کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2052206 | 1074224 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
bZIP, basic region-leucine zipperATF4, activating transcription factor 4 - ATF4، فعال سازی عامل رونویسی 4CRE, Cyclic AMP response element - CRE، عنصر پاسخ Cyclic AMPERK, extracellular-regulated kinase - ERK، kinase regulated extracellularER, endoplasmic reticulum - اندوپلاسمی رتیکولوم یا شبکهٔ آندوپلاسمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش گیاه شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element Cooperative interaction of Zhangfei and ATF4 in transactivation of the cyclic AMP response element](/preview/png/2052206.png)
چکیده انگلیسی
Zhangfei (ZF) is a basic region-leucine zipper protein that has been implicated in herpesvirus infection cycle and related cellular processes. Here we show both in vivo and in vitro data demonstrating that ZF is a novel cellular binding partner of activating transcription factor 4 (ATF4) (or CREB2). We found that ZF competed with ATF4 to form ATF4-ZF heterodimeric complexes through the bZIP regions. ZF enhanced ATF4 binding to the cAMP response element (CRE), and augmented activation of a CRE reporter by ATF4, in response to MEK1 activation. These results suggest an important role of ZF in the MEK1-ATF4 signaling pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: FEBS Letters - Volume 580, Issue 1, 9 January 2006, Pages 58–62
Journal: FEBS Letters - Volume 580, Issue 1, 9 January 2006, Pages 58–62
نویسندگان
Melissa R. Hogan, Gregory P. Cockram, Rui Lu,