Visfatin promotes angiogenesis by activation of extracellular signal-regulated kinase 1/2
Keywords: Visfatin; Vascular endothelial cells; Angiogenesis; ERK;
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Pain signalling pathways: From cytokines to ion channels
Keywords: NGF; nerve growth factor; TNFα; tumor necrosis factor α; IL-Iβ; interleukin 1β; PLCβ; phospholipase Cβ; PLA2; phospholipase A2; PKC; protein kinase C; TTX-R; tetrodotoxin-resistant; AA; arachidonic acid; PGE2; prostaglandin E2; COX; cyclooxygenase;
Severity of alcohol-induced painful peripheral neuropathy in female rats: Role of estrogen and protein kinase (A and Cε)
Keywords: ethanol; hyperalgesia; estrogen; second messenger signaling; CD; control diet; DMSO; dimethyl sulfoxide; ED; ethanol (6.5%, v:v) diet; ERK; extracellular-signal related kinase; IF; gonad-intact female; IM; gonad-intact male; MEK; mitogen and extracellular
Protein kinase C-regulated cAMP response element-binding protein phosphorylation in cultured rat striatal neurons
Keywords: PKA; CaMK; ERK; p38; Striatum; Nucleus accumbens
A Vitamin D Analogue Inhibits Colonic Carcinogenesis in the AOM/DSS Model
Keywords: inflammatory bowel diseases; colorectal cancer; vitamin D; chemoprevention; COX-2; c-Myc; ERK; HCA-7
Role of diacylglycerol kinase in cellular regulatory processes: A new regulator for cardiomyocyte hypertrophy
Keywords: ANF; atrial natriuretic factor; DAG; diacylglycerol; DGK; diacylglycerol kinase; DGKζ-TG; transgenic mouse with cardiac specific expression of DGKζ; ERK; extracellular signal regulated kinase; ET-1; endothelin-1; GPCR; G protein-coupled receptor; MHC; m
Inhibition of gene expression and production of iNOS and TNF-α in LPS-stimulated microglia by methanol extract of Phellodendri cortex
Keywords: Phellodendri cortex; Microglia; Inflammation; ERK; NF-κB; Cytokine
Low-dose treatment with atorvastatin leads to anti-oxidative and anti-inflammatory effects in diabetes mellitus
Keywords: Diabetes mellitus; Endothelial dysfunction; Adhesion molecule; Inflammation; Atorvastatin; Oxidative stress; NF-κB; ERK
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons
Keywords: Integrin; NMDA receptor; MAP kinase; ERK; Calcium; GRGDSP; Cortical neuron
WISP3 suppresses insulin-like growth factor signaling in human chondrocytes
Keywords: CCN6; Chondrocytes; Collagen II; ERK; IGF-IR; IRS-1; SEDT-PA; WISP3
Neural induction in the absence of organizer in salamanders is mediated by MAPK
Keywords: Ambystoma maculatum; Xenopus; Ras; MAPK; ERK; BMP; FGF; Brain differentiation; Smad1; Embryonic induction
Inhibitors of Raf kinase and MEK signaling
Keywords: Target; RAS; RAF; MEK; ERK; Signal; Transduction; Inhibitors
Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells
Keywords: IQDMA; K562 cells; JNK; ERK; p38 MAPK
Danggui Buxue Tang – A Chinese herbal decoction activates the phosphorylations of extracellular signal-regulated kinase and estrogen receptor α in cultured MCF-7 cells
Keywords: DBT, Danggui Buxue Tang; RA, Radix astragali; RAS, Radix angelicae sinensis; ER, estrogen receptor; Erk, extracellular signal-regulated kinaseChinese medicine; Erk; Estrogen receptor; Phosphorylation; Estrogenic effects; Signaling
Regulatory expression of bone morphogenetic protein-6 system in aldosterone production by human adrenocortical cells
Keywords: ACD; actinomycin D; ACTH; adrenocorticotropin; ALK; activin receptor-like kinase; ActRII; activin type II receptor; Ang II; angiotensin II; BMP; bone morphogenetic protein; BMPRII; BMP type II receptor; CHX; cycloheximide; ERK; extracellular signal-regula
Effects of acute cocaine on ERK and DARPP-32 phosphorylation pathways in the caudate-putamen of Fischer rats
Keywords: Cocaine; ERK; Elk-1; DARPP-32; RSK; STEP;
High glucose decreases endothelial cell proliferation via the extracellular signal regulated kinase/p15INK4b pathway
Keywords: Endothelial cells; Proliferation; Cell cycle; p15INK4b; ERK; Oxidative stress
An intrinsic ATPase activity of phospho-MEK-1 uncoupled from downstream ERK phosphorylation
Keywords: MAPK signal transduction; MEK; Raf; ERK; Intrinsic ATPase; Kinase; Inhibitor; Screening assay;
Sensitivity of TLR4- and -7-induced NFκB1 p105-TPL2-ERK pathway to TNF-receptor-associated-factor-6 revealed by RNAi in mouse macrophages
Keywords: TRAF6; TLR4; TLR7; TPL2; p105; IkappaB; ERK; JNK; LPS; R837; Macrophage; RAW264.7; RNAi
The inhibitory mechanism of methylmercury on differentiation of human neuroblastoma cells
Keywords: Methylmercury; Differentiation; Cell cycle; Retinoic acid; ERK; PKC
Valproic acid-mediated neuroprotection in intracerebral hemorrhage via histone deacetylase inhibition and transcriptional activation
Keywords: Intracerebral hemorrhage; Histone deacetylase; Valproic acid; Apoptosis; Inflammation; ERK; Heat shock protein
The role of Ras signaling in lupus T lymphocytes: Biology and pathogenesis
Keywords: T lymphocyte; Systemic lupus erythematosus; Ras; T cell receptor; Farnesylation; RasGRP1; CAPRI; Erk; PI 3-K
In-Cell Western analysis of Helicobacter pylori-induced phosphorylation of extracellular-signal related kinase via the transactivation of the epidermal growth factor receptor
Keywords: Helicobacter pylori; EGFR; ERK; Phosphorylation; EKB-569; EGFR inhibitor; ‘In-Cell Western’ assayEGFR, epidermal growth factor receptor; ERK, extracellular-signal related kinase; ICW, ‘In-Cell Western’; MAPK, mitogen-activated protein kinase; PAI, pathoge
Induction of neurite outgrowth in PC12 cells by the medium-chain fatty acid octanoic acid
Keywords: hexanoic acid; heptanoic acid; neurite outgrowth; p38 MAPK; ERK; NGFβIII-tubulin, β-tubulin isotope III; dbcAMP, dibutyryl cyclic AMP; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MAPK, mitogen-activated protein kinase; MCFA,
Expression of securin promotes colorectal cancer cell death via a p53-independent pathway after radiation
Keywords: PTTG; pituitary-tumor transforming gene; ERK; extracellular signal-regulated kinase; FITC; fluorescein isothiocyanate; PI; propidium iodide; MTT; 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyl tetrazolium bromide; FBS; fetal bovine serum; PBS; phosphate-buffe
Phosphorylation of p53 at serine 15 in A549 pulmonary epithelial cells exposed to vanadate: Involvement of ATM pathway
Keywords: ATM; ataxia telangiectasia mutated; ATR; ATM-Rad3-related protein; DMSO; dimethyl sulfoxide; DNA-PK; DNA-activated protein kinase; DSB; DNA double-strand break; ERK; extracellular signal-regulated protein kinase; HRP; horseradish peroxidase; MAPK; mitogen
SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells
Keywords: TGF; transforming growth factor; MEK1; mitogen-activated protein kinase kinase-1; ERK; extracellular signal-regulated protein kinase.; MEK1; SMAD3; Inflammation; Fibrosis; Airway epithelium; Smooth muscle;
Lithium regulates hippocampal neurogenesis by ERK pathway and facilitates recovery of spatial learning and memory in rats after transient global cerebral ischemia
Keywords: Lithium; Brain ischemia; Neurogenesis; Hippocampus; Learning and memory; ERK
EGFR plays a pivotal role in the regulation of polyamine-dependent apoptosis in intestinal epithelial cells
Keywords: Integrin; Src; Putrescine; EGF; DFMO; ERK; RGDS; IEC-6
Mitogen-activated protein kinases, Erk and p38, phosphorylate and regulate Foxo1
Keywords: Foxo1; Erk; p38; Ets-1; Flk-1; Transcription
Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction
Keywords: hSpry2; Grb2; SH3; ERK; FGFR;
Overexpression of cyclin D1 is associated with elevated levels of MAP kinases, Akt and Pak1 during diethylnitrosamine-induced progressive liver carcinogenesis
Keywords: Hepatocellular carcinoma; Cyclin D1; MAP kinases; Akt and PAK1 kinase; Disruption of G1/S; HCC; hepatocellular carcinoma; DEN; diethylnitrosamine; Rb; retinoblastoma protein; PCNA; proliferation cell nuclear antigen; MAP kinase; mitogen activated protein
EGF receptor transactivation and PI3-kinase mediate stimulation of ERK by α2A-adrenoreceptor in intestinal epithelial cells: A role in wound healing
Keywords: α2-adrenoreceptor; Intestinal epithelium; ERK; EGF receptor; PI3-kinase; Wound healing
Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells
Keywords: Cardiotoxin III; K562 cells; Akt; JNK; ERK; p38 MAPK
Activin acts with nerve growth factor to regulate calcitonin gene-related peptide mRNA in sensory neurons
Keywords: inflammation; neuropeptides; ERK; Smadactivin, activin A; ANOVA, analysis of variance; CFA, complete Freund’s adjuvant; CGRP, calcitonin gene-related peptide; DMSO, dimethyl sulfoxide; DRG, dorsal root ganglion; ERK, extracellular signal-regulated kinase;
The role of ERK signaling in protein hydrogel remodeling by vascular smooth muscle cells
Keywords: Collagen; Fibrin; Smooth muscle cells; ERK; Osteopontin; MMP-2
Protein kinase Cα mediates feedback inhibition of EGF receptor transactivation induced by Gq-coupled receptor agonists
Keywords: DAG; diacylglycerol; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; GPCR; G-protein-coupled receptor; HB-EGF; heparin-bound EGF-like growth factor; MMP; matrix metalloprotease; PDB; phorbo
Hippocampal Mek/Erk signaling mediates extinction of contextual freezing behavior
Keywords: Extinction; Erk; Proteome; Context; Freezing; Hippocampus; Mice
Lysophosphatidic acid induces prostate cancer PC3 cell migration via activation of LPA1, p42 and p38α
Keywords: LPA; lysophosphatidic acid; MAPK; mitogen-activated protein kinases; siRNA; small interfering RNA; PTX; pertussis toxin; PD; PD98059; SB; SB203580; U0; U0126; ERK; extracellular signal-regulated kinase; JNK; c-Jun/N terminal kinases; IGF; insulin-like gro
Cellular neuroscienceExpression of G protein β subunits in rat skeletal muscle after nerve injury: Implication in the regulation of neuregulin signaling
Keywords: G protein; ErbB receptor; MAP kinase; neuromuscular junction; nerve activity; AChR; acetylcholine receptor; Cdk; cyclin-dependent kinase; CGRP; calcitonin gene-related peptide; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; FBS;
Protein phosphatase 2A plays a crucial role in Giardia lamblia differentiation
Keywords: CWP; cyst wall protein; ERK; extracellular signal regulated kinase; ESV; encystation secretory vesicles; PBS; phosphate-buffered saline; PDI; protein disulfide isomerase; PDR; paraflagellar dense rods; PKA; protein kinase A; PP1; protein phosphatase 1; PP
Control of Myf5 activation in adult skeletal myonuclei requires ERK signalling
Keywords: Myf5; Skeletal muscle; ERK; IGF-1; Ca2+; Calcineurin; Calmodulin
Signal transduction pathways associated with ATP-induced proliferation of cell progenitors in the intact embryonic retina
Keywords: P2 receptors; Nucleotides; Proliferation; ERK; Phosphoinositides; Chick retina
A Role for MAP Kinase Signaling in Behavioral Models of Depression and Antidepressant Treatment
Keywords: BDNF; ERK; forced swim; learned helplessness; mouse; tail suspension
Sef-S, an alternative splice isoform of sef gene, inhibits NIH3T3 cell proliferation via a mitogen-activated protein kinases p42 and p44 (ERK1/2)-independent mechanism
Keywords: Sef-S; Sef; Alternative splice; FGF signaling; ERK; Proliferation
Signal transduction mechanisms of CD137 ligand in human monocytes
Keywords: ERK; extracellular signal-regulated kinase; MAPK; mitogen activated protein kinase; MEK; MAP/ERK kinase; PI3-K; Phosphoinositide-3-kinase; PKA; Protein kinase A; PKC; Protein kinase C.; Human; CD137 ligand; Monocytes; Signalling; Signal transduction;
Lipoteichoic acid downregulates FcεRI expression on human mast cells through Toll-like receptor 2
Keywords: Mast cells; basophils; Fc receptors; allergy; β-hex; β-Hexosaminidase; ERK; Extracellular signal-regulated kinase; FITC; Fluorescein isothiocyanate; LTA; Lipoteichoic acid; MC; Mast cell; MFI; Mean fluorescence intensity; NP; Nitrophenylacetyl; ODN; O
Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress
Keywords: Base excision repair; Ribosomal protein S3; ERK; Genotoxic stress; Nuclear translocation
MAP kinase pathways: The first twenty years
Keywords: MAP kinase; ERK; JNK; p38; SAPK; Protein phosphorylation; Protein kinase cascade; Signal transduction; Docking site; Scaffold protein; Transcriptional regulation; Cell fate
FLIP inhibits endothelial cell apoptosis during hyperoxia by suppressing Bax
Keywords: DCFDA; 6-carboxy-2â²,7â²-dichlorodihydroxyfluorescein diacetate-dicarboxymethyl ester; DISC; death-inducing signal complex; DMEM; Dulbecco's modified Eagle's medium; ERK; extracellular regulated kinase; FADD; Fas-associated death domain; FasL; Fas ligan