17β-estradiol; (Rp)-cAMPS, Rp-adenosine 3′,5′-cyclic monophosphorothioate; [Ca2+]i, intracellular Ca2+; [Ca2+]e, extracellular Ca2+; PKA, protein kinase A; PKC, protein kinase C; Erk, extracellular-regulated kinase; Tg, thapsigargin; XeC, xestospongin
Understanding neuronal molecular networks builds on neuronal cellular network architecture
Keywords: ERK، kinase regulated extracellular; AA, Aminoacid; AKT RAC, alpha serine/threonine-protein kinase; β2AR, β2 Adrenergic Receptor; CNS, Central Nervous System; Di, Disorder Index; DI, Global Disorder Index; EGFR, Epidermal growth factor receptor; ERK, Extracellular-regulated kinase; FCP, Fly-
Anti-inflammatory activity of fisetin in human mast cells (HMC-1)
Keywords: ERK، kinase regulated extracellular; HMC-1, human mast cell; TNF, tumor necrosis factor; IL, interleukin; NF, nuclear factor; MAPK, mitogen-activated protein kinase; ERK, extracellular-regulated kinase; JNK, c-Jun N-terminal kinase; PMA, phorbol 12-myristate 13-acetate; PMACI, PMA plus calci
Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells
Keywords: ERK، kinase regulated extracellular; HSC, hepatic stellate cells; ROS, reactive oxygen species; eIF4E, eukaryotic initiation factor 4E; mTOR, mammalian target of rapamycin; PI3K, phosphatidyl inositol 3 kinase; ERK, extracellular-regulated kinase; MAPK, mitogen-activated protein kinase; GSH,
Signaling pathways involved in antioxidant control of glioma cell proliferation
Keywords: ERK، kinase regulated extracellular; AP-1, activator protein-1; cdk, cyclin-dependent kinase; DCFH2-DA, dichlorodihydrofluorescein diacetate; DMEM, Dulbecco's modified Eagle's medium; ERK, extracellular-regulated kinase; FBS, fetal bovine serum; GAPDH, glyceraldehyde-3-phosphate dehydrogenas
Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
Keywords: ERK، kinase regulated extracellular; ATF4, activating transcription factor 4; bZIP, basic region-leucine zipper; CRE, cyclic AMP response element; ER, endoplasmic reticulum; ERAD, endoplasmic reticulum-associated protein degradation; ERK, extracellular-regulated kinase; MAPK, mitogen-activat
Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP
Keywords: ERK، kinase regulated extracellular; ATIP, AT2 receptor-interacting protein; ERK, extracellular-regulated kinase; MTUS1, mitochondrial tumor suppressor 1; TSG, tumor suppressor gene.ATIP; Brain; Cancer; Cerebellum; Human tissues; Real-time RT-PCR
Examination of behavioral deficits triggered by targeting BDNF in fetal or postnatal brains of mice
Keywords: ERK، kinase regulated extracellular; depression; neurotrophin; anxiety; mutant; aggressive; cre-loxPBDNF, brain-derived neurotrophic factor; CZD, chlordiazepoxide; DRN, dorsal raphe nucleus; EPM, elevated plus maze; ERK, extracellular-regulated kinase; TPH, tryptophan hydroxylase; TrkB, trop
Critical roles of AMP-activated protein kinase in the carcinogenic metal-induced expression of VEGF and HIF-1 proteins in DU145 prostate carcinoma
Keywords: ERK، kinase regulated extracellular; ACC, acetyl-CoA carboxylase; AMPK, AMP-activated protein kinase; As, sodium arsenite; Co, cobalt chloride; DN, dominant negative; ELISA, enzyme-linked immunosorbent assay; ERK, extracellular-regulated kinase; GSH, reduced glutathione; HIF-1, hypoxia-induc