Recent progress on MAP kinase pathway inhibitors
Keywords: MAPK; Kinase; B-RAF; MEK; ERK;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Keywords: A1AR; adenosine A1 receptor; ABC transporters; ATP-binding cassette; ABCB1/P-gp/MDR1; P-glycoprotein; ABCG2/BCRP; breast cancer resistant protein; Ang-1; angiopoietin 1; ASCs; Adipose stem cells; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-lar
The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity
Keywords: SIRT; sirtuin; NHE; sodium proton exchanger; Tro; troglitazone; JLA; juxtanuclear lysosome aggregation; EIPA; ethyl-isopropyl amiloride; LAMP-1; lysosome associated membrane protein 1; HDAC; histone deacetylase; pHe; extracellular pH; MTOC; microtubule or
Ratio of phosphorylated HSP27 to nonphosphorylated HSP27 biphasically acts as a determinant of cellular fate in gemcitabine-resistant pancreatic cancer cells
Keywords: Phosphorylated HSP27; Nonphosphorylated HSP27; Gemcitabine; Pancreatic cancer; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; DR5; death receptor 5; EGFP; enhanced green fluorescence protein; XIAP; X-linked inhibitor of apoptosis; MAPK; m
Activation of β2-adrenergic receptor by (R,Râ²)-4â²-methoxy-1-naphthylfenoterol inhibits proliferation and motility of melanoma cells
Keywords: AC; adenylate cyclase; α-MSH; α-melanocyte stimulating hormone; ANOVA; analysis of variance; AR; adrenergic receptor; ATR; ataxia telangiectasia and Rad3-related protein; BCA; bicinchoninic acid; cAMP; cyclic adenosine monophosphate; CI; cell index; CIM
Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes
Keywords: Akt; protein kinase B; Dex; dexamethasone; Dok1; downstream of tyrosine kinases-1; ERK1/2; extracellular signal-regulated kinase 1 and 2; ap2; fatty acid binding protein 4; IBMX; isobutylmethylxanthine; IRS; insulin receptor substrate; InsR; insulin recep
The carboxy-terminal tail or the intracellular loop 3 is required for β-arrestin-dependent internalization of a mammalian type II GnRH receptor
Keywords: GnRH receptor; Internalization; G protein-coupled receptor kinase; β-Arrestin; ERK; DMEM; Dulbecco's modified Eagle medium; EC50; concentration that stimulates half-maximal IP production; ERK; extracellular signal-regulated kinases; FSH; follicle-stimula
A novel Gynostemma pentaphyllum saponin and its adipogenesis inhibitory effect through modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion
Keywords: aP2; adipocyte protein 2; C/EBPα; CCAAT/enhancer-binding protein α; C/EBPβ; CCAAT enhancer-binding protein β; C/EBPδ; CCAAT/enhancer-binding protein δ; CHOP-10; C/EBP homologous protein; DVL; disheveled; ERK; extracellular signal-regulated kinase; F
Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging
Keywords: TRAP; tartrate-resistant acid phosphatase; RANKL; receptor activator of nuclear factor-κB ligand; ROS; reactive oxygen species; Nox1; NADPH (nicotinamide adenine dinucleotide phosphate) oxidase 1; SOD 1; superoxide dismutase 1; CAT; catalase; NFATc1; nuc
Molecular signatures of mood stabilisers highlight the role of the transcription factor REST/NRSF
Keywords: AP-1; activator protein 1; ENCODE; Encyclopaedia of DNA Elements; ERK; extracellular-signal-regulated kinase; GPR; Global Pattern Recognition; GÃE; GeneÃEnvironment; NRSF; neuron restrictive silencing factor; REST; repressor element-1 silencing transcri
Basic ScienceSubstance P stimulates proliferation of spinal neural stem cells in spinal cord injury via the mitogen-activated protein kinase signaling pathway
Keywords: ERK; Mitogen-activated protein kinase signaling pathway; Neuronal regeneration; Neural stem/progenitor cell; p38; Spinal cord injury; Substance P;
Activation of spinal chemokine receptor CXCR3 mediates bone cancer pain through an Akt-ERK crosstalk pathway in rats
Keywords: Bone cancer; Pain; CXCR3; ERK; Akt;
Fingolimod induces the transition to a nerve regeneration promoting Schwann cell phenotype
Keywords: Akt; PKB, protein kinase B; BDNF; brain derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CIDP; chronic inflammatory demyelinating polyneuropathy; CNS; central nervous system; Cx32; connexin-32; DMSO; dimethyl sulfoxide; DRG; dorsal root
Diallyl trisulfide protects against high glucose-induced cardiac apoptosis by stimulating the production of cystathionine gamma-lyase-derived hydrogen sulfide
Keywords: DM; diabetes mellitus; HGHigh; glucose; NADPH; nicotinamide adenine dinucleotide phosphate; ROS; reactive oxygen species; JNKc-Jun; N-terminal kinase; NF-κB; NF-kappaB; DATS; diallyl trisulfide; MAPK; mitogen-activated protein kinases; ERK; extracellular
Cell- and nuclear-penetrating anti-dsDNA autoantibodies have multiple arginines in CDR3 of VH and increase cellular level of pERK and Bcl-2 in mesangial cells
Keywords: Nuclear-penetrating; Anti-DNA autoantibody; Recombinant scFv; Recombinant VH domain; CDR3-VH; Arginine; ERK; Bcl-2; Lupus nephritis; Pathogenesis;
Embryonal Fyn-associated substrate (EFS) and CASS4: The lesser-known CAS protein family members
Keywords: 5-HT; 5-hydroxytryptamine, serotonin; A549; non-small cell lung cancer cell line; AD; Alzheimer's disease; ADPKD; autosomal dominant polycystic kidney disease; Aire; autoimmune regulator; AP-1; activator protein 1; APP; amyloid precursor protein; AREB6; Z
Interferon-γ in foam cell formation and progression of atherosclerosis
Keywords: IFN-γ; interferon-γ; IFNGR; IFN-γ receptor; VSMC; vascular smooth muscle cell; IL; interleukin; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor-α; STAT; signal transducer and activator of transcription; NF-κB; nuclear factor-κB; TLR; Toll-lik
Analysis of 3-MCPD- and 3-MCPD dipalmitate-induced proteomic changes in rat liver
Keywords: 3-Chloro-1,2-monopropanediol; Food carcinogen; Heat-induced process contaminant; Hepatotoxicity; 3-MCPD; 3-chloro-1,2-monopropanediol; ERK; extracellular signal-regulated kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IPA; ingenuity pathway anal
Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro
Keywords: Res; resveratrol; Mdr1; multidrug resistance 1; Pept1; peptide transporter 1; Mrp2; multidrug resistance-associated protein 2; IGF-1R; insulin-like growth factor 1 receptor; ERK; extracellular signal-regulated kinase; AKT; protein kinase B; ABC; ATP-bindi
Monoamine receptor agonists, acting preferentially at presynaptic autoreceptors and heteroreceptors, downregulate the cell fate adaptor FADD in rat brain cortex
Keywords: FADD and p-FADD; FLIP-L; Monoamine depletion; Monoamine receptor agonists and antagonists; MEK-ERK signaling; Neuroplasticity; AMPT; α-methyl-DL-p-tyrosine; ANOVA; analysis of variance; DISC; death inducing signaling complex; DMSO; dimethyl sulfoxide;
The TORC1/P70S6K and TORC1/4EBP1 signaling pathways have a stronger contribution on skeletal muscle growth than MAPK/ERK in an early vertebrate: Differential involvement of the IGF system and atrogenes
Keywords: Teleost fish; Atrophy; Hypertrophy; TORC; ERK; IGF system
Laminin α4 (LAMA4) expression promotes trophoblast cell invasion, migration, and angiogenesis, and is lowered in preeclamptic placentas
Keywords: Laminin; LAMA4; Placenta; Trophoblast; Preeclampsia; MAPK; p38; JNK; ERK; Methylation;
Inhibitory effects of ursolic acid on osteoclastogenesis and titanium particle-induced osteolysis are mediated primarily via suppression of NF-κB signaling
Keywords: Ursolic acid; Osteoclastogenesis; NF-κB; Titanium particle; Osteolysis; AP-1; activator protein-1; BV/TV; bone volume/tissue volume; BMD; bone mineral density; BMC; bone mineral content; BMMs; bone marrow monocytes; CK; cathepsin K; CT; computed tomograp
Carbon nanotubes enhance intercalated disc assembly in cardiac myocytes via the β1-integrin-mediated signaling pathway
Keywords: Carbon nanotubes; Collagen; Intercalated disc; Neonatal cardiomyocytes; β1-integrin; ERK
The anti-inflammatory effect of 2-(4-hydroxy-3-prop-2-enyl-phenyl)-4-prop-2-enyl-phenol by targeting Lyn kinase in human neutrophils
Keywords: BSA; bovine serum albumin; cAMP; cyclic AMP; DPI; diphenyliodonium; ELISA; enzyme-linked immune-sorbent assay; ERK; extracellular signal-regulated kinase; FLPEP; N-formyl-nor-leucyl-leucyl-phenylalanyl-norleucyl-throsyl-lysine-fluorescein; fMLP; N-formyl-
Phosphorylation of Ser-279/282 and Tyr-265 positions on Cx43 as possible mediators of VEGF-165 inhibition of pregnancy-adapted Ca2+ burst function in ovine uterine artery endothelial cells
Keywords: VEGF; Pregnancy; Gap junction; CLA; Src; Ca2+; P; pregnant; NP; non-pregnant; UAEC; uterine artery endothelial cells; UA-Endo; uterine artery endothelium on intact vessel segment; Cx43; connexin 43; NO; nitric oxide; eNOS; endothelial nitric oxide synthas
Interplay between the E2F pathway and β-adrenergic signaling in the pathological hypertrophic response of myocardium
Keywords: β-AR; beta adrenergic receptor; DCM; dilated cardiomyopathy; ERK; extracellular receptor kinase; PDE4D; 5â²3â² cyclic AMP phosphodiesterase 4D; PKA-C; protein kinase A catalytic subunit; Pln; phospholamaban; Rb; retinoblastoma gene product (pocket prot
Actin cytoskeleton organization, cell surface modification and invasion rate of 5 glioblastoma cell lines differing in PTEN and p53 status
Keywords: CGM; complete growth medium; ECM; extracellular matrix; Erk; extracellular signal regulated kinase; FAK; focal adhesion kinase; FBS; fetal bovine serum; GBM; Glioblastoma multiforme; MEK; MAPK/Erk kinase; MMP; matrix metalloproteinase; PTEN; phosphatase a
Mechanisms of Nrf2/HO-1 pathway up-regulation induced by pu-erh black tea extract supplementation for quinocetone-treated Sprague-Dawley rats
Keywords: Pu-erh tea; BTE; QCT; Nrf2/HO-1; Oxidative stress; ERK;
A newly designed molecule J2326 for Alzheimer's disease disaggregates amyloid fibrils and induces neurite outgrowth
Keywords: Alzheimer's disease; β-amyloid; Disaggregation; Neurite outgrowth and neurodegeneration; AD; Alzheimer's disease; Aβ; β-amyloid; fAβ; Aβ fibrils; NGF; nerve growth factor; AChE; acetylcholinesterase; GAP43; growth-associated protein 43; MAPK; mitogen
Harpagoside ameliorates the amyloid-β-induced cognitive impairment in rats via up-regulating BDNF expression and MAPK/PI3K pathways
Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; Aβ; β-amyloid; BCA; bicinchoninic acid; BDNF; brain-derived neurotrophic factor; ChAT; choline acetyltransferase; DAB; 3,3â²-diaminobenzidine; DMEM; Dulbecco's Modified Eagle Medium; ELISA; enzym
Research ReportExtracellular α-crystallin protects astrocytes from cell death through activation of MAPK, PI3K/Akt signaling pathway and blockade of ROS release from mitochondria
Keywords: Akt; protein kinase B; EAE; experimental allergic encephalomyelitis; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; JNK; c-Jun N-terminal kinases; LDH; lactate dehydrogenase; MAPK; mitogen-activated protein kinases; MEK; mitogen-activa
ReviewHomer 1a and mGluR5 phosphorylation in reward-sensitive metaplasticity: A hypothesis of neuronal selection and bidirectional synaptic plasticity
Keywords: Arc; activity-regulated cytoskeleton-associated protein; D1R; dopamine receptor 1; ERK; extracellular signal-regulated kinase; EVH1; Ena/VASP Homology 1; H1a; Homer 1a; HFS; high-frequency stimulation; IEG; immediate early gene; KCl; potassium chloride; L
Resveratrol upregulates Egr-1 expression and activity involving extracellular signal-regulated protein kinase and ternary complex factors
Keywords: bZIP; basic region leucine zipper; MAP kinase; mitogen activated protein kinase; SRE; serum response element; SRF; serum response factor; TCF; ternary complex factors; TPA; 12-O-tetradecanoylphorbol-13-acetate; Egr-1; Elk-1; ERK; Lentivirus; Resveratrol;
Tgfbi/Bigh3 silencing activates ERK in mouse retina
Keywords: BIGH3/TGFBI; Retina; Cornea; ERK; Apoptosis;
Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR
Keywords: mgp96; uPAR; Liver cancer; MAPK; DFS; ADAMTS9; a disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; AIMP1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; AKT; v-akt murine thymoma viral oncogene homo
MAPK pathway activation by chronic lead-exposure increases vascular reactivity through oxidative stress/cyclooxygenase-2-dependent pathways
Keywords: ROS; reactive oxygen species; COX-2; cyclooxygenase; MAPK; mitogen-activated protein kinases; DHE; dihydroethidium; ERK; extracellular signal-regulated protein kinases; JNK; c-Jun N-terminal kinases; Lead exposure; MAPK pathway; Oxidative stress; Cyclooxy
T11TS inhibits Angiopoietin-1/Tie-2 signaling, EGFR activation and Raf/MEK/ERK pathway in brain endothelial cells restraining angiogenesis in glioma model
Keywords: Ang-1; angiopoietin-1; T11TS; T11 target structure; EGFR; epidermal growth factor receptor; ERK; extracellular signal regulated kinase; MEK; mitogen activated protein kinase kinase; EC; endothelial cell; Angiopoietin-1; Glioma; Tie-2 signaling; EGFR; T11T
Dehydroepiandrosterone prevents linoleic acid-induced endothelial cell senescence by increasing autophagy
Keywords: ANOVA; one-way analysis of variance; AMPK; AMP-activated protein kinase; ATG; autophagy related genes; CVD; cardiovascular disease; DHEA; dehydroepiandrosterone; DHEA-S; dehydroepiandrosterone sulfate; DMSO; dimethyl sulfoxide; eNOS; endothelial nitric ox
The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells
Keywords: BCS; breast cancer cell; ER; oestrogen receptor; CSC; cancer stem cell; FACS; fluorescence activated cell sorting; γH2AX; gamma-histone 2AX; mTOR; mammalian/mechanistic target of rapamycin; PARP; poly(ADP-ribose) polymerase; BCL-2; B-cell lymphoma-2; Bax
Folic acid mediates activation of the pro-oncogene STAT3 via the Folate Receptor alpha
Keywords: CNTF(R); Ciliary neurotrophic factor (receptor); EGF; Epidermal growth factor; ERK; Extracellular signal-regulated kinase; FRα; Folate receptor alpha; GPI; glycophosphatidylinositol; IFN; Interferon; IL-6(R); Interleukin 6 (receptor); ISG; Interferon sti
Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Keywords: Atherosclerosis; Cytokines; Chemokines; Inflammation; Therapeutic avenues; ABC; ATP-binding cassette; ACAT-1; acyl-CoA acyl transferase-1; ADRP; adipocyte differentiation related protein; Apo; apolipoprotein; BMT; bone marrow transplantation; CANTOS; Cana
MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch
Keywords: Crk; CT10 regulator of kinase; CRKL; Crk-like protein; ERK; extracellular signal regulated kinase; FCS; foetal calf serum; Gab1; Grb2-associated binder 1; Grb2; growth factor receptor bound protein 2; IL-6; interleukin-6; JAK; Janus kinase; HEK; human emb
Herbs to curb cyclic nucleotide phosphodiesterase and their potential role in Alzheimer's disease
Keywords: cAMP; cyclic adenosine monophosphate; cGMP; cyclic guanosine monophosphate; AD; Alzheimer's disease; PDE; phosphodiesterases; Aβ; amyloid beta; NFTs; neurofibrillary tangles; FAD; familial Alzheimer's disease; SAD; sporadic Alzheimer's disease; APP
A natural diarylheptanoid promotes neuronal differentiation via activating ERK and PI3K-Akt dependent pathways
Keywords: BrdU; bromodeoxyuridine; DG; dentate gyrus; DIV; day in vitro; ERK; extracellular signal-regulated kinase; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; MAPK/ERK kinase; MTT; 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetr
Research reportAntidepressant-like effects of alarin produced by activation of TrkB receptor signaling pathways in chronic stress mice
Keywords: TrkB; tropomyosin-related kinase B; FST; forced swim test; UCMS; unpredictable chronic mild stress; aCSF; artificial cerebrospinal fluid; RTKs; receptor tyrosine kinases; MAPK; mitogen-activated protein kinase; PI3K; phosphatidylinositol 3-kinase; ERK; ex
AAV.shRNA-mediated downregulation of ROCK2 attenuates degeneration of dopaminergic neurons in toxin-induced models of Parkinson's disease in vitro and in vivo
Keywords: 6-OHDA; 6-hydroxydopamine; AAV; adeno-associated viral vector; Bcl-2; B-cell lymphoma 2; CNS; central nervous system; ctl; contralateral; DAPI; 4â²,6-diamidino-2-phenylindole; DIV; day in vitro; DOPAC; 3,4-dihydroxyphenylacetic acid; EGFP; enhanced green
GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease
Keywords: 6-OHDA; 6-hydroxy-dopamine; Akt, PKB; protein kinase B, serine/threonine-specific protein kinase; BDNF; brain derived neurotrophic factor; CaMKIIβ; calcium-calmodulin-dependent protein kinase II β isoform; cAMP; 3â²,5â²-cyclic adenosine monophosphate;
Opposing roles of miR-21 and miR-29 in the progression of fibrosis in Duchenne muscular dystrophy
Keywords: α-SMA; α-smooth muscle actin; COL1A1; collagen type I alpha 1; COL3A1; collagen type III alpha 1; COL6A1; collagen type VI alpha 1; DMD; Duchenne muscle dystrophy; ECM; extracellular matrix; ERK; extracellular signal-regulated kinase; FBN1; fibrillin 1;
Overexpression of activin-A and -B in malignant mesothelioma - Attenuated Smad3 signaling responses and ERK activation promote cell migration and invasive growth
Keywords: ACVR2; type 2 activin receptor; ALK; activin receptor-like kinase; ERK; extracellular signal-regulated kinase; FST; follistatin; FSTL3; follistatin like 3; JNK; c-Jun N-terminal kinase; TGF-β; transforming growth factor-β; Mesothelioma; Activin; Invasiv